Chml (CHM like Rab escort protein) - Rat Genome Database

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Gene: Chml (CHM like Rab escort protein) Rattus norvegicus
Analyze
Symbol: Chml
Name: CHM like Rab escort protein
RGD ID: 1596201
Description: Predicted to enable small GTPase binding activity. Predicted to be involved in intracellular protein transport and small GTPase-mediated signal transduction. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of Rab-protein geranylgeranyltransferase complex. Human ortholog(s) of this gene implicated in asthma. Orthologous to human CHML (CHM like Rab escort protein); INTERACTS WITH 6-propyl-2-thiouracil; acetamide; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CHM like, Rab escort protein 2; choroideremia-like; choroideremia-like (Rab escort protein 2); LOC689102; rab proteins geranylgeranyltransferase component A 2; similar to Rab proteins geranylgeranyltransferase component A 2 (Rab escort protein 2) (REP-2) (Choroideraemia-like protein)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81390,141,880 - 90,152,097 (-)NCBIGRCr8
mRatBN7.21387,609,647 - 87,619,868 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1387,589,298 - 87,619,862 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1390,113,464 - 90,115,329 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01391,513,723 - 91,515,588 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01388,692,863 - 88,694,728 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01393,740,759 - 93,742,624 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01398,205,028 - 98,206,893 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41391,420,770 - 91,422,635 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1387,212,029 - 87,213,894 (-)NCBICelera
Cytogenetic Map13q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
2. Developmental aspects of automatic word processing: language lateralization of early ERP components in children, young adults and middle-aged subjects. Spironelli C and Angrilli A, Biol Psychol. 2009 Jan;80(1):35-45. Epub 2008 Feb 7.
Additional References at PubMed
PMID:12356470   PMID:15186776  


Genomics

Comparative Map Data
Chml
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81390,141,880 - 90,152,097 (-)NCBIGRCr8
mRatBN7.21387,609,647 - 87,619,868 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1387,589,298 - 87,619,862 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1390,113,464 - 90,115,329 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01391,513,723 - 91,515,588 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01388,692,863 - 88,694,728 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01393,740,759 - 93,742,624 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01398,205,028 - 98,206,893 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41391,420,770 - 91,422,635 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1387,212,029 - 87,213,894 (-)NCBICelera
Cytogenetic Map13q24NCBI
CHML
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381241,628,851 - 241,640,369 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1241,628,851 - 241,640,369 (-)EnsemblGRCh38hg38GRCh38
GRCh371241,792,153 - 241,803,671 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361239,858,789 - 239,865,855 (-)NCBINCBI36Build 36hg18NCBI36
Build 341238,118,203 - 238,125,273NCBI
Celera1215,047,269 - 215,054,335 (-)NCBICelera
Cytogenetic Map1q43NCBI
HuRef1212,250,224 - 212,257,290 (-)NCBIHuRef
CHM1_11243,064,835 - 243,071,901 (-)NCBICHM1_1
T2T-CHM13v2.01241,040,328 - 241,051,843 (-)NCBIT2T-CHM13v2.0
Chml
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391175,509,803 - 175,520,198 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1175,509,803 - 175,520,467 (-)EnsemblGRCm39 Ensembl
GRCm381175,682,237 - 175,688,353 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1175,682,237 - 175,692,901 (-)EnsemblGRCm38mm10GRCm38
MGSCv371177,612,368 - 177,618,484 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361177,523,163 - 177,525,028 (-)NCBIMGSCv36mm8
Celera1182,767,895 - 182,774,011 (-)NCBICelera
Cytogenetic Map1H3NCBI
cM Map181.7NCBI
Chml
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540610,455,367 - 10,461,934 (+)NCBIChiLan1.0ChiLan1.0
CHML
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v217,511,348 - 7,518,257 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan117,734,966 - 7,741,875 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01217,191,065 - 217,202,578 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11222,171,842 - 222,182,951 (-)NCBIpanpan1.1PanPan1.1panPan2
CHML
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1733,027,051 - 33,040,711 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha732,504,522 - 32,513,774 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0732,853,744 - 32,862,999 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl732,860,224 - 32,867,701 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1732,688,279 - 32,697,533 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0732,712,648 - 32,721,906 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0732,960,620 - 32,969,892 (-)NCBIUU_Cfam_GSD_1.0
Chml
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934445,903,365 - 45,909,195 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365268,833,921 - 8,844,484 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHML
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1011,835,582 - 11,845,804 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11011,835,472 - 11,845,833 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21014,057,719 - 14,062,929 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CHML
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12578,712,003 - 78,714,842 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605580,845,319 - 80,848,158 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Chml
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477111,981,078 - 11,987,379 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Chml
42 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
12879444Bp397Blood pressure QTL 397arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134504940490049404Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134551471990514719Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1374862117101339893Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000111169   ⟹   ENSRNOP00000088776
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1387,589,298 - 87,619,862 (-)Ensembl
RefSeq Acc Id: NM_001109524   ⟹   NP_001102994
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81390,141,880 - 90,152,097 (-)NCBI
mRatBN7.21387,609,647 - 87,619,868 (-)NCBI
Rnor_6.01393,740,759 - 93,742,624 (-)NCBI
Rnor_5.01398,205,028 - 98,206,893 (-)NCBI
RGSC_v3.41391,420,770 - 91,422,635 (-)RGD
Celera1387,212,029 - 87,213,894 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001102994 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL94772 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000088776
  ENSRNOP00000088776.1
Reference Protein Sequences
RefSeq Acc Id: NP_001102994   ⟸   NM_001109524
- UniProtKB: A0A8I6AAJ7 (UniProtKB/TrEMBL),   A6JGB6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000088776   ⟸   ENSRNOT00000111169

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1596201 AgrOrtholog
BioCyc Gene G2FUF-17229 BioCyc
Ensembl Genes ENSRNOG00000067369 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000111169 ENTREZGENE
  ENSRNOT00000111169.1 UniProtKB/TrEMBL
Gene3D-CATH 3.50.50.60 UniProtKB/TrEMBL
  Guanine Nucleotide Dissociation Inhibitor, domain 1 UniProtKB/TrEMBL
  Guanine Nucleotide Dissociation Inhibitor, domain 2 UniProtKB/TrEMBL
InterPro FAD/NAD-bd_sf UniProtKB/TrEMBL
  GDP_dissociation_inhibitor UniProtKB/TrEMBL
  Rab_escort UniProtKB/TrEMBL
KEGG Report rno:689102 UniProtKB/TrEMBL
NCBI Gene 689102 ENTREZGENE
PANTHER PTHR11787 UniProtKB/TrEMBL
  RAB PROTEINS GERANYLGERANYLTRANSFERASE COMPONENT A 2 UniProtKB/TrEMBL
Pfam GDI UniProtKB/TrEMBL
PhenoGen Chml PhenoGen
PIRSF Rab_ger_ger_transf_A_euk UniProtKB/TrEMBL
PRINTS RABESCORT UniProtKB/TrEMBL
  RABGDIREP UniProtKB/TrEMBL
RatGTEx ENSRNOG00000067369 RatGTEx
Superfamily-SCOP FAD-linked reductases, C-terminal domain UniProtKB/TrEMBL
  SSF51905 UniProtKB/TrEMBL
UniProt A0A8I6AAJ7 ENTREZGENE, UniProtKB/TrEMBL
  A6JGB6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-10 Chml  CHM like Rab escort protein  Chml  CHM like, Rab escort protein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2017-02-07 Chml  CHM like, Rab escort protein 2  Chml  choroideremia-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-12-09 Chml  choroideremia-like  Chml  choroideremia-like (Rab escort protein 2)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Chml  choroideremia-like (Rab escort protein 2)  Chml  choroideremia-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-07-08 Chml  choroideremia-like  LOC682080  similar to Rab proteins geranylgeranyltransferase component A 2 (Rab escort protein 2) (REP-2) (Choroideraemia-like protein)  Data merged from RGD:1588087 1643240 APPROVED
2008-03-06 Chml  choroideremia-like  LOC689102  similar to Rab proteins geranylgeranyltransferase component A 2 (Rab escort protein 2) (REP-2) (Choroideraemia-like protein)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC689102  similar to Rab proteins geranylgeranyltransferase component A 2 (Rab escort protein 2) (REP-2) (Choroideraemia-like protein)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC682080  similar to Rab proteins geranylgeranyltransferase component A 2 (Rab escort protein 2) (REP-2) (Choroideraemia-like protein)      Symbol and Name status set to provisional 70820 PROVISIONAL