Fbxw17 (F-box and WD-40 domain protein 17) - Rat Genome Database

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Gene: Fbxw17 (F-box and WD-40 domain protein 17) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Fbxw17
Name: F-box and WD-40 domain protein 17
RGD ID: 1566133
Description:
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC361219; RGD1566133; similar to Fbxw17 protein
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81714,511,173 - 14,529,021 (+)NCBIGRCr8
mRatBN7.21714,359,533 - 14,379,386 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1714,359,471 - 14,377,354 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1714,284,860 - 14,302,666 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01715,889,927 - 15,907,733 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01714,211,689 - 14,229,495 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01715,076,773 - 15,094,635 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1715,076,884 - 15,094,805 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01717,134,537 - 17,152,882 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41720,268,228 - 20,286,022 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1714,095,136 - 14,112,930 (+)NCBICelera
Cytogenetic Map17p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Variants

.
Variants in Fbxw17
54 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:267
Count of miRNA genes:166
Interacting mature miRNAs:184
Transcripts:ENSRNOT00000044073
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122871563Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131701463Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17131990913Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)17211514921881669Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat
631499Stl1Serum triglyceride level QTL 13.6blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)17327139827389946Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)17429913021293263Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)17429913021293263Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17429913035837242Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
2293648Bmd31Bone mineral density QTL 314.50.0001femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)17435448727028127Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17435448727028127Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17452803849528038Rat
1581553Pur14Proteinuria QTL 145.30.0001urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)17797996816317111Rat
2303561Bw91Body weight QTL 912body mass (VT:0001259)body weight (CMO:0000012)17886846253868462Rat
1582199Insul5Insulin level QTL 53.40.0119blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)17920136523653323Rat
1582208Kidm32Kidney mass QTL 323.90.0018kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17920136523653323Rat
1582224Epfw4Epididymal fat weight QTL 43.50.0058epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)17920136523653323Rat
1582225Bw67Body weight QTL 676.20.0001body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
1582226Bw64Body weight QTL 644.20.0017body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
1582241Bw70Body weight QTL 704.60.0003body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
1582245Bw73Body weight QTL 734.60.0004body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
1582258Bw76Body weight QTL 764.60.0005body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17999128640540197Rat
1549900Iddm20Insulin dependent diabetes mellitus QTL 203.7pancreas integrity trait (VT:0010560)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)171398677321975515Rat

Markers in Region
RH130600  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21714,377,059 - 14,377,253 (-)MAPPERmRatBN7.2
Rnor_6.01715,076,876 - 15,077,069NCBIRnor6.0
Rnor_5.01717,134,632 - 17,134,825UniSTSRnor5.0
RGSC_v3.41720,285,734 - 20,285,927UniSTSRGSC3.4
Celera1714,112,642 - 14,112,835UniSTS
RH 3.4 Map17156.1UniSTS
Cytogenetic Map17p14UniSTS
RH133232  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21714,368,273 - 14,368,477 (-)MAPPERmRatBN7.2
Rnor_6.01715,085,652 - 15,085,855NCBIRnor6.0
Rnor_5.01717,143,408 - 17,143,611UniSTSRnor5.0
RGSC_v3.41720,276,948 - 20,277,151UniSTSRGSC3.4
Celera1714,103,856 - 14,104,059UniSTS
RH 3.4 Map17145.2UniSTS
Cytogenetic Map17p14UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 1 5 24 17 31 11
Low 2 43 56 41 14 41 8 11 50 18 10 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001082409 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771542 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095860 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095862 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC167744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000044073   ⟹   ENSRNOP00000039789
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1714,359,471 - 14,377,354 (+)Ensembl
Rnor_6.0 Ensembl1715,076,884 - 15,094,805 (-)Ensembl
RefSeq Acc Id: NM_001082409   ⟹   NP_001075878
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81714,511,218 - 14,529,012 (+)NCBI
mRatBN7.21714,359,554 - 14,377,348 (+)NCBI
Rnor_6.01715,076,781 - 15,094,575 (-)NCBI
Rnor_5.01717,134,537 - 17,152,882 (-)NCBI
RGSC_v3.41720,268,228 - 20,286,022 (+)RGD
Celera1714,095,136 - 14,112,930 (+)RGD
Sequence:
RefSeq Acc Id: XM_008771541   ⟹   XP_008769763
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81714,511,173 - 14,529,021 (+)NCBI
mRatBN7.21714,359,533 - 14,379,386 (+)NCBI
Rnor_6.01715,076,773 - 15,094,635 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039095860   ⟹   XP_038951788
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81714,512,318 - 14,529,021 (+)NCBI
mRatBN7.21714,360,655 - 14,378,780 (+)NCBI
RefSeq Acc Id: XM_039095861   ⟹   XP_038951789
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81714,515,700 - 14,529,021 (+)NCBI
mRatBN7.21714,369,943 - 14,379,386 (+)NCBI
RefSeq Acc Id: XM_039095862   ⟹   XP_038951790
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81714,511,173 - 14,527,116 (+)NCBI
mRatBN7.21714,359,533 - 14,375,449 (+)NCBI
RefSeq Acc Id: XM_063276561   ⟹   XP_063132631
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81714,511,196 - 14,527,880 (+)NCBI
RefSeq Acc Id: XM_063276562   ⟹   XP_063132632
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81714,511,196 - 14,527,880 (+)NCBI
RefSeq Acc Id: XM_063276563   ⟹   XP_063132633
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81714,511,190 - 14,529,021 (+)NCBI
RefSeq Acc Id: XM_063276564   ⟹   XP_063132634
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81714,512,319 - 14,529,021 (+)NCBI
RefSeq Acc Id: XM_063276565   ⟹   XP_063132635
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81714,514,319 - 14,529,021 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001075878   ⟸   NM_001082409
- UniProtKB: D3Z9G1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008769763   ⟸   XM_008771541
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000039789   ⟸   ENSRNOT00000044073
RefSeq Acc Id: XP_038951790   ⟸   XM_039095862
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038951788   ⟸   XM_039095860
- Peptide Label: isoform X2
- UniProtKB: D3Z9G1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038951789   ⟸   XM_039095861
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063132633   ⟸   XM_063276563
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063132631   ⟸   XM_063276561
- Peptide Label: isoform X3
- UniProtKB: A6J6U9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132632   ⟸   XM_063276562
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063132634   ⟸   XM_063276564
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063132635   ⟸   XM_063276565
- Peptide Label: isoform X5
Protein Domains
F-box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3Z9G1-F1-model_v2 AlphaFold D3Z9G1 1-488 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1566133 AgrOrtholog
BioCyc Gene G2FUF-10040 BioCyc
Ensembl Genes ENSRNOG00000030027 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000044073 ENTREZGENE
  ENSRNOT00000044073.5 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1280.50 UniProtKB/TrEMBL
  2.130.10.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7099140 IMAGE-MGC_LOAD
InterPro F-box_dom_cyclin-like UniProtKB/TrEMBL
  F-box_dom_like UniProtKB/TrEMBL
  Quinoprotein_ADH-like_supfam UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
MGC_CLONE MGC:187221 IMAGE-MGC_LOAD
NCBI Gene 361219 ENTREZGENE
PANTHER EXPRESSED SEQUENCE C85627-RELATED UniProtKB/TrEMBL
  F-BOX ONLY PROTEIN 3 UniProtKB/TrEMBL
  F-BOX_WD REPEAT-CONTAINING PROTEIN 12 UniProtKB/TrEMBL
  WD REPEAT-CONTAINING PROTEIN 55 UniProtKB/TrEMBL
Pfam F-box-like UniProtKB/TrEMBL
  WD40 UniProtKB/TrEMBL
PhenoGen Fbxw17 PhenoGen
PROSITE FBOX UniProtKB/TrEMBL
RatGTEx ENSRNOG00000030027 RatGTEx
SMART WD40 UniProtKB/TrEMBL
Superfamily-SCOP F-box_dom_Skp2-like UniProtKB/TrEMBL
  Quinoprotein alcohol dehydrogenase-like UniProtKB/TrEMBL
  WD40_like UniProtKB/TrEMBL
UniProt A6J6U9 ENTREZGENE, UniProtKB/TrEMBL
  B3DM87_RAT UniProtKB/TrEMBL
  D3Z9G1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-19 Fbxw17  F-box and WD-40 domain protein 17  RGD1566133  similar to Fbxw17 protein   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1566133  similar to Fbxw17 protein   RGD1566133_predicted  similar to Fbxw17 protein (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1566133_predicted  similar to Fbxw17 protein (predicted)  LOC361219  similar to Fbxw17 protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC361219  similar to Fbxw17 protein      Symbol and Name status set to provisional 70820 PROVISIONAL