Tpm1_v5 (tropomyosin 1, variant 5) - Rat Genome Database

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Gene: Tpm1_v5 (tropomyosin 1, variant 5) Rattus norvegicus
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Symbol: Tpm1_v5
Name: tropomyosin 1, variant 5
RGD ID: 1581484
Description: splice variant of Tpm1; encodes isoform e; utilization of an alternative 3' exon results in a shorter protein with a different C-terminus than that of isoform a
ENCODES an splice that exhibits actin filament binding; INVOLVED IN cardiac muscle contraction; positive regulation of ATP-dependent activity
Type: splice  of Tpm1  
Previously known as: TMBr-1
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Cytogenetic Map8q24RGD


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Multiple combinations of alternatively spliced exons in rat tropomyosin-alpha gene mRNA: evidence for 20 new isoforms in adult tissues and cultured cells. Cooley BC and Bergtrom G, Arch Biochem Biophys 2001 Jun 1;390(1):71-7.
2. Importance of internal regions and the overall length of tropomyosin for actin binding and regulatory function. Hitchcock-DeGregori SE, etal., Biochemistry. 2001 Feb 20;40(7):2104-12.
3. Structural requirements of tropomodulin for tropomyosin binding and actin filament capping. Kostyukova AS, etal., Biochemistry. 2005 Mar 29;44(12):4905-10.
4. Identification of a multiprotein "motor" complex binding to water channel aquaporin-2. Noda Y, etal., Biochem Biophys Res Commun. 2005 May 20;330(4):1041-7.
5. Medium perfusion enables engineering of compact and contractile cardiac tissue. Radisic M, etal., Am J Physiol Heart Circ Physiol. 2004 Feb;286(2):H507-16. Epub 2003 Oct 9.

Genomics


Expression


Sequence


Protein Sequences
Protein RefSeqs NP_001029244 (Get FASTA)   NCBI Sequence Viewer  


Additional Information

Database Acc Id Source(s)
NCBI Gene 24851