Ftdc2 (ferritin domain containing 2) - Rat Genome Database

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Gene: Ftdc2 (ferritin domain containing 2) Rattus norvegicus
Analyze
Symbol: Ftdc2
Name: ferritin domain containing 2
RGD ID: 1590640
Description: Predicted to enable ferric iron binding activity and ferrous iron binding activity. Predicted to be involved in intracellular sequestering of iron ion. Predicted to be active in cytoplasm; INTERACTS WITH 2,3',4,4',5-Pentachlorobiphenyl (ortholog); epoxiconazole (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ferritin heavy chain; LOC680520; similar to CG4349-PA
RGD Orthologs
Mouse
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81155,437,980 - 55,441,566 (+)NCBIGRCr8
mRatBN7.21141,967,947 - 41,973,373 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1141,968,796 - 41,972,351 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01144,071,086 - 44,079,483 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1144,072,043 - 44,075,501 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01147,261,903 - 47,265,909 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41142,782,500 - 42,785,979 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1141,766,931 - 41,775,328 (+)NCBICelera
Cytogenetic Map11q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.

Genomics

Comparative Map Data
Ftdc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81155,437,980 - 55,441,566 (+)NCBIGRCr8
mRatBN7.21141,967,947 - 41,973,373 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1141,968,796 - 41,972,351 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01144,071,086 - 44,079,483 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1144,072,043 - 44,075,501 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01147,261,903 - 47,265,909 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41142,782,500 - 42,785,979 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1141,766,931 - 41,775,328 (+)NCBICelera
Cytogenetic Map11q12NCBI
Ftdc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391658,455,625 - 58,458,766 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1658,455,530 - 58,459,102 (-)EnsemblGRCm39 Ensembl
GRCm381658,635,262 - 58,638,403 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1658,635,167 - 58,638,739 (-)EnsemblGRCm38mm10GRCm38
MGSCv371658,635,375 - 58,638,516 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361658,577,805 - 58,580,946 (-)NCBIMGSCv36mm8
Celera1658,931,866 - 58,935,007 (-)NCBICelera
Cytogenetic Map16C1.2NCBI
cM Map1634.75NCBI

Variants

.
Variants in Ftdc2
23 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:14
Count of miRNA genes:14
Interacting mature miRNAs:14
Transcripts:ENSRNOT00000033716
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
1641927Alcrsp10Alcohol response QTL 10alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)11843667453436674Rat
724517Uae18Urinary albumin excretion QTL 183.7urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)111647204744285911Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)112952841860324829Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system exocrine system hemolymphoid system hepatobiliary system nervous system renal system reproductive system
High
Medium 7 2
Low 6 6 6 4 6
Below cutoff 1 4 3 2 3 2 11

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000033716   ⟹   ENSRNOP00000034394
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1141,968,796 - 41,972,351 (+)Ensembl
Rnor_6.0 Ensembl1144,072,043 - 44,075,501 (+)Ensembl
RefSeq Acc Id: XM_001057542   ⟹   XP_001057542
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81155,437,980 - 55,441,566 (+)NCBI
mRatBN7.21141,967,947 - 41,973,373 (+)NCBI
Rnor_6.01144,071,086 - 44,079,483 (+)NCBI
Rnor_5.01147,261,903 - 47,265,909 (+)NCBI
RGSC_v3.41142,782,500 - 42,785,979 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs XP_001057542 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM11017 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000034394
  ENSRNOP00000034394.2
Reference Protein Sequences
RefSeq Acc Id: XP_001057542   ⟸   XM_001057542
- UniProtKB: A6IQL4 (UniProtKB/TrEMBL),   D3ZJP9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000034394   ⟸   ENSRNOT00000033716
Protein Domains
Ferritin-like diiron

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZJP9-F1-model_v2 AlphaFold D3ZJP9 1-164 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1590640 AgrOrtholog
BioCyc Gene G2FUF-21569 BioCyc
Ensembl Genes ENSRNOG00000027997 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000033716.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1260.10 UniProtKB/TrEMBL
InterPro Ferritin UniProtKB/TrEMBL
  Ferritin-like UniProtKB/TrEMBL
  Ferritin-rel UniProtKB/TrEMBL
  Ferritin/RR-like UniProtKB/TrEMBL
  Ferritin_DPS_dom UniProtKB/TrEMBL
KEGG Report rno:680520 UniProtKB/TrEMBL
NCBI Gene 680520 ENTREZGENE
PANTHER FERRITIN UniProtKB/TrEMBL
  Ferritin_N UniProtKB/TrEMBL
Pfam Ferritin UniProtKB/TrEMBL
PhenoGen Ftdc2 PhenoGen
PROSITE FERRITIN_LIKE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000027997 RatGTEx
Superfamily-SCOP Ferritin/RR_like UniProtKB/TrEMBL
UniProt A6IQL4 ENTREZGENE, UniProtKB/TrEMBL
  D3ZJP9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-09-06 Ftdc2  ferritin domain containing 2  LOC680520  similar to CG4349-PA  Name and Symbol changed 629549 APPROVED
2006-11-20 LOC680520  similar to CG4349-PA      Symbol and Name status set to provisional 70820 PROVISIONAL