Bricd5 (BRICHOS domain containing 5) - Rat Genome Database

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Gene: Bricd5 (BRICHOS domain containing 5) Rattus norvegicus
Analyze
Symbol: Bricd5
Name: BRICHOS domain containing 5
RGD ID: 1596720
Description: Predicted to be involved in regulation of cell population proliferation. Predicted to be located in membrane. Predicted to be active in extracellular space. Orthologous to human BRICD5 (BRICHOS domain containing 5); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; Cuprizon.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: BRICHOS domain-containing protein 5; hypothetical protein LOC681370; LOC681370
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81014,003,276 - 14,004,809 (+)NCBIGRCr8
mRatBN7.21013,498,726 - 13,500,259 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1013,498,381 - 13,500,259 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1018,245,294 - 18,246,827 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01017,734,139 - 17,735,672 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01013,233,324 - 13,234,857 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01013,839,599 - 13,841,132 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1013,839,956 - 13,841,018 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01013,656,585 - 13,658,118 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41013,725,912 - 13,727,392 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1013,179,206 - 13,180,739 (+)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Bricd5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81014,003,276 - 14,004,809 (+)NCBIGRCr8
mRatBN7.21013,498,726 - 13,500,259 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1013,498,381 - 13,500,259 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1018,245,294 - 18,246,827 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01017,734,139 - 17,735,672 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01013,233,324 - 13,234,857 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01013,839,599 - 13,841,132 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1013,839,956 - 13,841,018 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01013,656,585 - 13,658,118 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41013,725,912 - 13,727,392 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1013,179,206 - 13,180,739 (+)NCBICelera
Cytogenetic Map10q12NCBI
BRICD5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38162,209,253 - 2,210,863 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl162,209,253 - 2,210,905 (-)EnsemblGRCh38hg38GRCh38
GRCh37162,259,254 - 2,260,864 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36162,199,255 - 2,201,012 (-)NCBINCBI36Build 36hg18NCBI36
Celera162,473,671 - 2,475,428 (-)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef162,185,432 - 2,187,247 (-)NCBIHuRef
CHM1_1162,259,180 - 2,260,995 (-)NCBICHM1_1
T2T-CHM13v2.0162,231,710 - 2,233,320 (-)NCBIT2T-CHM13v2.0
Bricd5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391724,692,858 - 24,694,443 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1724,692,858 - 24,694,443 (+)EnsemblGRCm39 Ensembl
GRCm381724,473,487 - 24,475,471 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1724,473,884 - 24,475,469 (+)EnsemblGRCm38mm10GRCm38
MGSCv371724,610,829 - 24,612,414 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361724,201,484 - 24,203,069 (+)NCBIMGSCv36mm8
Celera1724,989,660 - 24,991,245 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.39NCBI
Bricd5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544215,055,513 - 15,060,526 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544215,054,116 - 15,056,506 (+)NCBIChiLan1.0ChiLan1.0
BRICD5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2182,712,154 - 2,714,336 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1166,493,122 - 6,495,662 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0161,067,543 - 1,069,836 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1162,310,660 - 2,312,995 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl162,310,660 - 2,312,995 (-)Ensemblpanpan1.1panPan2
BRICD5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1638,760,164 - 38,761,718 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl638,758,254 - 38,761,735 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha639,998,655 - 40,001,015 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0639,067,850 - 39,070,210 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl639,068,650 - 39,070,105 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1638,752,860 - 38,755,220 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0638,725,186 - 38,727,546 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0639,203,907 - 39,206,267 (+)NCBIUU_Cfam_GSD_1.0
Bricd5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344104,870,513 - 104,872,046 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366941,837,357 - 1,838,819 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366941,836,566 - 1,838,950 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BRICD5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl339,780,940 - 39,782,466 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1339,780,707 - 39,782,478 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2342,398,543 - 42,400,868 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BRICD5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.152,105,125 - 2,107,353 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl52,105,235 - 2,106,695 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606828,952,865 - 28,956,678 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bricd5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462491348,343 - 50,669 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462491348,445 - 50,752 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Bricd5
2 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:42
Count of miRNA genes:40
Interacting mature miRNAs:42
Transcripts:ENSRNOT00000012794
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10124158324Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
1576304Schws7Schwannoma susceptibility QTL 70.0115nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)10476552719816042Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402717245662Rat
737820Alc9Alcohol consumption QTL 92.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402719233348Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10615418215990232Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat

Markers in Region
AA957863  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21013,498,417 - 13,498,606 (+)MAPPERmRatBN7.2
Rnor_6.01013,839,291 - 13,839,479NCBIRnor6.0
Rnor_5.01013,656,277 - 13,656,465UniSTSRnor5.0
RGSC_v3.41013,725,551 - 13,725,739UniSTSRGSC3.4
Celera1013,178,898 - 13,179,086UniSTS
RH 3.4 Map10174.1UniSTS
Cytogenetic Map10q12UniSTS
RH127723  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21013,497,645 - 13,497,827 (+)MAPPERmRatBN7.2
Rnor_6.01013,838,519 - 13,838,700NCBIRnor6.0
Rnor_5.01013,655,505 - 13,655,686UniSTSRnor5.0
RGSC_v3.41013,724,779 - 13,724,960UniSTSRGSC3.4
Celera1013,178,126 - 13,178,307UniSTS
Cytogenetic Map10q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hepatobiliary system nervous system renal system reproductive system
High
Medium 10
Low 28 18 18 18 63 22 20
Below cutoff 4 12 12 12 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000012794   ⟹   ENSRNOP00000012794
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1013,498,381 - 13,500,259 (+)Ensembl
Rnor_6.0 Ensembl1013,839,956 - 13,841,018 (+)Ensembl
RefSeq Acc Id: NM_001317348   ⟹   NP_001304277
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,003,276 - 14,004,809 (+)NCBI
mRatBN7.21013,498,726 - 13,500,259 (+)NCBI
Rnor_6.01013,839,599 - 13,841,132 (+)NCBI
Celera1013,179,206 - 13,180,739 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001304277 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000012794
  ENSRNOP00000012794.6
Reference Protein Sequences
RefSeq Acc Id: NP_001304277   ⟸   NM_001317348
- UniProtKB: D3ZD16 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000012794   ⟸   ENSRNOT00000012794
Protein Domains
BRICHOS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZD16-F1-model_v2 AlphaFold D3ZD16 1-173 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697033
Promoter ID:EPDNEW_R7536
Type:single initiation site
Name:Bricd5_1
Description:BRICHOS domain containing 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01013,840,007 - 13,840,067EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1596720 AgrOrtholog
BioCyc Gene G2FUF-25855 BioCyc
Ensembl Genes ENSRNOG00000009611 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012794 ENTREZGENE
  ENSRNOT00000012794.6 UniProtKB/TrEMBL
Gene3D-CATH 3.30.390.150 UniProtKB/TrEMBL
InterPro BRICHOS_dom UniProtKB/TrEMBL
NCBI Gene 681370 ENTREZGENE
PANTHER BRICHOS DOMAIN-CONTAINING PROTEIN 5 UniProtKB/TrEMBL
  GASTROKINE 1 UniProtKB/TrEMBL
Pfam BRICHOS UniProtKB/TrEMBL
PhenoGen Bricd5 PhenoGen
PROSITE BRICHOS UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009611 RatGTEx
SMART BRICHOS UniProtKB/TrEMBL
UniProt D3ZD16 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-09 Bricd5  BRICHOS domain containing 5  LOC681370  hypothetical protein LOC681370  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC681370  hypothetical protein LOC681370      Symbol and Name status set to provisional 70820 PROVISIONAL