Prss55 (serine protease 55) - Rat Genome Database

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Gene: Prss55 (serine protease 55) Rattus norvegicus
Analyze
Symbol: Prss55
Name: serine protease 55
RGD ID: 1586875
Description: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in binding activity of sperm to zona pellucida and flagellated sperm motility. Predicted to be located in acrosomal vesicle; cytosol; and plasma membrane. Orthologous to human PRSS55 (serine protease 55); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; Cuprizon.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC683415; protease, serine, 55; similar to adrenal mitochondrial protease
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81542,489,022 - 42,507,310 (-)NCBIGRCr8
mRatBN7.21538,297,674 - 38,345,059 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1538,312,982 - 38,323,103 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01547,433,575 - 47,470,809 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1547,433,566 - 47,442,664 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01551,170,257 - 51,201,168 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1537,993,684 - 38,029,468 (-)NCBICelera
Cytogenetic Map15p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOA pipeline RGD automated data pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:18844450   PMID:30032357  


Genomics

Comparative Map Data
Prss55
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81542,489,022 - 42,507,310 (-)NCBIGRCr8
mRatBN7.21538,297,674 - 38,345,059 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1538,312,982 - 38,323,103 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01547,433,575 - 47,470,809 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1547,433,566 - 47,442,664 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01551,170,257 - 51,201,168 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1537,993,684 - 38,029,468 (-)NCBICelera
Cytogenetic Map15p12NCBI
PRSS55
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38810,525,532 - 10,554,166 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl810,525,532 - 10,554,166 (+)EnsemblGRCh38hg38GRCh38
GRCh37810,383,042 - 10,411,676 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36810,420,491 - 10,433,738 (+)NCBINCBI36Build 36hg18NCBI36
Celera89,510,226 - 9,523,469 (+)NCBICelera
Cytogenetic Map8p23.1NCBI
HuRef89,313,584 - 9,342,227 (+)NCBIHuRef
CHM1_1810,448,797 - 10,477,412 (+)NCBICHM1_1
T2T-CHM13v2.089,184,962 - 9,213,620 (-)NCBIT2T-CHM13v2.0
Prss55
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391464,312,884 - 64,338,445 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1464,312,887 - 64,327,611 (-)EnsemblGRCm39 Ensembl
GRCm381464,075,435 - 64,085,449 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1464,075,438 - 64,090,162 (-)EnsemblGRCm38mm10GRCm38
MGSCv371464,694,280 - 64,704,226 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361463,029,553 - 63,039,499 (-)NCBIMGSCv36mm8
Celera1461,852,974 - 61,862,928 (-)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1433.35NCBI
PRSS55
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2726,978,803 - 27,007,361 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan183,011,250 - 3,024,572 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v088,656,519 - 8,685,039 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PRSS55
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12527,419,326 - 27,436,925 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2527,419,326 - 27,436,864 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2528,079,241 - 28,096,851 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02527,577,172 - 27,594,782 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2527,577,172 - 27,595,225 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12527,531,883 - 27,549,492 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02527,427,228 - 27,444,829 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02527,580,452 - 27,598,058 (-)NCBIUU_Cfam_GSD_1.0
Prss55
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049436,096,735 - 6,109,075 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366752,479,210 - 2,489,398 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366752,479,210 - 2,499,440 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRSS55
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1413,335,420 - 13,778,619 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11413,767,574 - 13,777,871 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21415,104,639 - 15,119,408 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PRSS55
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.188,549,461 - 8,579,003 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl88,565,279 - 8,578,680 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605233,845,799 - 33,875,418 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prss55
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475824,432,099 - 24,450,759 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475824,421,629 - 24,450,563 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Prss55
231 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:81
Count of miRNA genes:71
Interacting mature miRNAs:76
Transcripts:ENSRNOT00000072994
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)153405413979054139Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
2293691Bmd37Bone mineral density QTL 376.60.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)153361105871477291Rat
2293686Bmd36Bone mineral density QTL 367.40.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)153361105871477291Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 7
Low 4 1 1 1 62 12 5 1
Below cutoff 1 17 24 14 9 14 3 3 10 21 26 8 3

Sequence


RefSeq Acc Id: ENSRNOT00000072994   ⟹   ENSRNOP00000067083
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1538,312,982 - 38,323,103 (-)Ensembl
Rnor_6.0 Ensembl1547,433,566 - 47,442,664 (-)Ensembl
RefSeq Acc Id: XM_008770800   ⟹   XP_008769022
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81542,489,022 - 42,498,968 (-)NCBI
mRatBN7.21538,311,389 - 38,323,754 (-)NCBI
Rnor_6.01547,433,575 - 47,442,663 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039093918   ⟹   XP_038949846
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81542,489,022 - 42,501,386 (-)NCBI
mRatBN7.21538,311,389 - 38,326,553 (-)NCBI
RefSeq Acc Id: XM_039093920   ⟹   XP_038949848
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81542,489,022 - 42,503,221 (-)NCBI
mRatBN7.21538,311,389 - 38,327,346 (-)NCBI
RefSeq Acc Id: XM_063274876   ⟹   XP_063130946
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81542,489,022 - 42,507,310 (-)NCBI
RefSeq Acc Id: XM_063274877   ⟹   XP_063130947
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81542,489,022 - 42,498,574 (-)NCBI
RefSeq Acc Id: XM_063274878   ⟹   XP_063130948
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81542,489,022 - 42,494,983 (-)NCBI
RefSeq Acc Id: XP_008769022   ⟸   XM_008770800
- Peptide Label: isoform X1
- UniProtKB: M0RBY1 (UniProtKB/TrEMBL),   A6K6H1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000067083   ⟸   ENSRNOT00000072994
RefSeq Acc Id: XP_038949848   ⟸   XM_039093920
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038949846   ⟸   XM_039093918
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063130946   ⟸   XM_063274876
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063130947   ⟸   XM_063274877
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063130948   ⟸   XM_063274878
- Peptide Label: isoform X3
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0RBY1-F1-model_v2 AlphaFold M0RBY1 1-321 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699785
Promoter ID:EPDNEW_R10306
Type:multiple initiation site
Name:Prss55_1
Description:protease, serine, 55
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01547,442,598 - 47,442,658EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1586875 AgrOrtholog
BioCyc Gene G2FUF-13389 BioCyc
Ensembl Genes ENSRNOG00000047258 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000072994.3 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
InterPro Peptidase_S1 UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/TrEMBL
  Trypsin-like_Pept_dom UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
KEGG Report rno:683415 UniProtKB/TrEMBL
NCBI Gene 683415 ENTREZGENE
PANTHER SERINE PROTEASE 55 UniProtKB/TrEMBL
  TRANSMEMBRANE PROTEASE SERINE UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/TrEMBL
PhenoGen Prss55 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
RatGTEx ENSRNOG00000047258 RatGTEx
SMART Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP Pept_Ser_Cys UniProtKB/TrEMBL
UniProt A6K6H1 ENTREZGENE, UniProtKB/TrEMBL
  M0RBY1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-01-26 Prss55  serine protease 55  Prss55  protease, serine, 55  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-13 Prss55  protease, serine, 55  LOC683415  similar to adrenal mitochondrial protease  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC683415  similar to adrenal mitochondrial protease      Symbol and Name status set to provisional 70820 PROVISIONAL