Nek5 (NIMA-related kinase 5) - Rat Genome Database

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Gene: Nek5 (NIMA-related kinase 5) Rattus norvegicus
Analyze
Symbol: Nek5
Name: NIMA-related kinase 5
RGD ID: 1593817
Description: Predicted to enable protein kinase activity. Predicted to be involved in phosphorylation. Predicted to act upstream of or within positive regulation of striated muscle cell differentiation. Orthologous to human NEK5 (NIMA related kinase 5); INTERACTS WITH 6-propyl-2-thiouracil; amitrole; bisphenol A.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC685440; NIMA (never in mitosis gene a)-related kinase 5; serine/threonine-protein kinase Nek5; similar to NIMA (never in mitosis gene a)-related expressed kinase 5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81676,597,857 - 76,641,113 (+)NCBIGRCr8
mRatBN7.21669,895,414 - 69,938,668 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1669,895,422 - 69,939,429 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01674,809,513 - 74,851,895 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1674,810,938 - 74,848,113 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01674,440,016 - 74,481,952 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41674,552,157 - 74,594,006 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1667,780,818 - 67,823,597 (+)NCBICelera
Cytogenetic Map16q12.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:23727203  


Genomics

Comparative Map Data
Nek5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81676,597,857 - 76,641,113 (+)NCBIGRCr8
mRatBN7.21669,895,414 - 69,938,668 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1669,895,422 - 69,939,429 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01674,809,513 - 74,851,895 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1674,810,938 - 74,848,113 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01674,440,016 - 74,481,952 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41674,552,157 - 74,594,006 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1667,780,818 - 67,823,597 (+)NCBICelera
Cytogenetic Map16q12.5NCBI
NEK5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381352,033,611 - 52,129,073 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1352,033,611 - 52,129,092 (-)EnsemblGRCh38hg38GRCh38
GRCh371352,607,747 - 52,703,209 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361351,536,899 - 51,601,215 (-)NCBINCBI36Build 36hg18NCBI36
Celera1333,687,535 - 33,751,861 (-)NCBICelera
Cytogenetic Map13q14.3NCBI
HuRef1333,427,163 - 33,491,350 (-)NCBIHuRef
CHM1_11352,606,970 - 52,671,294 (-)NCBICHM1_1
T2T-CHM13v2.01351,248,427 - 51,343,906 (-)NCBIT2T-CHM13v2.0
Nek5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39822,563,631 - 22,615,443 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl822,563,632 - 22,615,069 (-)EnsemblGRCm39 Ensembl
GRCm38822,073,615 - 22,125,418 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl822,073,616 - 22,125,053 (-)EnsemblGRCm38mm10GRCm38
MGSCv37823,184,088 - 23,235,525 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36823,539,161 - 23,590,598 (-)NCBIMGSCv36mm8
Celera823,570,165 - 23,619,929 (-)NCBICelera
Cytogenetic Map8A2NCBI
cM Map810.95NCBI
Nek5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554315,318,987 - 5,377,398 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554315,312,243 - 5,378,998 (-)NCBIChiLan1.0ChiLan1.0
NEK5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21453,470,563 - 53,564,315 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11352,114,834 - 52,208,481 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01333,166,069 - 33,260,990 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11351,938,293 - 51,999,960 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1351,938,342 - 51,998,357 (-)Ensemblpanpan1.1panPan2
NEK5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.122108,089 - 134,987 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha22143,675 - 182,041 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02290,875 - 129,243 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12211,906 - 50,189 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02261,487 - 99,761 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02279,489 - 117,771 (+)NCBIUU_Cfam_GSD_1.0
Nek5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945161,295,651 - 161,352,087 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365654,779,933 - 4,836,093 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365654,779,843 - 4,836,093 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NEK5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1115,806,017 - 15,862,228 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11115,799,068 - 15,862,236 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21116,124,292 - 16,184,884 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NEK5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1329,950,605 - 30,015,114 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl329,951,153 - 30,013,658 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605713,800,570 - 13,890,966 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nek5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247481,979,634 - 2,054,174 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247481,977,294 - 2,069,211 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nek5
352 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:101
Count of miRNA genes:82
Interacting mature miRNAs:84
Transcripts:ENSRNOT00000058091
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165272646484729064Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165272646484729064Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat
1298527Arunc2Aerobic running capacity QTL 22.9exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)166853271675029966Rat

Markers in Region
D16Got77  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21669,901,716 - 69,902,014 (+)MAPPERmRatBN7.2
Rnor_6.01674,815,165 - 74,815,462NCBIRnor6.0
Rnor_5.01674,445,657 - 74,445,954UniSTSRnor5.0
RGSC_v3.41674,556,599 - 74,556,897RGDRGSC3.4
RGSC_v3.41674,556,600 - 74,556,897UniSTSRGSC3.4
RGSC_v3.11674,556,864 - 74,557,162RGD
Celera1667,786,495 - 67,786,792UniSTS
Cytogenetic Map16q12.5UniSTS
RH137859  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21669,907,342 - 69,907,508 (+)MAPPERmRatBN7.2
Rnor_6.01674,820,783 - 74,820,948NCBIRnor6.0
Rnor_5.01674,451,275 - 74,451,440UniSTSRnor5.0
RGSC_v3.41674,561,980 - 74,562,145UniSTSRGSC3.4
Celera1667,792,078 - 67,792,243UniSTS
RH 3.4 Map16691.6UniSTS
Cytogenetic Map16q12.5UniSTS
RH138560  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21669,938,280 - 69,938,489 (+)MAPPERmRatBN7.2
Rnor_6.01674,851,511 - 74,851,719NCBIRnor6.0
Rnor_5.01674,481,174 - 74,481,382UniSTSRnor5.0
RGSC_v3.41674,593,895 - 74,594,103UniSTSRGSC3.4
Celera1667,823,213 - 67,823,421UniSTS
RH 3.4 Map16691.21UniSTS
Cytogenetic Map16q12.5UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 8
Low 2 3 2 62 33 29 3
Below cutoff 1 18 22 12 14 12 1 1 12 2 9 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000058091   ⟹   ENSRNOP00000054899
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1669,895,422 - 69,938,431 (+)Ensembl
Rnor_6.0 Ensembl1674,810,938 - 74,848,113 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000112831   ⟹   ENSRNOP00000093104
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1669,895,422 - 69,939,429 (+)Ensembl
RefSeq Acc Id: XM_008771370   ⟹   XP_008769592
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81676,597,857 - 76,641,113 (+)NCBI
mRatBN7.21669,895,414 - 69,938,668 (+)NCBI
Rnor_6.01674,809,513 - 74,851,895 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039095235   ⟹   XP_038951163
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81676,597,857 - 76,641,113 (+)NCBI
mRatBN7.21669,895,414 - 69,938,668 (+)NCBI
RefSeq Acc Id: XM_039095237   ⟹   XP_038951165
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81676,597,857 - 76,641,113 (+)NCBI
mRatBN7.21669,895,414 - 69,938,668 (+)NCBI
RefSeq Acc Id: XM_039095238   ⟹   XP_038951166
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81676,597,857 - 76,632,262 (+)NCBI
mRatBN7.21669,895,414 - 69,929,822 (+)NCBI
RefSeq Acc Id: XM_039095243   ⟹   XP_038951171
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81676,597,857 - 76,641,113 (+)NCBI
mRatBN7.21669,895,414 - 69,938,668 (+)NCBI
RefSeq Acc Id: XR_005495038
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81676,597,857 - 76,624,374 (+)NCBI
mRatBN7.21669,895,414 - 69,921,976 (+)NCBI
RefSeq Acc Id: XR_010058486
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81676,597,857 - 76,624,362 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_008769592   ⟸   XM_008771370
- Peptide Label: isoform X1
- UniProtKB: D3ZSY9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000054899   ⟸   ENSRNOT00000058091
RefSeq Acc Id: XP_038951163   ⟸   XM_039095235
- Peptide Label: isoform X2
- UniProtKB: D3ZSY9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038951165   ⟸   XM_039095237
- Peptide Label: isoform X3
- UniProtKB: D3ZSY9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038951171   ⟸   XM_039095243
- Peptide Label: isoform X4
- UniProtKB: D3ZSY9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038951166   ⟸   XM_039095238
- Peptide Label: isoform X5
- UniProtKB: A6IW85 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000093104   ⟸   ENSRNOT00000112831
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZSY9-F1-model_v2 AlphaFold D3ZSY9 1-615 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1593817 AgrOrtholog
BioCyc Gene G2FUF-10860 BioCyc
Ensembl Genes ENSRNOG00000048769 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000058091.3 UniProtKB/TrEMBL
  ENSRNOT00000112831.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene 685440 ENTREZGENE
PANTHER CAMK FAMILY PROTEIN KINASE UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE NEK5 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PhenoGen Nek5 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000048769 RatGTEx
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt A0A8I6AJB7_RAT UniProtKB/TrEMBL
  A6IW85 ENTREZGENE, UniProtKB/TrEMBL
  D3ZSY9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-11-21 Nek5  NIMA-related kinase 5  Nek5  NIMA (never in mitosis gene a)-related kinase 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-01 Nek5  NIMA (never in mitosis gene a)-related kinase 5  Nek5  NIMA (never in mitosis gene a)-related kinase 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-01 Nek5  NIMA (never in mitosis gene a)-related kinase 5  LOC685440  similar to NIMA (never in mitosis gene a)-related expressed kinase 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC685440  similar to NIMA (never in mitosis gene a)-related expressed kinase 5      Symbol and Name status set to provisional 70820 PROVISIONAL