Ppil6 (peptidylprolyl isomerase like 6) - Rat Genome Database

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Gene: Ppil6 (peptidylprolyl isomerase like 6) Rattus norvegicus
Analyze
Symbol: Ppil6
Name: peptidylprolyl isomerase like 6
RGD ID: 1592581
Description: Predicted to be active in cytoplasm. Orthologous to human PPIL6 (peptidylprolyl isomerase like 6); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; bisphenol A.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC685567; peptidyl-prolyl cis-trans isomerase-like 6; peptidylprolyl isomerase (cyclophilin)-like 6; probable inactive peptidyl-prolyl cis-trans isomerase-like 6; similar to peptidylprolyl isomerase (cyclophilin)-like 6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82046,571,937 - 46,600,759 (+)NCBIGRCr8
mRatBN7.22044,989,509 - 45,017,833 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2044,988,943 - 45,018,340 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.02046,215,317 - 46,244,522 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2046,215,379 - 46,243,707 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02047,907,634 - 47,936,073 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42045,452,083 - 45,479,879 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2054,935,648 - 54,964,134 (-)NCBICelera
Cytogenetic Map20q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:20676357  


Genomics

Comparative Map Data
Ppil6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82046,571,937 - 46,600,759 (+)NCBIGRCr8
mRatBN7.22044,989,509 - 45,017,833 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2044,988,943 - 45,018,340 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.02046,215,317 - 46,244,522 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2046,215,379 - 46,243,707 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02047,907,634 - 47,936,073 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42045,452,083 - 45,479,879 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2054,935,648 - 54,964,134 (-)NCBICelera
Cytogenetic Map20q12NCBI
PPIL6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386109,390,215 - 109,441,171 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6109,390,215 - 109,441,171 (-)EnsemblGRCh38hg38GRCh38
GRCh376109,711,418 - 109,762,374 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366109,820,624 - 109,868,524 (-)NCBINCBI36Build 36hg18NCBI36
Build 346109,820,623 - 109,868,522NCBI
Celera6110,458,002 - 110,508,958 (-)NCBICelera
Cytogenetic Map6q21NCBI
HuRef6107,277,598 - 107,328,460 (-)NCBIHuRef
CHM1_16109,974,514 - 110,025,457 (-)NCBICHM1_1
T2T-CHM13v2.06110,568,252 - 110,619,209 (-)NCBIT2T-CHM13v2.0
Ppil6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391041,366,414 - 41,390,286 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1041,366,435 - 41,390,282 (+)EnsemblGRCm39 Ensembl
GRCm381041,490,371 - 41,514,295 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1041,490,439 - 41,514,286 (+)EnsemblGRCm38mm10GRCm38
MGSCv371041,210,245 - 41,234,094 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361041,178,854 - 41,202,705 (+)NCBIMGSCv36mm8
Celera1042,376,692 - 42,400,533 (+)NCBICelera
Cytogenetic Map10B1- B2NCBI
cM Map1022.43NCBI
Ppil6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541134,452,864 - 34,481,366 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541134,449,508 - 34,481,370 (-)NCBIChiLan1.0ChiLan1.0
PPIL6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25129,401,324 - 129,449,274 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16127,292,657 - 127,340,623 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06107,193,192 - 107,244,193 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16111,242,022 - 111,292,657 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6111,242,022 - 111,292,657 (-)Ensemblpanpan1.1panPan2
PPIL6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11266,316,326 - 66,347,991 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1266,316,425 - 66,342,950 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1266,135,976 - 66,167,216 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01267,198,984 - 67,230,466 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1267,196,646 - 67,231,936 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11266,549,196 - 66,580,435 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01266,398,045 - 66,429,274 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01266,669,784 - 66,701,009 (-)NCBIUU_Cfam_GSD_1.0
Ppil6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946101,258,089 - 101,290,271 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365645,533,417 - 5,565,759 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365645,533,417 - 5,565,105 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPIL6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl175,463,222 - 75,508,244 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1175,465,290 - 75,508,250 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2184,743,267 - 84,786,213 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PPIL6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11364,426,995 - 64,472,167 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604036,718,780 - 36,766,355 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppil6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624916667,163 - 697,803 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624916671,373 - 697,867 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ppil6
160 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:59
Count of miRNA genes:55
Interacting mature miRNAs:58
Transcripts:ENSRNOT00000066634, ENSRNOT00000068693
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201175751554435887Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201175751554435887Rat
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)201761783247606836Rat
2317880Alcrsp25Alcohol response QTL 252.3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)201769755054435887Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)201919072154435887Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202510672254435887Rat
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202510672254435887Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202510672254435887Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202520973454435887Rat
1598869Memor6Memory QTL 63.1exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)202924438854435887Rat

Markers in Region
BE106860  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22045,011,117 - 45,011,282 (+)MAPPERmRatBN7.2
Rnor_6.02046,237,490 - 46,237,654NCBIRnor6.0
Rnor_5.02047,929,845 - 47,930,009UniSTSRnor5.0
RGSC_v3.42045,473,662 - 45,473,826UniSTSRGSC3.4
Celera2054,942,524 - 54,942,688UniSTS
RH 3.4 Map20485.5UniSTS
Cytogenetic Map20q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 48 6 15 3
Low 3 34 32 16 19 16 2 2 26 29 26 8 2
Below cutoff 9 25 25 25 5 8 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000066634   ⟹   ENSRNOP00000061264
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2044,988,943 - 45,018,340 (+)Ensembl
Rnor_6.0 Ensembl2046,215,379 - 46,236,848 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000068693   ⟹   ENSRNOP00000061000
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2044,989,528 - 45,018,272 (+)Ensembl
Rnor_6.0 Ensembl2046,215,379 - 46,243,707 (+)Ensembl
RefSeq Acc Id: XM_001064326   ⟹   XP_001064326
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82046,571,937 - 46,600,759 (+)NCBI
mRatBN7.22044,989,509 - 45,017,833 (+)NCBI
Rnor_6.02046,215,318 - 46,244,522 (+)NCBI
Rnor_5.02047,907,634 - 47,936,073 (+)NCBI
RGSC_v3.42045,452,083 - 45,479,879 (+)RGD
Sequence:
RefSeq Acc Id: XM_017601826   ⟹   XP_017457315
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82046,571,937 - 46,600,759 (+)NCBI
mRatBN7.22044,989,509 - 45,017,833 (+)NCBI
Rnor_6.02046,215,317 - 46,244,522 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039099297   ⟹   XP_038955225
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82046,571,937 - 46,596,871 (+)NCBI
mRatBN7.22044,989,509 - 45,014,031 (+)NCBI
Protein Sequences
Protein RefSeqs XP_001064326 (Get FASTA)   NCBI Sequence Viewer  
  XP_017457315 (Get FASTA)   NCBI Sequence Viewer  
  XP_038955225 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000061000
  ENSRNOP00000061000.2
  ENSRNOP00000061264
  ENSRNOP00000061264.3
Reference Protein Sequences
RefSeq Acc Id: XP_001064326   ⟸   XM_001064326
- Peptide Label: isoform X2
- UniProtKB: D4A5Z2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017457315   ⟸   XM_017601826
- Peptide Label: isoform X1
- UniProtKB: D4A1I9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000061000   ⟸   ENSRNOT00000068693
RefSeq Acc Id: ENSRNOP00000061264   ⟸   ENSRNOT00000066634
RefSeq Acc Id: XP_038955225   ⟸   XM_039099297
- Peptide Label: isoform X3
Protein Domains
PPIase cyclophilin-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A1I9-F1-model_v2 AlphaFold D4A1I9 1-313 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701666
Promoter ID:EPDNEW_R12187
Type:single initiation site
Name:Ppil6_1
Description:peptidylprolyl isomerase like 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02046,215,360 - 46,215,420EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1592581 AgrOrtholog
BioCyc Gene G2FUF-3395 BioCyc
Ensembl Genes ENSRNOG00000043186 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000066634.3 UniProtKB/TrEMBL
  ENSRNOT00000068693.4 UniProtKB/TrEMBL
Gene3D-CATH 2.40.100.10 UniProtKB/TrEMBL
InterPro Cyclophilin-like_dom UniProtKB/TrEMBL
  PPIase_cyclophilin UniProtKB/TrEMBL
KEGG Report rno:685567 UniProtKB/TrEMBL
NCBI Gene 685567 ENTREZGENE
PANTHER PEPTIDYL-PROLYL CIS-TRANS ISOMERASE UniProtKB/TrEMBL
  PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED UniProtKB/TrEMBL
Pfam Pro_isomerase UniProtKB/TrEMBL
PhenoGen Ppil6 PhenoGen
PRINTS CSAPPISMRASE UniProtKB/TrEMBL
PROSITE CSA_PPIASE_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000043186 RatGTEx
Superfamily-SCOP SSF50891 UniProtKB/TrEMBL
UniProt D4A1I9 ENTREZGENE, UniProtKB/TrEMBL
  D4A5Z2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-02 Ppil6  peptidylprolyl isomerase like 6  Ppil6  peptidylprolyl isomerase (cyclophilin)-like 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-05-24 Ppil6  peptidylprolyl isomerase (cyclophilin)-like 6  LOC684245  similar to peptidylprolyl isomerase (cyclophilin)-like 6  Data merged from RGD:1592702 1643240 APPROVED
2008-03-05 Ppil6  peptidylprolyl isomerase (cyclophilin)-like 6  LOC685567  similar to peptidylprolyl isomerase (cyclophilin)-like 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC685567  similar to peptidylprolyl isomerase (cyclophilin)-like 6      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC684245  similar to peptidylprolyl isomerase (cyclophilin)-like 6      Symbol and Name status set to provisional 70820 PROVISIONAL