Bmyc (brain expressed myelocytomatosis oncogene) - Rat Genome Database

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Pathways
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Gene: Bmyc (brain expressed myelocytomatosis oncogene) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Bmyc
Name: brain expressed myelocytomatosis oncogene
RGD ID: 1584970
Description: Predicted to enable DNA-binding transcription factor activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus and spindle. Human ortholog(s) of this gene implicated in several diseases, including angiosarcoma; demyelinating disease; hematologic cancer (multiple); lung adenocarcinoma; and prostate cancer (multiple). Orthologous to human MYC (MYC proto-oncogene, bHLH transcription factor).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: avian myelocytomatosis viral (v-myc) related oncogene; B-myc; Bmyc protein (AA 1-178); Bmyc_mapped; brain expressed myelocytomatosis oncogene (mapped); Mycb; transforming protein B-Myc
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8328,910,689 - 28,911,448 (+)NCBIGRCr8
mRatBN7.238,512,569 - 8,513,328 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl38,512,325 - 8,513,623 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx311,618,220 - 11,618,979 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0320,204,454 - 20,205,213 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0318,394,296 - 18,395,055 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.032,916,662 - 2,917,421 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,916,662 - 2,917,421 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.032,898,075 - 2,898,834 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.433,864,740 - 3,865,499 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera33,337,166 - 3,337,926 (+)NCBICelera
Cytogenetic Map3p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IEA)
spindle  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Structure and expression of B-myc, a new member of the myc gene family. Ingvarsson S, etal., Mol Cell Biol 1988 Aug;8(8):3168-74.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:2687773   PMID:7478514   PMID:8423780  


Genomics

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:77
Count of miRNA genes:62
Interacting mature miRNAs:65
Transcripts:ENSRNOT00000064358
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat

Markers in Region
RH129186  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.238,513,312 - 8,513,493 (+)MAPPERmRatBN7.2
Rnor_6.032,917,406 - 2,917,586NCBIRnor6.0
Rnor_5.032,898,819 - 2,898,999UniSTSRnor5.0
RGSC_v3.433,865,484 - 3,865,664UniSTSRGSC3.4
Celera33,337,911 - 3,338,091UniSTS
Cytogenetic Map3p13UniSTS
AW060705  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.238,513,034 - 8,513,133 (+)MAPPERmRatBN7.2
Rnor_6.032,917,128 - 2,917,226NCBIRnor6.0
Rnor_5.032,898,541 - 2,898,639UniSTSRnor5.0
RGSC_v3.433,865,206 - 3,865,304UniSTSRGSC3.4
Celera33,337,633 - 3,337,731UniSTS
Cytogenetic Map3p13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 32 13 13 3 13 3 74 25 35 2
Low 11 44 28 16 28 8 8 10 6 9 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000064358   ⟹   ENSRNOP00000059721
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl38,512,325 - 8,513,623 (+)Ensembl
Rnor_6.0 Ensembl32,916,662 - 2,917,421 (+)Ensembl
RefSeq Acc Id: NM_001013163   ⟹   NP_001013181
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,910,689 - 28,911,448 (+)NCBI
mRatBN7.238,512,569 - 8,513,328 (+)NCBI
Rnor_6.032,916,662 - 2,917,421 (+)NCBI
Rnor_5.032,898,075 - 2,898,834 (+)NCBI
RGSC_v3.433,864,740 - 3,865,499 (+)RGD
Celera33,337,166 - 3,337,926 (+)RGD
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001013181   ⟸   NM_001013163
- UniProtKB: Q3HVJ5 (UniProtKB/Swiss-Prot),   P15063 (UniProtKB/Swiss-Prot),   A6JTA3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000059721   ⟸   ENSRNOT00000064358
Protein Domains
Transcription regulator Myc N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P15063-F1-model_v2 AlphaFold P15063 1-168 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1584970 AgrOrtholog
BioCyc Gene G2FUF-50425 BioCyc
Ensembl Genes ENSRNOG00000042556 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055000549 UniProtKB/Swiss-Prot
  ENSRNOG00060033122 UniProtKB/Swiss-Prot
  ENSRNOG00065028460 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000064358 ENTREZGENE
  ENSRNOT00000064358.2 UniProtKB/Swiss-Prot
  ENSRNOT00055000950 UniProtKB/Swiss-Prot
  ENSRNOT00060057443 UniProtKB/Swiss-Prot
  ENSRNOT00065049026 UniProtKB/Swiss-Prot
InterPro Tscrpt_reg_Myc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tscrpt_reg_Myc_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:311807 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 311807 ENTREZGENE
PANTHER MYC PROTO-ONCOGENE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MYC PROTO-ONCOGENE PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Myc_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Bmyc PhenoGen
PRINTS LEUZIPPRMYC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000042556 RatGTEx
  ENSRNOG00055000549 RatGTEx
  ENSRNOG00060033122 RatGTEx
  ENSRNOG00065028460 RatGTEx
UniProt A6JTA3 ENTREZGENE, UniProtKB/TrEMBL
  MYCB_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q3HVJ5 ENTREZGENE
UniProt Secondary Q3HVJ5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2007-04-13   brain expressed myelocytomatosis oncogene  Bmyc  brain expressed myelocytomatosis oncogene (mapped)  Name updated 737654 APPROVED
2007-04-10 Bmyc  brain expressed myelocytomatosis oncogene (mapped)  Bmyc_mapped  brain expressed myelocytomatosis oncogene (mapped)  Data merged from RGD:2215 737654 APPROVED
2006-11-19 Bmyc  brain expressed myelocytomatosis oncogene (mapped)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Bmyc_mapped  brain expressed myelocytomatosis oncogene (mapped)  Bmyc  brain expressed myelocytomatosis oncogene  Symbol and Name updated 1556543 APPROVED
2004-09-10 Bmyc  brain expressed myelocytomatosis oncogene    avian myelocytomatosis viral (v-myc) related oncogene  Name updated 1299863 APPROVED
2002-06-10 Bmyc  Avian myelocytomatosis viral (v-myc) related oncogene (Bmyc)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expressed in several organs and tissues, with highest expression in the brain 1300398