Btn3a2 (butyrophilin, subfamily 3, member A2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Btn3a2 (butyrophilin, subfamily 3, member A2) Rattus norvegicus
Analyze
Symbol: Btn3a2
Name: butyrophilin, subfamily 3, member A2
RGD ID: 1598538
Description: Predicted to be located in membrane.
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: Btnl4; butyrophilin subfamily 3 member A2; butyrophilin-like 4; LOC294268; RGD1562488; similar to butyrophilin-like 8
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8204,397,659 - 4,410,150 (+)NCBIGRCr8
mRatBN7.2204,398,254 - 4,405,681 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl204,398,254 - 4,405,681 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx205,158,446 - 5,165,907 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0204,520,186 - 4,527,647 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0204,993,478 - 5,000,948 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0204,240,270 - 4,247,115 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0206,319,626 - 6,326,471 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,471,149 - 4,528,035 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera206,000,866 - 6,008,294 (+)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15060004  


Genomics

Variants

.
Variants in Btn3a2
322 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
2306850Pia40Pristane induced arthritis QTL 400.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2015279595304575Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
61448Ciaa1CIA Autoantibody QTL 1300.001blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)2026463954597031Rat
61472Aia1Adjuvant induced arthritis QTL 1180.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2026463954597031Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2036216499243559Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362164910078919Rat
737973Pia21Pristane induced arthritis QTL 214.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2036216564606812Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat

Markers in Region
D20Yum69  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2204,343,228 - 4,343,417 (-)MAPPERmRatBN7.2
Rnor_6.0202,879,334 - 2,879,522NCBIRnor6.0
Rnor_5.0204,977,074 - 4,977,262UniSTSRnor5.0
RGSC_v3.4204,477,476 - 4,477,664UniSTSRGSC3.4
Cytogenetic Map20p12UniSTS
RH134883  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera205,979,708 - 5,979,925UniSTS
Celera206,007,981 - 6,008,315UniSTS
RH 3.4 Map2053.73UniSTS
Cytogenetic Map20p12UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000029451   ⟹   ENSRNOP00000034717
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl204,398,254 - 4,405,681 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000085662   ⟹   ENSRNOP00000070494
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl204,398,254 - 4,405,681 (+)Ensembl
RefSeq Acc Id: NM_001166344   ⟹   NP_001159816
RefSeq Status: INFERRED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,400,176 - 4,407,603 (+)NCBI
mRatBN7.2204,398,254 - 4,405,681 (+)NCBI
Rnor_6.0204,240,270 - 4,247,115 (-)NCBI
Rnor_5.0206,319,626 - 6,326,471 (-)NCBI
RGSC_v3.4204,471,149 - 4,528,035 (+)RGD
Celera206,000,866 - 6,008,294 (+)RGD
Sequence:
RefSeq Acc Id: XM_063279013   ⟹   XP_063135083
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,397,659 - 4,410,150 (+)NCBI
RefSeq Acc Id: XM_063279014   ⟹   XP_063135084
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,397,659 - 4,410,144 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001159816 (Get FASTA)   NCBI Sequence Viewer  
  XP_063135083 (Get FASTA)   NCBI Sequence Viewer  
  XP_063135084 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAE83951 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000034717
  ENSRNOP00000034717.5
  ENSRNOP00000070494.2
Reference Protein Sequences
RefSeq Acc Id: NP_001159816   ⟸   NM_001166344
- UniProtKB: F7F1D5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000070494   ⟸   ENSRNOT00000085662
RefSeq Acc Id: ENSRNOP00000034717   ⟸   ENSRNOT00000029451
RefSeq Acc Id: XP_063135083   ⟸   XM_063279013
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JY27 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063135084   ⟸   XM_063279014
- Peptide Label: isoform X2
Protein Domains
B30.2/SPRY   Ig-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F7F1D5-F1-model_v2 AlphaFold F7F1D5 1-589 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
BioCyc Gene G2FUF-4572 BioCyc
Ensembl Genes ENSRNOG00000068592 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000029451 ENTREZGENE
  ENSRNOT00000029451.5 UniProtKB/TrEMBL
  ENSRNOT00000085662.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.920 UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/TrEMBL
InterPro B30.2/SPRY UniProtKB/TrEMBL
  B30.2/SPRY_sf UniProtKB/TrEMBL
  Butyrophylin_SPRY UniProtKB/TrEMBL
  ConA-like_dom_sf UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_V-set UniProtKB/TrEMBL
  PRY UniProtKB/TrEMBL
  SPRY_dom UniProtKB/TrEMBL
KEGG Report rno:294268 UniProtKB/TrEMBL
NCBI Gene Btn3a2 ENTREZGENE
PANTHER BUTYROPHILIN UniProtKB/TrEMBL
  BUTYROPHILIN, SUBFAMILY 3, MEMBER A3-RELATED UniProtKB/TrEMBL
Pfam SPRY UniProtKB/TrEMBL
  V-set UniProtKB/TrEMBL
PhenoGen Btn3a2 PhenoGen
PRINTS BUTYPHLNCDUF UniProtKB/TrEMBL
PROSITE B302_SPRY UniProtKB/TrEMBL
  IG_LIKE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000068592 RatGTEx
SMART IGv UniProtKB/TrEMBL
  PRY UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
  SPRY UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
  SSF49899 UniProtKB/TrEMBL
UniProt A0A0G2JY27 ENTREZGENE, UniProtKB/TrEMBL
  F7F1D5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-07-13 Btn3a2  butyrophilin, subfamily 3, member A2  Btnl4  butyrophilin-like 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-13 Btnl4  butyrophilin-like 4  RGD1562488  similar to butyrophilin-like 8  Data merged from RGD:1562488 737654 APPROVED
2008-04-30 RGD1562488  similar to butyrophilin-like 8   RGD1562488_predicted  similar to butyrophilin-like 8 (predicted)  'predicted' is removed 2292626 APPROVED
2006-12-03 Btnl4  butyrophilin-like 4      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-07 RGD1562488_predicted  similar to butyrophilin-like 8 (predicted)  LOC294268  similar to butyrophilin-like 8  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC294268  similar to butyrophilin-like 8      Symbol and Name status set to provisional 70820 PROVISIONAL