Lhfpl7 (LHFPL tetraspan subfamily member 7) - Rat Genome Database

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Gene: Lhfpl7 (LHFPL tetraspan subfamily member 7) Rattus norvegicus
Analyze
Symbol: Lhfpl7
Name: LHFPL tetraspan subfamily member 7
RGD ID: 1584759
Description: Predicted to be active in membrane. Orthologous to human LHFPL7 (LHFPL tetraspan subfamily member 7); INTERACTS WITH 6-propyl-2-thiouracil; acrylamide; bisphenol A.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: hypothetical protein LOC679783; hypothetical protein LOC687903; LOC679783; Tmem211; transmembrane protein 211
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81249,053,607 - 49,057,890 (-)NCBIGRCr8
mRatBN7.21243,393,166 - 43,397,472 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1243,391,632 - 43,401,320 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01249,401,768 - 49,406,037 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1249,401,667 - 49,412,796 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01251,176,003 - 51,180,329 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41244,402,030 - 44,406,180 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1244,989,759 - 44,994,028 (-)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IBA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Lhfpl7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81249,053,607 - 49,057,890 (-)NCBIGRCr8
mRatBN7.21243,393,166 - 43,397,472 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1243,391,632 - 43,401,320 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01249,401,768 - 49,406,037 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1249,401,667 - 49,412,796 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01251,176,003 - 51,180,329 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41244,402,030 - 44,406,180 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1244,989,759 - 44,994,028 (-)NCBICelera
Cytogenetic Map12q16NCBI
LHFPL7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382224,935,098 - 24,946,694 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2224,935,098 - 24,946,695 (-)EnsemblGRCh38hg38GRCh38
GRCh372225,331,065 - 25,342,661 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362223,661,208 - 23,665,314 (-)NCBINCBI36Build 36hg18NCBI36
Celera229,135,586 - 9,139,692 (-)NCBICelera
Cytogenetic Map22q11.23NCBI
HuRef228,279,978 - 8,284,084 (-)NCBIHuRef
CHM1_12225,289,941 - 25,294,051 (-)NCBICHM1_1
T2T-CHM13v2.02225,396,656 - 25,408,280 (-)NCBIT2T-CHM13v2.0
Lhfpl7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395113,374,775 - 113,388,089 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5113,374,775 - 113,387,129 (+)EnsemblGRCm39 Ensembl
GRCm385113,226,909 - 113,240,223 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5113,226,909 - 113,239,263 (+)EnsemblGRCm38mm10GRCm38
MGSCv375113,655,929 - 113,668,283 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365113,467,212 - 113,479,566 (+)NCBIMGSCv36mm8
Celera5110,347,217 - 110,359,579 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map555.43NCBI
Lhfpl7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955455237,252 - 250,819 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955455237,462 - 251,622 (+)NCBIChiLan1.0ChiLan1.0
LHFPL7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22334,834,916 - 34,847,287 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12237,533,704 - 37,545,943 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0225,890,285 - 5,906,573 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12223,557,166 - 23,569,025 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2223,557,401 - 23,561,701 (-)Ensemblpanpan1.1panPan2
LHFPL7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12619,063,479 - 19,076,840 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2619,063,490 - 19,067,467 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2618,929,649 - 18,942,920 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02619,428,993 - 19,442,271 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2619,428,993 - 19,432,966 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12619,134,508 - 19,147,696 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02619,400,207 - 19,413,403 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02619,469,329 - 19,482,639 (-)NCBIUU_Cfam_GSD_1.0
Lhfpl7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118115,720,864 - 115,724,495 (+)NCBIHiC_Itri_2
LHFPL7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1442,980,659 - 42,989,722 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11442,980,177 - 42,987,894 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21445,711,611 - 45,716,115 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LHFPL7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1198,031,900 - 8,043,244 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl198,032,037 - 8,036,169 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045118,222,893 - 118,227,473 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lhfpl7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247472,097,246 - 2,103,065 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lhfpl7
38 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122032881946669029Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)122806443345899022Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)122806443346669029Rat
1300162Bp188Blood pressure QTL 1883.19arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123210317445899022Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 3 1 3
Below cutoff 1 2 4 4 4 3 3 13 6 10 1 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000076878   ⟹   ENSRNOP00000068428
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1249,401,890 - 49,406,037 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000092480   ⟹   ENSRNOP00000075893
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1243,391,632 - 43,401,320 (-)Ensembl
Rnor_6.0 Ensembl1249,401,667 - 49,412,796 (-)Ensembl
RefSeq Acc Id: XM_001054448   ⟹   XP_001054448
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81249,053,607 - 49,057,890 (-)NCBI
mRatBN7.21243,393,166 - 43,397,472 (-)NCBI
Rnor_6.01249,401,768 - 49,406,037 (-)NCBI
Rnor_5.01251,176,003 - 51,180,329 (-)NCBI
RGSC_v3.41244,402,030 - 44,406,180 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs XP_001054448 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000075893
  ENSRNOP00000075893.2
Reference Protein Sequences
RefSeq Acc Id: XP_001054448   ⟸   XM_001054448
- UniProtKB: A0A0U1RS14 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075893   ⟸   ENSRNOT00000092480
RefSeq Acc Id: ENSRNOP00000068428   ⟸   ENSRNOT00000076878

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A096MK95-F1-model_v2 AlphaFold A0A096MK95 1-195 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1584759 AgrOrtholog
BioCyc Gene G2FUF-18894 BioCyc
Ensembl Genes ENSRNOG00000051192 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000092480.2 UniProtKB/TrEMBL
InterPro Lipome_HGMIC_fus_partner-like UniProtKB/TrEMBL
NCBI Gene 679783 ENTREZGENE
PANTHER PTHR12489 UniProtKB/TrEMBL
  TRANSMEMBRANE PROTEIN 211 UniProtKB/TrEMBL
Pfam L_HGMIC_fpl UniProtKB/TrEMBL
PhenoGen Lhfpl7 PhenoGen
RatGTEx ENSRNOG00000051192 RatGTEx
UniProt A0A0U1RS14 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-12-16 Lhfpl7  LHFPL tetraspan subfamily member 7  Tmem211  transmembrane protein 211  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-05-24 Tmem211  transmembrane protein 211  LOC687903  hypothetical protein LOC687903  Data merged from RGD:1594945 1643240 APPROVED
2008-07-17 Tmem211  transmembrane protein 211  LOC679783  hypothetical protein LOC679783  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC687903  hypothetical protein LOC687903      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC679783  hypothetical protein LOC679783      Symbol and Name status set to provisional 70820 PROVISIONAL