Adat3 (adenosine deaminase, tRNA-specific 3) - Rat Genome Database

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Gene: Adat3 (adenosine deaminase, tRNA-specific 3) Rattus norvegicus
Analyze
Symbol: Adat3
Name: adenosine deaminase, tRNA-specific 3
RGD ID: 1642417
Description: Predicted to enable catalytic activity and metal ion binding activity. Predicted to contribute to tRNA-specific adenosine-34 deaminase activity. Predicted to be involved in tRNA processing. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with brain abnormalities, poor growth, and dysmorphic facies. Orthologous to human ADAT3 (adenosine deaminase tRNA specific 3); INTERACTS WITH acrylamide; bisphenol A; cadmium dichloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: adenosine deaminase, tRNA-specific 3, TAD3 homolog; adenosine deaminase, tRNA-specific 3, TAD3 homolog (S. cerevisiae); MGC112753; probable inactive tRNA-specific adenosine deaminase-like protein 3; tRNA-specific adenosine deaminase-like protein 3; tRNA-specific adenosine-34 deaminase subunit ADAT3
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr879,759,758 - 9,761,127 (-)NCBIGRCr8
mRatBN7.279,109,070 - 9,113,673 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,101,187 - 9,115,340 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx711,987,333 - 11,988,702 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0713,862,845 - 13,864,214 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0711,728,888 - 11,730,257 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0711,977,285 - 11,981,814 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0712,144,810 - 12,146,179 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4710,619,919 - 10,621,288 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera77,291,257 - 7,292,626 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IEA)
nucleus  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15489334   PMID:15632090  


Genomics

Comparative Map Data
Adat3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr879,759,758 - 9,761,127 (-)NCBIGRCr8
mRatBN7.279,109,070 - 9,113,673 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,101,187 - 9,115,340 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx711,987,333 - 11,988,702 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0713,862,845 - 13,864,214 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0711,728,888 - 11,730,257 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0711,977,285 - 11,981,814 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0712,144,810 - 12,146,179 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4710,619,919 - 10,621,288 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera77,291,257 - 7,292,626 (-)NCBICelera
Cytogenetic Map7q11NCBI
ADAT3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38191,905,399 - 1,913,447 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl191,905,399 - 1,913,447 (+)EnsemblGRCh38hg38GRCh38
GRCh37191,905,398 - 1,913,446 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36191,856,417 - 1,864,446 (+)NCBINCBI36Build 36hg18NCBI36
Celera191,839,500 - 1,847,520 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef191,676,853 - 1,684,944 (+)NCBIHuRef
CHM1_1191,904,960 - 1,913,035 (+)NCBICHM1_1
T2T-CHM13v2.0191,876,716 - 1,884,760 (+)NCBIT2T-CHM13v2.0
Adat3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391080,438,714 - 80,443,488 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1080,438,714 - 80,443,488 (+)EnsemblGRCm39 Ensembl
GRCm39 Ensembl1080,441,855 - 80,451,618 (+)EnsemblGRCm39 Ensembl
GRCm381080,602,880 - 80,607,654 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1080,606,021 - 80,615,784 (+)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl1080,602,880 - 80,607,654 (+)EnsemblGRCm38mm10GRCm38
MGSCv371080,065,625 - 80,070,399 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera1081,620,704 - 81,625,478 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
ADAT3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2206,276,650 - 6,284,607 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1195,507,422 - 5,515,555 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v019910,954 - 912,687 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1191,890,221 - 1,892,044 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl191,890,437 - 1,891,748 (+)Ensemblpanpan1.1panPan2
ADAT3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12057,062,706 - 57,065,492 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2056,856,950 - 56,861,365 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02057,794,907 - 57,799,327 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12056,851,736 - 56,856,137 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02057,331,731 - 57,336,147 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02057,532,745 - 57,537,165 (-)NCBIUU_Cfam_GSD_1.0
Adat3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118216,723,639 - 216,730,690 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365881,108,790 - 1,111,287 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADAT3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl276,628,633 - 76,634,262 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1276,628,626 - 76,634,282 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2277,333,682 - 77,339,154 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADAT3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.161,695,897 - 1,705,718 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660817,082,891 - 7,090,329 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Adat3
9 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000095368   ⟹   ENSRNOP00000089590
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl79,101,187 - 9,115,340 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000106355   ⟹   ENSRNOP00000077221
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl79,101,502 - 9,114,507 (-)Ensembl
RefSeq Acc Id: NM_001103361   ⟹   NP_001096831
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,759,758 - 9,761,127 (-)NCBI
mRatBN7.279,109,073 - 9,110,442 (-)NCBI
Rnor_6.0711,977,285 - 11,978,654 (-)NCBI
Rnor_5.0712,144,810 - 12,146,179 (-)NCBI
RGSC_v3.4710,619,919 - 10,621,288 (-)RGD
Celera77,291,257 - 7,292,626 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001096831 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH93394 (Get FASTA)   NCBI Sequence Viewer  
  EDL89262 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000077221.1
  ENSRNOP00000089590.1
GenBank Protein Q561R2 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001096831   ⟸   NM_001103361
- UniProtKB: Q561R2 (UniProtKB/Swiss-Prot),   A6K8J2 (UniProtKB/TrEMBL),   A0A8I5XVX2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000089590   ⟸   ENSRNOT00000095368
RefSeq Acc Id: ENSRNOP00000077221   ⟸   ENSRNOT00000106355
Protein Domains
CMP/dCMP-type deaminase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q561R2-F1-model_v2 AlphaFold Q561R2 1-349 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1642417 AgrOrtholog
BioCyc Gene G2FUF-34954 BioCyc
Ensembl Genes ENSRNOG00000063591 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000095368.1 UniProtKB/Swiss-Prot
  ENSRNOT00000106355.1 UniProtKB/TrEMBL
Gene3D-CATH Cytidine Deaminase, domain 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7388692 IMAGE-MGC_LOAD
InterPro CMP_dCMP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cytidine_deaminase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:100125374 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:112753 IMAGE-MGC_LOAD
NCBI Gene 100125374 ENTREZGENE
PANTHER CYTOSINE DEAMINASE FAMILY MEMBER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INACTIVE TRNA-SPECIFIC ADENOSINE DEAMINASE-LIKE PROTEIN 3-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam dCMP_cyt_deam_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Adat3 PhenoGen
PROSITE CYT_DCMP_DEAMINASES_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000063591 RatGTEx
Superfamily-SCOP SSF53927 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5XVX2 ENTREZGENE, UniProtKB/TrEMBL
  A6K8J2 ENTREZGENE, UniProtKB/TrEMBL
  ADAT3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-28 Adat3  adenosine deaminase, tRNA-specific 3  Adat3  adenosine deaminase, tRNA-specific 3, TAD3 homolog (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-18 Adat3  adenosine deaminase, tRNA-specific 3, TAD3 homolog (S. cerevisiae)  Adat3  adenosine deaminase, tRNA-specific 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-09-15 Adat3  adenosine deaminase, tRNA-specific 3      Symbol and Name status set to provisional 70820 PROVISIONAL