Zdhhc25 (zinc finger, DHHC-type containing 25) - Rat Genome Database

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Gene: Zdhhc25 (zinc finger, DHHC-type containing 25) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Zdhhc25
Name: zinc finger, DHHC-type containing 25
RGD ID: 1598341
Description: Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in protein targeting to membrane. Predicted to be located in membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: DHHC26; LOC300323; membrane-associated DHHC26 zinc finger protein; zinc finger, DHHC domain containing 25
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87121,572,354 - 121,573,586 (+)NCBIGRCr8
mRatBN7.27119,692,679 - 119,693,911 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7119,692,705 - 119,694,042 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7121,443,638 - 121,444,870 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07123,670,065 - 123,671,297 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07123,633,087 - 123,634,319 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07129,595,192 - 129,596,424 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7129,595,192 - 129,596,424 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07129,286,073 - 129,287,305 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera7116,171,187 - 116,172,419 (+)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Zdhhc25
1 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:108
Count of miRNA genes:89
Interacting mature miRNAs:99
Transcripts:ENSRNOT00000071151
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat
1582240Sffal1Serum free fatty acids level QTL 13.40.0021blood free fatty acid amount (VT:0001553)serum free fatty acids level (CMO:0000547)7116677010124049952Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)7116677189127103496Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7119513385135012528Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system hemolymphoid system integumental system musculoskeletal system nervous system reproductive system appendage
High
Medium 7
Low 1 1
Below cutoff 1 1 2 2 3 7 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000071151   ⟹   ENSRNOP00000064895
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7119,692,705 - 119,694,042 (+)Ensembl
Rnor_6.0 Ensembl7129,595,192 - 129,596,424 (+)Ensembl
RefSeq Acc Id: NM_001039333   ⟹   NP_001034422
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87121,572,354 - 121,573,586 (+)NCBI
mRatBN7.27119,692,679 - 119,693,911 (+)NCBI
Rnor_6.07129,595,192 - 129,596,424 (+)NCBI
Rnor_5.07129,286,073 - 129,287,305 (+)NCBI
Celera7116,171,187 - 116,172,419 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001034422 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAX73403 (Get FASTA)   NCBI Sequence Viewer  
  EDL76514 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000064895
  ENSRNOP00000064895.1
Reference Protein Sequences
RefSeq Acc Id: NP_001034422   ⟸   NM_001039333
- UniProtKB: Q2TGI4 (UniProtKB/TrEMBL),   M0R656 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000064895   ⟸   ENSRNOT00000071151
Protein Domains
Palmitoyltransferase DHHC

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q2TGI4-F1-model_v2 AlphaFold Q2TGI4 1-279 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695571
Promoter ID:EPDNEW_R6096
Type:initiation region
Name:Zdhhc25_1
Description:zinc finger, DHHC-type containing 25
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07129,595,207 - 129,595,267EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1598341 AgrOrtholog
BioCyc Gene G2FUF-32495 BioCyc
Ensembl Genes ENSRNOG00000046044 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000071151 ENTREZGENE
  ENSRNOT00000071151.2 UniProtKB/TrEMBL
InterPro Znf_DHHC UniProtKB/TrEMBL
KEGG Report rno:300323 UniProtKB/TrEMBL
NCBI Gene 300323 ENTREZGENE
PANTHER PALMITOYLTRANSFERASE ZDHHC16 UniProtKB/TrEMBL
  PALMITOYLTRANSFERASE ZDHHC16 UniProtKB/TrEMBL
Pfam zf-DHHC UniProtKB/TrEMBL
PhenoGen Zdhhc25 PhenoGen
PROSITE DHHC UniProtKB/TrEMBL
RatGTEx ENSRNOG00000046044 RatGTEx
UniProt M0R656 ENTREZGENE, UniProtKB/TrEMBL
  Q2TGI4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-07-26 Zdhhc25  zinc finger, DHHC-type containing 25  Zdhhc25  zinc finger, DHHC domain containing 25  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Zdhhc25  zinc finger, DHHC domain containing 25  LOC300323  membrane-associated DHHC26 zinc finger protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC300323  membrane-associated DHHC26 zinc finger protein      Symbol and Name status set to provisional 70820 PROVISIONAL