KRT72 (keratin 72) - Rat Genome Database

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Gene: KRT72 (keratin 72) Homo sapiens
Analyze
Symbol: KRT72
Name: keratin 72
RGD ID: 1605869
HGNC Page HGNC:28932
Description: Predicted to be a structural constituent of skin epidermis. Predicted to be involved in intermediate filament organization and keratinization. Located in extracellular exosome.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: CK-72; cytokeratin-72; K6irs; K6IRS2; K72; keratin 6, inner root sheath, 2; keratin 72, type II; keratin protein K6irs; keratin, type II cytoskeletal 72; keratin-72; KRT6; KRT6IRS2; MGC142246; type II inner root sheath-specific keratin-K6irs2; type-II keratin Kb35
RGD Orthologs
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381252,585,589 - 52,602,953 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1252,585,589 - 52,601,538 (-)EnsemblGRCh38hg38GRCh38
GRCh371252,979,373 - 52,995,247 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361251,265,640 - 51,281,559 (-)NCBINCBI36Build 36hg18NCBI36
Celera1252,625,614 - 52,641,566 (-)NCBICelera
Cytogenetic Map12q13.13NCBI
HuRef1250,023,222 - 50,039,177 (-)NCBIHuRef
CHM1_11252,946,225 - 52,962,175 (-)NCBICHM1_1
T2T-CHM13v2.01252,550,180 - 52,567,550 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9630597   PMID:11703281   PMID:12477932   PMID:12648212   PMID:14702039   PMID:16831889   PMID:17388661   PMID:20189848   PMID:21873635   PMID:22553810   PMID:23533145   PMID:25277244  
PMID:25416956   PMID:26496610   PMID:26618866   PMID:27240462   PMID:27591049   PMID:29507755   PMID:29845934   PMID:29859926   PMID:29911972   PMID:31253590   PMID:31862882   PMID:32041737  
PMID:32168425   PMID:32296183   PMID:33961781   PMID:34650049   PMID:36168627   PMID:36526897  


Genomics

Comparative Map Data
KRT72
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381252,585,589 - 52,602,953 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1252,585,589 - 52,601,538 (-)EnsemblGRCh38hg38GRCh38
GRCh371252,979,373 - 52,995,247 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361251,265,640 - 51,281,559 (-)NCBINCBI36Build 36hg18NCBI36
Celera1252,625,614 - 52,641,566 (-)NCBICelera
Cytogenetic Map12q13.13NCBI
HuRef1250,023,222 - 50,039,177 (-)NCBIHuRef
CHM1_11252,946,225 - 52,962,175 (-)NCBICHM1_1
T2T-CHM13v2.01252,550,180 - 52,567,550 (-)NCBIT2T-CHM13v2.0
Krt72
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915101,684,607 - 101,694,955 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15101,684,607 - 101,694,895 (-)EnsemblGRCm39 Ensembl
GRCm3815101,776,172 - 101,786,520 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15101,776,172 - 101,786,460 (-)EnsemblGRCm38mm10GRCm38
MGSCv3715101,606,991 - 101,616,889 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3615101,604,594 - 101,614,492 (-)NCBIMGSCv36mm8
Celera15103,930,270 - 103,940,118 (-)NCBICelera
Cytogenetic Map15F2NCBI
cM Map1557.02NCBI
Krt72
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87134,789,082 - 134,799,547 (-)NCBIGRCr8
mRatBN7.27132,910,379 - 132,920,844 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7132,910,613 - 132,920,783 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7134,672,553 - 134,682,368 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07136,902,076 - 136,911,891 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07136,872,803 - 136,883,237 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07143,382,378 - 143,392,818 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7143,382,606 - 143,392,777 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07141,180,801 - 141,190,972 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47140,470,238 - 140,480,408 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17140,546,674 - 140,556,845 (-)NCBI
Celera7129,351,245 - 129,361,414 (-)NCBICelera
Cytogenetic Map7q36NCBI
KRT72
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21041,591,828 - 41,611,020 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11241,588,591 - 41,607,783 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01236,162,451 - 36,178,580 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11236,940,225 - 36,956,184 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1236,940,225 - 36,956,184 (+)Ensemblpanpan1.1panPan2
KRT72
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1272,494,944 - 2,506,763 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2743,744,125 - 43,759,027 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0272,493,368 - 2,508,241 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl272,493,368 - 2,505,132 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1272,511,073 - 2,525,926 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0272,496,243 - 2,511,141 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02744,145,818 - 44,157,386 (-)NCBIUU_Cfam_GSD_1.0
Krt72
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494563,156,355 - 63,166,544 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365129,998,309 - 10,008,475 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365129,998,309 - 10,008,475 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KRT72
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl517,936,800 - 17,948,937 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1517,936,380 - 17,948,980 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2518,383,880 - 18,397,773 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103238360
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11148,727,867 - 48,746,096 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1148,728,261 - 48,743,722 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037197,327,973 - 197,344,050 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Krt72
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624904724,718 - 735,590 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624904724,374 - 735,590 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in KRT72
29 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_080747.2(KRT72):c.871G>A (p.Asp291Asn) single nucleotide variant Malignant melanoma [RCV000070046] Chr12:52591556 [GRCh38]
Chr12:52985340 [GRCh37]
Chr12:51271607 [NCBI36]
Chr12:12q13.13		 not provided
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3 copy number gain See cases [RCV000139555] Chr12:121271..133196807 [GRCh38]
Chr12:282465..133773393 [GRCh37]
Chr12:100698..132283466 [NCBI36]
Chr12:12p13.33-q24.33		 pathogenic
GRCh38/hg38 12q13.12-13.13(chr12:50633888-52851909)x1 copy number loss See cases [RCV000140716] Chr12:50633888..52851909 [GRCh38]
Chr12:51027671..53245693 [GRCh37]
Chr12:49313938..51531960 [NCBI36]
Chr12:12q13.12-13.13		 pathogenic
GRCh38/hg38 12q13.12-13.13(chr12:50122359-53248460)x1 copy number loss See cases [RCV000142033] Chr12:50122359..53248460 [GRCh38]
Chr12:50516142..53642244 [GRCh37]
Chr12:48802409..51928511 [NCBI36]
Chr12:12q13.12-13.13		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:1-133851895)x3 copy number gain See cases [RCV000258805] Chr12:1..133851895 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic|likely pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902)x3 copy number gain See cases [RCV000510482] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902) copy number gain See cases [RCV000511643] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
NC_000012.11:g.26370251_54361538inv inversion not specified [RCV000714265] Chr12:26370251..54361538 [GRCh37]
Chr12:12p12.1-q13.13		 uncertain significance
GRCh37/hg19 12p13.33-q24.33(chr12:621220-133779118)x3 copy number gain not provided [RCV000750253] Chr12:621220..133779118 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:191619-133777645)x3 copy number gain not provided [RCV000750246] Chr12:191619..133777645 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
NM_080747.3(KRT72):c.1499C>T (p.Ser500Leu) single nucleotide variant Inborn genetic diseases [RCV003243786] Chr12:52586019 [GRCh38]
Chr12:52979803 [GRCh37]
Chr12:12q13.13		 uncertain significance
GRCh37/hg19 12q13.13(chr12:52914323-53238344)x3 copy number gain not provided [RCV001006504] Chr12:52914323..53238344 [GRCh37]
Chr12:12q13.13		 uncertain significance
NM_080747.3(KRT72):c.725A>C (p.Asn242Thr) single nucleotide variant Inborn genetic diseases [RCV003276096] Chr12:52592469 [GRCh38]
Chr12:52986253 [GRCh37]
Chr12:12q13.13		 uncertain significance
GRCh37/hg19 12q13.13(chr12:52914324-53250644)x3 copy number gain not provided [RCV002474695] Chr12:52914324..53250644 [GRCh37]
Chr12:12q13.13		 uncertain significance
NM_080747.3(KRT72):c.1141G>A (p.Ala381Thr) single nucleotide variant Inborn genetic diseases [RCV002973635] Chr12:52587800 [GRCh38]
Chr12:52981584 [GRCh37]
Chr12:12q13.13		 uncertain significance
NM_080747.3(KRT72):c.243C>G (p.Ser81Arg) single nucleotide variant Inborn genetic diseases [RCV002753885] Chr12:52601210 [GRCh38]
Chr12:52994994 [GRCh37]
Chr12:12q13.13		 uncertain significance
NM_080747.3(KRT72):c.1355G>A (p.Ser452Asn) single nucleotide variant Inborn genetic diseases [RCV002968497] Chr12:52586163 [GRCh38]
Chr12:52979947 [GRCh37]
Chr12:12q13.13		 uncertain significance
NM_080747.3(KRT72):c.652G>A (p.Glu218Lys) single nucleotide variant Inborn genetic diseases [RCV002730043] Chr12:52592942 [GRCh38]
Chr12:52986726 [GRCh37]
Chr12:12q13.13		 uncertain significance
NM_080747.3(KRT72):c.841G>A (p.Val281Ile) single nucleotide variant Inborn genetic diseases [RCV002684065] Chr12:52591586 [GRCh38]
Chr12:52985370 [GRCh37]
Chr12:12q13.13		 likely benign
NM_080747.3(KRT72):c.212T>C (p.Leu71Pro) single nucleotide variant Inborn genetic diseases [RCV002682412] Chr12:52601241 [GRCh38]
Chr12:52995025 [GRCh37]
Chr12:12q13.13		 uncertain significance
NM_080747.3(KRT72):c.998G>A (p.Gly333Glu) single nucleotide variant Inborn genetic diseases [RCV002859749] Chr12:52590927 [GRCh38]
Chr12:52984711 [GRCh37]
Chr12:12q13.13		 uncertain significance
NM_080747.3(KRT72):c.116A>G (p.Lys39Arg) single nucleotide variant Inborn genetic diseases [RCV002762551] Chr12:52601337 [GRCh38]
Chr12:52995121 [GRCh37]
Chr12:12q13.13		 uncertain significance
NM_080747.3(KRT72):c.580G>A (p.Gly194Arg) single nucleotide variant Inborn genetic diseases [RCV002704404] Chr12:52598959 [GRCh38]
Chr12:52992743 [GRCh37]
Chr12:12q13.13		 likely benign
NM_080747.3(KRT72):c.460G>C (p.Glu154Gln) single nucleotide variant Inborn genetic diseases [RCV002693833] Chr12:52599079 [GRCh38]
Chr12:52992863 [GRCh37]
Chr12:12q13.13		 uncertain significance
NM_080747.3(KRT72):c.1183G>A (p.Ala395Thr) single nucleotide variant Inborn genetic diseases [RCV002660780] Chr12:52587758 [GRCh38]
Chr12:52981542 [GRCh37]
Chr12:12q13.13		 uncertain significance
NM_080747.3(KRT72):c.1096G>A (p.Asp366Asn) single nucleotide variant Inborn genetic diseases [RCV002884351] Chr12:52587845 [GRCh38]
Chr12:52981629 [GRCh37]
Chr12:12q13.13		 likely benign
NM_080747.3(KRT72):c.409G>T (p.Ala137Ser) single nucleotide variant Inborn genetic diseases [RCV002758947] Chr12:52601044 [GRCh38]
Chr12:52994828 [GRCh37]
Chr12:12q13.13		 uncertain significance
NM_080747.3(KRT72):c.1042C>T (p.Arg348Cys) single nucleotide variant Inborn genetic diseases [RCV002759940] Chr12:52590883 [GRCh38]
Chr12:52984667 [GRCh37]
Chr12:12q13.13		 uncertain significance
NM_080747.3(KRT72):c.733G>A (p.Glu245Lys) single nucleotide variant Inborn genetic diseases [RCV002888145] Chr12:52592461 [GRCh38]
Chr12:52986245 [GRCh37]
Chr12:12q13.13		 uncertain significance
NM_080747.3(KRT72):c.686T>C (p.Phe229Ser) single nucleotide variant Inborn genetic diseases [RCV002827376] Chr12:52592908 [GRCh38]
Chr12:52986692 [GRCh37]
Chr12:12q13.13		 uncertain significance
NM_080747.3(KRT72):c.1510T>G (p.Cys504Gly) single nucleotide variant Inborn genetic diseases [RCV002713035] Chr12:52586008 [GRCh38]
Chr12:52979792 [GRCh37]
Chr12:12q13.13		 uncertain significance
NM_080747.3(KRT72):c.632A>G (p.Tyr211Cys) single nucleotide variant Inborn genetic diseases [RCV002960239] Chr12:52598907 [GRCh38]
Chr12:52992691 [GRCh37]
Chr12:12q13.13		 uncertain significance
NM_080747.3(KRT72):c.546C>G (p.Asn182Lys) single nucleotide variant Inborn genetic diseases [RCV002879339] Chr12:52598993 [GRCh38]
Chr12:52992777 [GRCh37]
Chr12:12q13.13		 uncertain significance
NM_080747.3(KRT72):c.1156C>T (p.Arg386Trp) single nucleotide variant Inborn genetic diseases [RCV002670323] Chr12:52587785 [GRCh38]
Chr12:52981569 [GRCh37]
Chr12:12q13.13		 uncertain significance
NM_080747.3(KRT72):c.1012C>T (p.Leu338Phe) single nucleotide variant Inborn genetic diseases [RCV002920206] Chr12:52590913 [GRCh38]
Chr12:52984697 [GRCh37]
Chr12:12q13.13		 uncertain significance
NM_080747.3(KRT72):c.1171G>C (p.Glu391Gln) single nucleotide variant Inborn genetic diseases [RCV003214403] Chr12:52587770 [GRCh38]
Chr12:52981554 [GRCh37]
Chr12:12q13.13		 uncertain significance
NM_080747.3(KRT72):c.1346C>T (p.Ser449Phe) single nucleotide variant Inborn genetic diseases [RCV003282186] Chr12:52586172 [GRCh38]
Chr12:52979956 [GRCh37]
Chr12:12q13.13		 uncertain significance
NM_080747.3(KRT72):c.193C>T (p.Arg65Trp) single nucleotide variant Inborn genetic diseases [RCV003185099] Chr12:52601260 [GRCh38]
Chr12:52995044 [GRCh37]
Chr12:12q13.13		 uncertain significance
NM_080747.3(KRT72):c.1314G>A (p.Met438Ile) single nucleotide variant Inborn genetic diseases [RCV003173412] Chr12:52586977 [GRCh38]
Chr12:52980761 [GRCh37]
Chr12:12q13.13		 uncertain significance
NM_080747.3(KRT72):c.382C>A (p.Gln128Lys) single nucleotide variant Inborn genetic diseases [RCV003208107] Chr12:52601071 [GRCh38]
Chr12:52994855 [GRCh37]
Chr12:12q13.13		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2122
Count of miRNA genes:737
Interacting mature miRNAs:852
Transcripts:ENST00000293745, ENST00000354310, ENST00000398066, ENST00000537672, ENST00000549979, ENST00000550829
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D12S766  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371252,985,062 - 52,985,232UniSTSGRCh37
Build 361251,271,329 - 51,271,499RGDNCBI36
Celera1252,631,302 - 52,631,472RGD
Cytogenetic Map12q13.13UniSTS
HuRef1250,028,910 - 50,029,084UniSTS
K6IRS2__6498  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371252,979,214 - 52,979,889UniSTSGRCh37
Build 361251,265,481 - 51,266,156RGDNCBI36
Celera1252,625,455 - 52,626,130RGD
HuRef1250,023,063 - 50,023,738UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 22 165 4 205 744 341 13 2 454
Low 199 578 153 43 945 31 620 21 200 21 73 439 12 110 264
Below cutoff 1429 1606 1182 394 283 273 2017 1356 2393 186 650 767 123 971 1421 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_012427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001146225 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001146226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_080747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017018833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017018834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017018835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017018836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017018837 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024448846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047428321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047428322 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047428323 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047428324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047428325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047428326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054371143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054371144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054371145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054371146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054371147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054371148 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054371149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC055715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK093060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK293645 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK302016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY033495 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY033496 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC113686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX089867 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC007066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000293745   ⟹   ENSP00000293745
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1252,585,589 - 52,601,463 (-)Ensembl
RefSeq Acc Id: ENST00000354310   ⟹   ENSP00000346269
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1252,585,714 - 52,601,538 (-)Ensembl
RefSeq Acc Id: ENST00000537672   ⟹   ENSP00000441160
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1252,585,589 - 52,601,463 (-)Ensembl
RefSeq Acc Id: ENST00000549979   ⟹   ENSP00000449324
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1252,598,954 - 52,601,409 (-)Ensembl
RefSeq Acc Id: ENST00000550829   ⟹   ENSP00000446881
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1252,585,958 - 52,601,432 (-)Ensembl
RefSeq Acc Id: NM_001146225   ⟹   NP_001139697
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381252,585,589 - 52,601,463 (-)NCBI
GRCh371252,979,373 - 52,995,322 (-)RGD
Celera1252,625,614 - 52,641,566 (-)RGD
HuRef1250,023,222 - 50,039,177 (-)RGD
CHM1_11252,946,225 - 52,962,175 (-)NCBI
T2T-CHM13v2.01252,550,180 - 52,566,060 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001146226   ⟹   NP_001139698
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381252,585,589 - 52,601,463 (-)NCBI
GRCh371252,979,373 - 52,995,322 (-)RGD
Celera1252,625,614 - 52,641,566 (-)RGD
HuRef1250,023,222 - 50,039,177 (-)RGD
CHM1_11252,946,225 - 52,962,175 (-)NCBI
T2T-CHM13v2.01252,550,180 - 52,566,060 (-)NCBI
Sequence:
RefSeq Acc Id: NM_080747   ⟹   NP_542785
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381252,585,589 - 52,601,463 (-)NCBI
GRCh371252,979,373 - 52,995,322 (-)RGD
Build 361251,265,640 - 51,281,559 (-)NCBI Archive
Celera1252,625,614 - 52,641,566 (-)RGD
HuRef1250,023,222 - 50,039,177 (-)RGD
CHM1_11252,946,225 - 52,962,175 (-)NCBI
T2T-CHM13v2.01252,550,180 - 52,566,060 (-)NCBI
Sequence:
RefSeq Acc Id: XM_047428321   ⟹   XP_047284277
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381252,585,589 - 52,601,795 (-)NCBI
RefSeq Acc Id: XM_047428322   ⟹   XP_047284278
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381252,585,589 - 52,602,953 (-)NCBI
RefSeq Acc Id: XM_047428323   ⟹   XP_047284279
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381252,585,589 - 52,602,953 (-)NCBI
RefSeq Acc Id: XM_047428324   ⟹   XP_047284280
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381252,585,589 - 52,602,920 (-)NCBI
RefSeq Acc Id: XM_047428325   ⟹   XP_047284281
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381252,585,589 - 52,601,463 (-)NCBI
RefSeq Acc Id: XM_047428326   ⟹   XP_047284282
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381252,585,589 - 52,593,164 (-)NCBI
RefSeq Acc Id: XM_054371143   ⟹   XP_054227118
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01252,550,180 - 52,567,471 (-)NCBI
RefSeq Acc Id: XM_054371144   ⟹   XP_054227119
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01252,550,180 - 52,566,392 (-)NCBI
RefSeq Acc Id: XM_054371145   ⟹   XP_054227120
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01252,550,180 - 52,567,550 (-)NCBI
RefSeq Acc Id: XM_054371146   ⟹   XP_054227121
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01252,550,180 - 52,567,550 (-)NCBI
RefSeq Acc Id: XM_054371147   ⟹   XP_054227122
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01252,550,180 - 52,567,517 (-)NCBI
RefSeq Acc Id: XM_054371148   ⟹   XP_054227123
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01252,550,180 - 52,566,060 (-)NCBI
RefSeq Acc Id: XM_054371149   ⟹   XP_054227124
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01252,550,180 - 52,557,758 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001139697 (Get FASTA)   NCBI Sequence Viewer  
  NP_001139698 (Get FASTA)   NCBI Sequence Viewer  
  NP_542785 (Get FASTA)   NCBI Sequence Viewer  
  XP_047284277 (Get FASTA)   NCBI Sequence Viewer  
  XP_047284278 (Get FASTA)   NCBI Sequence Viewer  
  XP_047284279 (Get FASTA)   NCBI Sequence Viewer  
  XP_047284280 (Get FASTA)   NCBI Sequence Viewer  
  XP_047284281 (Get FASTA)   NCBI Sequence Viewer  
  XP_047284282 (Get FASTA)   NCBI Sequence Viewer  
  XP_054227118 (Get FASTA)   NCBI Sequence Viewer  
  XP_054227119 (Get FASTA)   NCBI Sequence Viewer  
  XP_054227120 (Get FASTA)   NCBI Sequence Viewer  
  XP_054227121 (Get FASTA)   NCBI Sequence Viewer  
  XP_054227122 (Get FASTA)   NCBI Sequence Viewer  
  XP_054227123 (Get FASTA)   NCBI Sequence Viewer  
  XP_054227124 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI13687 (Get FASTA)   NCBI Sequence Viewer  
  AAK55108 (Get FASTA)   NCBI Sequence Viewer  
  AAK55109 (Get FASTA)   NCBI Sequence Viewer  
  BAC04039 (Get FASTA)   NCBI Sequence Viewer  
  BAG57099 (Get FASTA)   NCBI Sequence Viewer  
  BAG63416 (Get FASTA)   NCBI Sequence Viewer  
  CBH19338 (Get FASTA)   NCBI Sequence Viewer  
  EAW96638 (Get FASTA)   NCBI Sequence Viewer  
  EAW96639 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000293745
  ENSP00000293745.2
  ENSP00000346269
  ENSP00000346269.4
  ENSP00000441160
  ENSP00000441160.2
  ENSP00000446881.1
  ENSP00000449324.1
GenBank Protein Q14CN4 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_542785   ⟸   NM_080747
- Peptide Label: isoform 1
- UniProtKB: Q8WWY9 (UniProtKB/Swiss-Prot),   Q8NA87 (UniProtKB/Swiss-Prot),   H9KV51 (UniProtKB/Swiss-Prot),   B4DEI8 (UniProtKB/Swiss-Prot),   Q8WWZ0 (UniProtKB/Swiss-Prot),   Q14CN4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001139697   ⟸   NM_001146225
- Peptide Label: isoform 1
- UniProtKB: Q8WWY9 (UniProtKB/Swiss-Prot),   Q8NA87 (UniProtKB/Swiss-Prot),   H9KV51 (UniProtKB/Swiss-Prot),   B4DEI8 (UniProtKB/Swiss-Prot),   Q8WWZ0 (UniProtKB/Swiss-Prot),   Q14CN4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001139698   ⟸   NM_001146226
- Peptide Label: isoform 2
- UniProtKB: Q14CN4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000293745   ⟸   ENST00000293745
RefSeq Acc Id: ENSP00000449324   ⟸   ENST00000549979
RefSeq Acc Id: ENSP00000441160   ⟸   ENST00000537672
RefSeq Acc Id: ENSP00000346269   ⟸   ENST00000354310
RefSeq Acc Id: ENSP00000446881   ⟸   ENST00000550829
RefSeq Acc Id: XP_047284279   ⟸   XM_047428323
- Peptide Label: isoform X3
RefSeq Acc Id: XP_047284278   ⟸   XM_047428322
- Peptide Label: isoform X2
RefSeq Acc Id: XP_047284280   ⟸   XM_047428324
- Peptide Label: isoform X4
RefSeq Acc Id: XP_047284277   ⟸   XM_047428321
- Peptide Label: isoform X1
RefSeq Acc Id: XP_047284281   ⟸   XM_047428325
- Peptide Label: isoform X5
- UniProtKB: B4DXK4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_047284282   ⟸   XM_047428326
- Peptide Label: isoform X6
RefSeq Acc Id: XP_054227121   ⟸   XM_054371146
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054227120   ⟸   XM_054371145
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054227122   ⟸   XM_054371147
- Peptide Label: isoform X4
RefSeq Acc Id: XP_054227118   ⟸   XM_054371143
- Peptide Label: isoform X7
RefSeq Acc Id: XP_054227119   ⟸   XM_054371144
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054227123   ⟸   XM_054371148
- Peptide Label: isoform X5
RefSeq Acc Id: XP_054227124   ⟸   XM_054371149
- Peptide Label: isoform X6
Protein Domains
IF rod   Keratin type II head

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q14CN4-F1-model_v2 AlphaFold Q14CN4 1-511 view protein structure

Promoters
RGD ID:7224019
Promoter ID:EPDNEW_H17756
Type:initiation region
Name:KRT72_1
Description:keratin 72
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381252,601,463 - 52,601,523EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:28932 AgrOrtholog
COSMIC KRT72 COSMIC
Ensembl Genes ENSG00000170486 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000293745 ENTREZGENE
  ENST00000293745.7 UniProtKB/Swiss-Prot
  ENST00000354310 ENTREZGENE
  ENST00000354310.4 UniProtKB/Swiss-Prot
  ENST00000537672 ENTREZGENE
  ENST00000537672.6 UniProtKB/Swiss-Prot
  ENST00000549979.1 UniProtKB/TrEMBL
  ENST00000550829.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Single helix bin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Vasodilator-stimulated phosphoprotein UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000170486 GTEx
HGNC ID HGNC:28932 ENTREZGENE
Human Proteome Map KRT72 Human Proteome Map
InterPro IF_conserved UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IF_rod_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Keratin_2_head UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Keratin_II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:140807 UniProtKB/Swiss-Prot
NCBI Gene 140807 ENTREZGENE
OMIM 608246 OMIM
PANTHER GATA-TYPE DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KERATIN, TYPE II CYTOSKELETAL 72 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Filament UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Keratin_2_head UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA147357719 PharmGKB
PRINTS TYPE2KERATIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE IF_ROD_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IF_ROD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Filament UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Intermediate filament protein, coiled coil region UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B4DEI8 ENTREZGENE
  B4DXK4 ENTREZGENE, UniProtKB/TrEMBL
  H0YHD9_HUMAN UniProtKB/TrEMBL
  H0YIG3_HUMAN UniProtKB/TrEMBL
  H9KV51 ENTREZGENE
  K2C72_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q8NA87 ENTREZGENE
  Q8WWY9 ENTREZGENE
  Q8WWZ0 ENTREZGENE
UniProt Secondary B4DEI8 UniProtKB/Swiss-Prot
  H9KV51 UniProtKB/Swiss-Prot
  Q8NA87 UniProtKB/Swiss-Prot
  Q8WWY9 UniProtKB/Swiss-Prot
  Q8WWZ0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-14 KRT72  keratin 72  KRT72  keratin 72, type II  Symbol and/or name change 5135510 APPROVED
2015-01-27 KRT72  keratin 72, type II  KRT72  keratin 72  Symbol and/or name change 5135510 APPROVED