Gene: Pappa2 (pappalysin 2) Rattus norvegicus
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Symbol: Pappa2
Name: pappalysin 2
Description: ENCODES a protein that exhibits metalloendopeptidase activity (ortholog); metallopeptidase activity (ortholog); INVOLVED IN response to salt stress; bone morphogenesis (ortholog); proteolysis (ortholog); ASSOCIATED WITH abnormal circadian regulation of systemic arterial blood pressure; salt-sensitive hypertension; FOUND IN apical plasma membrane; cytosol; extracellular exosome (ortholog); INTERACTS WITH aflatoxin B1 (ortholog); all-trans-retinoic acid (ortholog); Benzo[k]fluoranthene (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOC680069; LOC680415; pappalysin-2; similar to pappalysin 2 isoform 1; similar to Pappalysin-2 precursor (Pregnancy-associated plasma protein-A2) (PAPP-A2) (Pregnancy-associated plasma protein-E1) (PAPP-E)
Orthologs:
Homo sapiens (human) : PAPPA2 (pappalysin 2)  HGNC  AGR
Mus musculus (house mouse) : Pappa2 (pappalysin 2)  MGI  AGR
Chinchilla lanigera (long-tailed chinchilla) : Pappa2 (pappalysin 2)
Pan paniscus (bonobo/pygmy chimpanzee) : PAPPA2 (pappalysin 2)
Canis lupus familiaris (dog) : PAPPA2 (pappalysin 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pappa2 (pappalysin 2)
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Allele / Splice: Pappa2em4Mcwi   Pappa2em5Mcwi  
Genetic Models: SS.BN-(D13Hmgc1048-D13Hmgc1050)-Pappa2em4Mcwi SS.BN-(D13Hmgc1048-D13Hmgc1050)-Pappa2em5Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01376,389,150 - 76,660,248 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01381,303,663 - 81,574,402 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41374,286,881 - 74,379,736 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1370,687,413 - 70,959,267 (-)NCBICelera
Cytogenetic Map13q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
 
More on Pappa2
AGR Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1591785
Created: 2006-11-20
Species: Rattus norvegicus
Last Modified: 2017-10-03
Status: ACTIVE