Pwwp4 (PWWP domain containing 4) - Rat Genome Database

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Gene: Pwwp4 (PWWP domain containing 4) Rattus norvegicus
Analyze
Symbol: Pwwp4
Name: PWWP domain containing 4
RGD ID: 1585131
Description: ASSOCIATED WITH autistic disorder (ortholog); syndromic X-linked intellectual disability Lubs type (ortholog); INTERACTS WITH perfluorohexanesulfonic acid (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC100911148; LOC690082; PWWP domain-containing DNA repair factor 3B-like; PWWP domain-containing DNA repair factor 4; PWWP domain-containing protein MUM1-like; PWWP domain-containing protein MUM1L1-like; similar to melanoma ubiquitous mutated protein
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X156,159,344 - 156,165,457 (+)NCBIGRCr8
mRatBN7.2X151,008,141 - 151,014,223 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX151,008,123 - 151,014,216 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01146,966,354 - 146,974,136 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1146,966,527 - 146,968,689 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1147,080,783 - 147,082,945 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01153,261,509 - 153,267,599 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X159,184,315 - 159,186,653 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Cytogenetic MapXq37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
Pwwp4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X156,159,344 - 156,165,457 (+)NCBIGRCr8
mRatBN7.2X151,008,141 - 151,014,223 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX151,008,123 - 151,014,216 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01146,966,354 - 146,974,136 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1146,966,527 - 146,968,689 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1147,080,783 - 147,082,945 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01153,261,509 - 153,267,599 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X159,184,315 - 159,186,653 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Cytogenetic MapXq37NCBI
PWWP4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X153,266,147 - 153,279,145 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX153,266,152 - 153,279,145 (+)EnsemblGRCh38hg38GRCh38
GRCh37X152,531,608 - 152,544,602 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic MapXq28NCBI
HuRefX141,196,714 - 141,202,964 (+)NCBIHuRef
CHM1_1X152,411,523 - 152,417,677 (+)NCBICHM1_1
T2T-CHM13v2.0X151,533,668 - 151,546,674 (+)NCBIT2T-CHM13v2.0
Pwwp4a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X72,160,636 - 72,172,875 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX72,160,653 - 72,172,868 (+)EnsemblGRCm39 Ensembl
GRCm38X73,117,030 - 73,129,269 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX73,117,047 - 73,129,262 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X70,368,407 - 70,374,599 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X69,375,836 - 69,381,980 (+)NCBIMGSCv36mm8
Cytogenetic MapXA7.3NCBI
cM MapX37.29NCBI
LOC102152370
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X121,011,810 - 121,031,354 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX106,385,444 - 106,395,708 (-)NCBIDog10K_Boxer_Tasha
LOC110257816
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1X124,024,771 - 124,027,078 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1

Variants

.
Variants in Pwwp4
2 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:131
Count of miRNA genes:76
Interacting mature miRNAs:79
Transcripts:ENSRNOT00000023181, ENSRNOT00000065898
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X113937816152453651Rat
634346Insul4Insulin level QTL 40blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)X126975089152453651Rat

Markers in Region
RH132089  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X151,013,938 - 151,014,128 (-)MAPPERmRatBN7.2
mRatBN7.2X151,013,938 - 151,014,128 (+)MAPPERmRatBN7.2
Rnor_6.01147,082,834 - 147,083,023NCBIRnor6.0
Rnor_6.01146,966,449 - 146,966,638NCBIRnor6.0
Rnor_5.01153,377,653 - 153,377,842UniSTSRnor5.0
Rnor_5.01153,261,604 - 153,261,793UniSTSRnor5.0
RGSC_v3.4X159,186,369 - 159,186,558UniSTSRGSC3.4
Cytogenetic MapXq37UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000023181   ⟹   ENSRNOP00000023222
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1146,966,527 - 146,968,689 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000065898   ⟹   ENSRNOP00000060281
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1147,080,783 - 147,082,945 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000109322   ⟹   ENSRNOP00000083316
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX151,008,123 - 151,014,216 (+)Ensembl
RefSeq Acc Id: NM_001408900   ⟹   NP_001395829
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X156,159,375 - 156,165,457 (+)NCBI
mRatBN7.2X151,008,141 - 151,014,223 (+)NCBI
RefSeq Acc Id: XM_017590172   ⟹   XP_017445661
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X156,159,344 - 156,165,454 (+)NCBI
mRatBN7.2X151,008,202 - 151,014,223 (+)NCBI
Rnor_6.01146,966,354 - 146,972,444 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001395829 (Get FASTA)   NCBI Sequence Viewer  
  XP_017445661 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000083316
  ENSRNOP00000083316.1
Reference Protein Sequences
RefSeq Acc Id: XP_017445661   ⟸   XM_017590172
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZV76 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000023222   ⟸   ENSRNOT00000023181
RefSeq Acc Id: ENSRNOP00000060281   ⟸   ENSRNOT00000065898
RefSeq Acc Id: ENSRNOP00000083316   ⟸   ENSRNOT00000109322
RefSeq Acc Id: NP_001395829   ⟸   NM_001408900
- UniProtKB: A0A8I5ZV76 (UniProtKB/TrEMBL)
Protein Domains
MUM1-like PWWP   PWWP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A410-F1-model_v2 AlphaFold D4A410 1-692 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1585131 AgrOrtholog
BioCyc Gene G2FUF-683 BioCyc
Ensembl Genes ENSRNOG00000046157 Ensembl
  ENSRNOG00000047724 Ensembl
  ENSRNOG00000068777 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000109322.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.30.140 UniProtKB/TrEMBL
  6.10.300.20 UniProtKB/TrEMBL
InterPro MUM1-like_PWWP UniProtKB/TrEMBL
  PWP3A/B UniProtKB/TrEMBL
  PWP3A_3B_4_C UniProtKB/TrEMBL
  PWP3A_3B_4_N UniProtKB/TrEMBL
NCBI Gene 690082 ENTREZGENE
PANTHER PTHR31333 UniProtKB/TrEMBL
  PWWP DOMAIN-CONTAINING 4 UniProtKB/TrEMBL
Pfam MUM1-like_PWWP UniProtKB/TrEMBL
  PWP3A-B_C UniProtKB/TrEMBL
  PWP3A-B_N UniProtKB/TrEMBL
PhenoGen Pwwp4 PhenoGen
RatGTEx ENSRNOG00000046157 RatGTEx
  ENSRNOG00000047724 RatGTEx
  ENSRNOG00000068777 RatGTEx
Superfamily-SCOP beta-sandwich domain of Sec23/24 UniProtKB/TrEMBL
  Tudor/PWWP/MBT UniProtKB/TrEMBL
UniProt A0A8I5ZV76 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-18 Pwwp4  PWWP domain containing 4  LOC690082  similar to melanoma ubiquitous mutated protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2021-03-09 LOC690082  similar to melanoma ubiquitous mutated protein  LOC100911148  PWWP domain-containing protein MUM1-like  Data merged from RGD:6494662 737654 PROVISIONAL
2013-05-24 LOC690082  similar to melanoma ubiquitous mutated protein  LOC684135  similar to melanoma ubiquitous mutated protein  Data merged from RGD:1593918 1643240 APPROVED
2012-07-05 LOC100911148  PWWP domain-containing protein MUM1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC684135  similar to melanoma ubiquitous mutated protein      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC690082  similar to melanoma ubiquitous mutated protein      Symbol and Name status set to provisional 70820 PROVISIONAL