Mansc4 (MANSC domain containing 4) - Rat Genome Database

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Gene: Mansc4 (MANSC domain containing 4) Rattus norvegicus
Analyze
Symbol: Mansc4
Name: MANSC domain containing 4
RGD ID: 1585055
Description: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in epidermis development; epithelium development; and extracellular matrix organization. Predicted to be active in plasma membrane. Orthologous to human MANSC4 (MANSC domain containing 4); INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; cadmium dichloride.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: hypothetical protein LOC691362; LOC691362; MANSC domain-containing protein 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84181,722,478 - 181,731,410 (-)NCBIGRCr8
mRatBN7.24179,991,845 - 180,000,716 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4179,991,860 - 180,001,038 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.04181,468,411 - 181,478,237 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4181,468,511 - 181,477,281 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04245,618,289 - 245,627,623 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44184,676,275 - 184,685,060 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera4168,485,351 - 168,495,182 (-)NCBICelera
Cytogenetic Map4q44NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Mansc4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84181,722,478 - 181,731,410 (-)NCBIGRCr8
mRatBN7.24179,991,845 - 180,000,716 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4179,991,860 - 180,001,038 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.04181,468,411 - 181,478,237 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4181,468,511 - 181,477,281 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04245,618,289 - 245,627,623 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44184,676,275 - 184,685,060 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera4168,485,351 - 168,495,182 (-)NCBICelera
Cytogenetic Map4q44NCBI
MANSC4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381227,762,427 - 27,780,236 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1227,762,427 - 27,780,236 (-)EnsemblGRCh38hg38GRCh38
GRCh371227,915,360 - 27,933,169 (-)NCBIGRCh37GRCh37hg19GRCh37
Celera1233,061,159 - 33,069,766 (-)NCBICelera
Cytogenetic Map12p11.22NCBI
HuRef1227,684,671 - 27,693,281 (-)NCBIHuRef
CHM1_11227,880,608 - 27,889,215 (-)NCBICHM1_1
T2T-CHM13v2.01227,634,144 - 27,651,950 (-)NCBIT2T-CHM13v2.0
Mansc4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396146,976,560 - 146,988,530 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6146,976,558 - 146,988,530 (-)EnsemblGRCm39 Ensembl
GRCm386147,075,062 - 147,087,032 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6147,075,060 - 147,087,032 (-)EnsemblGRCm38mm10GRCm38
MGSCv376147,023,584 - 147,035,554 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366147,032,232 - 147,044,202 (-)NCBIMGSCv36mm8
Celera6150,111,005 - 150,120,780 (-)NCBICelera
Cytogenetic Map6G3NCBI
cM Map677.7NCBI
Mansc4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555057,111,825 - 7,118,612 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555057,077,810 - 7,119,434 (+)NCBIChiLan1.0ChiLan1.0
MANSC4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21069,040,904 - 69,052,717 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11269,038,691 - 69,049,114 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01258,531,753 - 58,549,560 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11261,158,489 - 61,167,621 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1261,158,615 - 61,167,381 (+)Ensemblpanpan1.1panPan2
MANSC4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12719,964,473 - 19,977,146 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2719,970,128 - 19,976,380 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2726,423,143 - 26,432,066 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02720,161,680 - 20,170,680 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2720,163,729 - 20,169,919 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12719,968,072 - 19,977,398 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02719,995,082 - 20,004,089 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02726,580,473 - 26,589,411 (-)NCBIUU_Cfam_GSD_1.0
Mansc4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494581,935,426 - 81,936,621 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049423491,334 - 2,772 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MANSC4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl545,955,090 - 45,970,274 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1545,962,175 - 45,970,957 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2549,530,285 - 49,553,859 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MANSC4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11127,484,157 - 27,494,512 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660697,559,762 - 7,568,551 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mansc4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624935268,411 - 275,779 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mansc4
46 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:19
Count of miRNA genes:16
Interacting mature miRNAs:19
Transcripts:ENSRNOT00000055463
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4155561574182687754Rat
1300109Rf13Renal function QTL 133.91renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)4157710145182687754Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 18 14 2 13 2 7 8 19 17 16 8 7
Below cutoff 3 15 23 19 6 19 1 3 33 18 19 3 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000055463   ⟹   ENSRNOP00000052329
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4179,991,860 - 180,001,038 (-)Ensembl
Rnor_6.0 Ensembl4181,468,511 - 181,477,281 (-)Ensembl
RefSeq Acc Id: XM_001077890   ⟹   XP_001077890
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84181,722,478 - 181,731,410 (-)NCBI
mRatBN7.24179,991,845 - 180,000,716 (-)NCBI
Rnor_6.04181,468,411 - 181,478,237 (-)NCBI
Rnor_5.04245,618,289 - 245,627,623 (-)NCBI
RGSC_v3.44184,676,275 - 184,685,060 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs XP_001077890 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000052329
  ENSRNOP00000052329.1
Reference Protein Sequences
RefSeq Acc Id: XP_001077890   ⟸   XM_001077890
- UniProtKB: D4ADQ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000052329   ⟸   ENSRNOT00000055463
Protein Domains
MANSC

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4ADQ5-F1-model_v2 AlphaFold D4ADQ5 1-339 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693519
Promoter ID:EPDNEW_R4035
Type:multiple initiation site
Name:Mansc4_1
Description:MANSC domain containing 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04181,477,268 - 181,477,328EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1585055 AgrOrtholog
BioCyc Gene G2FUF-42418 BioCyc
Ensembl Genes ENSRNOG00000036925 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000055463.2 UniProtKB/TrEMBL
InterPro MANSC UniProtKB/TrEMBL
  MANSC_N UniProtKB/TrEMBL
KEGG Report rno:691362 UniProtKB/TrEMBL
NCBI Gene 691362 ENTREZGENE
PANTHER KUNITZ-TYPE PROTEASE INHIBITOR 1 UniProtKB/TrEMBL
  MANSC DOMAIN-CONTAINING PROTEIN 4 UniProtKB/TrEMBL
Pfam MANEC UniProtKB/TrEMBL
PhenoGen Mansc4 PhenoGen
PROSITE MANSC UniProtKB/TrEMBL
RatGTEx ENSRNOG00000036925 RatGTEx
SMART MANEC UniProtKB/TrEMBL
UniProt D4ADQ5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-06-10 Mansc4  MANSC domain containing 4  LOC691362  hypothetical protein LOC691362  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC691362  hypothetical protein LOC691362  LOC686705  hypothetical protein LOC686705  Data merged from RGD:1593754 1643240 APPROVED
2006-11-20 LOC686705  hypothetical protein LOC686705      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC691362  hypothetical protein LOC691362      Symbol and Name status set to provisional 70820 PROVISIONAL