Mtres1 (mitochondrial transcription rescue factor 1) - Rat Genome Database

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Gene: Mtres1 (mitochondrial transcription rescue factor 1) Rattus norvegicus
Analyze
Symbol: Mtres1
Name: mitochondrial transcription rescue factor 1
RGD ID: 1597785
Description: Predicted to enable ribosomal large subunit binding activity and tRNA binding activity. Predicted to be involved in regulation of mitochondrial transcription and rescue of stalled ribosome. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Orthologous to human MTRES1 (mitochondrial transcription rescue factor 1); INTERACTS WITH fipronil; gentamycin; paracetamol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hypothetical protein LOC683897; LOC683897; similar to Protein C6orf203; uncharacterized protein C6orf203 homolog; uncharacterized protein LOC683897
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82048,604,479 - 48,622,364 (-)NCBIGRCr8
mRatBN7.22047,022,343 - 47,038,888 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2047,022,342 - 47,038,805 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2048,736,829 - 48,753,174 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02048,386,835 - 48,403,008 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02049,071,634 - 49,088,055 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02048,276,101 - 48,294,975 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2048,275,762 - 48,294,948 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02049,934,857 - 49,950,906 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2052,949,435 - 52,966,218 (+)NCBICelera
Cytogenetic Map20q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:18614015   PMID:20833797   PMID:31226201  


Genomics

Comparative Map Data
Mtres1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82048,604,479 - 48,622,364 (-)NCBIGRCr8
mRatBN7.22047,022,343 - 47,038,888 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2047,022,342 - 47,038,805 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2048,736,829 - 48,753,174 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02048,386,835 - 48,403,008 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02049,071,634 - 49,088,055 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02048,276,101 - 48,294,975 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2048,275,762 - 48,294,948 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02049,934,857 - 49,950,906 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2052,949,435 - 52,966,218 (+)NCBICelera
Cytogenetic Map20q13NCBI
MTRES1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386107,028,199 - 107,051,586 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6107,028,199 - 107,051,586 (+)EnsemblGRCh38hg38GRCh38
GRCh376107,349,403 - 107,372,790 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366107,456,110 - 107,479,238 (+)NCBINCBI36Build 36hg18NCBI36
Build 346107,456,109 - 107,479,238NCBI
Celera6108,097,763 - 108,120,882 (+)NCBICelera
Cytogenetic Map6q21NCBI
HuRef6104,921,421 - 104,943,891 (+)NCBIHuRef
CHM1_16107,612,048 - 107,635,159 (+)NCBICHM1_1
T2T-CHM13v2.06108,207,085 - 108,230,443 (+)NCBIT2T-CHM13v2.0
Mtres1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391043,401,115 - 43,417,037 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1043,401,129 - 43,416,990 (-)EnsemblGRCm39 Ensembl
GRCm381043,525,119 - 43,541,041 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1043,525,133 - 43,540,994 (-)EnsemblGRCm38mm10GRCm38
MGSCv371043,244,927 - 43,260,800 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361043,213,536 - 43,229,409 (-)NCBIMGSCv36mm8
Celera1044,391,825 - 44,407,796 (-)NCBICelera
Cytogenetic Map10B2NCBI
cM Map1023.01NCBI
Mtres1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541132,318,079 - 32,341,989 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541132,318,079 - 32,338,597 (+)NCBIChiLan1.0ChiLan1.0
MTRES1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25127,044,353 - 127,068,253 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16124,931,922 - 124,955,569 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06104,839,280 - 104,862,854 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16108,709,555 - 108,729,976 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6108,709,803 - 108,729,976 (+)Ensemblpanpan1.1panPan2
MTRES1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11264,278,569 - 64,293,999 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1264,244,529 - 64,303,579 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1264,065,280 - 64,080,933 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01265,122,203 - 65,137,957 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1265,122,128 - 65,147,799 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11264,482,216 - 64,497,961 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01264,326,248 - 64,341,811 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01264,599,931 - 64,615,890 (+)NCBIUU_Cfam_GSD_1.0
Mtres1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494699,192,327 - 99,207,645 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365643,467,192 - 3,482,720 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365643,467,223 - 3,482,507 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MTRES1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl173,162,364 - 73,180,017 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1173,162,330 - 73,174,266 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MTRES1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11366,798,141 - 66,818,964 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1366,798,134 - 66,807,567 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604039,125,651 - 39,146,174 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mtres1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478015,233,566 - 15,246,178 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478015,233,686 - 15,246,172 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mtres1
122 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:51
Count of miRNA genes:44
Interacting mature miRNAs:49
Transcripts:ENSRNOT00000072716
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201175751554435887Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201175751554435887Rat
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)201761783247606836Rat
2317880Alcrsp25Alcohol response QTL 252.3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)201769755054435887Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)201919072154435887Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202510672254435887Rat
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202510672254435887Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202510672254435887Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202520973454435887Rat
1598869Memor6Memory QTL 63.1exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)202924438854435887Rat

Markers in Region
BE109698  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22047,036,171 - 47,036,321 (+)MAPPERmRatBN7.2
Rnor_6.02048,292,316 - 48,292,465NCBIRnor6.0
Rnor_5.02049,948,247 - 49,948,396UniSTSRnor5.0
RGSC_v3.42047,463,698 - 47,463,847UniSTSRGSC3.4
Celera2052,951,945 - 52,952,094UniSTS
RH 3.4 Map20496.6UniSTS
RH137887  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.02049,950,213 - 49,950,336NCBIRnor5.0
RGSC_v3.42047,465,665 - 47,465,787UniSTSRGSC3.4
Celera2052,950,005 - 52,950,127UniSTS
RH 3.4 Map20495.21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 55 39 19 39 8 11 74 35 41 11 8
Low 2 2 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000072716   ⟹   ENSRNOP00000065494
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2047,022,387 - 47,038,805 (-)Ensembl
Rnor_6.0 Ensembl2048,275,762 - 48,294,948 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000097351   ⟹   ENSRNOP00000097401
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2047,022,345 - 47,038,805 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000104066   ⟹   ENSRNOP00000089834
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2047,022,342 - 47,034,535 (-)Ensembl
RefSeq Acc Id: NM_001109448   ⟹   NP_001102918
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82048,604,479 - 48,620,967 (-)NCBI
mRatBN7.22047,022,343 - 47,038,832 (-)NCBI
Rnor_6.02048,276,101 - 48,294,975 (-)NCBI
Rnor_5.02049,934,857 - 49,950,906 (-)NCBI
Celera2052,949,435 - 52,966,218 (+)RGD
Sequence:
RefSeq Acc Id: XM_006256581   ⟹   XP_006256643
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82048,604,479 - 48,620,960 (-)NCBI
mRatBN7.22047,022,343 - 47,038,824 (-)NCBI
Rnor_6.02048,276,101 - 48,294,954 (-)NCBI
Rnor_5.02049,934,857 - 49,950,906 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039099059   ⟹   XP_038954987
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82048,604,882 - 48,622,364 (-)NCBI
mRatBN7.22047,022,697 - 47,038,888 (-)NCBI
RefSeq Acc Id: XM_063279504   ⟹   XP_063135574
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82048,604,479 - 48,615,287 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001102918   ⟸   NM_001109448
- UniProtKB: Q3B8P7 (UniProtKB/TrEMBL),   A6K6W9 (UniProtKB/TrEMBL),   A0A8I6A8Y4 (UniProtKB/TrEMBL),   A0A8I6ARF0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256643   ⟸   XM_006256581
- Peptide Label: isoform X2
- UniProtKB: Q3B8P7 (UniProtKB/TrEMBL),   A6K6W9 (UniProtKB/TrEMBL),   A0A8I6A8Y4 (UniProtKB/TrEMBL),   A0A8I6ARF0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000065494   ⟸   ENSRNOT00000072716
RefSeq Acc Id: XP_038954987   ⟸   XM_039099059
- Peptide Label: isoform X3
RefSeq Acc Id: ENSRNOP00000089834   ⟸   ENSRNOT00000104066
RefSeq Acc Id: ENSRNOP00000097401   ⟸   ENSRNOT00000097351
RefSeq Acc Id: XP_063135574   ⟸   XM_063279504
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R7R2-F1-model_v2 AlphaFold M0R7R2 1-253 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701675
Promoter ID:EPDNEW_R12199
Type:initiation region
Name:LOC683897_1
Description:similar to Protein C6orf203
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02048,294,915 - 48,294,975EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1597785 AgrOrtholog
BioCyc Gene G2FUF-3341 BioCyc
Ensembl Genes ENSRNOG00000047118 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000072716.3 UniProtKB/TrEMBL
  ENSRNOT00000097351.1 UniProtKB/TrEMBL
  ENSRNOT00000104066 ENTREZGENE
  ENSRNOT00000104066.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7306492 IMAGE-MGC_LOAD
KEGG Report rno:683897 UniProtKB/TrEMBL
MGC_CLONE MGC:125046 IMAGE-MGC_LOAD
NCBI Gene 683897 ENTREZGENE
PANTHER MITOCHONDRIAL TRANSCRIPTION RESCUE FACTOR 1 UniProtKB/TrEMBL
  PTHR13633 UniProtKB/TrEMBL
PhenoGen Mtres1 PhenoGen
RatGTEx ENSRNOG00000047118 RatGTEx
UniProt A0A8I6A8Y4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ARF0 ENTREZGENE, UniProtKB/TrEMBL
  A6K6W9 ENTREZGENE, UniProtKB/TrEMBL
  M0R7R2_RAT UniProtKB/TrEMBL
  Q3B8P7 ENTREZGENE
UniProt Secondary Q3B8P7 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-08-13 Mtres1  mitochondrial transcription rescue factor 1  LOC683897  similar to Protein C6orf203  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC683897  similar to Protein C6orf203      Symbol and Name status set to provisional 70820 PROVISIONAL