Rnf186 (ring finger protein 186) - Rat Genome Database

Name: Rnf186
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Rnf186 (ring finger protein 186) Rattus norvegicus

Analyze

Symbol:

Rnf186

Name:

ring finger protein 186

RGD ID:

1596075

Description:

Predicted to enable ubiquitin protein ligase activity and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Predicted to act upstream of with a positive effect on regulation of autophagosome assembly. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human RNF186 (ring finger protein 186); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

E3 ubiquitin-protein ligase RNF186; LOC690433; similar to ring finger protein 186

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	RNF186 (ring finger protein 186)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Rnf186 (ring finger protein 186)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Rnf186 (ring finger protein 186)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	RNF186 (ring finger protein 186)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	RNF186 (ring finger protein 186)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Rnf186 (ring finger protein 186)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	RNF186 (ring finger protein 186)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	RNF186 (ring finger protein 186)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Rnf186 (ring finger protein 186)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	RNF186 (ring finger protein 186)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Rnf186 (ring finger protein 186)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	rnf186	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	156,493,750 - 156,494,974 (+)	NCBI		GRCr8
mRatBN7.2	5	151,210,492 - 151,211,716 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	151,210,492 - 151,211,716 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	153,907,775 - 153,908,999 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	155,682,075 - 155,683,299 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	155,663,993 - 155,665,217 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	157,416,897 - 157,418,121 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	157,416,897 - 157,418,121 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	161,156,805 - 161,158,029 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	157,790,446 - 157,791,670 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	5	149,595,940 - 149,597,164 (+)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

3-Hydroxy-3-Methylglutaryl-CoA Lyase Deficiency (ISO)

chromosome 1p36 deletion syndrome (ISO)

congenital disorder of glycosylation Ir (ISO)

genetic disease (ISO)

hyperprolinemia type 2 (ISO)

Parkinson's disease 6 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1-dichloroethene (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP)

17beta-estradiol 3-benzoate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

aflatoxin B1 (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlordecone (ISO)

ciguatoxin CTX1B (ISO)

copper(II) sulfate (ISO)

dibenz[a,h]anthracene (ISO)

dichloroacetic acid (ISO)

dioxygen (ISO)

endosulfan (EXP)

fonofos (ISO)

furan (EXP)

graphene oxide (ISO)

MeIQx (ISO)

paracetamol (ISO)

parathion (ISO)

phenobarbital (ISO)

PhIP (ISO)

pirinixic acid (ISO)

potassium dichromate (ISO)

pravastatin (EXP,ISO)

propiconazole (ISO)

rotenone (ISO)

sodium arsenite (ISO)

sulfasalazine (ISO)

tamoxifen (ISO)

terbufos (ISO)

tetrachloroethene (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

triptonide (ISO)

valproic acid (ISO)

vancomycin (ISO)

zaragozic acid A (EXP,ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (IBA,ISO)

proteasome-mediated ubiquitin-dependent protein catabolic process (IBA,ISO)

protein autoubiquitination (IBA,ISO)

protein K29-linked ubiquitination (IBA,ISO)

protein K63-linked ubiquitination (IBA,ISO)

protein localization to mitochondrion (IBA,ISO)

regulation of autophagosome assembly (ISO)

Cellular Component

endoplasmic reticulum (ISO)

endoplasmic reticulum membrane (IBA,ISO)

Molecular Function

protein binding (ISO)

ubiquitin protein ligase activity (IBA,ISO)

ubiquitin protein ligase binding (ISO)

ubiquitin-protein transferase activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:23896122

Genomics

Comparative Map Data

Rnf186
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	156,493,750 - 156,494,974 (+)	NCBI		GRCr8
mRatBN7.2	5	151,210,492 - 151,211,716 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	151,210,492 - 151,211,716 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	153,907,775 - 153,908,999 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	155,682,075 - 155,683,299 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	155,663,993 - 155,665,217 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	157,416,897 - 157,418,121 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	157,416,897 - 157,418,121 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	161,156,805 - 161,158,029 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	157,790,446 - 157,791,670 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	5	149,595,940 - 149,597,164 (+)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

RNF186
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	19,814,029 - 19,815,283 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	19,814,029 - 19,815,283 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	20,140,522 - 20,141,776 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	20,013,109 - 20,014,358 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	1	18,467,352 - 18,468,601 (-)	NCBI		Celera
Cytogenetic Map	1	p36.13	NCBI
HuRef	1	18,386,249 - 18,387,498 (-)	NCBI		HuRef
CHM1_1	1	20,249,753 - 20,251,002 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	19,637,417 - 19,638,671 (-)	NCBI		T2T-CHM13v2.0

Rnf186
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	138,694,430 - 138,695,676 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	138,694,423 - 138,695,676 (+)	Ensembl		GRCm39 Ensembl
GRCm38	4	138,967,119 - 138,968,365 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	138,967,112 - 138,968,360 (+)	Ensembl	GRCm38		mm10	GRCm38
GRCm38.p6 Ensembl	4	138,967,112 - 138,968,365 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	138,523,027 - 138,524,281 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	138,239,280 - 138,240,435 (+)	NCBI		MGSCv36	mm8
Celera	4	140,754,105 - 140,755,357 (+)	NCBI		Celera
Cytogenetic Map	4	D3	NCBI
cM Map	4	70.57	NCBI

Rnf186
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955452	433,413 - 450,261 (-)	NCBI	ChiLan1.0	ChiLan1.0

RNF186
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	207,301,629 - 207,304,516 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	206,418,499 - 206,421,352 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	18,770,083 - 18,772,399 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	19,813,395 - 19,814,638 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	19,813,784 - 19,814,467 (-)	Ensembl	panpan1.1		panPan2

RNF186
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	78,915,131 - 78,916,909 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	78,915,339 - 78,916,037 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	75,427,537 - 75,431,936 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	79,481,271 - 79,488,772 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	79,482,634 - 79,483,332 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	76,299,635 - 76,307,132 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	77,306,635 - 77,314,121 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	78,377,765 - 78,385,273 (+)	NCBI		UU_Cfam_GSD_1.0

Rnf186
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	40,121,950 - 40,123,137 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936474	5,947,077 - 5,947,772 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RNF186
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	78,192,337 - 78,198,597 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	78,195,692 - 78,199,058 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

RNF186
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	112,729,333 - 112,732,063 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	112,731,000 - 112,731,683 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	3,448,091 - 3,449,581 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rnf186
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624764	4,897,234 - 4,898,470 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Rnf186
5 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	245
Count of miRNA genes:	176
Interacting mature miRNAs:	200
Transcripts:	ENSRNOT00000023358
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1576314	Eutr1	Estrogen induced uterine response QTL 1			uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	2138965	166875058	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	46711509	161317411	Rat
61393	Bp7	Blood pressure QTL 7	4.5	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	60293434	161481680	Rat
1302790	Scl20	Serum cholesterol level QTL 20	6.4	0.0001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	82394392	166664054	Rat
7207488	Bss110	Bone structure and strength QTL 1	8.4		femur strength trait (VT:0010010)	femur stiffness (CMO:0001674)	5	106906205	151906205	Rat
7207491	Bss112	Bone structure and strength QTL 112	7		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	5	106906205	151906205	Rat
7207481	Bss106	Bone structure and strength QTL 106	7.9		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	5	106906205	151906205	Rat
7207486	Bss109	Bone structure and strength QTL 109			femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	5	106906205	151906205	Rat
1549838	Bss4	Bone structure and strength QTL 4	9.2		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	5	106906205	151906205	Rat
1298089	Scl14	Serum cholesterol level QTL 14	5.8	0.0004	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	108845856	153845856	Rat
1598847	Cm62	Cardiac mass QTL 62	3.4		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	108845856	153845856	Rat
8657050	Bw146	Body weight QTL 146	19.84	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	108938288	153938288	Rat
8694441	Bw169	Body weight QTL 169	17.61	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	5	111416838	156416838	Rat
8694198	Abfw3	Abdominal fat weight QTL 3	16.13	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	5	111416838	156416838	Rat
8694389	Bw160	Body weight QTL 160	6.17	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	5	111416838	156416838	Rat
8552960	Pigfal15	Plasma insulin-like growth factor 1 level QTL 15			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	111416838	156416838	Rat
1641920	Colcs1	Colorectal carcinoma susceptibility QTL 1	2.99	0.0055	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	5	121846814	166846814	Rat
10053720	Scort26	Serum corticosterone level QTL 26	2.06	0.0147	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	124965598	166875058	Rat
724525	Bp147	Blood pressure QTL 147	4.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	126424772	166875058	Rat
1598819	Bp292	Blood pressure QTL 292	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	127798274	166875058	Rat
1598861	Cm64	Cardiac mass QTL 64	2.9		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	127798274	166875058	Rat
8552908	Pigfal4	Plasma insulin-like growth factor 1 level QTL 4	6.6		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	128506074	166875058	Rat
8694169	Bw148	Body weight QTL 148	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	128506074	166875058	Rat
634349	Bp139	Blood pressure QTL 139		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	128924607	166875058	Rat
738018	Anxrr4	Anxiety related response QTL 4	5.1		exploratory behavior trait (VT:0010471)	percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)	5	130130159	166875058	Rat
7794791	Mcs33	Mammary carcinoma susceptibility QTL 33	1.93		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	5	131345754	166875058	Rat
631505	Bp103	Blood pressure QTL 103	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	132717196	165560427	Rat
631562	Apr2	Acute phase response QTL 2	3.7		blood murinoglobulin 1 amount (VT:0010597)	plasma murinoglobulin 1 level (CMO:0001931)	5	135927956	166875058	Rat
61444	Strs2	Sensitivity to stroke QTL 2	4.7		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	5	135929696	166875058	Rat
1331721	Bp210	Blood pressure QTL 210	3.413		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	5	143069996	166846814	Rat
2302369	Scl60	Serum cholesterol level QTL 60	3.13		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	143608201	161165651	Rat
631263	Cm24	Cardiac mass QTL 24	3.5		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	5	143799107	158428037	Rat
1300119	Bp180	Blood pressure QTL 180	3.82		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	5	144358090	157869054	Rat
2313096	Bmd78	Bone mineral density QTL 78	3.1	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	5	144377876	161317411	Rat
1298090	Bp155	Blood pressure QTL 155	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	5	151006154	161165494	Rat
1354631	Swd2	Spike wave discharge measurement QTL 2	3.64	0.0002	brain electrophysiology trait (VT:0010557)	brain total spike-and-wave discharge duration (CMO:0001740)	5	151113452	164465185	Rat
631272	Lanf1	Left ventricular atrial natriuretic factor QTL 1	12		heart left ventricle natriuretic peptide A amount (VT:0010596)	heart left ventricle natriuretic peptide A level (CMO:0002165)	5	151113452	166875058	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system
High
Medium	3								11
Low			18	18		18			24	14	1
Below cutoff		4	28	22	11	22	1	2		19	7

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001109592	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473968	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000023358 ⟹ ENSRNOP00000023358

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	151,210,492 - 151,211,716 (+)	Ensembl
Rnor_6.0 Ensembl	5	157,416,897 - 157,418,121 (+)	Ensembl

RefSeq Acc Id:

NM_001109592 ⟹ NP_001103062

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	156,493,750 - 156,494,974 (+)	NCBI
mRatBN7.2	5	151,210,492 - 151,211,716 (+)	NCBI
Rnor_6.0	5	157,416,897 - 157,418,121 (+)	NCBI
Rnor_5.0	5	161,156,805 - 161,158,029 (+)	NCBI
RGSC_v3.4	5	157,790,446 - 157,791,670 (+)	RGD
Celera	5	149,595,940 - 149,597,164 (+)	RGD

Sequence:

show sequence

GCAGAGAAGCAAGCTGAGCAACAGGAGAGCAAGATGCCAGACATCCGCTGTCAGCAGGTACCCG
CGGAGAGCAGAAAGGAGGCCGGAAGCGTCCCCACGGGGCCGGAACCCATGCAAGTCCCGGCAGC
TCCAGCGGACATCGCGTGCGGATGCCCCTGCGCGGAACAGCCTCATCCCCCCAGCTCCGTACCC
AGAGTGTCCTGTACTGAGGCCCCACAGCCTATCCCAGCGGGTGCCACCACCACAAACACCATCA
TTGCCTTGGGGCCCACTGGGCGTCTCAGTATCTCCGTGGAGGGTGACCTGGAATGCTTGGTGTG
CCGAGAGCCCTACAACTGTGCCCGCTCCCCCAAGCTGCTTAGCTGTCAGCACACCTTCTGTGCC
GTATGCTTGAAGCTTCTGCTGTATGTGCAGGAAGACACCTGGTCCATCCCCTGTCCACTGTGCC
GAAAGGTCACTGCCGTCCCGGGAGGCCTCATCTGCAGCCTGCGAGACCAGGAGGCGATGGTGGG
GCGTCTGGCCCTGCCATGCCCAGAGGTGCGCCTGTGTCCCCAGAGACTAGTGGGCCCTGCTGCT
TCAGCAGCAGCTCATCCAGCCAACCGGACAGGAGAAGACGAACAAGACGTAGTGAGTGTCAACC
GTGTAGCTGCCCGGCGTCTGGCTGTACACTTGCTCTTGTTGGCTCTTCTCATTGTACTTATCCT
GCCTTTCATCTACCCCGGCGTCATCCGGTGGGTGCTGGCCTTTGTCATTGCCCTAGCGCTCCTG
ATGTCCACCCTATTCTGCTGTCACCCCCAGAGCCAGAGCAGCAACTGGCCTTGCCCTAGGACTC
TGTTCTGCAGAGAGCAAAAGCAAACCCAGATCACTTCTATTGCCTGAGACATCTATATCCTCAC
AGGCCCAGCGCTGCCATGGTTCCCTCCTCCCCCAGACCTCACAGTCTGCACGGGTAAGGGGCTG
GCTCAGACTGAACTTGCCTGTCAAAGACAGACTGGCTGTGTTGGATCAAGGACTCCGTGCTGCA
CCAATGGGGGTCACACCTGTCTGTCTTTGTGTAGCATAGGAAGGAAAAAGGGGGAAGGGGAGGA
GACCTACCCCTGAGCGAGTGACTCAAGGGTGGTGGGGTCCCTATCCCTTTTCCAGAGCTCCTGG
GTTTTGTATATAGCTGTGGACATTTTGGGACATTGACCTTACTACAAAGCAAATAGAACCAGAC
CTCTTTTGT

hide sequence

Protein Sequences


Protein RefSeqs	NP_001103062	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL80898	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000023358
	ENSRNOP00000023358.3

RefSeq Acc Id:

NP_001103062 ⟸ NM_001109592

- UniProtKB:

D4A7F1 (UniProtKB/TrEMBL), A6ITJ7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPDIRCQQVPAESRKEAGSVPTGPEPMQVPAAPADIACGCPCAEQPHPPSSVPRVSCTEAPQPI
PAGATTTNTIIALGPTGRLSISVEGDLECLVCREPYNCARSPKLLSCQHTFCAVCLKLLLYVQE
DTWSIPCPLCRKVTAVPGGLICSLRDQEAMVGRLALPCPEVRLCPQRLVGPAASAAAHPANRTG
EDEQDVVSVNRVAARRLAVHLLLLALLIVLILPFIYPGVIRWVLAFVIALALLMSTLFCCHPQS
QSSNWPCPRTLFCREQKQTQITSIA

hide sequence

RefSeq Acc Id:

ENSRNOP00000023358 ⟸ ENSRNOT00000023358

Protein Domains

RING-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4A7F1-F1-model_v2	AlphaFold	D4A7F1	1-281	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13694196

Promoter ID:

EPDNEW_R4721

Type:

multiple initiation site

Name:

Rnf186_1

Description:

ring finger protein 186

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	5	157,416,899 - 157,416,959	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1596075	AgrOrtholog
BioCyc Gene	G2FUF-39434	BioCyc
Ensembl Genes	ENSRNOG00000017244	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000023358	ENTREZGENE
	ENSRNOT00000023358.4	UniProtKB/TrEMBL
Gene3D-CATH	3.30.40.10	UniProtKB/TrEMBL
InterPro	Znf-RING_euk	UniProtKB/TrEMBL
	Znf_RING	UniProtKB/TrEMBL
	Znf_RING/FYVE/PHD	UniProtKB/TrEMBL
	Znf_RING_CS	UniProtKB/TrEMBL
KEGG Report	rno:690433	UniProtKB/TrEMBL
NCBI Gene	690433	ENTREZGENE
PANTHER	E3 UBIQUITIN-PROTEIN LIGASE RNF186	UniProtKB/TrEMBL
	UNCHARACTERIZED	UniProtKB/TrEMBL
Pfam	zf-RING_UBOX	UniProtKB/TrEMBL
PhenoGen	Rnf186	PhenoGen
PROSITE	ZF_RING_1	UniProtKB/TrEMBL
	ZF_RING_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000017244	RatGTEx
SMART	RING	UniProtKB/TrEMBL
Superfamily-SCOP	RING/U-box	UniProtKB/TrEMBL
UniProt	A6ITJ7	ENTREZGENE, UniProtKB/TrEMBL
	D4A7F1	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-06	Rnf186	ring finger protein 186	LOC690433	similar to ring finger protein 186	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-01-09	LOC690433	similar to ring finger protein 186	LOC684585	similar to ring finger protein 186	Data merged from RGD:1589100	1643240	APPROVED
2006-11-20	LOC690433	similar to ring finger protein 186			Symbol and Name status set to provisional	70820	PROVISIONAL
2006-11-19	LOC684585	similar to ring finger protein 186			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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