Fzd10 (frizzled class receptor 10)

Gene: Fzd10 (frizzled class receptor 10) Rattus norvegicus

Analyze

Symbol:

Fzd10

Name:

frizzled class receptor 10

RGD ID:

1583825

Description:

Predicted to enable Wnt receptor activity and Wnt-protein binding activity. Predicted to be involved in canonical Wnt signaling pathway; non-canonical Wnt signaling pathway; and positive regulation of JNK cascade. Predicted to act upstream of or within Wnt signaling pathway. Predicted to be located in cell surface; cytoplasm; and nucleoplasm. Orthologous to human FZD10 (frizzled class receptor 10); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; INTERACTS WITH bisphenol A; copper atom; copper(0).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

frizzled family receptor 10; frizzled homolog 10 (Drosophila); frizzled homolog 10 (Drosophila), pseudogene 1; frizzled homolog 10, pseudogene 1; frizzled-10; Fzd10-ps1; LOC363913; similar to frizzled 10

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	33,734,364 - 33,737,559 (-)	NCBI		GRCr8
mRatBN7.2	12	28,098,371 - 28,101,566 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	28,098,371 - 28,101,566 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	12	29,242,381 - 29,245,573 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	29,852,962 - 29,856,154 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	28,906,457 - 28,909,649 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	31,757,407 - 31,760,604 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	31,757,407 - 31,760,604 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	33,680,149 - 33,683,346 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	29,164,632 - 29,166,832 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	12	29,789,351 - 29,792,546 (-)	NCBI		Celera
Cytogenetic Map	12	q13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-hydroxypropanoic acid (ISO)

3',5'-cyclic AMP (ISO)

4,4'-sulfonyldiphenol (ISO)

5-aza-2'-deoxycytidine (ISO)

8-Br-cAMP (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

cadmium dichloride (ISO)

copper atom (EXP,ISO)

copper(0) (EXP,ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

deguelin (ISO)

dorsomorphin (ISO)

entinostat (ISO)

ethanol (ISO)

folic acid (ISO)

L-ascorbic acid (ISO)

mercury dibromide (ISO)

methylmercury chloride (ISO)

mifepristone (ISO)

p-chloromercuribenzoic acid (ISO)

panobinostat (ISO)

phenylmercury acetate (ISO)

progesterone (ISO)

rac-lactic acid (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

succimer (ISO)

titanium dioxide (ISO)

torcetrapib (ISO)

trichostatin A (ISO)

trimellitic anhydride (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

canonical Wnt signaling pathway (ISO)

G protein-coupled receptor signaling pathway (IEA)

non-canonical Wnt signaling pathway (ISO)

positive regulation of JNK cascade (ISO)

regulation of actin cytoskeleton organization (ISO)

Wnt signaling pathway (ISO)

Cellular Component

cell surface (ISO)

cytoplasm (ISO)

nucleoplasm (IEA,ISO)

plasma membrane (IEA)

Molecular Function

G protein-coupled receptor activity (IEA)

protein binding (ISO)

Wnt receptor activity (ISO)

Wnt-protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

Wnt signaling pathway (ISO)

Wnt signaling, canonical pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
2.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:15923619	PMID:16007199	PMID:18271942	PMID:19137009	PMID:28733458	PMID:37728849

Genomics

Comparative Map Data

Fzd10
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	33,734,364 - 33,737,559 (-)	NCBI		GRCr8
mRatBN7.2	12	28,098,371 - 28,101,566 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	28,098,371 - 28,101,566 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	12	29,242,381 - 29,245,573 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	29,852,962 - 29,856,154 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	28,906,457 - 28,909,649 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	31,757,407 - 31,760,604 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	31,757,407 - 31,760,604 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	33,680,149 - 33,683,346 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	29,164,632 - 29,166,832 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	12	29,789,351 - 29,792,546 (-)	NCBI		Celera
Cytogenetic Map	12	q13	NCBI

FZD10
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	130,162,464 - 130,165,740 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	130,162,459 - 130,165,740 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	130,647,009 - 130,650,285 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	129,212,985 - 129,216,238 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	129,171,911 - 129,175,164	NCBI
Celera	12	130,261,495 - 130,264,748 (+)	NCBI		Celera
Cytogenetic Map	12	q24.33	NCBI
HuRef	12	127,631,981 - 127,635,399 (+)	NCBI		HuRef
CHM1_1	12	130,468,030 - 130,471,311 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	130,199,607 - 130,202,883 (+)	NCBI		T2T-CHM13v2.0

Fzd10
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	128,678,170 - 128,681,157 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	128,677,908 - 128,681,157 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	128,601,106 - 128,604,093 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	128,600,844 - 128,604,093 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	129,106,981 - 129,109,968 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	128,915,814 - 128,918,801 (+)	NCBI		MGSCv36	mm8
Celera	5	125,632,121 - 125,635,168 (+)	NCBI		Celera
Cytogenetic Map	5	G1.3	NCBI
cM Map	5	67.67	NCBI

Fzd10
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955482	1,557,088 - 1,558,782 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955482	1,556,123 - 1,558,782 (-)	NCBI	ChiLan1.0	ChiLan1.0

FZD10
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	138,222,549 - 138,225,824 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	138,219,069 - 138,222,344 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	127,775,141 - 127,778,420 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	131,989,762 - 131,992,399 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

FZD10
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	1,907,382 - 1,909,416 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	1,907,593 - 1,909,338 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	2,105,435 - 2,108,333 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	2,149,752 - 2,152,649 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	2,150,860 - 2,152,605 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	2,085,385 - 2,088,280 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	2,182,085 - 2,184,989 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	2,092,744 - 2,095,644 (-)	NCBI		UU_Cfam_GSD_1.0

Fzd10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	123,442,473 - 123,445,396 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936660	1,275,804 - 1,277,549 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936660	1,275,692 - 1,278,578 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FZD10
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	24,920,679 - 24,922,424 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	24,919,483 - 24,922,554 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	26,521,260 - 26,524,287 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

FZD10
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	125,518,667 - 125,522,115 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	125,519,315 - 125,521,060 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	119,503,368 - 119,506,650 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Fzd10
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624747	26,984,090 - 26,985,835 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624747	26,984,090 - 26,986,756 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Fzd10
16 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	71
Count of miRNA genes:	62
Interacting mature miRNAs:	65
Transcripts:	ENSRNOT00000029702
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1581516	Cm56	Cardiac mass QTL 56	4.2	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	12	1	29333307	Rat
1598855	Bp294	Blood pressure QTL 294	3.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	1	34851688	Rat
7411660	Foco28	Food consumption QTL 28	10.9	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	1	42110980	Rat
9590086	Insglur6	Insulin/glucose ratio QTL 6	18.97	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	12	1	42110980	Rat
8694179	Bw150	Body weight QTL 150	2.9	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	12	1	42110980	Rat
7411586	Foco5	Food consumption QTL 5	5.4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	1	42110980	Rat
7411595	Foco9	Food consumption QTL 9	4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	1	42110980	Rat
7411545	Bw128	Body weight QTL 128	5.2	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	12	1	42110980	Rat
9590147	Scort7	Serum corticosterone level QTL 7	13.61	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	12	1	42110980	Rat
2303575	Insul14	Insulin level QTL 14	4		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	12	1	42450532	Rat
737979	Pia22	Pristane induced arthritis QTL 22	53.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	1	44465750	Rat
634351	Apr5	Acute phase response QTL 5	6.7		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	12	1	44503507	Rat
2302042	Pia38	Pristane induced arthritis QTL 38	3.5	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	12	1	44503507	Rat
634350	Apr4	Acute phase response QTL 4	6		orosomucoid 1 amount (VT:0010541)	plasma orosomucoid 1 level (CMO:0001467)	12	1172005	46172005	Rat
8552918	Pigfal7	Plasma insulin-like growth factor 1 level QTL 7			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	5564495	46669029	Rat
7411547	Bw129	Body weight QTL 129		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	5564495	46669029	Rat
7411597	Foco10	Food consumption QTL 10		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	5564495	46669029	Rat
7411641	Foco19	Food consumption QTL 19	27.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	5564495	46669029	Rat
8552964	Pigfal17	Plasma insulin-like growth factor 1 level QTL 17	3.5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	5564495	46669029	Rat
7411588	Foco6	Food consumption QTL 6		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	5564495	46669029	Rat
8552912	Pigfal6	Plasma insulin-like growth factor 1 level QTL 6	5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	5564498	46669029	Rat
10059594	Kidm46	Kidney mass QTL 46	3.79	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	12	6107579	46669029	Rat
1302792	Scl21	Serum cholesterol level QTL 21	3.8	0.0011	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	12	7196730	46669029	Rat
2293086	Iddm30	Insulin dependent diabetes mellitus QTL 30	3.82		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	8449490	28302290	Rat
1300157	Rf21	Renal function QTL 21	4.4		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	12	9318216	32103380	Rat
1549829	Scl48	Serum cholesterol level QTL 48	5		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	12	9603277	46669029	Rat
2293699	Bss49	Bone structure and strength QTL 49	5.61	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	12	10474137	46669029	Rat
2300186	Bmd59	Bone mineral density QTL 59	7.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	12	10474137	46669029	Rat
1331761	Bp218	Blood pressure QTL 218	2.973		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	11073825	45055165	Rat
61404	Bw120	Body weight QTL 120	5.1		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	12	12351619	46669029	Rat
1641928	Alcrsp5	Alcohol response QTL 5			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	12	12812385	46669029	Rat
2303569	Gluco44	Glucose level QTL 44	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	12812385	46669029	Rat
1549902	Bp269	Blood pressure QTL 269			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	13182736	46669029	Rat
1549912	Bp268	Blood pressure QTL 268			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	10	13182736	46669029	Rat
2302060	Pia37	Pristane induced arthritis QTL 37	6.1	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	12	13198157	46669029	Rat
61416	Pia4	Pristane induced arthritis QTL 4	8.4		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	12	13635523	30827399	Rat
61421	Cia12	Collagen induced arthritis QTL 12	4.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	13635523	35682913	Rat
631543	Bp83	Blood pressure QTL 83	5.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	15550826	38478808	Rat
2293684	Bmd26	Bone mineral density QTL 26	4.4	0.0002	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	12	15872653	32974238	Rat
631560	Apr1	Acute phase response QTL 1	6.1		orosomucoid 1 amount (VT:0010541)	plasma orosomucoid 1 level (CMO:0001467)	12	19144362	46669029	Rat
737822	Alc10	Alcohol consumption QTL 10	2.2		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	12	19610870	40218516	Rat
5684888	Pia42	Pristane induced arthritis QTL 42			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	19610870	42828880	Rat
61324	Eae5	Experimental allergic encephalomyelitis QTL 5	14		nervous system integrity trait (VT:0010566)	percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)	12	19610870	46669029	Rat
1298081	Cia25	Collagen induced arthritis QTL 25	4.7		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	19610889	35682913	Rat
70213	Niddm27	Non-insulin dependent diabetes mellitus QTL 27	3.72		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	19835789	38193007	Rat
7411643	Foco20	Food consumption QTL 20		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	20328819	46669029	Rat
70169	Eae13	Experimental allergic encephalomyelitis QTL 13		0.032	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	12	24139202	36638073	Rat
1331763	Wbc2	White blood cell count QTL 2	3.162		leukocyte quantity (VT:0000217)	total white blood cell count (CMO:0000365)	12	24234777	31894213	Rat
1556747	Calcic1	Intracellular calcium level QTL 1		3.6	platelet calcium amount (VT:0010500)	platelet intracellular calcium level (CMO:0000922)	12	28064433	40130419	Rat
1300175	Cm5	Cardiac mass QTL 5	3.78		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	12	28064433	45899022	Rat
1600386	Calcic2	Intracellular calcium level QTL 2		0.001	platelet physiology trait (VT:0005464)	platelet intracellular calcium level (CMO:0000922)	12	28064433	46669029	Rat
1331787	Rf41	Renal function QTL 41	2.998		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	12	28064557	40218380	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium									33	4	12
Low	2	18	11	4	8	4	8	10	41	18	21	6	8
Below cutoff	1	8	15	11	11	11		1		12	5	5

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001271192	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473973	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000029702

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	28,098,371 - 28,101,566 (-)	Ensembl
Rnor_6.0 Ensembl	12	31,757,407 - 31,760,604 (-)	Ensembl

RefSeq Acc Id:

NM_001271192 ⟹ NP_001258121

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	33,734,364 - 33,737,559 (-)	NCBI
mRatBN7.2	12	28,098,371 - 28,101,566 (-)	NCBI
Rnor_6.0	12	31,757,407 - 31,760,604 (-)	NCBI
Rnor_5.0	12	33,680,149 - 33,683,346 (-)	NCBI
Celera	12	29,789,351 - 29,792,546 (-)	NCBI

Sequence:

show sequence

TCCCGGGACGCCGAGCTCAAAACAGCTGCGGGCGCCGGGAGGGAGGAGCTCCGGGGCCCGGGGC
CACGGTGCGCCCGCGCTGCCCCACTGAGGTCCGCGATCGCGCGCGCCCGGAAGAAGAGGCCAAA
GTTTGCGCGCAGAGCCGCGCTCGCTCTGCCGTATTGTTTGCAAACTTCGTTCCCCTCCCCCGCC
GCCCCGGACTCGGCCGAGGCCGCTCGCCCACCGCGGTGGCCCCGGGCGCCGCGAGCGCTCCAGC
CAGACTGGATGGGCATGCGCGGGGGCCCGAGCCGGGGCGCGGAGCCGCGGGCAGCAGCAACAGC
CGGTGCCCGGGAGCGGCGGCCCTGAGCGGCGCAGGGACACCGCGGGCGCCACCATGCAACACCC
GGGCCCACGCCTGTGGCTGATGCTGCAGGTAATGATGGGTTCGTGCGCGGCCATCAGCTCCATG
GACTTAGAGCGCCCTGGAGACGGCAAGTGCCAGCCGGTGGAGATTCCCATGTGCAAGGACATCG
GCTACAACACCACCCGCATGCCCAACCTGATGGGCCACGAGAACCAGCGGGAGGCGGCCATCCA
ACTGCATGAGTTCGCGCCGCTCGTGGAGTACGGCTGCCACGGCCACCTCCGCTTCTTCTTGTGC
TCGCTGTACGCGCCCATGTGCACCGAGCAGGTCTCCACACCCATCCCTGCTTGCCGGGTCATGT
GCGAGCAGGCCCGGCTCAAGTGCTCGCCGATCATGGAGCAGTTTAAATTCAGGTGGCCGGACTC
CCTGGATTGCAGCAAACTCCCCAACAAGAACGATCCCAACTACCTGTGCATGGAGGCACCCAAC
AACGGCTCCGATGAGCCCAGCCGTGGCTCTGGCATGTTCCCTCCGCTCTTCAGGCCCCAGAGGC
CCCACAGCGCGCAAGAGCACCCACTAAAGGACGGGGGTCCCGGGCGCGCAGGCTGTGACAACCC
AGGCAAGTTCCACCACGTGGAGAAGAGCGAATCCTGCGCACCGCTCTGCACTCCGGGGGTGGAT
GTGTATTGGAGCCGCGACGACAAGCGCTTCGCTGTGGTCTGGCTGGCCATCTGGTCCGTGCTGT
GTTTCTTCTCCAGCGCCTTCACCGTGCTCACCTTCCTCATCGACCCATCACGCTTCAGGTACCC
CGAACGTCCCATCATCTTTCTCTCCATGTGCTACTGCGTTTATTCTGTGGGCTATATCATCCGC
CTCTTCGCGGGCGCGGAGAGCATTGCCTGCGACCGGGACAGTGGGCAGCTGTATGTTATCCAGG
AAGGGCTGGAGAGCACGGGCTGTACCTTAGTCTTCTTGGTACTTTACTACTTCGGCATGGCCAG
CTCTTTATGGTGGGTGGTTCTCACCCTCACTTGGTTCCTGGCTGCTGGCAGGAAGTGGGGCCAT
GAGGCCATTGAAGCCAACAGCAGCTACTTTCACCTGGCAGCCTGGGCCATCCCGGCTGTGAAGA
CCATCTTGATCCTGGTGATGCGCAGGGTGGCAGGGGATGAGCTCACTGGTGTGTGTTATGTGGG
CAGCATGGATGTCAATGCTCTGACCGGCTTCGTGCTGGTCCCGCTGGCTTGCTACCTAGTCATC
GGCACTTCCTTCATCCTGTCTGGCTTTGTGGCTTTATTCCACATCCGGAGGGTGATGAAAACAG
GTGGGGAGAACACGGACAAGCTGGAGAAGCTCATGGTACGCATAGGGGTCTTCTCCCTCCTCTA
CACCGTGCCGGCCACCTGTGTGATTGCTTGTTACTTTTATGAACGCCTCAACATGGATTACTGG
AAGATGCTGGCCACCCAGCACAAGTGTAAAACGAACAATCAGACCAAGACAGCCGACTGCCTGA
TGACCACCTCCATCCCTGCTGTGGAGGTCTTCATGGTCAAAGTGTCCATGCTTCTGGTGGTGGG
CATTACCAGTGGGGTGTGGGTCTGGACTTCCAAGACCCTGCAATCCTGGCAACAGGTATGCAGC
CGGGGGTTAAAGAGAAAAAGCCGGAGGAAACCAGCCAGTGTGGTCACCAGTGCAGGGATCTACA
AAAAAGCCCAGCACCCCCAAAAACCTCATCTTGGGAAGTATGAGCTTCCTGCTCAGCCTTCAGC
CTGCGTGTGAAGGCTGCTGACTGCAAGAACAGGAGAGGCAAAGCCCAAATGGGCAGCTTTTCTT
CGTTGGCTGATTGTTGGTAAATCAAAGTAAAAAGTATATACACATATATGTGTATGCATGTGTG
TATAGATATACTTACACACACATATATGGAGTCTACCTTGAATTTCAGAACTACGTCATAGGCT
GCAGGTAAAGGGTTCTGTTCAGTTTGCTGTCTCCCTGAAGGGTCGCTCATTAAGGAAGGAGCCT
CTCGTGTAACTCATTTGTGGTAAAGTCGATGATTCAACCACCCTCTGGAAAACTTTTGTTTAGG
CCTCAAACACACGTGTGTGCATTCAGAAGACTGCCGCCTGTGTACAAACTTGAGGCTGTGTGAG
CTCCTTTGCCAGCCAAAGAGCTTCCTTTGGACCAGCAAATGAACCACCCCAGTCTGCTCTCCCT
CCCTCCCCGCAGCTGTATTGAGGGGGAGGGAGTGAGGGGGAGGAGGTAAAAGAAGGGACCCTGA
GCCCAAGGCCTGCCTGCAGGTCCCTTCTTTATAGCCGTGTTTCTCCCGACACAGAACCCACCCT
ACCCTCCCATCCCACTGCAACTCTAACACGGGAGAACTCAAATGGTGTGCAATACTGGTTTGTT
TTTTTTTTTTTTTACATTCCCCCCCCTCCCTATGAAAACAAATGAGAGGGGGGGGGGGAAGTAT
TCTGTTGTAAATAAAAGGCAACAAAAGAAATCATCCAACAAAAGAATTAAGAGGCCCAAGCCTC
AGGGGGGAAAAAAAACCCTTCAGCCTGATACATTTTGTGGCTTTTTAATGGAAACCAAGCCAGT
GTGTTCTACTCGTTTGGGACTTATTTGTGGAGAGGAGAGGGGAGGGGGGGAAACCAGTGGAGAG
CACCAGAGGGCTTATTGACTCTGAATTGTTAAACAAATGATTTCCATGAGTGGTGTTGGAGCAC
TTGGGAAGACAAACTTTGTTTCCAGCCAGGGAGGGCGATGCCTGCCTCTGTATATCTGTAATAT
ATGATATTTTTCATGCTCCACTATTTTATTAAAAATAAAATAGTTTGCTGCTGCTAGTCA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001258121	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM13526	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000083212
	ENSRNOP00000083212.1

RefSeq Acc Id:	NP_001258121 ⟸ NM_001271192
- Peptide Label:	precursor
- UniProtKB:	A0A8I5ZWS0 (UniProtKB/TrEMBL), A6J0T7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MQHPGPRLWLMLQVMMGSCAAISSMDLERPGDGKCQPVEIPMCKDIGYNTTRMPNLMGHENQRE AAIQLHEFAPLVEYGCHGHLRFFLCSLYAPMCTEQVSTPIPACRVMCEQARLKCSPIMEQFKFR WPDSLDCSKLPNKNDPNYLCMEAPNNGSDEPSRGSGMFPPLFRPQRPHSAQEHPLKDGGPGRAG CDNPGKFHHVEKSESCAPLCTPGVDVYWSRDDKRFAVVWLAIWSVLCFFSSAFTVLTFLIDPSR FRYPERPIIFLSMCYCVYSVGYIIRLFAGAESIACDRDSGQLYVIQEGLESTGCTLVFLVLYYF GMASSLWWVVLTLTWFLAAGRKWGHEAIEANSSYFHLAAWAIPAVKTILILVMRRVAGDELTGV CYVGSMDVNALTGFVLVPLACYLVIGTSFILSGFVALFHIRRVMKTGGENTDKLEKLMVRIGVF SLLYTVPATCVIACYFYERLNMDYWKMLATQHKCKTNNQTKTADCLMTTSIPAVEVFMVKVSML LVVGITSGVWVWTSKTLQSWQQVCSRGLKRKSRRKPASVVTSAGIYKKAQHPQKPHLGKYELPA QPSACV hide sequence

Protein Domains

FZ G-protein coupled receptors family 2 profile

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1583825	AgrOrtholog
BioCyc Gene	G2FUF-19460	BioCyc
Ensembl Genes	ENSRNOG00000022784	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000029702	ENTREZGENE
	ENSRNOT00000029702.5	UniProtKB/TrEMBL
Gene3D-CATH	1.10.2000.10	UniProtKB/TrEMBL
	Rhodopsin 7-helix transmembrane proteins	UniProtKB/TrEMBL
InterPro	Frizzled/SFRP	UniProtKB/TrEMBL
	Frizzled/Smoothened_TM	UniProtKB/TrEMBL
	Frizzled_dom	UniProtKB/TrEMBL
	Frizzled_dom_sf	UniProtKB/TrEMBL
	GPCR_2-like	UniProtKB/TrEMBL
KEGG Report	rno:363913	UniProtKB/TrEMBL
NCBI Gene	363913	ENTREZGENE
PANTHER	PTHR11309	UniProtKB/TrEMBL
	PTHR11309:SF86	UniProtKB/TrEMBL
Pfam	Frizzled	UniProtKB/TrEMBL
	PF01392	UniProtKB/TrEMBL
PhenoGen	Fzd10	PhenoGen
PRINTS	FRIZZLED	UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F2_4	UniProtKB/TrEMBL
	PROKAR_LIPOPROTEIN	UniProtKB/TrEMBL
	PS50038	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000022784	RatGTEx
SMART	FRI	UniProtKB/TrEMBL
	Frizzled	UniProtKB/TrEMBL
Superfamily-SCOP	SSF63501	UniProtKB/TrEMBL
UniProt	A0A8I5ZWS0	ENTREZGENE, UniProtKB/TrEMBL
	A6J0T7	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2014-02-06	Fzd10	frizzled class receptor 10	Fzd10	frizzled family receptor 10	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-03-05	Fzd10	frizzled homolog 10 (Drosophila)	Fzd10	frizzled homolog 10 (Drosophila)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-03-05	Fzd10	frizzled family receptor 10	Fzd10	frizzled homolog 10 (Drosophila)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2010-07-08	Fzd10-ps1	frizzled homolog 10 (Drosophila), pseudogene 1	LOC363913	similar to frizzled 10	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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