Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dichloroethane | affects expression | ISO | H2-Ob (Mus musculus) | 6480464 | ethylene dichloride affects the expression of H2-OB mRNA | CTD | PMID:28960355 | 1,2-dimethylhydrazine | increases expression | ISO | H2-Ob (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of H2-OB mRNA | CTD | PMID:22206623 | 1-naphthyl isothiocyanate | decreases expression | EXP | | 6480464 | 1-Naphthylisothiocyanate results in decreased expression of RT1-DOB mRNA | CTD | PMID:30723492 | 17beta-estradiol | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of RT1-DOB mRNA | CTD | PMID:32741896 | 17beta-estradiol 3-benzoate | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of RT1-DOB mRNA | CTD | PMID:32741896 | 2,2',4,4',5,5'-hexachlorobiphenyl | multiple interactions | ISO | H2-Ob (Mus musculus) | 6480464 | [2 more ... | CTD | PMID:25510870 | 2,2',5,5'-tetrachlorobiphenyl | multiple interactions | ISO | H2-Ob (Mus musculus) | 6480464 | [2 more ... | CTD | PMID:25510870 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | H2-Ob (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to H2-OB promoter] | CTD | PMID:19654925 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | H2-Ob (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of H2-OB mRNA | CTD | PMID:28213091 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | H2-Ob (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of H2-OB mRNA | CTD | PMID:26290441 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | H2-Ob (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of H2-OB mRNA | CTD | PMID:26377647 | 2-butoxyethanol | decreases expression | ISO | H2-Ob (Mus musculus) | 6480464 | n-butoxyethanol results in decreased expression of H2-OB mRNA | CTD | PMID:19812364 | 4,4'-diaminodiphenylmethane | increases expression | ISO | H2-Ob (Mus musculus) | 6480464 | 4 and 4'-diaminodiphenylmethane results in increased expression of H2-OB mRNA | CTD | PMID:18648102 | acrylamide | decreases expression | EXP | | 6480464 | Acrylamide results in decreased expression of RT1-DOB mRNA | CTD | PMID:28959563 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of RT1-DOB mRNA | CTD | PMID:16483693 | amphetamine | decreases expression | EXP | | 6480464 | Amphetamine results in decreased expression of RT1-DOB mRNA | CTD | PMID:30779732 | antirheumatic drug | decreases expression | ISO | HLA-DOB (Homo sapiens) | 6480464 | Antirheumatic Agents results in decreased expression of HLA-DOB mRNA | CTD | PMID:24449571 | arsane | decreases expression | ISO | H2-Ob (Mus musculus) | 6480464 | Arsenic results in decreased expression of H2-OB mRNA | CTD | PMID:19654921 | arsenic atom | decreases expression | ISO | H2-Ob (Mus musculus) | 6480464 | Arsenic results in decreased expression of H2-OB mRNA | CTD | PMID:19654921 | atrazine | affects methylation | EXP | | 6480464 | Atrazine affects the methylation of RT1-DOB gene | CTD | PMID:28931070 | benzalkonium chloride | affects response to substance | ISO | HLA-DOB (Homo sapiens) | 6480464 | HLA-DOB SNP affects the susceptibility to Benzalkonium Compounds | CTD | PMID:27258892 | benzo[a]pyrene | multiple interactions | ISO | H2-Ob (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of H2-OB mRNA | CTD | PMID:27858113 | benzo[a]pyrene | decreases expression | ISO | HLA-DOB (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of HLA-DOB mRNA | CTD | PMID:35870112 | benzo[a]pyrene | affects methylation | ISO | HLA-DOB (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of HLA-DOB promoter | CTD | PMID:27901495 | benzo[a]pyrene | increases expression | ISO | H2-Ob (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of H2-OB mRNA | CTD | PMID:32417428 | benzo[a]pyrene | decreases methylation | ISO | HLA-DOB (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of HLA-DOB exon | CTD | PMID:27901495 | benzo[b]fluoranthene | increases expression | ISO | H2-Ob (Mus musculus) | 6480464 | benzo(b)fluoranthene results in increased expression of H2-OB mRNA | CTD | PMID:26377693 | benzo[b]fluoranthene | multiple interactions | ISO | H2-Ob (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of H2-OB mRNA | CTD | PMID:27858113 | Benzo[ghi]perylene | increases expression | ISO | H2-Ob (Mus musculus) | 6480464 | 1 and 12-benzoperylene results in increased expression of H2-OB mRNA | CTD | PMID:26377693 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of HLA-DOB mRNA | CTD | PMID:25181051 | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of RT1-DOB gene | CTD | PMID:28505145 | buta-1,3-diene | decreases expression | ISO | H2-Ob (Mus musculus) | 6480464 | 1 and 3-butadiene results in decreased expression of H2-OB mRNA | CTD | PMID:29038090 | C60 fullerene | increases expression | EXP | | 6480464 | fullerene C60 results in increased expression of RT1-DOB mRNA | CTD | PMID:19167457 | cadmium dichloride | decreases methylation | EXP | | 6480464 | Cadmium Chloride results in decreased methylation of RT1-DOB promoter | CTD | PMID:22457795 | carbon nanotube | decreases expression | ISO | H2-Ob (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | chloroprene | decreases expression | ISO | H2-Ob (Mus musculus) | 6480464 | Chloroprene results in decreased expression of H2-OB mRNA | CTD | PMID:23125180 | chrysene | multiple interactions | ISO | H2-Ob (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of H2-OB mRNA | CTD | PMID:27858113 | dextran sulfate | increases expression | ISO | H2-Ob (Mus musculus) | 6480464 | Dextran Sulfate results in increased expression of H2-OB mRNA | CTD | PMID:23894361 | dimethylarsinic acid | multiple interactions | ISO | H2-Ob (Mus musculus) | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of H2-OB mRNA | CTD | PMID:34876320 | dioxygen | multiple interactions | ISO | H2-Ob (Mus musculus) | 6480464 | [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of H2-OB mRNA | CTD | PMID:30529165 | folic acid | decreases expression | ISO | H2-Ob (Mus musculus) | 6480464 | Folic Acid results in decreased expression of H2-OB mRNA | CTD | PMID:25629700 | furan | increases expression | EXP | | 6480464 | furan results in increased expression of RT1-DOB mRNA | CTD | PMID:27387713 | hydralazine | multiple interactions | ISO | HLA-DOB (Homo sapiens) | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of HLA-DOB mRNA | CTD | PMID:17183730 | hydrazine | decreases expression | ISO | H2-Ob (Mus musculus) | 6480464 | hydrazine results in decreased expression of H2-OB mRNA | CTD | PMID:15282401 | meropenem | affects expression | ISO | HLA-DOB (Homo sapiens) | 6480464 | meropenem affects the expression of HLA-DOB mRNA | CTD | PMID:25811541 | methotrexate | affects expression | ISO | H2-Ob (Mus musculus) | 6480464 | Methotrexate affects the expression of H2-OB mRNA | CTD | PMID:18502557 | methylarsonic acid | multiple interactions | ISO | H2-Ob (Mus musculus) | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of H2-OB mRNA | CTD | PMID:34876320 | mifepristone | decreases expression | ISO | HLA-DOB (Homo sapiens) | 6480464 | Mifepristone results in decreased expression of HLA-DOB mRNA | CTD | PMID:17584828 | nickel atom | increases expression | ISO | HLA-DOB (Homo sapiens) | 6480464 | Nickel results in increased expression of HLA-DOB mRNA | CTD | PMID:24768652 and PMID:25583101 | ozone | multiple interactions | ISO | H2-Ob (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of H2-OB mRNA and [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of H2-OB mRNA | CTD | PMID:34911549 | PCB138 | multiple interactions | ISO | H2-Ob (Mus musculus) | 6480464 | [2 more ... | CTD | PMID:25510870 | sodium arsenate | multiple interactions | ISO | H2-Ob (Mus musculus) | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of H2-OB mRNA | CTD | PMID:34876320 | sodium arsenite | multiple interactions | ISO | H2-Ob (Mus musculus) | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of H2-OB mRNA | CTD | PMID:34876320 | sodium arsenite | increases expression | ISO | H2-Ob (Mus musculus) | 6480464 | sodium arsenite results in increased expression of H2-OB mRNA | CTD | PMID:36209798 | testosterone | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of RT1-DOB mRNA | CTD | PMID:32741896 | tetraphene | increases expression | ISO | H2-Ob (Mus musculus) | 6480464 | benz(a)anthracene results in increased expression of H2-OB mRNA | CTD | PMID:26377693 | tetraphene | multiple interactions | ISO | H2-Ob (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of H2-OB mRNA | CTD | PMID:27858113 | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of RT1-DOB mRNA | CTD | PMID:34492290 | trimethoprim | affects expression | ISO | HLA-DOB (Homo sapiens) | 6480464 | Trimethoprim affects the expression of HLA-DOB mRNA | CTD | PMID:25811541 | valproic acid | multiple interactions | ISO | HLA-DOB (Homo sapiens) | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of HLA-DOB mRNA | CTD | PMID:17183730 | | 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