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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17beta-estradiol | increases expression | EXP | | 6480464 | Estradiol results in increased expression of KISS1 mRNA | CTD | PMID:15919741 | 17beta-estradiol | decreases expression | EXP | | 6480464 | Estradiol results in decreased expression of KISS1 mRNA | CTD | PMID:15919741 | 2,2',4,4',5,5'-hexachlorobiphenyl | multiple interactions | ISO | RGD:727850 | 6480464 | [2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of KISS1 protein | CTD | PMID:21190954 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of KISS1 mRNA | CTD | PMID:21167638 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:727850 | 6480464 | Tetrachlorodibenzodioxin affects the expression of KISS1 mRNA | CTD | PMID:22298810 | 2,4,6-trinitrotoluene | affects expression | ISO | RGD:727850 | 6480464 | Trinitrotoluene affects the expression of KISS1 mRNA | CTD | PMID:21346803 | 2,4-dinitrotoluene | affects expression | ISO | RGD:727850 | 6480464 | 2,4-dinitrotoluene affects the expression of KISS1 mRNA | CTD | PMID:21346803 | 3,4-methylenedioxymethamphetamine | increases expression | EXP | | 6480464 | N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of KISS1 mRNA | CTD | PMID:20188158 | 5-aza-2'-deoxycytidine | increases expression | ISO | RGD:1352127 | 6480464 | decitabine results in increased expression of KISS1 mRNA | CTD | PMID:16367923 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of KISS1 mRNA | CTD | PMID:21182934 | bisphenol A | decreases expression | ISO | RGD:727850 | 6480464 | bisphenol A results in decreased expression of KISS1 protein | CTD | PMID:19442818 | bisphenol A | decreases expression | ISO | RGD:727850 | 6480464 | bisphenol A results in decreased expression of KISS1 mRNA | CTD | PMID:19106226 | bisphenol A | decreases expression | ISO | RGD:727850 | 6480464 | bisphenol A results in decreased expression of KISS1 mRNA | CTD | PMID:22101008 PMID:19106226 | bisphenol A | decreases expression | ISO | RGD:727850 | 6480464 | bisphenol A results in decreased expression of KISS1 mRNA | CTD | PMID:19106226 PMID:22101008 | calcium atom | multiple interactions | EXP | | 6480464 | 2-aminoethyl diphenylborinate inhibits the reaction [[KISS1 protein results in increased activity of KISS1R protein] which results in increased abundance of Calcium]; more ... | CTD | PMID:18948403 | calcium(0) | multiple interactions | EXP | | 6480464 | 2-aminoethyl diphenylborinate inhibits the reaction [[KISS1 protein results in increased activity of KISS1R protein] which results in increased abundance of Calcium]; more ... | CTD | PMID:18948403 | cisplatin | increases response to substance | ISO | RGD:1352127 | 6480464 | KISS1 mRNA results in increased susceptibility to Cisplatin | CTD | PMID:21383688 | flufenamic acid | multiple interactions | EXP | | 6480464 | Flufenamic Acid inhibits the reaction [[KISS1 protein results in increased activity of KISS1R protein] which results in increased abundance of Calcium] | CTD | PMID:18948403 | genistein | decreases expression | ISO | RGD:727850 | 6480464 | Genistein results in decreased expression of KISS1 protein | CTD | PMID:20951797 | methotrexate | decreases expression | ISO | RGD:1352127 | 6480464 | Methotrexate results in decreased expression of KISS1 mRNA | CTD | PMID:17400583 | methoxychlor | increases expression | ISO | RGD:727850 | 6480464 | Methoxychlor results in increased expression of KISS1 mRNA | CTD | PMID:22016562 | tetrodotoxin | multiple interactions | EXP | | 6480464 | Tetrodotoxin inhibits the reaction [[KISS1 protein results in increased activity of KISS1R protein] which results in increased abundance of Calcium]; more ... | CTD | PMID:18948403 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsPhenotype AnnotationsDisease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Phenotype Annotations
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References - curated| 1. |
Dhillo WS, etal., Am J Physiol Endocrinol Metab. 2006 Nov;291(5):E878-84. Epub 2006 Jun 6. |
| 2. |
Farina A, etal., Prenat Diagn. 2006 Dec;26(12):1115-20. |
| 3. |
Jiang T, etal., Zhonghua Zhong Liu Za Zhi. 2005 Apr;27(4):229-31. |
| 4. |
Jiang Y, etal., Clin Exp Metastasis. 2005;22(5):369-76. |
| 5. |
Marot D, etal., Endocr Relat Cancer. 2007 Sep;14(3):691-702. |
| 6. |
Martin TA, etal., Clin Exp Metastasis. 2005;22(6):503-11. |
| 7. |
Nicolle G, etal., Ann Oncol. 2007 Mar;18(3):605-7. Epub 2006 Dec 12. |
| 8. |
Prentice LM, etal., BMC Med. 2007 Nov 15;5:33. |
| 9. |
RGD automated import pipeline |
| 10. |
RGD automated import pipeline for gene-chemical interactions |
| 11. |
Sanchez-Carbayo M, etal., Am J Pathol. 2003 Feb;162(2):609-17. |
| 12. |
Stark AM, etal., J Cancer Res Clin Oncol. 2005 Mar;131(3):191-8. Epub 2004 Dec 8. |
References - uncurated| PubMed | 12359743 |
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RGD Disease Portals| Kiss1 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Kiss1 (Mus musculus) |
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| KISS1 (Homo sapiens) |
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| Kiss1 (Rattus norvegicus) |
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Position Markers| Kiss1 |
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QTLs in Region (Mouse Genome Assembly Build 37)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_178260 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AA023297 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHY01011070 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AB162440 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AB666166 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AC024068 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AC068906 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF472576 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC117046 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC119348 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH466520 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_178260 | |||||||||||||||||||||||||
| RefSeq Status: | VALIDATED | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_839991 | |||||||||||||||||||||||||
| Peptide Label: | precursor | |||||||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_839991 | (Get FASTA) |
| GenBank Protein | AAI17047 | (Get FASTA) |
| AAI19349 | (Get FASTA) | |
| AAP13356 | (Get FASTA) | |
| BAD36756 | (Get FASTA) | |
| BAM11250 | (Get FASTA) | |
| EDL39651 | (Get FASTA) | |
| Q6Y4S4 | (Get FASTA) |
External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSMUSG00000091251 | ENTREZGENE |
| Ensembl Protein | ENSMUSP00000136746 | ENTREZGENE |
| Ensembl Transcript | ENSMUST00000178033 | ENTREZGENE |
| Entrez Gene | 280287 | ENTREZGENE |
| Germonline | ENSMUSG00000041717 | |
| HomoloGene Group ID | 1701 | ENTREZGENE |
| InterPro | Metastasis-suppressor_KiSS-1 | UniProtKB/Swiss-Prot |
| IPI | IPI00265221 | UniProtKB/Swiss-Prot |
| IPI00553415 | UniProtKB/Swiss-Prot | |
| KEGG Report | mmu:280287 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGD | MGI:2663985 | ENTREZGENE |
| ProDom | Metastasis-suppressor_KiSS-1 | UniProtKB/Swiss-Prot |
| UniGene | Mm.458301 | ENTREZGENE |
| UniProt | I0J0X7_MOUSE | UniProtKB/TrEMBL |
| KISS1_MOUSE | UniProtKB/Swiss-Prot |
| More on Kiss1 | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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MGI Report |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 1618007 |
| Created: | 2007-05-01 |
| Species: | Mus musculus |
| Last Modified: | 2013-04-23 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.