Zfp136 (zinc finger protein 136) - Rat Genome Database

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Gene: Zfp136 (zinc finger protein 136) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Zfp136
Name: zinc finger protein 136
RGD ID: 1565635
Description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZNF14 (zinc finger protein 14); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; bromobenzene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC291802; RGD1565635; similar to zinc finger protein 124; zinc finger protein 709
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr818882,417 - 891,029 (+)NCBIGRCr8
mRatBN7.218609,472 - 618,190 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl18474,716 - 615,539 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.018746,647 - 755,267 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl18750,776 - 752,616 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.018790,736 - 799,259 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.418872,229 - 877,952 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera18506,765 - 515,385 (+)NCBICelera
Cytogenetic Map18p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IBA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Zfp136
56 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:11
Count of miRNA genes:11
Interacting mature miRNAs:11
Transcripts:ENSRNOT00000021981
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552968Pigfal19Plasma insulin-like growth factor 1 level QTL 1911.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)18125758124Rat
9590248Scort10Serum corticosterone level QTL 1019.710.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)18125758124Rat
2312598Bp340Blood pressure QTL 3400.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18130558703Rat
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18134291613Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18134291613Rat
61388Bp2Blood pressure QTL 23.23arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)18135374722Rat
9589153Insul31Insulin level QTL 317.150.05blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)18142547119Rat

Markers in Region
RH141856  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.218617,711 - 617,931 (+)MAPPERmRatBN7.2
Rnor_6.018754,789 - 755,008NCBIRnor6.0
Rnor_5.018798,781 - 799,000UniSTSRnor5.0
RGSC_v3.418880,018 - 880,237UniSTSRGSC3.4
Celera18514,907 - 515,126UniSTS
RH 3.4 Map1835.1UniSTS
Cytogenetic Map18p13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 6 12 45 1 14 5
Low 2 40 50 40 7 40 8 9 29 34 27 6 8
Below cutoff 1 3 1 1 1 1

Sequence


RefSeq Acc Id: ENSRNOT00000021981   ⟹   ENSRNOP00000021981
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl18474,716 - 615,539 (+)Ensembl
Rnor_6.0 Ensembl18750,776 - 752,616 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000104372   ⟹   ENSRNOP00000080192
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl18474,716 - 615,539 (+)Ensembl
RefSeq Acc Id: NM_001408853   ⟹   NP_001395782
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr818882,747 - 891,025 (+)NCBI
mRatBN7.218609,908 - 618,186 (+)NCBI
RefSeq Acc Id: XM_006254395   ⟹   XP_006254457
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr818882,417 - 891,029 (+)NCBI
mRatBN7.218609,476 - 618,190 (+)NCBI
Rnor_6.018746,647 - 755,267 (+)NCBI
Rnor_5.018790,736 - 799,259 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063277275   ⟹   XP_063133345
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr818882,419 - 891,029 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001395782 (Get FASTA)   NCBI Sequence Viewer  
  XP_006254457 (Get FASTA)   NCBI Sequence Viewer  
  XP_063133345 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL86657 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000021981.6
  ENSRNOP00000080192.1
RefSeq Acc Id: XP_006254457   ⟸   XM_006254395
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000021981   ⟸   ENSRNOT00000021981
RefSeq Acc Id: ENSRNOP00000080192   ⟸   ENSRNOT00000104372
RefSeq Acc Id: NP_001395782   ⟸   NM_001408853
RefSeq Acc Id: XP_063133345   ⟸   XM_063277275
- Peptide Label: isoform X2
Protein Domains
C2H2-type   KRAB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M4E4-F1-model_v2 AlphaFold F1M4E4 1-554 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565635 AgrOrtholog
BioCyc Gene G2FUF-8432 BioCyc
Ensembl Genes ENSRNOG00000016417 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000021981.6 UniProtKB/TrEMBL
  ENSRNOT00000104372.1 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.140 UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/TrEMBL
InterPro KRAB_dom_sf UniProtKB/TrEMBL
  Krueppel-associated_box UniProtKB/TrEMBL
  Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
NCBI Gene 291802 ENTREZGENE
PANTHER KRAB AND ZINC FINGER DOMAIN-CONTAINING UniProtKB/TrEMBL
  ZINC FINGER AND BTB DOMAIN-CONTAINING UniProtKB/TrEMBL
  ZINC FINGER PROTEIN 709 UniProtKB/TrEMBL
  ZINC FINGER PROTEIN 709 UniProtKB/TrEMBL
Pfam KRAB UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
PhenoGen Zfp136 PhenoGen
PROSITE KRAB UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016417 RatGTEx
SMART KRAB UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF109640 UniProtKB/TrEMBL
  SSF57667 UniProtKB/TrEMBL
UniProt A0A8I5ZP71_RAT UniProtKB/TrEMBL
  F1M4E4_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-02 Zfp136  zinc finger protein 136  RGD1565635  similar to zinc finger protein 124  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1565635  similar to zinc finger protein 124   RGD1565635_predicted  similar to zinc finger protein 124 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1565635_predicted  similar to zinc finger protein 124 (predicted)  LOC291802  similar to zinc finger protein 124  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC291802  similar to zinc finger protein 124      Symbol and Name status set to provisional 70820 PROVISIONAL