Ndufs6 (NADH:ubiquinone oxidoreductase subunit S6) - Rat Genome Database

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Gene: Ndufs6 (NADH:ubiquinone oxidoreductase subunit S6) Rattus norvegicus
Analyze
Symbol: Ndufs6 (Ensembl: Ndufs6l1)
Name: NADH:ubiquinone oxidoreductase subunit S6 (Ensembl:NADH:ubiquinone oxidoreductase subunit S6-like 1)
RGD ID: 1584802
Description: Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone. Predicted to act upstream of or within several processes, including fatty acid metabolic process; mitochondrial respiratory chain complex I assembly; and respiratory electron transport chain. Predicted to be located in mitochondrial inner membrane. Predicted to be part of mitochondrial respiratory chain complex I. Human ortholog(s) of this gene implicated in cervical cancer and nuclear type mitochondrial complex I deficiency 9. Orthologous to human NDUFS6 (NADH:ubiquinone oxidoreductase subunit S6); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC679739; LOC100912599; LOC679739; NADH dehydrogenase (ubiquinone) Fe-S protein 6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial-like; NADH:ubiquinone oxidoreductase subunit S6-like 1; Ndufs6l1; uncharacterized protein LOC679739
RGD Orthologs
Human
Mouse
Alliance Genes
More Info more info ...
Related Pseudogenes: Ndufs6-ps1  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8131,797,400 - 31,805,965 (+)NCBIGRCr8
mRatBN7.2129,968,833 - 29,977,423 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl129,968,842 - 29,977,467 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0132,573,204 - 32,581,785 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0133,996,559 - 34,005,137 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera128,608,880 - 28,617,461 (+)NCBICelera
Cytogenetic Map1p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:21700703  


Genomics

Comparative Map Data
Ndufs6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8131,797,400 - 31,805,965 (+)NCBIGRCr8
mRatBN7.2129,968,833 - 29,977,423 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl129,968,842 - 29,977,467 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0132,573,204 - 32,581,785 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0133,996,559 - 34,005,137 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera128,608,880 - 28,617,461 (+)NCBICelera
Cytogenetic Map1p11NCBI
NDUFS6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3851,801,407 - 1,816,048 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl51,801,407 - 1,816,048 (+)EnsemblGRCh38hg38GRCh38
GRCh3751,801,521 - 1,816,162 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3651,854,509 - 1,869,165 (+)NCBINCBI36Build 36hg18NCBI36
Build 3451,854,508 - 1,882,609NCBI
Celera51,838,161 - 1,852,826 (+)NCBICelera
Cytogenetic Map5p15.33NCBI
HuRef51,783,132 - 1,798,367 (+)NCBIHuRef
CHM1_151,801,142 - 1,815,808 (+)NCBICHM1_1
T2T-CHM13v2.051,716,295 - 1,731,268 (+)NCBIT2T-CHM13v2.0
Ndufs6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391373,467,995 - 73,476,574 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1373,467,957 - 73,476,661 (-)EnsemblGRCm39 Ensembl
GRCm381373,319,876 - 73,328,482 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1373,319,838 - 73,328,542 (-)EnsemblGRCm38mm10GRCm38
MGSCv371373,457,324 - 73,465,930 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361373,785,874 - 73,794,457 (-)NCBIMGSCv36mm8
Celera1375,647,714 - 75,656,320 (-)NCBICelera
Cytogenetic Map13C1NCBI
cM Map1339.69NCBI

Variants

.
Variants in Ndufs6
56 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313053Bss51Bone structure and strength QTL 513.80.0001tibia length (VT:0004357)tibia length (CMO:0000450)1132356093Rat
2313070Bss52Bone structure and strength QTL 524.40.0001body length (VT:0001256)body length (CMO:0000013)1132356093Rat
2313090Bmd69Bone mineral density QTL 694.40.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)1132356093Rat
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1578650Bmd6Bone mineral density QTL 612.2femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)150910843284926Rat
1578651Bmd7Bone mineral density QTL 714.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)150910843284926Rat
1578669Bss9Bone structure and strength QTL 96.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)150910843284926Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1224439043433040Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1439328949393289Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)1985600154856001Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11099206555992065Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2317755Glom22Glomerulus QTL 223.8urine protein amount (VT:0005160)urine protein level (CMO:0000591)11148148232355910Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)11183518156835181Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)11543162149361612Rat
5684999Bss102Bone structure and strength QTL 1025.50.00000072tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)11543162149361612Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11620621049268520Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)11933357156983283Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)12076315844095856Rat
724520Bp145Blood pressure QTL 1452.10.0024arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12078482865784828Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1357400Bw62Body weight QTL624.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)12234064767340647Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)12887978078430678Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 1 1 1 1 3 1 1
Below cutoff 3 23 20 20 2 20 2 57 20 21 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000028988   ⟹   ENSRNOP00000036045
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl129,968,842 - 29,977,467 (+)Ensembl
Rnor_6.0 Ensembl131,264,755 - 31,273,159 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000072206   ⟹   ENSRNOP00000066688
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl129,969,335 - 29,977,419 (+)Ensembl
Rnor_6.0 Ensembl132,573,228 - 32,581,781 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000075959   ⟹   ENSRNOP00000068326
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl132,573,228 - 32,581,781 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000076091   ⟹   ENSRNOP00000068010
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl131,264,755 - 31,273,159 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000076142   ⟹   ENSRNOP00000068404
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl132,573,238 - 32,581,781 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000076399   ⟹   ENSRNOP00000068026
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl131,264,765 - 31,273,159 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000118645   ⟹   ENSRNOP00000094937
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl129,968,866 - 29,977,413 (+)Ensembl
RefSeq Acc Id: NM_001423689   ⟹   NP_001410618
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8131,797,400 - 31,805,965 (+)NCBI
RefSeq Acc Id: NR_186903
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8131,797,400 - 31,805,965 (+)NCBI
RefSeq Acc Id: XM_063273286   ⟹   XP_063129356
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8131,797,402 - 31,805,963 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001410618 (Get FASTA)   NCBI Sequence Viewer  
  XP_063129356 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000036045.2
  ENSRNOP00000066688.2
  ENSRNOP00000094937.1
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000068326   ⟸   ENSRNOT00000075959
RefSeq Acc Id: ENSRNOP00000036045   ⟸   ENSRNOT00000028988
RefSeq Acc Id: ENSRNOP00000066688   ⟸   ENSRNOT00000072206
RefSeq Acc Id: ENSRNOP00000068026   ⟸   ENSRNOT00000076399
RefSeq Acc Id: ENSRNOP00000068404   ⟸   ENSRNOT00000076142
RefSeq Acc Id: ENSRNOP00000068010   ⟸   ENSRNOT00000076091
RefSeq Acc Id: ENSRNOP00000094937   ⟸   ENSRNOT00000118645
RefSeq Acc Id: NP_001410618   ⟸   NM_001423689
- UniProtKB: P52504 (UniProtKB/Swiss-Prot),   A6I4Z8 (UniProtKB/TrEMBL),   A6JUY2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129356   ⟸   XM_063273286
- Peptide Label: isoform X1
Protein Domains
Zinc finger CHCC-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZCZ9-F1-model_v2 AlphaFold D3ZCZ9 1-116 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689580
Promoter ID:EPDNEW_R95
Type:multiple initiation site
Name:LOC679739_1
Description:NADH dehydrogenase Fe-S protein 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0132,573,235 - 32,573,295EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1584802 AgrOrtholog
BioCyc Gene G2FUF-61917 BioCyc
BioCyc Pathway PWY-3781 [aerobic respiration I (cytochrome c)] BioCyc
BioCyc Pathway Image PWY-3781 BioCyc
Ensembl Genes ENSRNOG00000023387 Ensembl
  ENSRNOG00000049394 Ensembl
  ENSRNOG00000062531 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000028988.3 UniProtKB/TrEMBL
  ENSRNOT00000072206.3 UniProtKB/TrEMBL
  ENSRNOT00000118645.1 UniProtKB/TrEMBL
Gene3D-CATH q5lls5 like domains UniProtKB/TrEMBL
InterPro NDUFS6 UniProtKB/TrEMBL
  Znf_CHCC UniProtKB/TrEMBL
KEGG Report rno:679739 UniProtKB/TrEMBL
NCBI Gene 679739 ENTREZGENE
PANTHER NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 6, MITOCHONDRIAL UniProtKB/TrEMBL
  NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-A SUBUNIT UniProtKB/TrEMBL
Pfam zf-CHCC UniProtKB/TrEMBL
PhenoGen Ndufs6 PhenoGen
PIRSF CI-13KD-A UniProtKB/TrEMBL
RatGTEx ENSRNOG00000023387 RatGTEx
  ENSRNOG00000049394 RatGTEx
  ENSRNOG00000062531 RatGTEx
UniProt A0A8I6GLD7_RAT UniProtKB/TrEMBL
  A6I4Z8 ENTREZGENE, UniProtKB/TrEMBL
  A6JUY2 ENTREZGENE, UniProtKB/TrEMBL
  D3ZCZ9_RAT UniProtKB/TrEMBL
  M0RAX2_RAT UniProtKB/TrEMBL
  P52504 ENTREZGENE
UniProt Secondary A0A096MK72 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-08-07 Ndufs6  NADH:ubiquinone oxidoreductase subunit S6  Ndufs6l1  NADH:ubiquinone oxidoreductase subunit S6-like 1  Name and Symbol changed 629549 APPROVED
2022-03-01 Ndufs6l1  NADH:ubiquinone oxidoreductase subunit S6-like 1  LOC679739  NADH dehydrogenase (ubiquinone) Fe-S protein 6  Name and Symbol changed 629549 APPROVED
2021-03-09 LOC679739  NADH dehydrogenase (ubiquinone) Fe-S protein 6  LOC100912599  NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial-like  Data merged from RGD:6485961 737654 PROVISIONAL
2012-07-05 LOC100912599  NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC679739  NADH dehydrogenase (ubiquinone) Fe-S protein 6      Symbol and Name status set to provisional 70820 PROVISIONAL