Gene: Cbfa2t2 (core-binding factor, runt domain, alpha subunit 2, translocated to, 2 (human))
Mus musculus
Symbol:
Cbfa2t2
Name:
core-binding factor, runt domain, alpha subunit 2, translocated to, 2 (human)
Description:
ENCODES a protein that exhibits transcription corepressor activity; INVOLVED IN epithelial cell differentiation; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; ASSOCIATED WITH abnormal intestinal enteroendocrine cell morphology; abnormal intestinal epithelium morphology; abnormal intestinal goblet cell morphology; FOUND IN nucleus (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; benzo[a]pyrene; choline
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
A430091M07; C330013D05Rik; CBFA2T2 identified gene homolog; Cbfa2t2h; core-binding factor runt domain alpha subunit 2 translocated to 2 homolog; core-binding factor, runt domain, alpha subunit 2, translocated to, 2 homolog; MTG8-like protein; MTG8-related protein 1; MTGR1; OTTMUSP00000016820; OTTMUSP00000016821; OTTMUSP00000016822; protein CBFA2T2
Orthologs:
Homo sapiens : CBFA2T2
(core-binding factor, runt domain, alpha subunit 2; translocated to, 2)
HGNC
Rattus norvegicus : Cbfa2t2
(core-binding factor, runt domain, alpha subunit 2; translocated to, 2)
Related Pseudogenes:
Cbfa2t2-ps1
Latest Assembly:
Mouse Genome Assembly Build 37
Position:
Map Chr Position Strand Source Mouse Genome Assembly GRCm38 2 154,436,484 - 154,539,356 + NCBI Mouse cM Map 2 + NCBI Mouse Celera Assembly 2 160,348,902 - 160,453,695 + NCBI Mouse Genome Assembly Build 37 2 154,262,220 - 154,365,092 + NCBI Mouse Genome Assembly Build 36.1 2 154,262,254 - 154,365,092 + NCBI Mouse Cytogenetic Map 2 C3.2 NCBI
Model
Gene Ontology Annotations
Biological Process
epithelial cell differentiation IMP MGI:MGI:3607923 2290270 MGI:MGI:3607021|PMID:16227606 MGI MGI:MGI:3607021 PMID:16227606 negative regulation of transcription, DNA-dependent IDA 2290270 MGI:MGI:3607021|PMID:16227606 MGI MGI:MGI:3607021 PMID:16227606 positive regulation of neuron projection development ISO UniProtKB:O43439 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 positive regulation of transcription from RNA polymerase II promoter IGI MGI:MGI:1338013|MGI:MGI:98480|MGI:MGI:98510 2290270 MGI:MGI:4412329|PMID:19799863 MGI MGI:MGI:4412329 PMID:19799863 regulation of RNA biosynthetic process ISO UniProtKB:O43439 2290270 MGI:MGI:4834177 GOC MGI:MGI:4834177 regulation of transcription, DNA-dependent IEA InterPro:IPR003894 2290270 MGI:MGI:2152098 UniProtKB MGI:MGI:2152098
1300871 Mob5_m multigenic obesity 5 (mouse) Not determined 2 65277459 162502742 Mouse 5491197 Mobq5_m multigenic obesity QTL 5 (mouse) Not determined 2 65277459 162502742 Mouse 1301618 Bglu1_m blood glucose level 1 (mouse) Not determined 2 117938185 174308571 Mouse 1300798 Actre3_m activity response to ethanol 3 (mouse) Not determined 2 121125171 155125370 Mouse 1300676 Prdt2_m prion disease incubation time 2 (mouse) Not determined 2 121731402 181608066 Mouse 1301294 Hrtfm5_m heart failure modifier 5 (mouse) Not determined 2 122866831 156866947 Mouse 1301822 Pgia2_m proteoglycan induced arthritis 2 (mouse) Not determined 2 123921127 157921240 Mouse 1357780 Alcrsp2_m alcohol response 2 (mouse) Not determined 2 125515683 159515951 Mouse 1302143 Bwq5_m body weight (mouse) Not determined 2 127647835 161647934 Mouse 1301031 Bdln3_m body length 3 (mouse) Not determined 2 127647835 161647934 Mouse 1357764 Athla1_m atherosclerotic lesion area 1 (mouse) Not determined 2 131505908 165505991 Mouse 1301066 Otx2m2_m orthodenticle homolog 2 (Drosophila) modifier 2 (mouse) Not determined 2 131684054 165684193 Mouse 4141083 Wg6_m weight gain in high growth mice 6 (mouse) Not determined 2 132007975 166008146 Mouse 1301961 Bts1_m bladder tumor susceptibility 1 (mouse) Not determined 2 132007975 166008146 Mouse 1301280 Bglq2_m body growth late QTL 2 (mouse) Not determined 2 134624757 168624945 Mouse 4141740 Vmmt3_m vertebral morphology and mechanical traits 3 (mouse) Not determined 2 135683037 169683177 Mouse 1301907 Rends_m renal disease susceptibility (mouse) Not determined 2 135683037 169683177 Mouse 4141703 Chlq13_m circulating hormone level QTL 13 (mouse) Not determined 2 135683037 169683177 Mouse 1301865 Hdlq19_m HDL QTL 19 (mouse) Not determined 2 135683037 169683177 Mouse 1302164 Psl2_m promotion susceptibility QTL 2 (mouse) Not determined 2 137338345 171338483 Mouse 4142019 Swq6_m spleen weight QTL 6 (mouse) Not determined 2 138693152 172693260 Mouse 4141980 Tcq2_m total cholesterol QTL 2 (mouse) Not determined 2 138693152 172693260 Mouse 1558815 Gstml_m gestational survival modifier locus (mouse) Not determined 2 138950416 172950545 Mouse 1300846 Pbwg11_m postnatal body weight growth 11 (mouse) Not determined 2 138950416 172950545 Mouse 4142387 Bdlnq7_m body length QTL 7 (mouse) Not determined 2 143286681 177286824 Mouse 1558972 Erars1_m erosive arthritis susceptibility 1 (mouse) Not determined 2 145170578 179170702 Mouse 1300806 Aod4_m autoimmune ovarian dysgenesis 4 (mouse) Not determined 2 145212535 179212657 Mouse 4142211 Nilac3_m nicotine induced locomotor activity 3 (mouse) Not determined 2 148648473 181880033 Mouse 4141170 Ua1_m urinary albuminuria 1 (mouse) Not determined 2 148648473 181880033 Mouse 1558917 Gct8_m granulosa cell tumorigenesis 8 (mouse) Not determined 2 149220487 181880033 Mouse 1300751 Bdt1_m bone density traits 1 (mouse) Not determined 2 149972482 181880033 Mouse 1301085 Lrnx10_m learning-contextual 10 (mouse) Not determined 2 150195801 181880033 Mouse 4142450 Lmr16_m leishmaniasis resistance 16 (mouse) Not determined 2 150195801 181880033 Mouse 4141997 Bmgr3_m bone marrow graft rejection 3 (mouse) Not determined 2 150857642 181880033 Mouse 1301019 Bmd6_m bone mineral density 6 (mouse) Not determined 2 151761877 181880033 Mouse 1558867 Gnf3_m growth and fatness 3 (mouse) Not determined 2 152101357 169683177 Mouse 4141098 Hemq2_m hematocrit QTL 2 (mouse) Not determined 2 152101357 181880033 Mouse 1301270 Dloc1_m duration of locomotor activity 1 (mouse) Not determined 2 152101357 181880033 Mouse 1301354 Hcs4_m hepatocarcinogenesis susceptibility 4 (mouse) Not determined 2 153958112 181880033 Mouse