Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | decreases expression | ISO | Prrc2b (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of PRRC2B mRNA | CTD | PMID:22206623 | 1,2-dimethylhydrazine | multiple interactions | ISO | Prrc2b (Mus musculus) | 6480464 | Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in decreased expression of PRRC2B mRNA] | CTD | PMID:22206623 | 17beta-estradiol | decreases expression | EXP | | 6480464 | Estradiol results in decreased expression of PRRC2B mRNA | CTD | PMID:32145629 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PRRC2B mRNA | CTD | PMID:33387578 | 2-hydroxypropanoic acid | increases expression | ISO | PRRC2B (Homo sapiens) | 6480464 | Lactic Acid results in increased expression of PRRC2B mRNA | CTD | PMID:30851411 | 3,4-methylenedioxymethamphetamine | increases methylation | ISO | Prrc2b (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased methylation of PRRC2B promoter | CTD | PMID:26251327 | 3,4-methylenedioxymethamphetamine | decreases expression | ISO | Prrc2b (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of PRRC2B mRNA | CTD | PMID:26251327 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | PRRC2B (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PRRC2B mRNA | CTD | PMID:28628672 | aflatoxin B1 | increases expression | ISO | Prrc2b (Mus musculus) | 6480464 | Aflatoxin B1 results in increased expression of PRRC2B mRNA | CTD | PMID:19770486 | aflatoxin B1 | increases methylation | ISO | PRRC2B (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of PRRC2B gene | CTD | PMID:28458013 | Aflatoxin B2 alpha | decreases methylation | ISO | PRRC2B (Homo sapiens) | 6480464 | aflatoxin B2 results in decreased methylation of PRRC2B intron | CTD | PMID:30157460 | all-trans-retinoic acid | decreases expression | ISO | PRRC2B (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of PRRC2B mRNA | CTD | PMID:33167477 | amphetamine | decreases expression | EXP | | 6480464 | Amphetamine results in decreased expression of PRRC2B mRNA | CTD | PMID:30779732 | arsane | affects methylation | ISO | PRRC2B (Homo sapiens) | 6480464 | Arsenic affects the methylation of PRRC2B gene | CTD | PMID:25304211 | arsenic atom | affects methylation | ISO | PRRC2B (Homo sapiens) | 6480464 | Arsenic affects the methylation of PRRC2B gene | CTD | PMID:25304211 | arsenite(3-) | multiple interactions | ISO | PRRC2B (Homo sapiens) | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to PRRC2B mRNA] | CTD | PMID:32406909 | benzo[a]pyrene | increases mutagenesis | ISO | PRRC2B (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased mutagenesis of PRRC2B gene | CTD | PMID:25435355 | benzo[a]pyrene | increases methylation | ISO | Prrc2b (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased methylation of PRRC2B 3' UTR more ... | CTD | PMID:27901495 | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of PRRC2B mRNA | CTD | PMID:25181051 more ... | bisphenol A | decreases expression | ISO | Prrc2b (Mus musculus) | 6480464 | bisphenol A results in decreased expression of PRRC2B mRNA | CTD | PMID:38074096 | bisphenol A | multiple interactions | ISO | PRRC2B (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of PRRC2B gene | CTD | PMID:31601247 | bisphenol A | decreases methylation | ISO | PRRC2B (Homo sapiens) | 6480464 | bisphenol A results in decreased methylation of PRRC2B gene | CTD | PMID:31601247 | bisphenol A | increases expression | ISO | Prrc2b (Mus musculus) | 6480464 | bisphenol A results in increased expression of PRRC2B mRNA | CTD | PMID:33221593 | bisphenol F | multiple interactions | ISO | PRRC2B (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PRRC2B mRNA | CTD | PMID:28628672 | buta-1,3-diene | decreases expression | ISO | Prrc2b (Mus musculus) | 6480464 | 1 and 3-butadiene results in decreased expression of PRRC2B mRNA | CTD | PMID:29038090 | C60 fullerene | decreases expression | EXP | | 6480464 | fullerene C60 results in decreased expression of PRRC2B mRNA | CTD | PMID:19167457 | caffeine | affects phosphorylation | ISO | PRRC2B (Homo sapiens) | 6480464 | Caffeine affects the phosphorylation of PRRC2B protein | CTD | PMID:35688186 | cantharidin | decreases expression | ISO | Prrc2b (Mus musculus) | 6480464 | Cantharidin results in decreased expression of PRRC2B mRNA | CTD | PMID:36907384 | carbon nanotube | decreases expression | ISO | Prrc2b (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | cisplatin | decreases expression | ISO | PRRC2B (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of PRRC2B mRNA | CTD | PMID:27594783 | clobetasol | decreases expression | ISO | Prrc2b (Mus musculus) | 6480464 | Clobetasol results in decreased expression of PRRC2B mRNA | CTD | PMID:27462272 | coumarin | increases phosphorylation | ISO | PRRC2B (Homo sapiens) | 6480464 | coumarin results in increased phosphorylation of PRRC2B protein | CTD | PMID:35688186 | dexamethasone | multiple interactions | ISO | PRRC2B (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PRRC2B mRNA | CTD | PMID:28628672 | dicrotophos | increases expression | ISO | PRRC2B (Homo sapiens) | 6480464 | dicrotophos results in increased expression of PRRC2B mRNA | CTD | PMID:28302478 | enzyme inhibitor | multiple interactions | ISO | PRRC2B (Homo sapiens) | 6480464 | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of PRRC2B protein | CTD | PMID:23301498 | epoxiconazole | decreases expression | ISO | Prrc2b (Mus musculus) | 6480464 | epoxiconazole results in decreased expression of PRRC2B mRNA | CTD | PMID:35436446 | ethanol | decreases expression | ISO | Prrc2b (Mus musculus) | 6480464 | Ethanol results in decreased expression of PRRC2B mRNA | CTD | PMID:29018328 | ethanol | increases expression | ISO | Prrc2b (Mus musculus) | 6480464 | Ethanol results in increased expression of PRRC2B mRNA | CTD | PMID:30319688 | ethanol | multiple interactions | ISO | Prrc2b (Mus musculus) | 6480464 | Ethanol affects the expression of and affects the splicing of PRRC2B mRNA | CTD | PMID:30319688 | ethyl methanesulfonate | increases expression | ISO | PRRC2B (Homo sapiens) | 6480464 | Ethyl Methanesulfonate results in increased expression of PRRC2B mRNA | CTD | PMID:23649840 | fenthion | decreases expression | ISO | Prrc2b (Mus musculus) | 6480464 | Fenthion results in decreased expression of PRRC2B mRNA | CTD | PMID:34813904 | fenvalerate | increases expression | EXP | | 6480464 | fenvalerate results in increased expression of PRRC2B mRNA | CTD | PMID:30307764 | folic acid | multiple interactions | ISO | Prrc2b (Mus musculus) | 6480464 | Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in decreased expression of PRRC2B mRNA] | CTD | PMID:22206623 | FR900359 | affects phosphorylation | ISO | PRRC2B (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of PRRC2B protein | CTD | PMID:37730182 | fulvestrant | multiple interactions | ISO | PRRC2B (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of PRRC2B gene | CTD | PMID:31601247 | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of PRRC2B mRNA | CTD | PMID:22061828 | hexadecanoic acid | affects phosphorylation | ISO | PRRC2B (Homo sapiens) | 6480464 | Palmitic Acid affects the phosphorylation of PRRC2B protein | CTD | PMID:28073184 | indometacin | multiple interactions | ISO | PRRC2B (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PRRC2B mRNA | CTD | PMID:28628672 | methidathion | decreases expression | ISO | Prrc2b (Mus musculus) | 6480464 | methidathion results in decreased expression of PRRC2B mRNA | CTD | PMID:34813904 | Mono-carboxy isooctyl phthalate | affects expression | ISO | PRRC2B (Homo sapiens) | 6480464 | mono(carboxy-isooctyl)phthalate affects the expression of PRRC2B mRNA | CTD | PMID:34478338 | N-nitrosodiethylamine | multiple interactions | ISO | Prrc2b (Mus musculus) | 6480464 | [Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of PRRC2B gene | CTD | PMID:23968726 | paracetamol | increases expression | ISO | PRRC2B (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of PRRC2B mRNA | CTD | PMID:29067470 | pentachlorophenol | increases expression | ISO | Prrc2b (Mus musculus) | 6480464 | Pentachlorophenol results in increased expression of PRRC2B mRNA | CTD | PMID:23892564 | piperonyl butoxide | multiple interactions | ISO | Prrc2b (Mus musculus) | 6480464 | [Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of PRRC2B gene | CTD | PMID:23968726 | propiconazole | decreases expression | ISO | Prrc2b (Mus musculus) | 6480464 | propiconazole results in decreased expression of PRRC2B mRNA | CTD | PMID:21278054 | quercetin | increases expression | ISO | PRRC2B (Homo sapiens) | 6480464 | Quercetin results in increased expression of PRRC2B mRNA | CTD | PMID:21632981 | rac-lactic acid | increases expression | ISO | PRRC2B (Homo sapiens) | 6480464 | Lactic Acid results in increased expression of PRRC2B mRNA | CTD | PMID:30851411 | resveratrol | multiple interactions | ISO | PRRC2B (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in increased expression of PRRC2B mRNA | CTD | PMID:23557933 | testosterone | increases expression | ISO | Prrc2b (Mus musculus) | 6480464 | Testosterone deficiency results in increased expression of PRRC2B mRNA | CTD | PMID:33848595 | troglitazone | decreases expression | ISO | Prrc2b (Mus musculus) | 6480464 | troglitazone results in decreased expression of PRRC2B mRNA | CTD | PMID:28973697 | tungsten | decreases expression | ISO | Prrc2b (Mus musculus) | 6480464 | Tungsten results in decreased expression of PRRC2B mRNA | CTD | PMID:30912803 | valproic acid | increases methylation | ISO | PRRC2B (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of PRRC2B gene | CTD | PMID:29154799 | valproic acid | affects splicing | EXP | | 6480464 | Valproic Acid affects the splicing of PRRC2B mRNA | CTD | PMID:29427782 | vorinostat | decreases expression | ISO | PRRC2B (Homo sapiens) | 6480464 | vorinostat results in decreased expression of PRRC2B mRNA | CTD | PMID:27188386 | xylitol | increases expression | ISO | PRRC2B (Homo sapiens) | 6480464 | Xylitol results in increased expression of PRRC2B mRNA | CTD | PMID:32275922 | |