Defa3 (defensin alpha 3) - Rat Genome Database

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Gene: Defa3 (defensin alpha 3) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Defa3 (Ensembl: Defa11)
Name: defensin alpha 3 (Ensembl:defensin alpha 11)
RGD ID: 1587186
Description: Predicted to enable protein homodimerization activity. Predicted to be involved in several processes, including cellular response to lipopolysaccharide; defense response to other organism; and estrogen receptor signaling pathway. Predicted to act upstream of or within defense response to bacterium and response to xenobiotic stimulus. Predicted to be active in extracellular space. Orthologous to human DEFA5 (defensin alpha 5).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: alpha-defensin 11; Defa11; defensin alpha 11; neutrophil defensin 4
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81677,235,885 - 77,238,041 (-)NCBIGRCr8
mRatBN7.21670,533,436 - 70,535,592 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1670,533,436 - 70,535,604 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1675,810,363 - 75,811,194 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01679,255,833 - 79,256,664 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01674,505,274 - 74,506,105 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01675,517,421 - 75,519,605 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1675,517,505 - 75,518,336 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01675,118,070 - 75,120,254 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41675,324,009 - 75,324,840 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1668,395,242 - 68,396,073 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Defa3
29 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:12
Count of miRNA genes:12
Interacting mature miRNAs:12
Transcripts:ENSRNOT00000058037
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165272646484729064Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165272646484729064Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat
1298527Arunc2Aerobic running capacity QTL 22.9exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)166853271675029966Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
renal system
reproductive system
respiratory system
1 37 37 30 23 30 64 23 10 17 7

Sequence


Ensembl Acc Id: ENSRNOT00000058037   ⟹   ENSRNOP00000054846
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1670,533,436 - 70,535,604 (-)Ensembl
Rnor_6.0 Ensembl1675,517,505 - 75,518,336 (-)Ensembl
RefSeq Acc Id: NM_001033078   ⟹   NP_001028250
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81677,235,885 - 77,238,041 (-)NCBI
mRatBN7.21670,533,436 - 70,535,592 (-)NCBI
Rnor_6.01675,517,505 - 75,518,336 (-)NCBI
Rnor_5.01675,118,070 - 75,120,254 (-)NCBI
RGSC_v3.41675,324,009 - 75,324,840 (-)RGD
Celera1668,395,242 - 68,396,073 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001028250 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAT68754 (Get FASTA)   NCBI Sequence Viewer  
  AAT68762 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000054846.1
RefSeq Acc Id: NP_001028250   ⟸   NM_001033078
- Peptide Label: precursor
- UniProtKB: Q4JEI3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000054846   ⟸   ENSRNOT00000058037
Protein Domains
Mammalian defensins

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4JEI3-F1-model_v2 AlphaFold Q4JEI3 1-104 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1587186 AgrOrtholog
BioCyc Gene G2FUF-10826 BioCyc
Ensembl Genes ENSRNOG00000038133 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000058037.2 UniProtKB/TrEMBL
InterPro Alpha-defensin UniProtKB/TrEMBL
  Defensin_alpha UniProtKB/TrEMBL
  Defensin_mammal UniProtKB/TrEMBL
  Defensin_propep UniProtKB/TrEMBL
KEGG Report rno:613225 UniProtKB/TrEMBL
NCBI Gene 613225 ENTREZGENE
PANTHER DEFENSIN ALPHA 10-RELATED UniProtKB/TrEMBL
  PTHR11876 UniProtKB/TrEMBL
Pfam Defensin_1 UniProtKB/TrEMBL
  Defensin_propep UniProtKB/TrEMBL
PhenoGen Defa3 PhenoGen
PIRSF Alpha-defensin UniProtKB/TrEMBL
PROSITE DEFENSIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000038133 RatGTEx
SMART Defensin_propep UniProtKB/TrEMBL
  DEFSN UniProtKB/TrEMBL
Superfamily-SCOP Defensin-like UniProtKB/TrEMBL
UniProt Q4JEI3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-07-09 Defa3  defensin alpha 3  Defa11  defensin alpha 11  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 Defa11  defensin alpha 11      Symbol and Name status set to provisional 70820 PROVISIONAL