Qsox2 (quiescin sulfhydryl oxidase 2) - Rat Genome Database

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Gene: Qsox2 (quiescin sulfhydryl oxidase 2) Rattus norvegicus
Analyze
Symbol: Qsox2
Name: quiescin sulfhydryl oxidase 2
RGD ID: 1584720
Description: Predicted to enable flavin-dependent sulfhydryl oxidase activity and protein disulfide isomerase activity. Predicted to be involved in protein folding. Predicted to be located in Golgi apparatus and nucleoplasm. Predicted to be active in extracellular space. Orthologous to human QSOX2 (quiescin sulfhydryl oxidase 2); INTERACTS WITH (+)-schisandrin B; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC103691753; LOC681023; quiescin Q6 sulfhydryl oxidase 2; similar to quiescin Q6-like 1; sulfhydryl oxidase 2; uncharacterized LOC103691753
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8329,433,091 - 29,462,739 (-)NCBIGRCr8
mRatBN7.239,034,994 - 9,064,649 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl39,034,994 - 9,064,664 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx312,088,077 - 12,118,048 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0320,671,309 - 20,701,280 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0318,926,649 - 18,956,616 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.033,662,324 - 3,691,972 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl33,662,324 - 3,691,972 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.039,024,117 - 9,053,765 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.434,389,622 - 4,419,326 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera33,857,475 - 3,887,123 (-)NCBICelera
Cytogenetic Map3p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Qsox2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8329,433,091 - 29,462,739 (-)NCBIGRCr8
mRatBN7.239,034,994 - 9,064,649 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl39,034,994 - 9,064,664 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx312,088,077 - 12,118,048 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0320,671,309 - 20,701,280 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0318,926,649 - 18,956,616 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.033,662,324 - 3,691,972 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl33,662,324 - 3,691,972 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.039,024,117 - 9,053,765 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.434,389,622 - 4,419,326 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera33,857,475 - 3,887,123 (-)NCBICelera
Cytogenetic Map3p13NCBI
QSOX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389136,206,333 - 136,245,812 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9136,206,333 - 136,245,812 (-)EnsemblGRCh38hg38GRCh38
GRCh379139,098,179 - 139,137,658 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369138,238,000 - 138,277,508 (-)NCBINCBI36Build 36hg18NCBI36
Build 349136,324,127 - 136,344,667NCBI
Celera9109,616,549 - 109,656,505 (-)NCBICelera
Cytogenetic Map9q34.3NCBI
HuRef9108,562,182 - 108,601,716 (-)NCBIHuRef
CHM1_19139,246,942 - 139,286,427 (-)NCBICHM1_1
T2T-CHM13v2.09148,435,876 - 148,475,457 (-)NCBIT2T-CHM13v2.0
Qsox2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39226,099,136 - 26,127,411 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl226,098,649 - 26,127,537 (-)EnsemblGRCm39 Ensembl
GRCm38226,209,124 - 26,237,399 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl226,208,637 - 26,237,525 (-)EnsemblGRCm38mm10GRCm38
MGSCv37226,064,650 - 26,092,940 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36226,031,139 - 26,059,429 (-)NCBIMGSCv36mm8
Celera225,931,643 - 25,959,981 (-)NCBICelera
Cytogenetic Map2A3NCBI
cM Map218.45NCBI
Qsox2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555134,438,015 - 4,463,319 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555134,438,078 - 4,463,276 (+)NCBIChiLan1.0ChiLan1.0
QSOX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2113,138,755 - 3,177,977 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan193,141,090 - 3,179,132 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09107,281,207 - 107,320,420 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19136,261,578 - 136,282,200 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9136,261,578 - 136,282,774 (-)Ensemblpanpan1.1panPan2
QSOX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1949,213,295 - 49,245,164 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl949,213,295 - 49,245,176 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha948,463,027 - 48,495,634 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0950,081,664 - 50,121,764 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl950,089,907 - 50,119,948 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1948,869,590 - 48,902,205 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0949,163,908 - 49,196,505 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0949,211,459 - 49,244,059 (+)NCBIUU_Cfam_GSD_1.0
Qsox2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947201,812,004 - 201,832,451 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366691,542,607 - 1,565,688 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366691,542,607 - 1,561,118 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
QSOX2
(Sus scrofa - pig)		 No map positions available.
QSOX2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1121,956,441 - 1,997,344 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660583,217,205 - 3,258,541 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Qsox2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247601,435,969 - 1,459,578 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247601,436,169 - 1,459,522 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Qsox2
123 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:500
Count of miRNA genes:245
Interacting mature miRNAs:315
Transcripts:ENSRNOT00000061735
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)3865816227494778Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3865816227494778Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 2 13 8 4 8 66 20 39 11
Low 41 44 33 15 33 8 11 8 15 2 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000061735   ⟹   ENSRNOP00000058448
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl39,034,994 - 9,064,642 (-)Ensembl
Rnor_6.0 Ensembl33,662,324 - 3,691,972 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000116146   ⟹   ENSRNOP00000096929
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl39,034,994 - 9,064,664 (-)Ensembl
RefSeq Acc Id: NM_001109434   ⟹   NP_001102904
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8329,433,091 - 29,462,739 (-)NCBI
mRatBN7.239,034,994 - 9,064,642 (-)NCBI
Rnor_6.033,662,324 - 3,691,972 (-)NCBI
Rnor_5.039,024,117 - 9,053,765 (-)NCBI
RGSC_v3.434,389,622 - 4,419,326 (-)RGD
Celera33,857,475 - 3,887,123 (-)RGD
Sequence:
RefSeq Acc Id: XM_017592040   ⟹   XP_017447529
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8329,433,391 - 29,462,717 (-)NCBI
mRatBN7.239,036,773 - 9,064,649 (-)NCBI
Rnor_6.033,662,606 - 3,691,958 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039105855   ⟹   XP_038961783
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8329,433,391 - 29,462,495 (-)NCBI
mRatBN7.239,036,773 - 9,064,418 (-)NCBI
RefSeq Acc Id: XM_063284545   ⟹   XP_063140615
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8329,433,391 - 29,462,306 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001102904   ⟸   NM_001109434
- UniProtKB: D3ZP13 (UniProtKB/TrEMBL),   A6JTC7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447529   ⟸   XM_017592040
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ARL2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000058448   ⟸   ENSRNOT00000061735
RefSeq Acc Id: XP_038961783   ⟸   XM_039105855
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000096929   ⟸   ENSRNOT00000116146
RefSeq Acc Id: XP_063140615   ⟸   XM_063284545
- Peptide Label: isoform X2
Protein Domains
ERV/ALR sulfhydryl oxidase   Thioredoxin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZP13-F1-model_v2 AlphaFold D3ZP13 1-708 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691898
Promoter ID:EPDNEW_R2423
Type:multiple initiation site
Name:Qsox2_1
Description:quiescin sulfhydryl oxidase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.033,691,929 - 3,691,989EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1584720 AgrOrtholog
BioCyc Gene G2FUF-50392 BioCyc
Ensembl Genes ENSRNOG00000018574 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000061735 ENTREZGENE
  ENSRNOT00000061735.3 UniProtKB/TrEMBL
  ENSRNOT00000116146.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.120.1960 UniProtKB/TrEMBL
  1.20.120.310 UniProtKB/TrEMBL
  Glutaredoxin UniProtKB/TrEMBL
InterPro ERV/ALR_sulphydryl_oxid_sf UniProtKB/TrEMBL
  ERV/ALR_sulphydryl_oxidase UniProtKB/TrEMBL
  QSOX_FAD-bd_dom UniProtKB/TrEMBL
  QSOX_FAD-bd_sf UniProtKB/TrEMBL
  QSOX_Trx1 UniProtKB/TrEMBL
  Sulfhydryl_oxidase UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/TrEMBL
  Thioredoxin_domain UniProtKB/TrEMBL
KEGG Report rno:681023 UniProtKB/TrEMBL
NCBI Gene 681023 ENTREZGENE
PANTHER PTHR22897 UniProtKB/TrEMBL
  SULFHYDRYL OXIDASE 2 UniProtKB/TrEMBL
Pfam Evr1_Alr UniProtKB/TrEMBL
  FAD_SOX UniProtKB/TrEMBL
  QSOX_Trx1 UniProtKB/TrEMBL
  Thioredoxin UniProtKB/TrEMBL
PhenoGen Qsox2 PhenoGen
PROSITE ERV_ALR UniProtKB/TrEMBL
  THIOREDOXIN_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018574 RatGTEx
Superfamily-SCOP Evr1_Alr UniProtKB/TrEMBL
  Thiordxn-like_fd UniProtKB/TrEMBL
UniProt A0A8I6ARL2 ENTREZGENE, UniProtKB/TrEMBL
  A6JTC7 ENTREZGENE, UniProtKB/TrEMBL
  D3ZP13 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Qsox2  quiescin sulfhydryl oxidase 2  LOC103691753  uncharacterized LOC103691753  Data merged from RGD:9242896 737654 PROVISIONAL
2015-12-02 Qsox2  quiescin sulfhydryl oxidase 2  Qsox2  quiescin Q6 sulfhydryl oxidase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-08-25 LOC103691753  uncharacterized LOC103691753      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-03-05 Qsox2  quiescin Q6 sulfhydryl oxidase 2  LOC681023  similar to quiescin Q6-like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC681023  similar to quiescin Q6-like 1  LOC687383  similar to quiescin Q6-like 1  Data merged from RGD:1586516 1643240 APPROVED
2006-11-19 LOC681023  similar to quiescin Q6-like 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC687383  similar to quiescin Q6-like 1      Symbol and Name status set to provisional 70820 PROVISIONAL