Hpse2 (heparanase 2) - Rat Genome Database

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Gene: Hpse2 (heparanase 2) Mus musculus
Analyze
Symbol: Hpse2
Name: heparanase 2
RGD ID: 1621195
MGI Page MGI
Description: Predicted to enable heparan sulfate proteoglycan binding activity. Acts upstream of or within extracellular matrix organization and positive regulation of cell population proliferation. Predicted to be located in extracellular region and membrane. Predicted to be active in extracellular matrix and extracellular space. Is expressed in bladder; brain; metanephros; and ureter. Used to study urofacial syndrome. Human ortholog(s) of this gene implicated in urofacial syndrome. Orthologous to human HPSE2 (heparanase 2 (inactive)).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Gm968; heparanase-2; Hpa2; inactive heparanase-2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391942,774,980 - 43,376,913 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1942,774,978 - 43,376,794 (-)EnsemblGRCm39 Ensembl
GRCm381942,786,541 - 43,388,476 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1942,786,539 - 43,388,355 (-)EnsemblGRCm38mm10GRCm38
MGSCv371942,863,085 - 43,462,801 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361942,841,906 - 43,441,622 (-)NCBIMGSCv36mm8
MGSCv361942,676,998 - 43,277,483 (-)NCBIMGSCv36mm8
Celera1943,584,218 - 44,179,795 (-)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1936.57NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
2. Mouse MP Annotation Import Pipeline RGD automated import pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14610273   PMID:14691545   PMID:16141072   PMID:16141073   PMID:20560210   PMID:21873635  
PMID:25145936   PMID:25510506   PMID:30885509   PMID:37180718   PMID:37491420  


Genomics

Comparative Map Data
Hpse2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391942,774,980 - 43,376,913 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1942,774,978 - 43,376,794 (-)EnsemblGRCm39 Ensembl
GRCm381942,786,541 - 43,388,476 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1942,786,539 - 43,388,355 (-)EnsemblGRCm38mm10GRCm38
MGSCv371942,863,085 - 43,462,801 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361942,841,906 - 43,441,622 (-)NCBIMGSCv36mm8
MGSCv361942,676,998 - 43,277,483 (-)NCBIMGSCv36mm8
Celera1943,584,218 - 44,179,795 (-)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1936.57NCBI
HPSE2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381098,457,077 - 99,315,951 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1098,457,077 - 99,235,862 (-)EnsemblGRCh38hg38GRCh38
GRCh3710100,216,834 - 100,995,632 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610100,208,867 - 100,985,609 (-)NCBINCBI36Build 36hg18NCBI36
Build 3410100,208,864 - 100,985,609NCBI
Celera1093,953,460 - 94,732,450 (-)NCBICelera
Cytogenetic Map10q24.2NCBI
HuRef1094,130,091 - 94,622,164 (-)NCBIHuRef
HuRef1093,841,617 - 94,106,699 (-)NCBIHuRef
CHM1_110100,498,701 - 101,277,572 (-)NCBICHM1_1
T2T-CHM13v2.01099,337,053 - 100,197,827 (-)NCBIT2T-CHM13v2.0
Hpse2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81251,532,149 - 252,231,316 (-)NCBIGRCr8
mRatBN7.21241,582,904 - 242,284,348 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1241,583,187 - 242,246,118 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1249,730,681 - 250,396,023 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01256,427,848 - 257,093,195 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01249,080,851 - 249,746,182 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01262,020,903 - 263,138,299 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01270,576,436 - 270,580,047 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01269,475,568 - 270,128,189 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41247,458,939 - 248,100,231 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11247,958,907 - 247,971,603 (+)NCBI
Celera1237,417,175 - 238,067,548 (-)NCBICelera
Cytogenetic Map1q54NCBI
Hpse2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555074,445,772 - 5,205,957 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555074,442,677 - 5,205,976 (-)NCBIChiLan1.0ChiLan1.0
HPSE2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28110,363,078 - 111,143,128 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110110,368,396 - 111,148,445 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01095,071,571 - 95,851,896 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11098,566,705 - 99,344,205 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1098,592,019 - 99,344,132 (-)Ensemblpanpan1.1panPan2
HPSE2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12811,584,440 - 12,215,732 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2811,585,807 - 12,215,614 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2811,766,981 - 12,399,809 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02811,909,883 - 12,161,577 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2811,912,217 - 12,683,674 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12811,593,608 - 12,230,470 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02811,630,471 - 12,261,439 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02811,770,213 - 12,402,804 (-)NCBIUU_Cfam_GSD_1.0
Hpse2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721334,735,574 - 35,362,965 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936636774,778 - 1,399,702 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936636774,705 - 1,402,009 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HPSE2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14109,764,170 - 110,469,141 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114109,764,511 - 110,469,064 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214119,262,145 - 119,752,959 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103216367
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1991,616,277 - 92,346,206 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604852,670,244 - 52,785,944 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hpse2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473710,058,787 - 10,976,525 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473710,055,408 - 10,976,525 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hpse2
17615 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:182
Count of miRNA genes:172
Interacting mature miRNAs:178
Transcripts:ENSMUST00000099428
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301228Iba4_minduction of brown adipocytes 4 (mouse)Not determined19930571543305821Mouse
1302019Pgia23_mproteoglycan induced arthritis 23 (mouse)Not determined19978745343787602Mouse
14928311Manh85_mmandible shape 85 (mouse)191191478945914789Mouse
10413881Moe2_mmodifier of epilepsy 2 (mouse)191492301648923138Mouse
1301336Alcp23_malcohol preference locus 23 (mouse)Not determined191591260749912719Mouse
1301633Alcp24_malcohol preference locus 24 (mouse)Not determined191591260749912719Mouse
1302063Eae19_mexperimental allergic encephalomyelitis 19 (mouse)Not determined191829516252295381Mouse
1302004Lfp2_mlong free running period 2 (mouse)Not determined191829516252295381Mouse
4142343Moen2_mmodifier of engrailed QTL 2 (mouse)Not determined192023431454234461Mouse
10412251Mnp_mmodifier of Niemann Pick type C1 (mouse)Not determined192023431454234461Mouse
4141659Pbwg20_mpostnatal body weight growth 20 (mouse)Not determined192137870555378928Mouse
1558876W3q14_mweight 3 weeks QTL 14 (mouse)Not determined192231332653911504Mouse
12790634Ebm1_mEpidermolysis Bullosa modifier 1 (mouse)192498843958988439Mouse
1301451Ath16_matherosclerosis 16 (mouse)Not determined192542691759427005Mouse
13506250Renmq1_mrenal mercury accumulation QTL 1 (mouse)192738559461385705Mouse
4141138Femwf11_mfemur work to failure 11 (mouse)Not determined2814034861420004Mouse
1300683Fembm7_mfemoral bone morphometry 7 (mouse)Not determined193014122461420004Mouse
1301942Pas13_mpulmonary adenoma susceptibility 13 (mouse)Not determined193014123161420004Mouse
1301410Cd8mts6_mCD8 memory T cell subset 6 (mouse)Not determined193014123161420004Mouse
1300856Nobq2_mNew Zealand obese QTL 2 (mouse)Not determined193089788061420004Mouse
1301741Lith2_mlithogenic gene 2 (mouse)Not determined193299215861420004Mouse
1301639Stnn_mstriatal neuron number (mouse)Not determined193395195261420004Mouse
4141019Tgq29_mtriglyceride QTL 29 (mouse)Not determined3459678661420004Mouse
1301479Sluc1_msusceptibility to lung cancer 1 (mouse)Not determined193601694446761521Mouse
1302170Tanidd1_mtally ho associated non-insulin dependednt diabetes mellitus 1 (mouse)Not determined193675259761420004Mouse
13504736Ifvrq6_minfluenza virus resistance QTL 6 (mouse)193690291044913949Mouse
4141650Chldq9_mcholesterol and HDL QTL 9 (mouse)Not determined193788298261420004Mouse
1301466T2dm2_mtype 2 diabetes mellitus 2 (mouse)Not determined193837605061420004Mouse
1302104Lfp1_mlong free running period 1 (mouse)Not determined193918406461420004Mouse
10043896Bw21_mbody weight QTL 21 (mouse)Not determined193959606661420004Mouse
1300585Pgia12_mproteoglycan induced arthritis 12 (mouse)Not determined194258685961420004Mouse

Markers in Region
MHAa70e12.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381942,858,267 - 42,858,464UniSTSGRCm38
MGSCv371942,932,757 - 42,932,954UniSTSGRCm37
Celera1943,653,692 - 43,653,889UniSTS
Cytogenetic Map19C3UniSTS
Whitehead/MRC_RH19408.55UniSTS
UniSTS:237943  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381943,280,846 - 43,281,051UniSTSGRCm38
MGSCv371943,355,336 - 43,355,541UniSTSGRCm37
Celera1944,072,343 - 44,072,548UniSTS
Cytogenetic Map19C3UniSTS
Cytogenetic Map9FUniSTS
cM Map971.1UniSTS
AI414725  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381943,283,769 - 43,283,855UniSTSGRCm38
GRCm389123,697,971 - 123,698,057UniSTSGRCm38
MGSCv379123,607,089 - 123,607,175UniSTSGRCm37
MGSCv371943,358,259 - 43,358,345UniSTSGRCm37
Celera1944,075,265 - 44,075,351UniSTS
Celera9124,154,204 - 124,154,290UniSTS
Cytogenetic Map19C3UniSTS
Cytogenetic Map9FUniSTS
cM Map971.1UniSTS
cM Map971.2UniSTS
Whitehead/MRC_RH19431.41UniSTS
D19Dcr32  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381942,975,388 - 42,975,491UniSTSGRCm38
Celera1943,773,050 - 43,773,153UniSTS
Cytogenetic Map19C3UniSTS
cM Map19 UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000099428   ⟹   ENSMUSP00000097026
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1942,774,978 - 43,376,794 (-)Ensembl
GRCm38.p6 Ensembl1942,786,539 - 43,388,355 (-)Ensembl
RefSeq Acc Id: ENSMUST00000236823
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1943,282,640 - 43,376,693 (-)Ensembl
GRCm38.p6 Ensembl1943,294,201 - 43,388,254 (-)Ensembl
RefSeq Acc Id: ENSMUST00000238153
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1942,897,023 - 43,212,128 (-)Ensembl
GRCm38.p6 Ensembl1942,908,584 - 43,223,689 (-)Ensembl
RefSeq Acc Id: NM_001081257   ⟹   NP_001074726
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391942,774,980 - 43,376,800 (-)NCBI
GRCm381942,788,595 - 43,388,355 (-)NCBI
MGSCv371942,863,085 - 43,462,801 (-)RGD
Celera1943,584,218 - 44,179,839 (-)ENTREZGENE
cM Map19 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006527214   ⟹   XP_006527277
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391942,774,980 - 43,376,894 (-)NCBI
GRCm381942,786,541 - 43,388,455 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011247294   ⟹   XP_011245596
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391942,889,912 - 43,376,908 (-)NCBI
GRCm381942,901,473 - 43,388,469 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011247295   ⟹   XP_011245597
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391942,774,980 - 43,376,537 (-)NCBI
GRCm381942,786,541 - 43,388,098 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004940157
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391942,897,058 - 43,376,913 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001074726   ⟸   NM_001081257
- Peptide Label: precursor
- UniProtKB: B2RY83 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006527277   ⟸   XM_006527214
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_011245597   ⟸   XM_011247295
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_011245596   ⟸   XM_011247294
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSMUSP00000097026   ⟸   ENSMUST00000099428

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2RY83-F1-model_v2 AlphaFold B2RY83 1-592 view protein structure

Promoters
RGD ID:13679536
Promoter ID:EPDNEW_M23918
Type:initiation region
Name:Hpse2_1
Description:Mus musculus heparanase 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381943,388,298 - 43,388,358EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2685814 AgrOrtholog
Ensembl Genes ENSMUSG00000074852 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000099428 ENTREZGENE
  ENSMUST00000099428.5 UniProtKB/Swiss-Prot
Gene3D-CATH Glycosidases UniProtKB/Swiss-Prot
InterPro Glyco_hydro_79 UniProtKB/Swiss-Prot
  Glycoside_hydrolase_SF UniProtKB/Swiss-Prot
KEGG Report mmu:545291 UniProtKB/Swiss-Prot
MGD MGI:2685814 ENTREZGENE
NCBI Gene 545291 ENTREZGENE
PANTHER HEPARANASE UniProtKB/Swiss-Prot
  INACTIVE HEPARANASE-2 UniProtKB/Swiss-Prot
Pfam Glyco_hydro_79n UniProtKB/Swiss-Prot
PhenoGen Hpse2 PhenoGen
Superfamily-SCOP SSF51445 UniProtKB/Swiss-Prot
UniProt B2RY83 ENTREZGENE, UniProtKB/Swiss-Prot