Erich3 (glutamate-rich 3) - Rat Genome Database

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Gene: Erich3 (glutamate-rich 3) Rattus norvegicus
Analyze
Symbol: Erich3
Name: glutamate-rich 3
RGD ID: 1593279
Description: Predicted to be involved in cilium assembly. Predicted to be located in cytoplasm and non-motile cilium. Orthologous to human ERICH3 (glutamate rich 3); INTERACTS WITH atrazine; bisphenol A; cadmium dichloride.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: glutamate-rich protein 3; LOC295528; similar to T06D8.1a
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82246,275,438 - 246,377,673 (+)NCBIGRCr8
mRatBN7.22243,615,777 - 243,717,973 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2243,615,872 - 243,715,317 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.02260,947,970 - 261,049,973 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2260,997,497 - 261,032,821 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02279,609,567 - 279,710,598 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42252,504,847 - 252,606,168 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2235,540,060 - 235,640,461 (+)NCBICelera
Cytogenetic Map2q45NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Erich3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82246,275,438 - 246,377,673 (+)NCBIGRCr8
mRatBN7.22243,615,777 - 243,717,973 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2243,615,872 - 243,715,317 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.02260,947,970 - 261,049,973 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2260,997,497 - 261,032,821 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02279,609,567 - 279,710,598 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42252,504,847 - 252,606,168 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2235,540,060 - 235,640,461 (+)NCBICelera
Cytogenetic Map2q45NCBI
ERICH3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38174,568,123 - 74,674,343 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl174,568,117 - 74,673,792 (-)EnsemblGRCh38hg38GRCh38
GRCh37175,033,807 - 75,139,476 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36174,806,383 - 74,912,010 (-)NCBINCBI36Build 36hg18NCBI36
Celera173,279,099 - 73,384,675 (-)NCBICelera
Cytogenetic Map1p31.1NCBI
HuRef173,168,296 - 73,273,823 (-)NCBIHuRef
CHM1_1175,149,271 - 75,254,893 (-)NCBICHM1_1
T2T-CHM13v2.0174,409,490 - 74,515,692 (-)NCBIT2T-CHM13v2.0
Erich3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393154,416,770 - 154,454,649 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3154,369,496 - 154,473,427 (+)EnsemblGRCm39 Ensembl
GRCm383154,663,731 - 154,767,790 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3154,663,859 - 154,767,790 (+)EnsemblGRCm38mm10GRCm38
MGSCv373154,374,097 - 154,411,976 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363154,658,596 - 154,676,255 (+)NCBIMGSCv36mm8
Celera3161,169,504 - 161,207,061 (+)NCBICelera
Cytogenetic Map3H4NCBI
cM Map379.28NCBI
Erich3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542318,010,090 - 18,108,513 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542318,009,243 - 18,110,340 (+)NCBIChiLan1.0ChiLan1.0
ERICH3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21152,205,953 - 152,311,776 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11151,366,352 - 151,472,201 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0173,796,620 - 73,902,429 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1175,771,318 - 75,876,673 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl175,774,304 - 75,876,673 (-)Ensemblpanpan1.1panPan2
ERICH3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1671,706,954 - 71,802,470 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl671,746,262 - 71,788,635 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha674,370,736 - 74,467,798 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0672,300,511 - 72,397,488 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1671,794,381 - 71,889,537 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0671,741,133 - 71,836,657 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0672,235,646 - 72,333,606 (+)NCBIUU_Cfam_GSD_1.0
Erich3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505886,354,911 - 86,458,294 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365711,864,070 - 1,968,743 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365711,865,342 - 1,968,737 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ERICH3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.16138,503,816 - 138,615,967 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26128,368,008 - 128,479,525 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ERICH3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12058,485,324 - 58,596,543 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2058,485,373 - 58,600,011 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603358,856,243 - 58,970,695 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Erich3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474222,007,473 - 22,113,643 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Erich3
498 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:20
Count of miRNA genes:19
Interacting mature miRNAs:20
Transcripts:ENSRNOT00000012638
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2200990457245990457Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2211744537249053267Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2211744537249053267Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2211744537249053267Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2211744537249053267Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2211744537249053267Rat
2317885Alcrsp28Alcohol response QTL 282.10.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2212828222249053267Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2214226044247136170Rat
2293833Kiddil8Kidney dilation QTL 82.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
2293844Kiddil7Kidney dilation QTL 73.5kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
9587428Epfw6Epididymal fat weight QTL 67.470.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)2223389739249053267Rat
7411555Bw132Body weight QTL 1320.001body mass (VT:0001259)body weight gain (CMO:0000420)2223389739249053267Rat
631563Hcuc3Hepatic copper content QTL 33.87liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)2229059610249053267Rat

Markers in Region
BI286971  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22243,700,536 - 243,700,715 (+)MAPPERmRatBN7.2
Rnor_6.02261,032,840 - 261,033,018NCBIRnor6.0
Rnor_5.02279,694,460 - 279,694,638UniSTSRnor5.0
RGSC_v3.42252,591,030 - 252,591,208UniSTSRGSC3.4
Celera2235,623,024 - 235,623,202UniSTS
RH 3.4 Map21629.2UniSTS
Cytogenetic Map2q45UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 35 8 1
Low 10 14 2 5 2 2 2 33 6 22 10 2
Below cutoff 3 23 23 19 14 19 5 6 6 12 10 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000012638   ⟹   ENSRNOP00000012638
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2243,615,872 - 243,715,317 (+)Ensembl
Rnor_6.0 Ensembl2260,997,497 - 261,032,821 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000100545   ⟹   ENSRNOP00000082310
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2243,615,875 - 243,715,317 (+)Ensembl
RefSeq Acc Id: XM_017591359   ⟹   XP_017446848
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82246,275,501 - 246,377,673 (+)NCBI
mRatBN7.22243,615,777 - 243,717,973 (+)NCBI
Rnor_6.02260,947,970 - 261,049,973 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017591360   ⟹   XP_017446849
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82246,275,438 - 246,377,673 (+)NCBI
mRatBN7.22243,615,796 - 243,717,973 (+)NCBI
Rnor_6.02260,947,971 - 261,049,973 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039103891   ⟹   XP_038959819
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82246,307,165 - 246,377,673 (+)NCBI
mRatBN7.22243,653,497 - 243,717,973 (+)NCBI
RefSeq Acc Id: XM_063282934   ⟹   XP_063139004
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82246,327,697 - 246,377,673 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_017446848   ⟸   XM_017591359
- Peptide Label: isoform X1
- UniProtKB: A0A8I6G9B4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017446849   ⟸   XM_017591360
- Peptide Label: isoform X2
- UniProtKB: F1MA76 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000012638   ⟸   ENSRNOT00000012638
RefSeq Acc Id: XP_038959819   ⟸   XM_039103891
- Peptide Label: isoform X3
RefSeq Acc Id: ENSRNOP00000082310   ⟸   ENSRNOT00000100545
RefSeq Acc Id: XP_063139004   ⟸   XM_063282934
- Peptide Label: isoform X4
Protein Domains
DUF4590

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1MA76-F1-model_v2 AlphaFold F1MA76 1-521 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691840
Promoter ID:EPDNEW_R2358
Type:initiation region
Name:Erich3_1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02260,997,573 - 260,997,633EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1593279 AgrOrtholog
BioCyc Gene G2FUF-50752 BioCyc
Ensembl Genes ENSRNOG00000009533 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012638.8 UniProtKB/TrEMBL
  ENSRNOT00000100545.1 UniProtKB/TrEMBL
InterPro DUF4590 UniProtKB/TrEMBL
  DUF4590 UniProtKB/TrEMBL
KEGG Report rno:295528 UniProtKB/TrEMBL
NCBI Gene 295528 ENTREZGENE
PANTHER GLUTAMATE-RICH PROTEIN 3 UniProtKB/TrEMBL
  PTHR23034 UniProtKB/TrEMBL
Pfam DUF4590 UniProtKB/TrEMBL
PhenoGen Erich3 PhenoGen
RatGTEx ENSRNOG00000009533 RatGTEx
UniProt A0A8I6G9B4 ENTREZGENE, UniProtKB/TrEMBL
  F1MA76 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-03-07 Erich3  glutamate-rich 3  LOC295528  similar to T06D8.1a  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC295528  similar to T06D8.1a      Symbol and Name status set to provisional 70820 PROVISIONAL