Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | affects expression | ISO | Dedd2 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine affects the expression of DEDD2 mRNA | CTD | PMID:22206623 | 1,2-dimethylhydrazine | multiple interactions | ISO | Dedd2 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of DEDD2 mRNA | CTD | PMID:22206623 | 17beta-estradiol | increases expression | ISO | DEDD2 (Homo sapiens) | 6480464 | Estradiol results in increased expression of DEDD2 mRNA | CTD | PMID:20106945 | 17beta-estradiol | decreases expression | ISO | DEDD2 (Homo sapiens) | 6480464 | Estradiol results in decreased expression of DEDD2 mRNA | CTD | PMID:31614463 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Dedd2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of DEDD2 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of DEDD2 mRNA | CTD | PMID:32109520 and PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Dedd2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of DEDD2 mRNA | CTD | PMID:19465110 | 2-hydroxypropanoic acid | decreases expression | ISO | DEDD2 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of DEDD2 mRNA | CTD | PMID:30851411 | 2-methylcholine | affects expression | ISO | DEDD2 (Homo sapiens) | 6480464 | beta-methylcholine affects the expression of DEDD2 mRNA | CTD | PMID:21179406 | acrylamide | increases expression | ISO | DEDD2 (Homo sapiens) | 6480464 | Acrylamide results in increased expression of DEDD2 mRNA | CTD | PMID:32763439 | aflatoxin B1 | increases expression | ISO | Dedd2 (Mus musculus) | 6480464 | Aflatoxin B1 results in increased expression of DEDD2 mRNA | CTD | PMID:19770486 | aflatoxin B1 | increases methylation | ISO | DEDD2 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of DEDD2 intron | CTD | PMID:30157460 | antirheumatic drug | decreases expression | ISO | DEDD2 (Homo sapiens) | 6480464 | Antirheumatic Agents results in decreased expression of DEDD2 mRNA | CTD | PMID:24449571 | aristolochic acid A | increases expression | ISO | DEDD2 (Homo sapiens) | 6480464 | aristolochic acid I results in increased expression of DEDD2 mRNA | CTD | PMID:33212167 | arsane | increases expression | ISO | DEDD2 (Homo sapiens) | 6480464 | Arsenic results in increased expression of DEDD2 mRNA | CTD | PMID:29248574 | arsenic atom | increases expression | ISO | DEDD2 (Homo sapiens) | 6480464 | Arsenic results in increased expression of DEDD2 mRNA | CTD | PMID:29248574 | arsenous acid | multiple interactions | ISO | DEDD2 (Homo sapiens) | 6480464 | [sanguinarine co-treated with Arsenic Trioxide] results in increased expression of DEDD2 mRNA | CTD | PMID:24345465 | benzo[a]pyrene | increases expression | ISO | Dedd2 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of DEDD2 mRNA | CTD | PMID:21569818 and PMID:22228805 | benzo[a]pyrene | decreases methylation | ISO | DEDD2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of DEDD2 3' UTR | CTD | PMID:27901495 | benzo[a]pyrene | increases expression | ISO | DEDD2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of DEDD2 mRNA | CTD | PMID:20106945 and PMID:21632981 | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of DEDD2 mRNA | CTD | PMID:30816183 and PMID:32528016 | bisphenol A | multiple interactions | ISO | DEDD2 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of DEDD2 gene | CTD | PMID:31601247 | bisphenol A | increases expression | ISO | Dedd2 (Mus musculus) | 6480464 | bisphenol A results in increased expression of DEDD2 mRNA | CTD | PMID:33221593 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of DEDD2 mRNA | CTD | PMID:34947998 | bortezomib | increases expression | ISO | DEDD2 (Homo sapiens) | 6480464 | Bortezomib results in increased expression of DEDD2 mRNA | CTD | PMID:17659339 | butanal | increases expression | ISO | DEDD2 (Homo sapiens) | 6480464 | butyraldehyde results in increased expression of DEDD2 mRNA | CTD | PMID:26079696 | cadmium atom | increases expression | ISO | DEDD2 (Homo sapiens) | 6480464 | Cadmium results in increased expression of DEDD2 mRNA | CTD | PMID:21120746 | cadmium atom | multiple interactions | ISO | DEDD2 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of DEDD2 mRNA | CTD | PMID:31738976 | cadmium dichloride | multiple interactions | ISO | DEDD2 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of DEDD2 mRNA | CTD | PMID:31738976 | carbon nanotube | decreases expression | ISO | Dedd2 (Mus musculus) | 6480464 | Nanotubes and Carbon results in decreased expression of DEDD2 mRNA | CTD | PMID:25620056 | chloropicrin | increases expression | ISO | DEDD2 (Homo sapiens) | 6480464 | chloropicrin results in increased expression of DEDD2 mRNA | CTD | PMID:26352163 | chlorpyrifos | increases expression | ISO | Dedd2 (Mus musculus) | 6480464 | Chlorpyrifos results in increased expression of DEDD2 mRNA | CTD | PMID:37019170 | ciguatoxin CTX1B | affects expression | ISO | Dedd2 (Mus musculus) | 6480464 | Ciguatoxins affects the expression of DEDD2 mRNA | CTD | PMID:18353800 | cobalt dichloride | increases expression | ISO | DEDD2 (Homo sapiens) | 6480464 | cobaltous chloride results in increased expression of DEDD2 mRNA | CTD | PMID:19320972 | cobalt dichloride | increases expression | EXP | | 6480464 | cobaltous chloride results in increased expression of DEDD2 mRNA | CTD | PMID:24386269 | copper atom | multiple interactions | ISO | DEDD2 (Homo sapiens) | 6480464 | [Disulfiram binds to Copper] which results in decreased expression of DEDD2 mRNA | CTD | PMID:24690739 | copper(0) | multiple interactions | ISO | DEDD2 (Homo sapiens) | 6480464 | [Disulfiram binds to Copper] which results in decreased expression of DEDD2 mRNA | CTD | PMID:24690739 | copper(II) sulfate | increases expression | ISO | DEDD2 (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of DEDD2 mRNA | CTD | PMID:19549813 | crotonaldehyde | increases expression | ISO | DEDD2 (Homo sapiens) | 6480464 | 2-butenal results in increased expression of DEDD2 mRNA | CTD | PMID:20471460 | cyclosporin A | increases expression | ISO | DEDD2 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of DEDD2 mRNA | CTD | PMID:20106945 more ... | diarsenic trioxide | multiple interactions | ISO | DEDD2 (Homo sapiens) | 6480464 | [sanguinarine co-treated with Arsenic Trioxide] results in increased expression of DEDD2 mRNA | CTD | PMID:24345465 | diazinon | increases methylation | ISO | DEDD2 (Homo sapiens) | 6480464 | Diazinon results in increased methylation of DEDD2 gene | CTD | PMID:22964155 | dibenz[a,h]anthracene | decreases expression | ISO | Dedd2 (Mus musculus) | 6480464 | 1 more ... | CTD | PMID:26377693 | disulfiram | multiple interactions | ISO | DEDD2 (Homo sapiens) | 6480464 | [Disulfiram binds to Copper] which results in decreased expression of DEDD2 mRNA | CTD | PMID:24690739 | diuron | decreases expression | ISO | DEDD2 (Homo sapiens) | 6480464 | Diuron results in decreased expression of DEDD2 mRNA | CTD | PMID:35967413 | endosulfan | increases expression | EXP | | 6480464 | Endosulfan results in increased expression of DEDD2 mRNA | CTD | PMID:29391264 | ethyl methanesulfonate | increases expression | ISO | DEDD2 (Homo sapiens) | 6480464 | Ethyl Methanesulfonate results in increased expression of DEDD2 mRNA | CTD | PMID:23649840 | fenthion | decreases expression | ISO | Dedd2 (Mus musculus) | 6480464 | Fenthion results in decreased expression of DEDD2 mRNA | CTD | PMID:34813904 | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of DEDD2 mRNA | CTD | PMID:24136188 | folic acid | multiple interactions | ISO | Dedd2 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of DEDD2 mRNA | CTD | PMID:22206623 | formaldehyde | increases expression | ISO | DEDD2 (Homo sapiens) | 6480464 | Formaldehyde results in increased expression of DEDD2 mRNA | CTD | PMID:23649840 | fulvestrant | multiple interactions | ISO | DEDD2 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of DEDD2 gene | CTD | PMID:31601247 | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of DEDD2 mRNA | CTD | PMID:33387578 | lead diacetate | increases expression | ISO | Dedd2 (Mus musculus) | 6480464 | lead acetate results in increased expression of DEDD2 mRNA | CTD | PMID:21829687 | leflunomide | decreases expression | ISO | DEDD2 (Homo sapiens) | 6480464 | leflunomide results in decreased expression of DEDD2 mRNA | CTD | PMID:28988120 | Licochalcone B | increases expression | ISO | DEDD2 (Homo sapiens) | 6480464 | licochalcone B results in increased expression of DEDD2 mRNA | CTD | PMID:33647349 | methidathion | decreases expression | ISO | Dedd2 (Mus musculus) | 6480464 | methidathion results in decreased expression of DEDD2 mRNA | CTD | PMID:34813904 | methyl methanesulfonate | increases expression | ISO | DEDD2 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in increased expression of DEDD2 mRNA | CTD | PMID:23649840 | methylisothiazolinone | increases expression | ISO | DEDD2 (Homo sapiens) | 6480464 | 2-methyl-4-isothiazolin-3-one results in increased expression of DEDD2 mRNA | CTD | PMID:31629900 | motexafin gadolinium | increases expression | ISO | DEDD2 (Homo sapiens) | 6480464 | motexafin gadolinium results in increased expression of DEDD2 mRNA | CTD | PMID:16357179 | motexafin gadolinium | multiple interactions | ISO | DEDD2 (Homo sapiens) | 6480464 | motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of DEDD2 mRNA] | CTD | PMID:16357179 | ozone | multiple interactions | ISO | DEDD2 (Homo sapiens) | 6480464 | [Air Pollutants results in increased abundance of Ozone] which affects the expression of DEDD2 mRNA | CTD | PMID:35430440 | paracetamol | increases expression | ISO | DEDD2 (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of DEDD2 mRNA | CTD | PMID:21420995 | parathion | increases expression | ISO | Dedd2 (Mus musculus) | 6480464 | Parathion results in increased expression of DEDD2 mRNA | CTD | PMID:34813904 | phenobarbital | increases expression | ISO | Dedd2 (Mus musculus) | 6480464 | Phenobarbital results in increased expression of DEDD2 mRNA | CTD | PMID:19270015 | rac-lactic acid | decreases expression | ISO | DEDD2 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of DEDD2 mRNA | CTD | PMID:30851411 | sanguinarine | multiple interactions | ISO | DEDD2 (Homo sapiens) | 6480464 | [sanguinarine co-treated with arsenic trioxide] results in increased expression of DEDD2 mRNA | CTD | PMID:24345465 | silicon dioxide | increases expression | ISO | DEDD2 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in increased expression of DEDD2 mRNA | CTD | PMID:25895662 | silver atom | increases expression | ISO | DEDD2 (Homo sapiens) | 6480464 | Silver results in increased expression of DEDD2 mRNA | CTD | PMID:26014281 and PMID:28959546 | silver atom | increases expression | ISO | Dedd2 (Mus musculus) | 6480464 | Silver results in increased expression of DEDD2 mRNA | CTD | PMID:27131904 | silver(0) | increases expression | ISO | DEDD2 (Homo sapiens) | 6480464 | Silver results in increased expression of DEDD2 mRNA | CTD | PMID:26014281 and PMID:28959546 | silver(0) | increases expression | ISO | Dedd2 (Mus musculus) | 6480464 | Silver results in increased expression of DEDD2 mRNA | CTD | PMID:27131904 | sodium arsenite | increases expression | ISO | Dedd2 (Mus musculus) | 6480464 | sodium arsenite results in increased expression of DEDD2 mRNA | CTD | PMID:16014739 | sulforaphane | multiple interactions | ISO | Dedd2 (Mus musculus) | 6480464 | [NFE2L2 protein affects the susceptibility to sulforaphane] which affects the expression of DEDD2 mRNA | CTD | PMID:30529165 | tetrachloromethane | decreases expression | ISO | Dedd2 (Mus musculus) | 6480464 | Carbon Tetrachloride results in decreased expression of DEDD2 mRNA | CTD | PMID:31919559 | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of DEDD2 mRNA | CTD | PMID:34492290 | titanium dioxide | increases expression | ISO | Dedd2 (Mus musculus) | 6480464 | titanium dioxide results in increased expression of DEDD2 mRNA | CTD | PMID:23409001 | titanium dioxide | decreases expression | ISO | Dedd2 (Mus musculus) | 6480464 | titanium dioxide results in decreased expression of DEDD2 mRNA | CTD | PMID:29264374 | topotecan | decreases expression | EXP | | 6480464 | Topotecan results in decreased expression of DEDD2 mRNA | CTD | PMID:25729387 | Tributyltin oxide | increases expression | ISO | DEDD2 (Homo sapiens) | 6480464 | bis(tri-n-butyltin)oxide results in increased expression of DEDD2 mRNA | CTD | PMID:24247028 | trichostatin A | decreases expression | ISO | DEDD2 (Homo sapiens) | 6480464 | trichostatin A results in decreased expression of DEDD2 mRNA | CTD | PMID:24935251 | tunicamycin | increases expression | ISO | DEDD2 (Homo sapiens) | 6480464 | Tunicamycin results in increased expression of DEDD2 mRNA | CTD | PMID:22378314 | urethane | increases expression | ISO | DEDD2 (Homo sapiens) | 6480464 | Urethane results in increased expression of DEDD2 mRNA | CTD | PMID:28818685 | valproic acid | increases expression | ISO | Dedd2 (Mus musculus) | 6480464 | Valproic Acid results in increased expression of DEDD2 mRNA | CTD | PMID:20546886 and PMID:21427059 | valproic acid | decreases expression | ISO | DEDD2 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of DEDD2 mRNA | CTD | PMID:37505509 | valproic acid | increases methylation | ISO | DEDD2 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of DEDD2 gene | CTD | PMID:29154799 | zinc acetate | increases expression | ISO | DEDD2 (Homo sapiens) | 6480464 | Zinc Acetate results in increased expression of DEDD2 mRNA | CTD | PMID:16357179 | zinc acetate | multiple interactions | ISO | DEDD2 (Homo sapiens) | 6480464 | motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of DEDD2 mRNA] | CTD | PMID:16357179 | zinc atom | multiple interactions | ISO | DEDD2 (Homo sapiens) | 6480464 | [PCI 5002 co-treated with Zinc] results in increased expression of DEDD2 mRNA | CTD | PMID:18593933 | zinc(0) | multiple interactions | ISO | DEDD2 (Homo sapiens) | 6480464 | [PCI 5002 co-treated with Zinc] results in increased expression of DEDD2 mRNA | CTD | PMID:18593933 | |