Ocrl (OCRL, inositol polyphosphate-5-phosphatase) - Rat Genome Database

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Gene: Ocrl (OCRL, inositol polyphosphate-5-phosphatase) Rattus norvegicus
Analyze
Symbol: Ocrl
Name: OCRL, inositol polyphosphate-5-phosphatase
RGD ID: 1594526
Description: Predicted to enable GTPase activator activity; phosphatase activity; and small GTPase binding activity. Predicted to be involved in cilium assembly and phosphatidylinositol dephosphorylation. Predicted to act upstream of or within in utero embryonic development. Predicted to be located in several cellular components, including cytoplasmic vesicle; photoreceptor outer segment; and trans-Golgi network. Predicted to be active in cytoplasm and membrane. Human ortholog(s) of this gene implicated in Dent disease and oculocerebrorenal syndrome. Orthologous to human OCRL (OCRL inositol polyphosphate-5-phosphatase); PARTICIPATES IN inositol phosphate metabolic pathway; phosphatidylinositol 3-kinase signaling pathway; INTERACTS WITH 2,6-dinitrotoluene; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: inositol polyphosphate 5-phosphatase OCRL; inositol polyphosphate 5-phosphatase OCRL-1; OCRL-1; Ocrl_mapped; oculocerebrorenal syndrome of Lowe; oculocerebrorenal syndrome of Lowe (mapped); phosphatidylinositol 3,4,5-triphosphate 5-phosphatase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X131,955,775 - 132,018,298 (+)NCBIGRCr8
mRatBN7.2X127,089,508 - 127,140,362 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX127,089,590 - 127,140,362 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX129,215,952 - 129,266,773 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X132,786,279 - 132,837,107 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X130,313,088 - 130,363,915 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X134,742,226 - 134,793,411 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX134,742,356 - 134,792,618 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X134,814,622 - 134,865,807 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X134,271,916 - 134,322,751 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX126,040,210 - 126,091,039 (+)NCBICelera
Cytogenetic MapXq35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
8. Interaction of Rab31 and OCRL-1 in oligodendrocytes: its role in transport of mannose 6-phosphate receptors. Rodriguez-Gabin AG, etal., J Neurosci Res. 2010 Feb 15;88(3):589-604. doi: 10.1002/jnr.22236.
9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:9593760   PMID:12915445   PMID:16902405   PMID:19211563   PMID:20195868   PMID:21233288   PMID:22228094   PMID:22543976   PMID:23376485   PMID:25869668   PMID:25931508   PMID:29476059  


Genomics

Comparative Map Data
Ocrl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X131,955,775 - 132,018,298 (+)NCBIGRCr8
mRatBN7.2X127,089,508 - 127,140,362 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX127,089,590 - 127,140,362 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX129,215,952 - 129,266,773 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X132,786,279 - 132,837,107 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X130,313,088 - 130,363,915 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X134,742,226 - 134,793,411 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX134,742,356 - 134,792,618 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X134,814,622 - 134,865,807 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X134,271,916 - 134,322,751 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX126,040,210 - 126,091,039 (+)NCBICelera
Cytogenetic MapXq35NCBI
OCRL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X129,540,259 - 129,592,556 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX129,539,849 - 129,592,561 (+)EnsemblGRCh38hg38GRCh38
GRCh37X128,674,236 - 128,726,533 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X128,501,933 - 128,554,214 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X128,399,786 - 128,452,063NCBI
CeleraX129,062,951 - 129,113,094 (+)NCBICelera
Cytogenetic MapXq26.1NCBI
HuRefX118,081,643 - 118,132,141 (+)NCBIHuRef
CHM1_1X128,585,639 - 128,637,898 (+)NCBICHM1_1
T2T-CHM13v2.0X127,859,040 - 127,911,341 (+)NCBIT2T-CHM13v2.0
Ocrl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X47,001,289 - 47,055,305 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX47,001,264 - 47,054,745 (+)EnsemblGRCm39 Ensembl
GRCm38X47,912,418 - 47,966,428 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX47,912,387 - 47,965,868 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X45,265,633 - 45,319,045 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X44,157,083 - 44,210,495 (+)NCBIMGSCv36mm8
CeleraX35,414,246 - 35,467,331 (+)NCBICelera
Cytogenetic MapXA4NCBI
cM MapX25.43NCBI
Ocrl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554735,431,395 - 5,482,385 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554735,429,084 - 5,482,377 (-)NCBIChiLan1.0ChiLan1.0
OCRL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X128,963,342 - 129,015,706 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X128,966,955 - 129,019,325 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X118,670,612 - 118,721,108 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X128,968,751 - 129,020,444 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX128,968,760 - 129,018,157 (+)Ensemblpanpan1.1panPan2
OCRL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X100,760,302 - 100,817,673 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX100,757,373 - 100,831,500 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX86,935,904 - 86,989,289 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X102,613,937 - 102,667,382 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX102,613,968 - 102,667,382 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X100,031,797 - 100,085,435 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X101,877,493 - 101,930,941 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X101,655,530 - 101,708,953 (+)NCBIUU_Cfam_GSD_1.0
Ocrl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X98,975,434 - 99,033,762 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364791,953,488 - 2,012,018 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364791,955,362 - 2,011,608 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OCRL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX106,135,431 - 106,190,110 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X106,124,991 - 106,188,066 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X121,904,287 - 121,959,049 (+)NCBISscrofa10.2Sscrofa10.2susScr3
OCRL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X104,784,900 - 104,834,718 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX104,785,526 - 104,837,243 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606542,269,909 - 42,321,337 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ocrl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247978,730,713 - 8,792,727 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247978,731,130 - 8,792,300 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ocrl
80 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1255
Count of miRNA genes:346
Interacting mature miRNAs:495
Transcripts:ENSRNOT00000005267
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX100567703150256146Rat
738029Stresp2Stress response QTL 23.40.0004stress-related behavior trait (VT:0010451)defensive burying - approachX112934952138400867Rat
634346Insul4Insulin level QTL 40blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)X126975089152453651Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X113937816152453651Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X103312877148312877Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X103312877148312877Rat
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X93956491138956491Rat

Markers in Region
DXWox29  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X127,143,992 - 127,144,286 (+)MAPPERmRatBN7.2
Rnor_6.0X134,797,042 - 134,797,335NCBIRnor6.0
Rnor_5.0X134,869,438 - 134,869,731UniSTSRnor5.0
RGSC_v3.4X134,326,391 - 134,326,684UniSTSRGSC3.4
CeleraX126,094,670 - 126,094,963UniSTS
Cytogenetic MapXq35UniSTS
AI010734  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X127,140,118 - 127,140,272 (+)MAPPERmRatBN7.2
Rnor_6.0X134,793,168 - 134,793,321NCBIRnor6.0
Rnor_5.0X134,865,564 - 134,865,717UniSTSRnor5.0
RGSC_v3.4X134,322,517 - 134,322,670UniSTSRGSC3.4
CeleraX126,090,796 - 126,090,949UniSTS
RH 3.4 MapX907.9UniSTS
Cytogenetic MapXq35UniSTS
BF394020  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X127,135,238 - 127,135,461 (+)MAPPERmRatBN7.2
Rnor_6.0X134,788,288 - 134,788,510NCBIRnor6.0
Rnor_5.0X134,860,684 - 134,860,906UniSTSRnor5.0
RGSC_v3.4X134,317,637 - 134,317,859UniSTSRGSC3.4
CeleraX126,085,916 - 126,086,138UniSTS
RH 3.4 MapX907.7UniSTS
Cytogenetic MapXq35UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 14 6 1 6 74 21 34 10
Low 1 43 43 35 18 35 8 11 14 7 1 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000005267   ⟹   ENSRNOP00000005267
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX127,089,590 - 127,140,362 (+)Ensembl
Rnor_6.0 EnsemblX134,742,356 - 134,792,618 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000082363   ⟹   ENSRNOP00000072408
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX127,089,590 - 127,140,362 (+)Ensembl
Rnor_6.0 EnsemblX134,742,429 - 134,791,157 (+)Ensembl
RefSeq Acc Id: NM_001108256   ⟹   NP_001101726
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X131,967,471 - 132,018,298 (+)NCBI
mRatBN7.2X127,089,536 - 127,140,362 (+)NCBI
Rnor_6.0X134,742,226 - 134,793,411 (+)NCBI
Rnor_5.0X134,814,622 - 134,865,807 (+)NCBI
RGSC_v3.4X134,271,916 - 134,322,751 (+)RGD
CeleraX126,040,210 - 126,091,039 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039099845   ⟹   XP_038955773
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X131,967,444 - 132,018,294 (+)NCBI
mRatBN7.2X127,089,508 - 127,140,362 (+)NCBI
RefSeq Acc Id: XM_039099847   ⟹   XP_038955775
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X131,967,444 - 132,010,286 (+)NCBI
mRatBN7.2X127,089,509 - 127,132,350 (+)NCBI
RefSeq Acc Id: XM_063280089   ⟹   XP_063136159
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X131,955,775 - 132,018,294 (+)NCBI
RefSeq Acc Id: XM_063280090   ⟹   XP_063136160
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X131,955,775 - 132,018,294 (+)NCBI
RefSeq Acc Id: NP_001101726   ⟸   NM_001108256
- UniProtKB: D3ZGS3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000072408   ⟸   ENSRNOT00000082363
RefSeq Acc Id: ENSRNOP00000005267   ⟸   ENSRNOT00000005267
RefSeq Acc Id: XP_038955773   ⟸   XM_039099845
- Peptide Label: isoform X1
- UniProtKB: D3ZGS3 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038955775   ⟸   XM_039099847
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063136160   ⟸   XM_063280090
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063136159   ⟸   XM_063280089
- Peptide Label: isoform X2
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZGS3-F1-model_v2 AlphaFold D3ZGS3 1-902 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1594526 AgrOrtholog
BioCyc Gene G2FUF-1145 BioCyc
Ensembl Genes ENSRNOG00000003875 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005267 ENTREZGENE
  ENSRNOT00000005267.8 UniProtKB/TrEMBL
  ENSRNOT00000082363.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.555.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.29.110 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.60.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Endo/exonu/phosph_ase_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IP5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IPPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OCRL-1_2_ASH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OCRL1/INPP5B_INPP5c UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OCRL1_PH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OCRL_clath-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rho_GTPase_activation_prot UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGAP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGAP_OCRL1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 317576 ENTREZGENE
PANTHER INOSITOL 5-PHOSPHATASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INOSITOL POLYPHOSPHATE 5-PHOSPHATASE OCRL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam OCRL-like_ASH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OCRL_clath_bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ocrl PhenoGen
PROSITE RHOGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003875 RatGTEx
SMART IPPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48350 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56219 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2R5U9_RAT UniProtKB/TrEMBL
  A6JMP0_RAT UniProtKB/TrEMBL
  A6JMP1_RAT UniProtKB/TrEMBL
  D3ZGS3 ENTREZGENE, UniProtKB/Swiss-Prot
  R9PXS2_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-02 Ocrl  OCRL, inositol polyphosphate-5-phosphatase  Ocrl  oculocerebrorenal syndrome of Lowe  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-04-13   oculocerebrorenal syndrome of Lowe  Ocrl  oculocerebrorenal syndrome of Lowe (mapped)  Name updated 737654 APPROVED
2007-04-11 Ocrl  oculocerebrorenal syndrome of Lowe (mapped)  Ocrl_mapped  oculocerebrorenal syndrome of Lowe (mapped)  Data merged from RGD:3223 737654 APPROVED
2006-11-20 Ocrl  oculocerebrorenal syndrome of Lowe (mapped)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Ocrl_mapped  oculocerebrorenal syndrome of Lowe (mapped)  Ocrl  oculocerebrorenal syndrome of Lowe  Symbol and Name updated 1556543 APPROVED
2002-06-10 Ocrl  Oculocerebrorenal syndrome of Lowe      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_homology mutation in human OCRL causes Lowe syndrome, also known as oculocerebrorenal syndrome 1302257
gene_homology human homolog OCRL possesses phosphoinositide 5-phosphatase activity 1302257
gene_homology human homolog OCRL is involved in lipid metabolism 1302257
gene_homology mouse homolog RIKEN cDNA 9530014D17 possesses an inositol polyphosphate phosphatase domain 737633