Zfp326 (zinc finger protein 326) - Rat Genome Database

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Gene: Zfp326 (zinc finger protein 326) Rattus norvegicus
Analyze
Symbol: Zfp326
Name: zinc finger protein 326
RGD ID: 1592829
Description: Predicted to enable DNA binding activity; RNA polymerase II complex binding activity; and zinc ion binding activity. Predicted to be involved in regulation of DNA-templated transcription elongation and regulation of RNA splicing. Predicted to act upstream of or within positive regulation of DNA-templated transcription. Predicted to be located in nuclear matrix and nucleoplasm. Predicted to be part of DBIRD complex. Orthologous to human ZNF326 (zinc finger protein 326); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; methoxychlor.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: DBIRD complex subunit ZNF326; LOC682914; similar to Zinc finger protein 326 (Zinc finger protein-associated with nuclear matrix of 75 kDa); uncharacterized protein Zfp326
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8144,246,081 - 4,286,805 (-)NCBIGRCr8
mRatBN7.2143,941,210 - 3,980,419 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl143,941,958 - 3,980,384 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0144,998,530 - 5,006,759 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0145,016,764 - 5,036,663 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl144,998,539 - 5,033,942 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0144,976,313 - 5,028,404 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera144,091,649 - 4,144,131 (-)NCBICelera
Cytogenetic Map14p22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9809746   PMID:10798446   PMID:22446626   PMID:22658674   PMID:22681889  


Genomics

Comparative Map Data
Zfp326
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8144,246,081 - 4,286,805 (-)NCBIGRCr8
mRatBN7.2143,941,210 - 3,980,419 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl143,941,958 - 3,980,384 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0144,998,530 - 5,006,759 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0145,016,764 - 5,036,663 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl144,998,539 - 5,033,942 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0144,976,313 - 5,028,404 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera144,091,649 - 4,144,131 (-)NCBICelera
Cytogenetic Map14p22NCBI
ZNF326
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38189,995,110 - 90,035,533 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl189,995,110 - 90,035,533 (+)EnsemblGRCh38hg38GRCh38
GRCh37190,460,669 - 90,501,092 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36190,233,266 - 90,266,682 (+)NCBINCBI36Build 36hg18NCBI36
Celera188,706,370 - 88,739,792 (+)NCBICelera
Cytogenetic Map1p22.2NCBI
HuRef188,577,877 - 88,611,300 (+)NCBIHuRef
CHM1_1190,576,010 - 90,609,429 (+)NCBICHM1_1
T2T-CHM13v2.0189,838,332 - 89,878,758 (+)NCBIT2T-CHM13v2.0
Zfp326
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395106,024,422 - 106,063,684 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5106,024,431 - 106,063,684 (+)EnsemblGRCm39 Ensembl
GRCm385105,876,556 - 105,915,818 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5105,876,565 - 105,915,818 (+)EnsemblGRCm38mm10GRCm38
MGSCv375106,305,587 - 106,344,837 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365106,116,904 - 106,156,114 (+)NCBIMGSCv36mm8
Celera5102,957,510 - 103,029,034 (+)NCBICelera
Cytogenetic Map5E5NCBI
cM Map550.88NCBI
Znf326
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554234,145,998 - 4,178,320 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554234,145,169 - 4,178,409 (-)NCBIChiLan1.0ChiLan1.0
ZNF326
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21136,990,980 - 137,029,528 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11136,151,732 - 136,185,304 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0192,656,490 - 92,693,995 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1191,405,460 - 91,438,913 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl191,405,472 - 91,438,913 (+)Ensemblpanpan1.1panPan2
ZNF326
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1658,597,606 - 58,632,781 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl658,598,416 - 58,632,776 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha661,306,237 - 61,343,925 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0658,991,407 - 59,029,111 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl658,991,686 - 59,029,075 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1658,682,678 - 58,720,428 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0658,634,913 - 58,672,669 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0659,115,669 - 59,153,389 (-)NCBIUU_Cfam_GSD_1.0
Znf326
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405058100,150,106 - 100,188,552 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365378,760,834 - 8,797,730 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365378,760,311 - 8,797,869 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100737600
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4126,679,581 - 126,717,815 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14126,679,269 - 126,703,983 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24138,557,134 - 138,565,558 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ZNF326
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12043,447,762 - 43,483,594 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2043,448,595 - 43,483,462 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603374,450,099 - 74,485,865 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Znf326
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247427,714,797 - 7,760,022 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247427,713,965 - 7,760,193 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Zfp326
614 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:115
Count of miRNA genes:101
Interacting mature miRNAs:104
Transcripts:ENSRNOT00000072818, ENSRNOT00000075334
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
71115Niddm15Non-insulin dependent diabetes mellitus QTL 154.8blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14121760611030812Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14121760616960180Rat
724541Niddm53Non-insulin dependent diabetes mellitus QTL 530.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1438130749088978Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)14381307418274691Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)14381307418274691Rat
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14381307421217635Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14381307424531477Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14381307430767156Rat

Markers in Region
D14Got157  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2143,933,111 - 3,933,350 (+)MAPPERmRatBN7.2
Rnor_6.0144,989,427 - 4,989,670NCBIRnor6.0
Rnor_5.0144,982,825 - 4,983,091UniSTSRnor5.0
Celera144,096,468 - 4,096,706UniSTS
RH138071  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2143,947,392 - 3,947,595 (+)MAPPERmRatBN7.2
Rnor_6.0145,003,653 - 5,003,855NCBIRnor6.0
Rnor_5.0144,996,357 - 4,996,559UniSTSRnor5.0
Celera144,110,500 - 4,110,702UniSTS
RH 3.4 Map1474.2UniSTS
RH138731  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2143,941,484 - 3,941,677 (+)MAPPERmRatBN7.2
Rnor_6.0144,997,901 - 4,998,093NCBIRnor6.0
Rnor_5.0144,990,605 - 4,990,797UniSTSRnor5.0
Celera144,104,786 - 4,104,978UniSTS
BF387711  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2143,946,561 - 3,946,722 (+)MAPPERmRatBN7.2
Rnor_6.0145,002,822 - 5,002,982NCBIRnor6.0
Rnor_5.0144,995,526 - 4,995,686UniSTSRnor5.0
Celera144,109,669 - 4,109,829UniSTS
RH 3.4 Map1480.8UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 35 48 32 19 32 1 3 74 35 40 11 1
Low 8 9 9 9 7 8 1 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000072818   ⟹   ENSRNOP00000064117
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl143,941,958 - 3,971,636 (-)Ensembl
Rnor_6.0 Ensembl145,017,698 - 5,033,941 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000076571   ⟹   ENSRNOP00000068484
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl143,942,008 - 3,980,384 (-)Ensembl
Rnor_6.0 Ensembl144,998,539 - 5,006,594 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000082331   ⟹   ENSRNOP00000075187
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl143,942,201 - 3,978,211 (-)Ensembl
Rnor_6.0 Ensembl144,998,539 - 5,033,942 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000095214   ⟹   ENSRNOP00000093693
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl143,967,782 - 3,980,384 (-)Ensembl
RefSeq Acc Id: XM_039092633   ⟹   XP_038948561
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8144,246,081 - 4,285,258 (-)NCBI
mRatBN7.2143,941,210 - 3,980,414 (-)NCBI
RefSeq Acc Id: XM_039092634   ⟹   XP_038948562
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8144,246,081 - 4,285,259 (-)NCBI
mRatBN7.2143,941,210 - 3,980,419 (-)NCBI
RefSeq Acc Id: XM_039092635   ⟹   XP_038948563
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8144,247,203 - 4,285,257 (-)NCBI
mRatBN7.2143,942,265 - 3,980,413 (-)NCBI
RefSeq Acc Id: XM_063273731   ⟹   XP_063129801
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8144,246,081 - 4,276,433 (-)NCBI
RefSeq Acc Id: XM_063273732   ⟹   XP_063129802
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8144,273,811 - 4,286,805 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000064117   ⟸   ENSRNOT00000072818
RefSeq Acc Id: ENSRNOP00000075187   ⟸   ENSRNOT00000082331
RefSeq Acc Id: ENSRNOP00000068484   ⟸   ENSRNOT00000076571
RefSeq Acc Id: XP_038948562   ⟸   XM_039092634
- Peptide Label: isoform X2
- UniProtKB: A0A096MKE5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948561   ⟸   XM_039092633
- Peptide Label: isoform X1
- UniProtKB: A0A096MKE5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948563   ⟸   XM_039092635
- Peptide Label: isoform X3
RefSeq Acc Id: ENSRNOP00000093693   ⟸   ENSRNOT00000095214
RefSeq Acc Id: XP_063129801   ⟸   XM_063273731
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063129802   ⟸   XM_063273732
- Peptide Label: isoform X5
Protein Domains
C2H2 AKAP95-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K9Y9-F1-model_v2 AlphaFold A0A0G2K9Y9 1-504 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1592829 AgrOrtholog
BioCyc Gene G2FUF-16557 BioCyc
Ensembl Genes ENSRNOG00000047761 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000072818.3 UniProtKB/TrEMBL
  ENSRNOT00000076571.3 UniProtKB/TrEMBL
  ENSRNOT00000082331.2 UniProtKB/TrEMBL
  ENSRNOT00000095214.1 UniProtKB/TrEMBL
InterPro AKAP95 UniProtKB/TrEMBL
  ZF_C2H2_AKAP95 UniProtKB/TrEMBL
NCBI Gene 682914 ENTREZGENE
PANTHER DBIRD COMPLEX SUBUNIT ZNF326 UniProtKB/TrEMBL
  PTHR12190 UniProtKB/TrEMBL
Pfam AKAP95 UniProtKB/TrEMBL
PhenoGen Zfp326 PhenoGen
PROSITE ZF_C2H2_AKAP95 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000047761 RatGTEx
UniProt A0A096MKE5 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K9Y9_RAT UniProtKB/TrEMBL
  A0A8I6AKW1_RAT UniProtKB/TrEMBL
  M0R440_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-10-03 Zfp326  zinc finger protein 326  LOC682914  similar to Zinc finger protein 326 (Zinc finger protein-associated with nuclear matrix of 75 kDa)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC682914  similar to Zinc finger protein 326 (Zinc finger protein-associated with nuclear matrix of 75 kDa)      Symbol and Name status set to provisional 70820 PROVISIONAL