Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | multiple interactions | EXP | | 6480464 | [APC protein affects the susceptibility to 1 and 2-Dimethylhydrazine] which results in increased expression of ARHGEF4 mRNA | CTD | PMID:27840820 | 17beta-estradiol | multiple interactions | ISO | ARHGEF4 (Homo sapiens) | 6480464 | [Estradiol co-treated with TGFB1 protein] results in decreased expression of ARHGEF4 mRNA | CTD | PMID:30165855 | 2,2',5,5'-tetrachlorobiphenyl | affects expression | EXP | | 6480464 | 2 more ... | CTD | PMID:23829299 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Arhgef4 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of ARHGEF4 mRNA | CTD | PMID:21570461 | 2,3,7,8-Tetrachlorodibenzofuran | decreases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:32109520 | 4,4'-sulfonyldiphenol | increases methylation | ISO | Arhgef4 (Mus musculus) | 6480464 | bisphenol S results in increased methylation of ARHGEF4 exon | CTD | PMID:33297965 | 4,4'-sulfonyldiphenol | affects methylation | ISO | Arhgef4 (Mus musculus) | 6480464 | bisphenol S affects the methylation of ARHGEF4 gene | CTD | PMID:31683443 | 4-hydroxyphenyl retinamide | decreases expression | ISO | Arhgef4 (Mus musculus) | 6480464 | Fenretinide results in decreased expression of ARHGEF4 mRNA | CTD | PMID:28973697 | 8-Br-cAMP | increases expression | ISO | ARHGEF4 (Homo sapiens) | 6480464 | 8-Bromo Cyclic Adenosine Monophosphate results in increased expression of ARHGEF4 mRNA | CTD | PMID:22079614 | acrylamide | decreases expression | ISO | ARHGEF4 (Homo sapiens) | 6480464 | Acrylamide results in decreased expression of ARHGEF4 mRNA | CTD | PMID:32763439 | aflatoxin B1 | decreases methylation | ISO | ARHGEF4 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of ARHGEF4 gene | CTD | PMID:27153756 | aflatoxin B1 | decreases expression | ISO | ARHGEF4 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased expression of ARHGEF4 mRNA | CTD | PMID:32234424 | Aflatoxin B2 alpha | increases methylation | ISO | ARHGEF4 (Homo sapiens) | 6480464 | aflatoxin B2 results in increased methylation of ARHGEF4 intron | CTD | PMID:30157460 | all-trans-retinoic acid | decreases expression | ISO | ARHGEF4 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of ARHGEF4 mRNA | CTD | PMID:21934132 | all-trans-retinoic acid | multiple interactions | ISO | Arhgef4 (Mus musculus) | 6480464 | [mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in decreased expression of ARHGEF4 mRNA | CTD | PMID:36189433 | amosite asbestos | decreases methylation | ISO | ARHGEF4 (Homo sapiens) | 6480464 | Asbestos and Amosite results in decreased methylation of ARHGEF4 promoter | CTD | PMID:29626692 | antirheumatic drug | increases expression | ISO | ARHGEF4 (Homo sapiens) | 6480464 | Antirheumatic Agents results in increased expression of ARHGEF4 mRNA | CTD | PMID:24449571 | aristolochic acid A | decreases expression | ISO | ARHGEF4 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of ARHGEF4 mRNA | CTD | PMID:33212167 | belinostat | decreases expression | ISO | ARHGEF4 (Homo sapiens) | 6480464 | belinostat results in decreased expression of ARHGEF4 mRNA | CTD | PMID:27188386 | benzo[a]pyrene | increases methylation | ISO | ARHGEF4 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of ARHGEF4 5' UTR and Benzo(a)pyrene results in increased methylation of ARHGEF4 promoter | CTD | PMID:27901495 | benzo[a]pyrene | affects methylation | ISO | ARHGEF4 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of ARHGEF4 intron | CTD | PMID:30157460 | benzo[e]pyrene | increases methylation | ISO | ARHGEF4 (Homo sapiens) | 6480464 | benzo(e)pyrene results in increased methylation of ARHGEF4 intron | CTD | PMID:30157460 | bis(2-ethylhexyl) phthalate | decreases expression | ISO | ARHGEF4 (Homo sapiens) | 6480464 | Diethylhexyl Phthalate results in decreased expression of ARHGEF4 mRNA | CTD | PMID:31163220 | bisphenol A | decreases expression | ISO | ARHGEF4 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of ARHGEF4 mRNA | CTD | PMID:25047013 | bisphenol A | multiple interactions | ISO | ARHGEF4 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of ARHGEF4 gene | CTD | PMID:31601247 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of ARHGEF4 mRNA | CTD | PMID:30816183 | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of ARHGEF4 mRNA | CTD | PMID:25181051 | butanal | increases expression | ISO | ARHGEF4 (Homo sapiens) | 6480464 | butyraldehyde results in increased expression of ARHGEF4 mRNA | CTD | PMID:26079696 | C60 fullerene | decreases expression | EXP | | 6480464 | fullerene C60 results in decreased expression of ARHGEF4 mRNA | CTD | PMID:19167457 | carbon nanotube | decreases expression | ISO | Arhgef4 (Mus musculus) | 6480464 | Nanotubes and Carbon results in decreased expression of ARHGEF4 mRNA | CTD | PMID:25554681 | CGP 52608 | multiple interactions | ISO | ARHGEF4 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to ARHGEF4 gene] | CTD | PMID:28238834 | clobetasol | decreases expression | ISO | Arhgef4 (Mus musculus) | 6480464 | Clobetasol results in decreased expression of ARHGEF4 mRNA | CTD | PMID:27462272 | crocidolite asbestos | decreases methylation | ISO | ARHGEF4 (Homo sapiens) | 6480464 | Asbestos and Crocidolite results in decreased methylation of ARHGEF4 promoter | CTD | PMID:29626692 | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of ARHGEF4 mRNA | CTD | PMID:21266533 | dibutyl phthalate | decreases expression | ISO | Arhgef4 (Mus musculus) | 6480464 | Dibutyl Phthalate results in decreased expression of ARHGEF4 mRNA | CTD | PMID:17361019 and PMID:21266533 | dioxygen | increases expression | ISO | ARHGEF4 (Homo sapiens) | 6480464 | Oxygen deficiency results in increased expression of ARHGEF4 mRNA | CTD | PMID:17175027 | dorsomorphin | multiple interactions | ISO | ARHGEF4 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | doxorubicin | increases expression | ISO | Arhgef4 (Mus musculus) | 6480464 | Doxorubicin results in increased expression of ARHGEF4 mRNA | CTD | PMID:36227756 | folic acid | increases expression | ISO | Arhgef4 (Mus musculus) | 6480464 | Folic Acid results in increased expression of ARHGEF4 mRNA | CTD | PMID:25629700 | fulvestrant | multiple interactions | ISO | ARHGEF4 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of ARHGEF4 gene | CTD | PMID:31601247 | glyphosate | affects methylation | EXP | | 6480464 | Glyphosate affects the methylation of ARHGEF4 gene | CTD | PMID:35440735 | lead(0) | affects expression | ISO | ARHGEF4 (Homo sapiens) | 6480464 | Lead affects the expression of ARHGEF4 mRNA | CTD | PMID:28903495 | lead(0) | affects methylation | ISO | ARHGEF4 (Homo sapiens) | 6480464 | Lead affects the methylation of ARHGEF4 gene | CTD | PMID:31636367 | manganese atom | increases expression | ISO | ARHGEF4 (Homo sapiens) | 6480464 | Manganese results in increased expression of ARHGEF4 mRNA | CTD | PMID:17175027 | manganese(0) | increases expression | ISO | ARHGEF4 (Homo sapiens) | 6480464 | Manganese results in increased expression of ARHGEF4 mRNA | CTD | PMID:17175027 | manganese(II) chloride | increases expression | ISO | ARHGEF4 (Homo sapiens) | 6480464 | manganese chloride results in increased expression of ARHGEF4 mRNA | CTD | PMID:17175027 | manganese(II) chloride | increases methylation | EXP | | 6480464 | manganese chloride results in increased methylation of ARHGEF4 gene | CTD | PMID:28801915 | methapyrilene | increases methylation | ISO | ARHGEF4 (Homo sapiens) | 6480464 | Methapyrilene results in increased methylation of ARHGEF4 intron | CTD | PMID:30157460 | methylmercury chloride | decreases expression | ISO | ARHGEF4 (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of ARHGEF4 mRNA | CTD | PMID:28001369 | mono(2-ethylhexyl) phthalate | multiple interactions | ISO | Arhgef4 (Mus musculus) | 6480464 | [mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in decreased expression of ARHGEF4 mRNA | CTD | PMID:36189433 | N-methyl-4-phenylpyridinium | increases methylation | EXP | | 6480464 | 1-Methyl-4-phenylpyridinium results in increased methylation of ARHGEF4 gene | CTD | PMID:28801915 | N-methyl-4-phenylpyridinium | decreases expression | EXP | | 6480464 | 1-Methyl-4-phenylpyridinium results in decreased expression of ARHGEF4 mRNA | CTD | PMID:28801915 | paracetamol | decreases expression | ISO | ARHGEF4 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of ARHGEF4 mRNA | CTD | PMID:26690555 | paracetamol | increases expression | ISO | ARHGEF4 (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of ARHGEF4 mRNA | CTD | PMID:29067470 | PCB138 | decreases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:23829299 | pentanal | increases expression | ISO | ARHGEF4 (Homo sapiens) | 6480464 | pentanal results in increased expression of ARHGEF4 mRNA | CTD | PMID:26079696 | phenylmercury acetate | decreases expression | ISO | ARHGEF4 (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in decreased expression of ARHGEF4 mRNA | CTD | PMID:26272509 | phenylmercury acetate | multiple interactions | ISO | ARHGEF4 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ARHGEF4 mRNA | CTD | PMID:27188386 | propanal | increases expression | ISO | ARHGEF4 (Homo sapiens) | 6480464 | propionaldehyde results in increased expression of ARHGEF4 mRNA | CTD | PMID:26079696 | SB 431542 | multiple interactions | ISO | ARHGEF4 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | serpentine asbestos | decreases methylation | ISO | ARHGEF4 (Homo sapiens) | 6480464 | Asbestos and Serpentine results in decreased methylation of ARHGEF4 promoter | CTD | PMID:29626692 | silicon dioxide | increases expression | ISO | ARHGEF4 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in increased expression of ARHGEF4 mRNA | CTD | PMID:25895662 | sodium arsenite | increases expression | ISO | ARHGEF4 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of ARHGEF4 mRNA | CTD | PMID:29301061 and PMID:34032870 | Soman | decreases expression | EXP | | 6480464 | Soman results in decreased expression of ARHGEF4 mRNA | CTD | PMID:19281266 | sunitinib | decreases expression | ISO | ARHGEF4 (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of ARHGEF4 mRNA | CTD | PMID:31533062 | temozolomide | increases expression | ISO | ARHGEF4 (Homo sapiens) | 6480464 | Temozolomide results in increased expression of ARHGEF4 mRNA | CTD | PMID:31758290 | testosterone | increases expression | ISO | Arhgef4 (Mus musculus) | 6480464 | Testosterone deficiency results in increased expression of ARHGEF4 mRNA | CTD | PMID:33848595 | testosterone | decreases expression | ISO | ARHGEF4 (Homo sapiens) | 6480464 | Testosterone results in decreased expression of ARHGEF4 mRNA | CTD | PMID:33359661 | thimerosal | decreases expression | ISO | ARHGEF4 (Homo sapiens) | 6480464 | Thimerosal results in decreased expression of ARHGEF4 mRNA | CTD | PMID:27188386 | titanium dioxide | decreases expression | ISO | Arhgef4 (Mus musculus) | 6480464 | titanium dioxide results in decreased expression of ARHGEF4 mRNA | CTD | PMID:29264374 | trichloroethene | decreases expression | EXP | | 6480464 | Trichloroethylene results in decreased expression of ARHGEF4 mRNA | CTD | PMID:33387578 | trichostatin A | decreases expression | ISO | ARHGEF4 (Homo sapiens) | 6480464 | trichostatin A results in decreased expression of ARHGEF4 mRNA | CTD | PMID:24935251 and PMID:26272509 | trichostatin A | multiple interactions | ISO | ARHGEF4 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ARHGEF4 mRNA | CTD | PMID:27188386 | triptonide | affects expression | ISO | Arhgef4 (Mus musculus) | 6480464 | triptonide affects the expression of ARHGEF4 mRNA | CTD | PMID:33045310 | valproic acid | decreases methylation | ISO | ARHGEF4 (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of ARHGEF4 gene | CTD | PMID:29154799 | valproic acid | affects expression | ISO | Arhgef4 (Mus musculus) | 6480464 | Valproic Acid affects the expression of ARHGEF4 mRNA | CTD | PMID:17963808 | valproic acid | affects expression | ISO | ARHGEF4 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of ARHGEF4 mRNA | CTD | PMID:25979313 | valproic acid | decreases expression | ISO | ARHGEF4 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of ARHGEF4 mRNA | CTD | PMID:23179753 more ... | valproic acid | multiple interactions | ISO | ARHGEF4 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ARHGEF4 mRNA | CTD | PMID:27188386 | vorinostat | decreases expression | ISO | ARHGEF4 (Homo sapiens) | 6480464 | vorinostat results in decreased expression of ARHGEF4 mRNA | CTD | PMID:26272509 and PMID:27188386 | vorinostat | multiple interactions | ISO | ARHGEF4 (Homo sapiens) | 6480464 | [NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ARHGEF4 mRNA | CTD | PMID:27188386 | zoledronic acid | decreases expression | ISO | ARHGEF4 (Homo sapiens) | 6480464 | zoledronic acid results in decreased expression of ARHGEF4 mRNA | CTD | PMID:24714768 | |