Tasl (TLR adaptor interacting with endolysosomal SLC15A4) - Rat Genome Database

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Gene: Tasl (TLR adaptor interacting with endolysosomal SLC15A4) Rattus norvegicus
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Symbol: Tasl
Name: TLR adaptor interacting with endolysosomal SLC15A4
RGD ID: 1565785
Description: Predicted to be involved in positive regulation of toll-like receptor 7 signaling pathway; positive regulation of toll-like receptor 8 signaling pathway; and regulation of lysosomal lumen pH. Predicted to be located in endolysosome membrane and nucleoplasm. Orthologous to human TASL (TLR adaptor interacting with endolysosomal SLC15A4); INTERACTS WITH 17beta-estradiol; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hypothetical protein LOC501570; LOC501570; RGD1565785; similar to chromosome X open reading frame 21; TLR adapter interacting with SLC15A4 on the lysosome; uncharacterized protein CXorf21 homolog; uncharacterized protein LOC501570
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X54,354,755 - 54,373,930 (+)NCBIGRCr8
mRatBN7.2X50,403,962 - 50,423,141 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX50,361,248 - 50,423,269 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX51,733,739 - 51,752,906 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X55,234,110 - 55,253,281 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X52,865,125 - 52,884,294 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X54,390,733 - 54,409,466 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX54,390,733 - 54,409,466 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X54,590,577 - 54,609,310 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X72,641,314 - 72,660,592 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX50,943,855 - 50,963,014 (+)NCBICelera
Cytogenetic MapXq21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:31001245  


Genomics

Comparative Map Data
Tasl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X54,354,755 - 54,373,930 (+)NCBIGRCr8
mRatBN7.2X50,403,962 - 50,423,141 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX50,361,248 - 50,423,269 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX51,733,739 - 51,752,906 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X55,234,110 - 55,253,281 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X52,865,125 - 52,884,294 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X54,390,733 - 54,409,466 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX54,390,733 - 54,409,466 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X54,590,577 - 54,609,310 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X72,641,314 - 72,660,592 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX50,943,855 - 50,963,014 (+)NCBICelera
Cytogenetic MapXq21NCBI
TASL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X30,558,809 - 30,577,766 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX30,558,809 - 30,577,766 (-)EnsemblGRCh38hg38GRCh38
GRCh37X30,576,926 - 30,595,883 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X30,486,862 - 30,505,835 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X30,336,597 - 30,355,571NCBI
CeleraX34,698,462 - 34,717,597 (-)NCBICelera
Cytogenetic MapXp21.2NCBI
HuRefX28,314,203 - 28,333,300 (-)NCBIHuRef
CHM1_1X30,607,829 - 30,626,921 (-)NCBICHM1_1
T2T-CHM13v2.0X30,150,830 - 30,169,806 (-)NCBIT2T-CHM13v2.0
Tasl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X84,820,445 - 84,935,105 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX84,913,960 - 84,935,105 (+)EnsemblGRCm39 Ensembl
GRCm38X85,776,968 - 85,891,499 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX85,870,354 - 85,891,499 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X83,115,612 - 83,136,838 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X82,122,992 - 82,144,218 (+)NCBIMGSCv36mm8
CeleraX77,064,940 - 77,086,117 (+)NCBICelera
Cytogenetic MapXC1NCBI
cM MapX39.39NCBI
Tasl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955531267,216 - 293,127 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955531207,614 - 293,127 (+)NCBIChiLan1.0ChiLan1.0
TASL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X32,351,736 - 32,372,522 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X32,355,112 - 32,375,901 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X23,159,321 - 23,178,192 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X30,716,157 - 30,735,059 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX30,716,617 - 30,717,522 (-)Ensemblpanpan1.1panPan2
TASL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X25,664,361 - 25,679,044 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX30,639,199 - 30,653,660 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X25,695,592 - 25,710,287 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1X25,741,501 - 25,755,942 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X25,732,975 - 25,747,432 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X25,829,165 - 25,843,624 (-)NCBIUU_Cfam_GSD_1.0
Tasl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X18,534,520 - 18,554,443 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365536,628,131 - 6,629,027 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365536,628,131 - 6,629,027 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TASL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX26,365,027 - 26,384,760 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X26,363,808 - 26,384,933 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X28,635,141 - 28,651,261 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TASL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X28,953,805 - 28,973,055 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX28,954,266 - 28,955,171 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605630,933,802 - 30,953,001 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tasl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476225,430,926 - 25,448,114 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476225,427,519 - 25,448,180 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tasl
35 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:216
Count of miRNA genes:151
Interacting mature miRNAs:174
Transcripts:ENSRNOT00000004977
Prediction methods:Microtar, Miranda, Pita, Pita,Microtar, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
71116Niddm16Non-insulin dependent diabetes mellitus QTL 167.81blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X1529780260297802Rat

Markers in Region
DXGot154  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X50,407,965 - 50,408,262 (+)MAPPERmRatBN7.2
Rnor_6.0X54,394,782 - 54,395,078NCBIRnor6.0
Rnor_5.0X54,594,626 - 54,594,922UniSTSRnor5.0
RGSC_v3.4X72,645,579 - 72,645,875UniSTSRGSC3.4
CeleraX50,947,903 - 50,948,199UniSTS
Cytogenetic MapXq22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 10
Low 3 7 50 36 9 36 12 13 12 11
Below cutoff 32 7 5 5 8 10 50 22 27 8

Sequence


RefSeq Acc Id: ENSRNOT00000004977   ⟹   ENSRNOP00000004977
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX50,403,845 - 50,423,269 (+)Ensembl
Rnor_6.0 EnsemblX54,390,733 - 54,409,466 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000119697   ⟹   ENSRNOP00000090482
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX50,361,248 - 50,423,269 (+)Ensembl
RefSeq Acc Id: NM_001109318   ⟹   NP_001102788
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X54,354,755 - 54,373,930 (+)NCBI
mRatBN7.2X50,403,962 - 50,423,141 (+)NCBI
Rnor_6.0X54,390,733 - 54,409,466 (+)NCBI
Rnor_5.0X54,590,577 - 54,609,310 (+)NCBI
RGSC_v3.4X72,641,314 - 72,660,592 (+)RGD
CeleraX50,943,855 - 50,963,014 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001102788 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL96049 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000004977
  ENSRNOP00000004977.3
  ENSRNOP00000090482.1
RefSeq Acc Id: NP_001102788   ⟸   NM_001109318
- UniProtKB: D3ZRK2 (UniProtKB/TrEMBL),   A6IPW4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000004977   ⟸   ENSRNOT00000004977
RefSeq Acc Id: ENSRNOP00000090482   ⟸   ENSRNOT00000119697

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZRK2-F1-model_v2 AlphaFold D3ZRK2 1-298 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565785 AgrOrtholog
BioCyc Gene G2FUF-2343 BioCyc
Ensembl Genes ENSRNOG00000003748 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000004977 ENTREZGENE
  ENSRNOT00000004977.5 UniProtKB/TrEMBL
  ENSRNOT00000119697.1 UniProtKB/TrEMBL
InterPro DUF4569 UniProtKB/TrEMBL
KEGG Report rno:501570 UniProtKB/TrEMBL
NCBI Gene 501570 ENTREZGENE
PANTHER PTHR14889 UniProtKB/TrEMBL
  TLR ADAPTER INTERACTING WITH SLC15A4 ON THE LYSOSOME UniProtKB/TrEMBL
Pfam DUF4569 UniProtKB/TrEMBL
PhenoGen Tasl PhenoGen
RatGTEx ENSRNOG00000003748 RatGTEx
UniProt A6IPW4 ENTREZGENE, UniProtKB/TrEMBL
  D3ZRK2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-08-13 Tasl  TLR adaptor interacting with endolysosomal SLC15A4  RGD1565785  similar to chromosome X open reading frame 21  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1565785  similar to chromosome X open reading frame 21   RGD1565785_predicted  similar to chromosome X open reading frame 21 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1565785_predicted  similar to chromosome X open reading frame 21 (predicted)  LOC501570  similar to chromosome X open reading frame 21  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC501570  similar to chromosome X open reading frame 21      Symbol and Name status set to provisional 70820 PROVISIONAL