Klk5 (kallikrein related-peptidase 5)

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Keyword

Gene: Klk5 (kallikrein related-peptidase 5) Rattus norvegicus

Symbol:

Klk5

Name:

kallikrein related-peptidase 5

Description:

ENCODES a protein that exhibits serine-type endopeptidase activity (ortholog); INVOLVED IN positive regulation of G-protein coupled receptor protein signaling pathway (ortholog); FOUND IN epidermal lamellar body (ortholog); INTERACTS WITH ciguatoxin CTX1B (ortholog); cisplatin (ortholog); citric acid (ortholog)

Type:

protein-coding

Also known as:

kallikrein 5; kallikrein related-peptidase 5; kallikrein-5; LOC690603; loc690603; similar to kallikrein 5 preproprotein

Orthologs:

Homo sapiens : KLK5 (kallikrein-related peptidase 5) HGNC
Mus musculus : Klk5 (kallikrein related-peptidase 5) MGI

Latest Assembly:

RGSC Genome Assembly v3.4

NCBI Annotation Information:

Genome Annotation Status: not on current assembly

Position:

Map	Chr	Position	Strand	Source
Rat Cytogenetic Map	1	q22		NCBI
RGSC Genome Assembly v3.4	1	94,273,869 - 94,281,384	+	NCBI

Model

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Annotation (Toggle Detail/Summary View)

Gene-Chemical Interaction Annotations

Gene Ontology Annotations

References - curated

Genomics

Comparative Map Data

QTLs in Region (RGSC Genome Assembly v3.4)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631688	Hcas2	Hepatocarcinoma susceptibility QTL 2	3	.0001	Liver tumor susceptibility	nodule number	1	6253946	116153262	Rat
631495	Bp96	Blood pressure QTL 96	4.52		Blood pressure	systolic	1	22842898	102532417	Rat
1358359	Sradr1	Stress Responsive Adrenal Weight QTL 1	4.74		Hypothalamic-pituitary-adrenal axis	adrenal gland weight	1	28716493	124749065	Rat
2313051	Bss57	Bone structure and strength QTL 57	3.7	.0001	Bone strength		1	37646940	119780561	Rat
2313059	Bss55	Bone structure and strength QTL 55	3.2	.0001	Bone structure		1	37646940	119780561	Rat
2313072	Bss53	Bone structure and strength QTL 53	4.3	.0001	Bone structure		1	37646940	119780561	Rat
2313078	Bss54	Bone structure and strength QTL 54	3.5	.0001	Bone structure		1	37646940	119780561	Rat
2313094	Bss58	Bone structure and strength QTL 58	3.7	.0001	Bone strength		1	37646940	119780561	Rat
2313098	Bmd70	Bone mineral density QTL 70	3.6	.0001	Bone mineral density		1	37646940	119780561	Rat
2313099	Bss56	Bone structure and strength QTL 56	2.4	.0001	Bone structure		1	37646940	119780561	Rat
2313402	Anxrr24	Anxiety related response QTL 24			Anxiety response	domestication	1	43426139	146971983	Rat
1578654	Bss10	Bone structure and strength QTL 10	4		Bone structure	femoral neck cortical area	1	43872710	162735928	Rat
634314	Niddm44	Non-insulin dependent diabetes mellitus QTL 44			Glucose level		1	43872827	204280278	Rat
2298545	Neuinf8	Neuroinflammation QTL 8	2.9		Neuroinflammation		1	55083934	154002647	Rat
2300324	Fetw1	Fetal weight QTL 1	12.1	.005	Fetal weight		1	55540384	100540384	Rat
2300164	Bmd44	Bone mineral density QTL 44	5.4	.0001	Bone mineral density		1	56601368	101601368	Rat
1300121	Hrtrt1	Heart rate QTL 1	3.7		Heart rate	salt-loaded	1	64744882	116153262	Rat
1549903	Bp267	Blood pressure QTL 267			Blood pressure	systolic, nighttime	1	77541583	106445306	Rat
1582234	Gluco18	Glucose level QTL 18	3.4	.0003	Glucose level	uptake	1	79749065	124749065	Rat
4889494	Scort2	Serum corticosterone level QTL 2	4.2		Hormone level	corticosterone	1	80851478	125851478	Rat
1578780	Cm52	Cardiac mass QTL 52	3.3	.0001	Cardiac mass		1	81342810	225814178	Rat
2313083	Bmd74	Bone mineral density QTL 74	4	.0001	Bone mineral density		1	81947770	119780561	Rat
631519	Pia11	Pristane induced arthritis QTL 11	5.3		Joint/bone inflammation	arthritis severity	1	83489176	186472032	Rat
738022	Anxrr13	Anxiety related response QTL 13	4.6	.00039	Anxiety response	open field inner locomotion	1	83945235	128945235	Rat
724529	Cm16	Cardiac mass QTL 16	2.7		Cardiac mass		1	87465281	153578547	Rat
1358902	Bw47	Body weight QTL 47	1.67		Body weight		1	90282040	184857893	Rat
724521	Uae1	Urinary albumin excretion QTL 1	3.8	.0001	Renal function	urine albumin level	1	90282040	185923619	Rat
1302788	Scl19	Serum cholesterol QTL 19	4.6	.001	Lipid level	cholesterol level	1	90306033	124749065	Rat
1300153	Bp171	Blood pressure QTL 171	3.37		Blood pressure	salt-loaded diastolic	1	90448902	145865373	Rat
724567	Tcas6	Tongue tumor susceptibility QTL 6	6.85		Tongue tumor susceptibility		1	92101613	146971983	Rat

Sequence

Nucleotide Sequences

Protein Sequences

Strain Variation

Strain Sequence Variants

ACI/Eur (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.5.9-r16 and GATK v1.3-14

ACI/N (KNAW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLID
Secondary Analysis:	SAP42 (Developed at RNAAS)
Breeder:	National Institutes of Health
Grant Information:	EURATRANS (HEALTH-F4-2010-241504)

BN-Lx (ICL)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Imperial College London (Dr Timothy Aitman)
Platform:	SOLID
Secondary Analysis:	BWA, GATK, Samtools
Breeder:	Academy of Sciences of the Czech Republic (Dr.Michal Pravenec)
Grant Information:	MC-A654-5QB00

BN-Lx (KNAW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Platform:	SOLID
Secondary Analysis:	SAP42 (Developed at RNAAS)
Breeder:	Academy of Sciences of the Czech Republic (Dr.Michal Pravenec)
Grant Information:	EURATRANS (HEALTH-F4-2010-241504)

BN/NHsdMcwi (KNAW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLID
Secondary Analysis:	SAP42 (Developed at RNAAS)
Breeder:	Medical College of Wisconsin
Grant Information:	EURATRANS (HEALTH-F4-2010-241504)

BN/SsN (KNAW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLID
Secondary Analysis:	SAP42 (Developed at RNAAS)
Breeder:	National Institutes of Health
Grant Information:	EURATRANS (HEALTH-F4-2010-241504)

Buf/N (KNAW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLID
Secondary Analysis:	SAP42 (Developed at RNAAS)
Breeder:	National Institutes of Health
Grant Information:	EURATRANS (HEALTH-F4-2010-241504)

COP/Crl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) Univiersity of Wisconsin (Jim Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.5.9-r16 and GATK v2.3-5
Breeder:	Charles River
Grant Information:	NIH (CA77876)

F344/N (KNAW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLID
Breeder:	National Institutes of Health
Grant Information:	EURATRANS (HEALTH-F4-2010-241504)

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.5.9-r16 and GATK v1.3-14

FHH/EurMcwi (MDC)

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Sequenced By:	Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	Illumina/Solexa, Genome Analyzer II
Secondary Analysis:	CASAVA Software v1.7
Breeder:	Medical College of Wisconsin
Grant Information:	EURATRANS (HEALTH-F4-2010-241504)

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.5.9-r16 and GATK v1.3-14

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.5.9-r16 and GATK v2.3-5

LE/Stm (KNAW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLID
Secondary Analysis:	SAP42 (Developed at RNAAS)
Breeder:	Dr. Tadao Serikawa, Kyoto Japan.
Grant Information:	EURATRANS (HEALTH-F4-2010-241504)

M520/N (KNAW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLID
Secondary Analysis:	SAP42 (Developed at RNAAS)
Breeder:	National Institutes of Health
Grant Information:	EURATRANS (HEALTH-F4-2010-241504)

MR/N (KNAW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLID
Breeder:	National Institutes of Health
Grant Information:	EURATRANS (HEALTH-F4-2010-241504)

SHR/Olalpcv (ICL)

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Sequenced By:	Imperial College London (Dr Timothy Aitman) University of British Columbia (Dr. Steven Jones)
Platform:	Illumina Hi-seq 2000 and GAII
Secondary Analysis:	BWA, GATK
Breeder:	Institute of Physiology, Academy of Sciences of the Czech Republic, Prague
Grant Information:	LSHG-CT-2005-019015, HEALTH-F4-2010-241504

SHR/Olalpcv (KNAW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Imperial College London (Dr Timothy Aitman)
Platform:	Illumina
Secondary Analysis:	GATK
Grant Information:	EURATRANS (HEALTH-F4-2010-241504)

SHRSP/Gcrc (MDC)

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Sequenced By:	Max Delbruch Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	Illumina/Solexa, Genome Analyzer II
Secondary Analysis:	CASAVA Software v1.7
Breeder:	University of Glasgow, Anna Dominiczak
Grant Information:	EURATRANS (HEALTH-F4-2010-241504)

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.5.9-r16 and GATK v1.3-14
Breeder:	Harlan

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.5.9-r16 and GATK v1.3-14
Grant Information:	R01 HL089930

SS/JrHsdMcwi (MDC)

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Sequenced By:	Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	Illumina/Solexa, Genome Analyzer II
Secondary Analysis:	CASAVA Software v1.7
Breeder:	Medical College of Wisconsin
Grant Information:	EURATRANS (HEALTH-F4-2010-241504)

WKY/N (KNAW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLID
Secondary Analysis:	SAP42 (Developed at RNAAS)
Breeder:	National Institutes of Health
Grant Information:	EURATRANS (HEALTH-F4-2010-241504)

WN/N (KNAW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLID
Secondary Analysis:	SAP42 (Developed at RNAAS)
Breeder:	National Institutes of Health
Grant Information:	EURATRANS (HEALTH-F4-2010-241504)

Additional Information

External Database Links

Nomenclature History

More on Klk5
	Entrez Gene

	Genome Browser
	NCBI Map Viewer
	Vista
	Vista + UCSC

RGD Object Information
RGD ID:	1593461
Created:	2006-11-20
Species:	Rattus norvegicus
Last Modified:	2013-05-28
Status:	ACTIVE