Gene: Fance (Fanconi anemia, complementation group E)  Mus musculus
Symbol: Fance
Name: Fanconi anemia, complementation group E
Description: This gene encodes the complementation group E subunit of the multimeric Fanconi anemia (FA) nuclear complex composed of proteins encoded by over ten Fanconi anemia complementation (FANC) group genes: FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The FA complex is necessary for protection against DNA damage. This gene product is required for the nuclear accumulation of FANCC and provides a critical bridge between the FA complex and FANCD2. Defects in the related human gene are a cause of Fanconi anemia, a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. Translation of this protein is initiated at a non-AUG (CUG) start codon, which is inferred from the related human gene and the notion that this protein is functionally indispensable. Multiple transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2009]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 2810451D06Rik; AI415634; AW209126; Fanconi anemia, complementation group E; OTTMUSP00000027312
Orthologs: Homo sapiens : FANCE (Fanconi anemia, complementation group E)  HGNC
Rattus norvegicus : Fance (Fanconi anemia, complementation group E)
Latest Assembly: Mouse Genome Assembly Build 37
Position:
MapChrPositionStrandSource
Mouse Genome Assembly GRCm381728,313,530 - 28,326,574+NCBI
Mouse cM Map17 +NCBI
Mouse Celera Assembly1728,867,357 - 28,880,396+NCBI
Mouse Genome Assembly Build 371728,450,475 - 28,463,519+NCBI
Mouse Genome Assembly Build 36.11728,450,325 - 28,463,518+NCBI
Mouse Cytogenetic Map17 A3.3 NCBI
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Sequence

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Nomenclature History
  
More on Fance
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RGD Object Information
RGD ID: 1614308
Created: 2007-04-30
Species: Mus musculus
Last Modified: 2013-02-27
Status: ACTIVE



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