Vom2r50 (vomeronasal 2 receptor, 50) - Rat Genome Database

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Gene: Vom2r50 (vomeronasal 2 receptor, 50) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Vom2r50
Name: vomeronasal 2 receptor, 50
RGD ID: 1566165
Description: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane; INTERACTS WITH ammonium chloride; pirinixic acid.
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: LOC500312; putative pheromone receptor V2R1-1; similar to putative pheromone receptor V2R1b; vomeronasal 2 receptor 50
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84158,487,009 - 158,509,252 (+)NCBIGRCr8
mRatBN7.24156,801,318 - 156,823,561 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4156,733,772 - 156,823,648 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4163,058,147 - 163,080,349 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04158,841,047 - 158,863,249 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04157,486,438 - 157,508,639 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04156,482,446 - 156,504,818 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4156,482,446 - 156,504,818 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04223,498,145 - 223,520,517 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44160,097,932 - 160,120,175 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera4145,589,970 - 145,612,197 (+)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9292726   PMID:17382427  


Genomics

Variants

.
Variants in Vom2r50
36 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:23
Count of miRNA genes:22
Interacting mature miRNAs:23
Transcripts:ENSRNOT00000039327
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4119428175157578333Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132642577167139601Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4147278504167139601Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4148090542168069246Rat
61446Coreg2Compensatory renal growth QTL 23.5kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)4148423102157580971Rat
1581574Eae20Experimental allergic encephalomyelitis QTL 207.8nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)4153031106158841762Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4155561574182687754Rat
731178Oia7Oil induced arthritis QTL 70.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4156050654157232313Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

renal system
High
Medium
Low
Below cutoff 1

Sequence


RefSeq Acc Id: ENSRNOT00000039327   ⟹   ENSRNOP00000032535
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl4156,482,446 - 156,504,818 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000094979   ⟹   ENSRNOP00000077775
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4156,733,772 - 156,781,504 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000099231   ⟹   ENSRNOP00000094694
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4156,801,037 - 156,823,648 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000103514   ⟹   ENSRNOP00000093556
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4156,801,109 - 156,823,648 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000104435   ⟹   ENSRNOP00000083639
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4156,801,109 - 156,823,648 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000109744   ⟹   ENSRNOP00000079005
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4156,733,772 - 156,823,561 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000112541   ⟹   ENSRNOP00000088056
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4156,733,842 - 156,781,504 (+)Ensembl
RefSeq Acc Id: NM_001099507   ⟹   NP_001092977
RefSeq Status: INFERRED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84158,487,009 - 158,509,252 (+)NCBI
mRatBN7.24156,801,318 - 156,823,561 (+)NCBI
Rnor_6.04156,482,446 - 156,504,818 (+)NCBI
Rnor_5.04223,498,145 - 223,520,517 (+)NCBI
RGSC_v3.44160,097,932 - 160,120,175 (+)RGD
Celera4145,589,970 - 145,612,197 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001092977 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC08415 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000079005.1
  ENSRNOP00000083639
  ENSRNOP00000083639.1
  ENSRNOP00000093556.1
  ENSRNOP00000094694.1
RefSeq Acc Id: NP_001092977   ⟸   NM_001099507
- Peptide Label: precursor
- UniProtKB: A0A8I5ZXC9 (UniProtKB/TrEMBL),   A0A8I5ZMK0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000032535   ⟸   ENSRNOT00000039327
RefSeq Acc Id: ENSRNOP00000088056   ⟸   ENSRNOT00000112541
RefSeq Acc Id: ENSRNOP00000079005   ⟸   ENSRNOT00000109744
RefSeq Acc Id: ENSRNOP00000083639   ⟸   ENSRNOT00000104435
RefSeq Acc Id: ENSRNOP00000094694   ⟸   ENSRNOT00000099231
RefSeq Acc Id: ENSRNOP00000093556   ⟸   ENSRNOT00000103514
RefSeq Acc Id: ENSRNOP00000077775   ⟸   ENSRNOT00000094979
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZV97-F1-model_v2 AlphaFold D3ZV97 1-857 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1566165 AgrOrtholog
BioCyc Gene G2FUF-43120 BioCyc
Ensembl Genes ENSRNOG00000049200 Ensembl
  ENSRNOG00000070578 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000099231.1 UniProtKB/TrEMBL
  ENSRNOT00000103514.1 UniProtKB/TrEMBL
  ENSRNOT00000104435 ENTREZGENE
  ENSRNOT00000104435.1 UniProtKB/TrEMBL
  ENSRNOT00000109744.1 UniProtKB/TrEMBL
Gene3D-CATH 2.10.50.30 UniProtKB/TrEMBL
  3.40.50.2300 UniProtKB/TrEMBL
InterPro ANF_lig-bd_rcpt UniProtKB/TrEMBL
  GPCR_3 UniProtKB/TrEMBL
  GPCR_3_9-Cys_dom UniProtKB/TrEMBL
  GPCR_3_9-Cys_sf UniProtKB/TrEMBL
  GPCR_3_C UniProtKB/TrEMBL
  GPCR_3_Ca_sens_rcpt-rel UniProtKB/TrEMBL
  GPCR_3_CS UniProtKB/TrEMBL
  GPCR_3_vmron_rcpt_2 UniProtKB/TrEMBL
  Peripla_BP_I UniProtKB/TrEMBL
KEGG Report rno:500312 UniProtKB/TrEMBL
NCBI Gene 500312 ENTREZGENE
PANTHER PTHR24061 UniProtKB/TrEMBL
  VOMERONASAL 2, RECEPTOR 19-RELATED UniProtKB/TrEMBL
Pfam 7tm_3 UniProtKB/TrEMBL
  ANF_receptor UniProtKB/TrEMBL
  NCD3G UniProtKB/TrEMBL
PhenoGen Vom2r50 PhenoGen
PRINTS GPCRMGR UniProtKB/TrEMBL
  VOMERONASL2R UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F3_3 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F3_4 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000049200 RatGTEx
  ENSRNOG00000070578 RatGTEx
Superfamily-SCOP SSF53822 UniProtKB/TrEMBL
UniProt A0A8I5ZMK0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZXC9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AJU8_RAT UniProtKB/TrEMBL
  A0A8I6AMS7_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Vom2r50  vomeronasal 2 receptor, 50  Vom2r50  vomeronasal 2 receptor, 50  Data merged from RGD:149736303 737654 PROVISIONAL
2021-08-09 Vom2r50  vomeronasal 2 receptor, 50      Symbol and Name status set to provisional 45752 PROVISIONAL
2008-07-23 Vom2r50  vomeronasal 2 receptor, 50    vomeronasal 2 receptor 50  Symbol and Name updated 1299863 APPROVED
2008-07-17 Vom2r50  vomeronasal 2 receptor 50  LOC500312  similar to putative pheromone receptor V2R1b  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 LOC500312  similar to putative pheromone receptor V2R1b      Symbol and Name status set to provisional 70820 PROVISIONAL