Borcs8 (BLOC-1 related complex subunit 8) - Rat Genome Database

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Gene: Borcs8 (BLOC-1 related complex subunit 8) Rattus norvegicus
Analyze
Symbol: Borcs8
Name: BLOC-1 related complex subunit 8
RGD ID: 1582941
Description: Predicted to be involved in heart development. Predicted to be located in lysosomal membrane. Predicted to be part of BORC complex. Orthologous to human BORCS8 (BLOC-1 related complex subunit 8); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: BLOC-1-related complex subunit 8; hypothetical protein LOC688966; LOC688966; MEF2B neighbor; Mef2bnb; similar to K11B4.2; uncharacterized protein LOC688966
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81619,308,247 - 19,314,910 (-)NCBIGRCr8
mRatBN7.21619,274,305 - 19,280,969 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1619,274,023 - 19,280,339 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1619,314,091 - 19,320,754 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01620,446,197 - 20,452,876 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01619,367,050 - 19,373,713 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01621,022,500 - 21,029,163 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1621,023,996 - 21,029,134 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01620,872,444 - 20,879,034 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41619,757,638 - 19,764,480 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1619,462,947 - 19,469,545 (-)NCBICelera
Cytogenetic Map16p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10458488   PMID:25898167  


Genomics

Comparative Map Data
Borcs8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81619,308,247 - 19,314,910 (-)NCBIGRCr8
mRatBN7.21619,274,305 - 19,280,969 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1619,274,023 - 19,280,339 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1619,314,091 - 19,320,754 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01620,446,197 - 20,452,876 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01619,367,050 - 19,373,713 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01621,022,500 - 21,029,163 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1621,023,996 - 21,029,134 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01620,872,444 - 20,879,034 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41619,757,638 - 19,764,480 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1619,462,947 - 19,469,545 (-)NCBICelera
Cytogenetic Map16p14NCBI
BORCS8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381919,176,906 - 19,192,152 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1919,176,903 - 19,192,591 (-)EnsemblGRCh38hg38GRCh38
GRCh371919,287,715 - 19,302,961 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361919,153,685 - 19,164,425 (-)NCBINCBI36Build 36hg18NCBI36
Celera1919,192,547 - 19,208,203 (-)NCBICelera
Cytogenetic Map19p13.11NCBI
HuRef1918,851,509 - 18,867,171 (-)NCBIHuRef
CHM1_11919,288,223 - 19,303,916 (-)NCBICHM1_1
T2T-CHM13v2.01919,313,447 - 19,328,701 (-)NCBIT2T-CHM13v2.0
Borcs8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39870,592,149 - 70,601,285 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl870,592,149 - 70,599,969 (+)EnsemblGRCm39 Ensembl
GRCm38870,139,499 - 70,148,635 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl870,139,499 - 70,147,319 (+)EnsemblGRCm38mm10GRCm38
MGSCv37872,663,612 - 72,671,160 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36873,069,266 - 73,076,308 (+)NCBIMGSCv36mm8
Celera872,695,151 - 72,702,730 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.15NCBI
Borcs8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555242,641,907 - 2,646,275 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555242,641,907 - 2,646,275 (+)NCBIChiLan1.0ChiLan1.0
BORCS8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22024,044,251 - 24,054,336 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11923,025,584 - 23,060,632 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01918,615,221 - 18,630,230 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11919,590,791 - 19,632,239 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1919,617,791 - 19,632,239 (-)Ensemblpanpan1.1panPan2
BORCS8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12043,983,476 - 43,994,575 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2043,984,075 - 43,992,955 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2043,900,881 - 43,911,653 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02044,471,896 - 44,482,668 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2044,472,200 - 44,482,668 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12043,708,999 - 43,719,851 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02044,118,780 - 44,129,548 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02044,394,268 - 44,404,907 (+)NCBIUU_Cfam_GSD_1.0
Borcs8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118202,682,803 - 202,693,447 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365962,231,954 - 2,242,919 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365962,232,183 - 2,242,267 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BORCS8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl258,684,543 - 58,698,173 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1258,684,508 - 58,696,586 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
LOC103234208
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1617,648,714 - 17,660,931 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl617,648,758 - 17,660,877 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660741,651,620 - 1,707,912 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Borcs8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249082,081,229 - 2,089,913 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249082,082,745 - 2,089,666 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Borcs8
29 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:39
Count of miRNA genes:38
Interacting mature miRNAs:38
Transcripts:ENSRNOT00000064090
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
631517Scl9Serum cholesterol level QTL 93.3blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)161572643321034895Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338015021361552Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat

Markers in Region
RH141544  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map16241.62UniSTS
Cytogenetic Map16p14UniSTS
AI406750  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21619,275,417 - 19,275,616 (+)MAPPERmRatBN7.2
Rnor_6.01621,023,613 - 21,023,811NCBIRnor6.0
Rnor_5.01620,873,556 - 20,873,754UniSTSRnor5.0
RGSC_v3.41619,758,923 - 19,759,121UniSTSRGSC3.4
Celera1619,464,061 - 19,464,259UniSTS
RH 3.4 Map16236.91UniSTS
Cytogenetic Map16p14UniSTS
RH132032  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21619,280,381 - 19,280,566 (+)MAPPERmRatBN7.2
Rnor_6.01621,028,576 - 21,028,760NCBIRnor6.0
Rnor_5.01620,878,447 - 20,878,631UniSTSRnor5.0
RGSC_v3.41619,763,893 - 19,764,077UniSTSRGSC3.4
Celera1619,468,958 - 19,469,142UniSTS
RH 3.4 Map16223.4UniSTS
Cytogenetic Map16p14UniSTS
BE095517  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21619,276,268 - 19,276,465 (+)MAPPERmRatBN7.2
Rnor_6.01621,024,464 - 21,024,660NCBIRnor6.0
Rnor_5.01620,874,407 - 20,874,603UniSTSRnor5.0
RGSC_v3.41619,759,775 - 19,759,971UniSTSRGSC3.4
Celera1619,464,912 - 19,465,108UniSTS
RH 3.4 Map16220.9UniSTS
Cytogenetic Map16p14UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 41 57 41 19 41 8 11 74 35 41 11 8
Low 2
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000064090   ⟹   ENSRNOP00000062405
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1619,274,023 - 19,280,339 (-)Ensembl
Rnor_6.0 Ensembl1621,023,996 - 21,029,134 (-)Ensembl
RefSeq Acc Id: NM_001145726   ⟹   NP_001139198
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81619,308,247 - 19,314,910 (-)NCBI
mRatBN7.21619,274,305 - 19,280,969 (-)NCBI
Rnor_6.01621,022,500 - 21,029,163 (-)NCBI
Rnor_5.01620,872,444 - 20,879,034 (-)NCBI
RGSC_v3.41619,757,638 - 19,764,480 (-)RGD
Celera1619,462,947 - 19,469,545 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001139198 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000062405
  ENSRNOP00000062405.2
RefSeq Acc Id: NP_001139198   ⟸   NM_001145726
- UniProtKB: D3Z8D3 (UniProtKB/TrEMBL),   A6KA83 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000062405   ⟸   ENSRNOT00000064090

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700043
Promoter ID:EPDNEW_R10567
Type:multiple initiation site
Name:Borcs8_1
Description:BLOC-1 related complex subunit 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01621,029,155 - 21,029,215EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1582941 AgrOrtholog
BioCyc Gene G2FUF-11759 BioCyc
Ensembl Genes ENSRNOG00000020427 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000064090 ENTREZGENE
  ENSRNOT00000064090.3 UniProtKB/TrEMBL
InterPro DUF_NEP UniProtKB/TrEMBL
KEGG Report rno:688966 UniProtKB/TrEMBL
NCBI Gene 688966 ENTREZGENE
PANTHER BLOC-1-RELATED COMPLEX SUBUNIT 8 UniProtKB/TrEMBL
  DUF_NEP UniProtKB/TrEMBL
Pfam NEP UniProtKB/TrEMBL
PhenoGen Borcs8 PhenoGen
RatGTEx ENSRNOG00000020427 RatGTEx
UniProt A6KA83 ENTREZGENE, UniProtKB/TrEMBL
  D3Z8D3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-08-13 Borcs8  BLOC-1 related complex subunit 8  Mef2bnb  MEF2B neighbor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-05-24 Mef2bnb  MEF2B neighbor  LOC684626  similar to K11B4.2  Data merged from RGD:1587946 1643240 APPROVED
2011-05-31 Mef2bnb  MEF2B neighbor  LOC688966  similar to K11B4.2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC688966  similar to K11B4.2      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC684626  similar to K11B4.2      Symbol and Name status set to provisional 70820 PROVISIONAL