Hint1l2 (histidine triad nucleotide binding protein 1 like 2) - Rat Genome Database

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Gene: Hint1l2 (histidine triad nucleotide binding protein 1 like 2) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Hint1l2 (Ensembl: LOC684427)
Name: histidine triad nucleotide binding protein 1 like 2 (Ensembl:similar to Histidine triad nucleotide-binding protein 1 (Adenosine 5-monophosphoramidase) (Protein kinase C inhibitor 1) (Protein kinase C-interacting protein 1) (PKCI-1))
RGD ID: 1590340
Description: Predicted to enable nucleotide binding activity and peptidase activity. Predicted to be involved in proteolysis.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: adenosine 5'-monophosphoramidase HINT1-like; histidine triad nucleotide-binding protein 1-like; LOC684427; similar to Histidine triad nucleotide-binding protein 1 (Adenosine 5-monophosphoramidase) (Protein kinase C inhibitor 1) (Protein kinase C-interacting protein 1) (PKCI-1)
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81213,782,261 - 14,647,661 (-)NCBIGRCr8
mRatBN7.2128,668,438 - 8,668,940 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl128,668,545 - 8,668,925 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01210,396,268 - 10,396,687 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01212,498,021 - 12,501,103 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1210,482,506 - 10,483,030 (-)NCBICelera
Cytogenetic Map12p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IEA)
nucleus  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.

Genomics

Variants

.
Variants in Hint1l2
3 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)1219318387Rat
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12119611090Rat
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12122591684Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
724526Uae3Urinary albumin excretion QTL 34.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)12390696910373166Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1600391Edcs2Endometrial carcinoma susceptibility QTL23.50.01uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)12683319017870186Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12844949028302290Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12852542328064601Rat


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000096275   ⟹   ENSRNOP00000080711
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl128,668,545 - 8,668,925 (-)Ensembl
RefSeq Acc Id: XM_039089889   ⟹   XP_038945817
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81213,782,261 - 14,647,661 (-)NCBI
mRatBN7.2128,668,438 - 8,668,940 (-)NCBI
Protein Sequences
Protein RefSeqs XP_038945817 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000007437.1
  ENSRNOP00000080711
  ENSRNOP00000080711.1
Reference Protein Sequences
RefSeq Acc Id: XP_038945817   ⟸   XM_039089889
- UniProtKB: A0A8I5ZQ74 (UniProtKB/TrEMBL),   D4A269 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000080711   ⟸   ENSRNOT00000096275
Protein Domains
HIT

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
BioCyc Gene G2FUF-20081 BioCyc
Ensembl Genes ENSRNOG00000005630 UniProtKB/TrEMBL
  ENSRNOG00000069792 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000007437.3 UniProtKB/TrEMBL
  ENSRNOT00000096275.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.428.10 UniProtKB/TrEMBL
InterPro Histidine_triad_CS UniProtKB/TrEMBL
  Histidine_triad_HIT UniProtKB/TrEMBL
  HIT-like UniProtKB/TrEMBL
  HIT-like_sf UniProtKB/TrEMBL
NCBI Gene 684427 ENTREZGENE
PANTHER HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN 1 UniProtKB/TrEMBL
  PTHR23089 UniProtKB/TrEMBL
Pfam HIT UniProtKB/TrEMBL
PhenoGen Hint1l2 PhenoGen
PRINTS HISTRIAD UniProtKB/TrEMBL
PROSITE HIT_1 UniProtKB/TrEMBL
  HIT_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005630 RatGTEx
  ENSRNOG00000069792 RatGTEx
Superfamily-SCOP SSF54197 UniProtKB/TrEMBL
UniProt A0A8I5ZQ74 ENTREZGENE, UniProtKB/TrEMBL
  D4A269 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Hint1l2  histidine triad nucleotide binding protein 1 like 2  LOC684427  similar to Histidine triad nucleotide-binding protein 1 (Adenosine 5-monophosphoramidase) (Protein kinase C inhibitor 1) (Protein kinase C-interacting protein 1) (PKCI-1)  Symbol and Name Changed 1299863 APPROVED
2006-11-20 LOC684427  similar to Histidine triad nucleotide-binding protein 1 (Adenosine 5-monophosphoramidase) (Protein kinase C inhibitor 1) (Protein kinase C-interacting protein 1) (PKCI-1)      Symbol and Name status set to provisional 70820 PROVISIONAL