Myh15 (myosin, heavy chain 15) - Rat Genome Database

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Gene: Myh15 (myosin, heavy chain 15) Rattus norvegicus
Analyze
Symbol: Myh15
Name: myosin, heavy chain 15
RGD ID: 1565858
Description: Predicted to enable ATP binding activity. Involved in extraocular skeletal muscle development. Predicted to be located in cytosol and intracellular membrane-bounded organelle. Orthologous to human MYH15 (myosin heavy chain 15); PARTICIPATES IN myocarditis pathway; INTERACTS WITH atrazine; bisphenol A; decabromodiphenyl ether.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC303965; myosin-15; RGD1565858; similar to KIAA1000 protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81165,084,666 - 65,226,010 (-)NCBIGRCr8
mRatBN7.21151,621,924 - 51,763,037 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1151,622,413 - 51,762,971 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01154,205,771 - 54,344,662 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1154,204,775 - 54,344,615 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01157,366,049 - 57,505,916 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41152,774,445 - 53,004,691 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1151,233,907 - 51,370,019 (-)NCBICelera
Cytogenetic Map11q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Five common gene variants identify elevated genetic risk for coronary heart disease. Bare LA, etal., Genet Med. 2007 Oct;9(10):682-9.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Polymorphisms associated with both noncardioembolic stroke and coronary heart disease: vienna stroke registry. Luke MM, etal., Cerebrovasc Dis. 2009;28(5):499-504. Epub 2009 Sep 12.
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. Two novel/ancient myosins in mammalian skeletal muscles: MYH14/7b and MYH15 are expressed in extraocular muscles and muscle spindles. Rossi AC, etal., J Physiol. 2010 Jan 15;588(Pt 2):353-64. Epub 2009 Nov 30.

Genomics

Comparative Map Data
Myh15
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81165,084,666 - 65,226,010 (-)NCBIGRCr8
mRatBN7.21151,621,924 - 51,763,037 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1151,622,413 - 51,762,971 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01154,205,771 - 54,344,662 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1154,204,775 - 54,344,615 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01157,366,049 - 57,505,916 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41152,774,445 - 53,004,691 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1151,233,907 - 51,370,019 (-)NCBICelera
Cytogenetic Map11q21NCBI
MYH15
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383108,380,368 - 108,551,072 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3108,380,368 - 108,529,322 (-)EnsemblGRCh38hg38GRCh38
GRCh373108,099,215 - 108,229,443 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363109,581,906 - 109,730,859 (-)NCBINCBI36Build 36hg18NCBI36
Celera3106,495,842 - 106,644,781 (-)NCBICelera
Cytogenetic Map3q13.13NCBI
HuRef3105,472,505 - 105,621,389 (-)NCBIHuRef
CHM1_13108,063,378 - 108,212,288 (-)NCBICHM1_1
T2T-CHM13v2.03111,100,157 - 111,269,214 (-)NCBIT2T-CHM13v2.0
Myh15
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391648,877,763 - 49,019,926 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1648,877,849 - 49,019,467 (+)EnsemblGRCm39 Ensembl
GRCm381649,057,400 - 49,199,563 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1649,057,486 - 49,199,104 (+)EnsemblGRCm38mm10GRCm38
MGSCv371649,057,599 - 49,199,217 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361648,977,112 - 49,116,649 (+)NCBIMGSCv36mm8
Celera1649,407,858 - 49,550,080 (+)NCBICelera
Cytogenetic Map16B5NCBI
cM Map1630.75NCBI
Myh15
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554279,259,811 - 9,400,526 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554279,257,716 - 9,400,526 (-)NCBIChiLan1.0ChiLan1.0
MYH15
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22106,348,464 - 106,486,617 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13106,353,609 - 106,491,386 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03105,498,196 - 105,635,979 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13112,432,416 - 112,586,559 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3112,432,417 - 112,586,559 (-)Ensemblpanpan1.1panPan2
MYH15
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13313,620,132 - 13,758,477 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3313,620,520 - 13,758,862 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3313,721,182 - 13,875,249 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03313,781,218 - 13,935,290 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3313,786,338 - 13,930,754 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13313,650,681 - 13,804,668 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03313,716,572 - 13,870,812 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03314,129,265 - 14,283,448 (-)NCBIUU_Cfam_GSD_1.0
Myh15
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602140,659,871 - 141,189,411 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366451,656,823 - 2,184,210 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYH15
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13150,981,827 - 151,155,145 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113151,008,571 - 151,156,933 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213160,079,574 - 160,195,529 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MYH15
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12272,279,080 - 72,413,029 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2272,278,723 - 72,410,847 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604194,071,081 - 94,207,400 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Myh15
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473140,620,340 - 40,828,320 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Myh15
705 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
1641927Alcrsp10Alcohol response QTL 10alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)11843667453436674Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)112952841860324829Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)114545932375190161Rat

Markers in Region
D11Got139  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21151,710,779 - 51,710,912 (+)MAPPERmRatBN7.2
Rnor_6.01154,293,183 - 54,293,315NCBIRnor6.0
Rnor_5.01157,454,475 - 57,454,607UniSTSRnor5.0
RGSC_v3.41152,946,487 - 52,946,619UniSTSRGSC3.4
Celera1151,323,172 - 51,323,292UniSTS
Cytogenetic Map11q21UniSTS
BE113554  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21151,619,362 - 51,619,513 (+)MAPPERmRatBN7.2
Rnor_6.01154,201,725 - 54,201,875NCBIRnor6.0
Rnor_5.01157,363,017 - 57,363,167UniSTSRnor5.0
RGSC_v3.41152,855,054 - 52,855,204UniSTSRGSC3.4
Celera1151,229,861 - 51,230,011UniSTS
Cytogenetic Map11q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 11 10 7
Below cutoff 1 5 1 4 1 7 7 49 19 19 1 7

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000090307   ⟹   ENSRNOP00000070522
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1151,622,413 - 51,762,971 (-)Ensembl
Rnor_6.0 Ensembl1154,204,775 - 54,344,615 (-)Ensembl
RefSeq Acc Id: XM_039088868   ⟹   XP_038944796
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,084,666 - 65,163,932 (-)NCBI
mRatBN7.21151,621,924 - 51,701,438 (-)NCBI
RefSeq Acc Id: XM_039088869   ⟹   XP_038944797
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,084,675 - 65,226,010 (-)NCBI
mRatBN7.21151,621,924 - 51,763,037 (-)NCBI
Protein Sequences
Protein RefSeqs XP_038944796 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944797 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000070522
  ENSRNOP00000070522.2
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000070522   ⟸   ENSRNOT00000090307
RefSeq Acc Id: XP_038944797   ⟸   XM_039088869
- Peptide Label: isoform X2
- UniProtKB: A0A0G2JY53 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038944796   ⟸   XM_039088868
- Peptide Label: isoform X1
Protein Domains
Myosin motor   Myosin N-terminal SH3-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JY53-F1-model_v2 AlphaFold A0A0G2JY53 1-1915 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565858 AgrOrtholog
BioCyc Gene G2FUF-21427 BioCyc
Ensembl Genes ENSRNOG00000061038 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000090307.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.820 UniProtKB/TrEMBL
  1.20.5.340 UniProtKB/TrEMBL
  1.20.5.370 UniProtKB/TrEMBL
  1.20.5.4820 UniProtKB/TrEMBL
  1.20.58.530 UniProtKB/TrEMBL
  2.30.30.360 UniProtKB/TrEMBL
  3.40.850.10 UniProtKB/TrEMBL
  Myosin VI head, motor domain, U50 subdomain UniProtKB/TrEMBL
InterPro IQ_motif_EF-hand-BS UniProtKB/TrEMBL
  Kinesin_motor_dom_sf UniProtKB/TrEMBL
  Myosin_head_motor_dom UniProtKB/TrEMBL
  Myosin_N UniProtKB/TrEMBL
  Myosin_S1_N UniProtKB/TrEMBL
  Myosin_tail UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  XRCC4-like_C UniProtKB/TrEMBL
NCBI Gene 303965 ENTREZGENE
PANTHER MYOSIN HEAVY CHAIN, NON-MUSCLE UniProtKB/TrEMBL
  MYOSIN-15 UniProtKB/TrEMBL
Pfam Myosin_head UniProtKB/TrEMBL
  Myosin_N UniProtKB/TrEMBL
  Myosin_tail_1 UniProtKB/TrEMBL
PharmGKB MYH15 RGD
PhenoGen Myh15 PhenoGen
PRINTS MYOSINHEAVY UniProtKB/TrEMBL
PROSITE MYOSIN_MOTOR UniProtKB/TrEMBL
  PS50096 UniProtKB/TrEMBL
  SH3_LIKE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000061038 RatGTEx
SMART MYSc UniProtKB/TrEMBL
Superfamily-SCOP Myosin rod fragments UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A0G2JY53 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-12-07 Myh15  myosin, heavy chain 15  RGD1565858  similar to KIAA1000 protein   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1565858  similar to KIAA1000 protein   RGD1565858_predicted  similar to KIAA1000 protein (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1565858_predicted  similar to KIAA1000 protein (predicted)  LOC303965  similar to KIAA1000 protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC303965  similar to KIAA1000 protein      Symbol and Name status set to provisional 70820 PROVISIONAL