Magea4 (MAGE family member A4) - Rat Genome Database

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Gene: Magea4 (MAGE family member A4) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Magea4 (Ensembl: Magea10-ps5)
Name: MAGE family member A4 (Ensembl:MAGE family member A10, pseudogene 5)
RGD ID: 1587522
Description: Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to several human genes including MAGEA10 (MAGE family member A10); INTERACTS WITH bisphenol A; copper atom; copper(0).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC689858; melanoma antigen, family A, 4; similar to melanoma antigen family A, 4
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X155,073,718 - 155,080,164 (+)NCBIGRCr8
mRatBN7.2X150,035,874 - 150,038,095 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX150,032,515 - 150,038,086 (+)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 EnsemblX40,373,522 - 40,374,469 (+)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 EnsemblX40,297,704 - 40,298,651 (+)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 EnsemblX42,146,837 - 42,156,546 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX152,228,125 - 152,229,069 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X155,762,332 - 155,763,276 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X153,303,906 - 153,304,850 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X152,192,043 - 152,197,596 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX152,196,129 - 152,197,203 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01147,921,456 - 147,922,530 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X158,378,563 - 158,379,507 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1131,014,196 - 131,015,140 (+)NCBICelera
Cytogenetic MapXq37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IBA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:110
Count of miRNA genes:98
Interacting mature miRNAs:104
Transcripts:ENSRNOT00000049577
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX100567703150256146Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X113937816152453651Rat
634346Insul4Insulin level QTL 40blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)X126975089152453651Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system exocrine system hepatobiliary system nervous system reproductive system
High
Medium 1
Low 18
Below cutoff 1 1 1 1 5

Sequence


RefSeq Acc Id: ENSRNOT00000087679   ⟹   ENSRNOP00000070549
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX40,373,522 - 40,374,469 (+)Ensembl
Rnor_6.0 EnsemblX152,196,129 - 152,197,203 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000111111   ⟹   ENSRNOP00000090679
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX40,297,704 - 40,298,651 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000114992   ⟹   ENSRNOP00000084666
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX150,032,515 - 150,038,086 (+)Ensembl
RefSeq Acc Id: NM_001109550   ⟹   NP_001103020
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X155,078,754 - 155,079,698 (+)NCBI
mRatBN7.2X150,036,709 - 150,037,653 (+)NCBI
Rnor_6.0X152,196,129 - 152,197,203 (+)NCBI
Rnor_5.01147,921,456 - 147,922,530 (+)NCBI
RGSC_v3.4X158,378,563 - 158,379,507 (-)RGD
Celera1131,014,196 - 131,015,140 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039100081   ⟹   XP_038956009
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X155,074,041 - 155,080,164 (+)NCBI
mRatBN7.2X150,035,874 - 150,038,095 (+)NCBI
RefSeq Acc Id: XM_063280309   ⟹   XP_063136379
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X155,074,041 - 155,080,164 (+)NCBI
RefSeq Acc Id: XM_063280310   ⟹   XP_063136380
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X155,073,722 - 155,080,164 (+)NCBI
RefSeq Acc Id: XM_063280311   ⟹   XP_063136381
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X155,073,718 - 155,080,164 (+)NCBI
RefSeq Acc Id: NP_001103020   ⟸   NM_001109550
- UniProtKB: A0A8I6GC30 (UniProtKB/TrEMBL),   A6KSX3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000070549   ⟸   ENSRNOT00000087679
RefSeq Acc Id: XP_038956009   ⟸   XM_039100081
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GC30 (UniProtKB/TrEMBL),   A6KSX3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000084666   ⟸   ENSRNOT00000114992
RefSeq Acc Id: ENSRNOP00000090679   ⟸   ENSRNOT00000111111
RefSeq Acc Id: XP_063136381   ⟸   XM_063280311
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063136380   ⟸   XM_063280310
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063136379   ⟸   XM_063280309
- Peptide Label: isoform X1
Protein Domains
MAGE

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZW04-F1-model_v2 AlphaFold D3ZW04 1-312 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1587522 AgrOrtholog
BioCyc Gene G2FUF-710 BioCyc
Ensembl Genes ENSRNOG00000054784 Ensembl
  ENSRNOG00000062420 Ensembl
  ENSRNOG00000064790 Ensembl
  ENSRNOG00000066349 Ensembl
  ENSRNOG00000068983 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000114992.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.1200 UniProtKB/TrEMBL
  1.10.10.1210 UniProtKB/TrEMBL
InterPro MAGE UniProtKB/TrEMBL
  MAGE UniProtKB/TrEMBL
  MAGE_WH1 UniProtKB/TrEMBL
  MAGE_WH2 UniProtKB/TrEMBL
  Melanoma_ass_antigen_N UniProtKB/TrEMBL
KEGG Report rno:689858 UniProtKB/TrEMBL
NCBI Gene 689858 ENTREZGENE
PANTHER MAGE DOMAIN-CONTAINING PROTEIN-RELATED UniProtKB/TrEMBL
  PTHR11736 UniProtKB/TrEMBL
Pfam MAGE UniProtKB/TrEMBL
  MAGE_N UniProtKB/TrEMBL
PhenoGen Magea4 PhenoGen
PROSITE MAGE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000054784 RatGTEx
  ENSRNOG00000062420 RatGTEx
  ENSRNOG00000064790 RatGTEx
  ENSRNOG00000066349 RatGTEx
  ENSRNOG00000068983 RatGTEx
SMART MAGE UniProtKB/TrEMBL
  MAGE_N UniProtKB/TrEMBL
UniProt A0A8I6GC30 ENTREZGENE, UniProtKB/TrEMBL
  A6KSX3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-09-08 Magea4  MAGE family member A4  Magea4  melanoma antigen, family A, 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Magea4  melanoma antigen, family A, 4  LOC689858  similar to melanoma antigen family A, 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC689858  similar to melanoma antigen family A, 4      Symbol and Name status set to provisional 70820 PROVISIONAL