Fndc10 (fibronectin type III domain containing 10) - Rat Genome Database

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Gene: Fndc10 (fibronectin type III domain containing 10) Rattus norvegicus
Analyze
Symbol: Fndc10 (Ensembl: LOC100364191)
Name: fibronectin type III domain containing 10 (Ensembl:hCG1994130-like)
RGD ID: 1589420
Description: Predicted to be located in membrane. Orthologous to human FNDC10 (fibronectin type III domain containing 10); INTERACTS WITH 17beta-estradiol; bisphenol A; ochratoxin A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: fibronectin type III domain-containing protein 10; Fibronectin type-III domain-containing transmembrane protein C1orf233 homolog; hypothetical protein LOC680656; LOC108348319; LOC680656; uncharacterized LOC108348319
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85171,581,960 - 171,584,519 (+)NCBIGRCr8
mRatBN7.25166,299,587 - 166,311,477 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5166,300,122 - 166,310,326 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.05173,139,345 - 173,141,564 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05176,614,303 - 176,616,937 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45172,546,730 - 172,548,701 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera5164,500,919 - 164,502,927 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
translation  (IEA)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15057822  


Genomics

Comparative Map Data
Fndc10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85171,581,960 - 171,584,519 (+)NCBIGRCr8
mRatBN7.25166,299,587 - 166,311,477 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5166,300,122 - 166,310,326 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.05173,139,345 - 173,141,564 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05176,614,303 - 176,616,937 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45172,546,730 - 172,548,701 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera5164,500,919 - 164,502,927 (+)NCBICelera
Cytogenetic Map5q36NCBI
FNDC10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811,598,012 - 1,600,135 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11,598,012 - 1,600,135 (-)EnsemblGRCh38hg38GRCh38
GRCh3711,533,392 - 1,535,515 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611,523,251 - 1,525,333 (-)NCBINCBI36Build 36hg18NCBI36
Celera11,045,618 - 1,046,671 (+)NCBICelera
Cytogenetic Map1p36.33NCBI
HuRef1806,717 - 841,794 (-)NCBIHuRef
CHM1_111,520,545 - 1,522,568 (-)NCBICHM1_1
T2T-CHM13v2.011,032,518 - 1,034,641 (-)NCBIT2T-CHM13v2.0
Fndc10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394155,778,775 - 155,780,942 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4155,778,799 - 155,780,938 (+)EnsemblGRCm39 Ensembl
GRCm384155,694,342 - 155,696,485 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4155,694,342 - 155,696,481 (+)EnsemblGRCm38mm10GRCm38
MGSCv374155,068,581 - 155,070,594 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364154,538,142 - 154,540,281 (+)NCBIMGSCv36mm8
Celera4157,966,421 - 157,968,460 (+)NCBICelera
Cytogenetic Map4E2NCBI
cM Map487.03NCBI
Fndc10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554869,301,802 - 9,303,246 (+)NCBIChiLan1.0ChiLan1.0
FNDC10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21226,620,329 - 226,622,479 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11225,276,347 - 225,278,496 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01359,080 - 361,223 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111,519,622 - 1,521,256 (-)NCBIpanpan1.1PanPan1.1panPan2
FNDC10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1556,660,721 - 56,662,696 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha556,736,733 - 56,738,756 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0556,862,833 - 56,864,856 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1556,853,453 - 56,855,476 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0556,745,801 - 56,747,824 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0557,135,946 - 57,137,969 (-)NCBIUU_Cfam_GSD_1.0
Fndc10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505827,797,867 - 27,807,018 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049367371,658,932 - 1,668,081 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FNDC10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl663,764,815 - 63,765,483 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1663,762,059 - 63,765,483 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2658,193,842 - 58,203,996 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103225788
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120129,906,052 - 129,908,148 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20129,906,142 - 129,906,819 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236695272,481 - 4,513 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fndc10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248188,120,230 - 8,122,171 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248188,120,230 - 8,126,439 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fndc10
58 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5151113452166875058Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5154828214166875058Rat

Markers in Region
RH137719  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25166,301,979 - 166,302,194 (+)MAPPERmRatBN7.2
Rnor_6.05173,141,279 - 173,141,493NCBIRnor6.0
Rnor_5.05176,616,652 - 176,616,866UniSTSRnor5.0
RGSC_v3.45172,548,416 - 172,548,630UniSTSRGSC3.4
Celera5164,502,642 - 164,502,856UniSTS
RH 3.4 Map51175.2UniSTS
Cytogenetic Map5q36UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000041753   ⟹   ENSRNOP00000051016
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5166,300,122 - 166,310,326 (+)Ensembl
RefSeq Acc Id: NM_001419679   ⟹   NP_001406608
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85171,582,366 - 171,584,518 (+)NCBI
mRatBN7.25166,300,112 - 166,302,264 (+)NCBI
RefSeq Acc Id: XM_063288393   ⟹   XP_063144463
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85171,581,960 - 171,584,519 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001406608 (Get FASTA)   NCBI Sequence Viewer  
  XP_063144463 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein D4A2Q0 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000051016
  ENSRNOP00000051016.4
  ENSRNOP00055021786
  ENSRNOP00060005593
  ENSRNOP00065012376
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000051016   ⟸   ENSRNOT00000041753
RefSeq Acc Id: NP_001406608   ⟸   NM_001419679
- Peptide Label: precursor
- UniProtKB: D4A2Q0 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063144463   ⟸   XM_063288393
- Peptide Label: isoform X1
Protein Domains
Fibronectin type-III

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZS61-F1-model_v2 AlphaFold D3ZS61 1-130 view protein structure
AF-D4A2Q0-F1-model_v2 AlphaFold D4A2Q0 1-225 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1589420 AgrOrtholog
BioCyc Gene G2FUF-38911 BioCyc
Ensembl Genes ENSRNOG00000030447 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055015835 UniProtKB/Swiss-Prot
  ENSRNOG00060004399 UniProtKB/Swiss-Prot
  ENSRNOG00065010129 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000041753 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000041753.6 UniProtKB/Swiss-Prot
  ENSRNOT00055026961 UniProtKB/Swiss-Prot
  ENSRNOT00060007378 UniProtKB/Swiss-Prot
  ENSRNOT00065016315 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.1370.30 UniProtKB/TrEMBL
  3.30.1490.10 UniProtKB/TrEMBL
InterPro Fndc10 UniProtKB/Swiss-Prot
  Ribosomal_uS8 UniProtKB/TrEMBL
  Ribosomal_uS8_CS UniProtKB/TrEMBL
  Ribosomal_uS8_sf UniProtKB/TrEMBL
KEGG Report rno:680656 UniProtKB/Swiss-Prot
NCBI Gene 680656 ENTREZGENE
PANTHER 40S RIBOSOMAL PROTEIN S15A UniProtKB/TrEMBL
  40S RIBOSOMAL PROTEIN S15A UniProtKB/TrEMBL
  FIBRONECTIN TYPE III DOMAIN-CONTAINING PROTEIN 10 UniProtKB/Swiss-Prot
  PTHR39233 UniProtKB/Swiss-Prot
Pfam DUF5579 UniProtKB/Swiss-Prot
  Ribosomal_S8 UniProtKB/TrEMBL
PhenoGen Fndc10 PhenoGen
PROSITE RIBOSOMAL_S8 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000030447 RatGTEx
  ENSRNOG00055015835 RatGTEx
  ENSRNOG00060004399 RatGTEx
  ENSRNOG00065010129 RatGTEx
Superfamily-SCOP Ribosomal protein S8 UniProtKB/TrEMBL
UniProt D3ZS61_RAT UniProtKB/TrEMBL
  D4A2Q0 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Fndc10  fibronectin type III domain containing 10  LOC108348319  uncharacterized LOC108348319  Data merged from RGD:11375690 737654 PROVISIONAL
2016-08-02 LOC108348319  uncharacterized LOC108348319      Symbol and Name status set to provisional 70820 PROVISIONAL
2016-06-29 Fndc10  fibronectin type III domain containing 10  LOC680656  hypothetical protein LOC680656  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC680656  hypothetical protein LOC680656  LOC687227  hypothetical protein LOC687227  Data merged from RGD:1587751 1643240 APPROVED
2006-11-19 LOC680656  hypothetical protein LOC680656      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC687227  hypothetical protein LOC687227      Symbol and Name status set to provisional 70820 PROVISIONAL