Cks1l (CDC28 protein kinase regulatory subunit 1-like) - Rat Genome Database

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Gene: Cks1l (CDC28 protein kinase regulatory subunit 1-like) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Cks1l (Ensembl: AABR07049223.1)
Name: CDC28 protein kinase regulatory subunit 1-like
RGD ID: 1583529
Description: Predicted to be involved in cell division. Orthologous to human CKS1B (CDC28 protein kinase regulatory subunit 1B); INTERACTS WITH 17beta-estradiol; bisphenol A; lidocaine.
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: CDC28 protein kinase 1B-like; CDC28 protein kinase regulatory subunit 1B; CDC28 protein kinase regulatory subunit 1B pseudogene 6; Cks1bp6; cyclin-dependent kinases regulatory subunit 1; LOC681162; similar to Cyclin-dependent kinases regulatory subunit 1 (CKS-1) (Sid 1334)
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85112,098,270 - 112,099,009 (-)NCBIGRCr8
mRatBN7.25106,982,443 - 106,983,182 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5106,982,882 - 106,983,121 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.05110,831,843 - 110,832,242 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05114,776,056 - 114,776,407 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45112,237,120 - 112,237,359 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera5105,647,947 - 105,648,346 (-)NCBICelera
Cytogenetic Map5q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:22017545  


Genomics

Variants

.
Variants in Cks1l
3 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)534944474113558310Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)558829236128034027Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
2316957Pur21Proteinuria QTL 216.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)559793528113558156Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
2290005Mcs24Mammary carcinoma susceptibility QTL 24mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)564719390109719390Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)566174080124160948Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
1298070Scl18Serum cholesterol level QTL 183.7blood LDL cholesterol amount (VT:0000181)calculated plasma low density lipoprotein cholesterol level (CMO:0001245)579584860124584860Rat
1598846Bp293Blood pressure QTL 2933.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)579584860124584860Rat
1598859Cm66Cardiac mass QTL 662heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)579584860124584860Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1298086Bp156Blood pressure QTL 156arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)584132602129132602Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)587468046132468046Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)587765973132765973Rat
1358889Bp261Blood pressure QTL 2612.86arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)590067849128034027Rat
1358909Kidm25Kidney mass QTL 251.87kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)590067849128034027Rat
631527Tls1T-lymphoma susceptibility QTL 100.001thymus integrity trait (VT:0010555)post-insult time to onset of T-cell lymphoma (CMO:0001907)590450144135450144Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)597570330136479578Rat
1582212Livw2Liver weight QTL 23.50.0004liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)599016066119085810Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)599216724148607142Rat
7394708Emca11Estrogen-induced mammary cancer QTL 11mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)599753548113061097Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)5103689353148689353Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat


Expression


Sequence


Reference Sequences
RefSeq Acc Id: NM_001408800   ⟹   NP_001395729
RefSeq Status: INFERRED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85112,098,270 - 112,099,009 (-)NCBI
mRatBN7.25106,982,443 - 106,983,182 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001395729 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000048897
  ENSRNOP00000048897.4
Reference Protein Sequences
RefSeq Acc Id: NP_001395729   ⟸   NM_001408800
- UniProtKB: F1M990 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M990-F1-model_v2 AlphaFold F1M990 1-79 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1583529 AgrOrtholog
BioCyc Gene G2FUF-40728 BioCyc
Ensembl Genes ENSRNOG00000032516 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000052379 ENTREZGENE
  ENSRNOT00000052379.5 UniProtKB/TrEMBL
Gene3D-CATH 3.30.170.10 UniProtKB/TrEMBL
InterPro Cyclin-dep_kinase_reg-sub UniProtKB/TrEMBL
  Cyclin-dep_kinase_reg-sub_sf UniProtKB/TrEMBL
NCBI Gene 681162 ENTREZGENE
PANTHER CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT 1 UniProtKB/TrEMBL
  CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7 UniProtKB/TrEMBL
Pfam CKS UniProtKB/TrEMBL
PhenoGen Cks1l PhenoGen
PRINTS CYCLINKINASE UniProtKB/TrEMBL
PROSITE CKS_1 UniProtKB/TrEMBL
  CKS_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000032516 RatGTEx
SMART CKS UniProtKB/TrEMBL
Superfamily-SCOP SSF55637 UniProtKB/TrEMBL
UniProt F1M990 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-24 Cks1l  CDC28 protein kinase regulatory subunit 1-like  LOC100364205  CDC28 protein kinase 1B-like  Data merged from RGD:2321453 1643240 APPROVED
2013-03-05 Cks1l  CDC28 protein kinase regulatory subunit 1-like  Cks1bp6  CDC28 protein kinase regulatory subunit 1B pseudogene 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-16 Cks1bp6  CDC28 protein kinase regulatory subunit 1B pseudogene 6  Cks1bp6  CDC28 protein kinase regulatory subunit 1B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-05-03 Cks1bp6  CDC28 protein kinase regulatory subunit 1B  LOC681162  similar to Cyclin-dependent kinases regulatory subunit 1 (CKS-1) (Sid 1334)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-06 LOC100364205  CDC28 protein kinase 1B-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-01-09 LOC681162  similar to Cyclin-dependent kinases regulatory subunit 1 (CKS-1) (Sid 1334)  LOC681497  similar to Cyclin-dependent kinases regulatory subunit 1 (CKS-1) (Sid 1334)  Data merged from RGD:1595338 1643240 APPROVED
2006-11-20 LOC681497  similar to Cyclin-dependent kinases regulatory subunit 1 (CKS-1) (Sid 1334)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC681162  similar to Cyclin-dependent kinases regulatory subunit 1 (CKS-1) (Sid 1334)      Symbol and Name status set to provisional 70820 PROVISIONAL