Rex2l3 (reduced expression 2 like 3) - Rat Genome Database

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Gene: Rex2l3 (reduced expression 2 like 3) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Rex2l3 (Ensembl: RGD1565622)
Name: reduced expression 2 like 3 (Ensembl:RGD1565622)
RGD ID: 1565622
Description: Predicted to be located in nucleus. Orthologous to human ZNF300 (zinc finger protein 300) and ZNF320 (zinc finger protein 320); INTERACTS WITH paracetamol; tetrachloromethane; trichloroethene.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC500582; reduced expression 2 like 2; Rex2l2; RGD1565622; RGD1565622; zinc finger protein 2 homolog; zinc finger protein 501; zinc finger protein 501-like
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85163,480,797 - 163,545,887 (-)NCBIGRCr8
mRatBN7.25158,197,614 - 158,206,543 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5158,198,851 - 158,228,089 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.05164,419,299 - 164,425,034 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5164,419,265 - 164,502,469 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05168,089,665 - 168,093,805 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45164,845,832 - 164,874,760 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera5156,482,520 - 156,511,770 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline

Genomics

Variants

.
Variants in Rex2l3
82 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:57
Count of miRNA genes:49
Interacting mature miRNAs:53
Transcripts:ENSRNOT00000051887
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5143608201161165651Rat
631263Cm24Cardiac mass QTL 243.5heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)5143799107158428037Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5144377876161317411Rat
1298090Bp155Blood pressure QTL 1553.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)5151006154161165494Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5151113452164465185Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5151113452166875058Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5154828214166875058Rat

Markers in Region
RH138971  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.05168,088,499 - 168,088,693NCBIRnor5.0
Rnor_5.05168,162,152 - 168,162,350NCBIRnor5.0
Rnor_5.05168,089,718 - 168,089,912NCBIRnor5.0
RGSC_v3.45164,694,646 - 164,694,839UniSTSRGSC3.4
RGSC_v3.45164,844,300 - 164,844,497UniSTSRGSC3.4
Celera5156,481,503 - 156,481,700UniSTS
Celera5156,367,038 - 156,367,231UniSTS
Cytogenetic Map5q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 9 16 1 11 8
Low 3 43 48 41 3 41 8 10 74 34 30 3 8
Below cutoff 1

Sequence


RefSeq Acc Id: ENSRNOT00000051887   ⟹   ENSRNOP00000049810
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5158,083,294 - 158,120,229 (-)Ensembl
Rnor_6.0 Ensembl5164,419,265 - 164,502,469 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000112809   ⟹   ENSRNOP00000095352
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5158,198,851 - 158,228,089 (-)Ensembl
RefSeq Acc Id: XM_008764313   ⟹   XP_008762535
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85163,480,797 - 163,545,887 (-)NCBI
mRatBN7.25158,197,614 - 158,206,543 (-)NCBI
Rnor_6.05164,419,299 - 164,425,034 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_008762535 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL81074 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000095352
  ENSRNOP00000095352.1
RefSeq Acc Id: XP_008762535   ⟸   XM_008764313
- UniProtKB: A0A8I6AJH0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000049810   ⟸   ENSRNOT00000051887
RefSeq Acc Id: ENSRNOP00000095352   ⟸   ENSRNOT00000112809
Protein Domains
C2H2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LZG2-F1-model_v2 AlphaFold F1LZG2 1-510 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565622 AgrOrtholog
BioCyc Gene G2FUF-39208 BioCyc
Ensembl Genes ENSRNOG00000033792 Ensembl
  ENSRNOG00000062859 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000112809.1 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
InterPro Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
NCBI Gene 500582 ENTREZGENE
PANTHER ZINC FINGER AND SCAN DOMAIN-CONTAINING UniProtKB/TrEMBL
  ZNF1 UniProtKB/TrEMBL
Pfam zf-C2H2 UniProtKB/TrEMBL
PhenoGen Rex2l3 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000033792 RatGTEx
  ENSRNOG00000062859 RatGTEx
SMART ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/TrEMBL
UniProt A0A8I6AJH0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-01-22 Rex2l3  reduced expression 2 like 3  Rex2l3a  reduced expression 2 like 3a  Name and Symbol changed 629549 APPROVED
2024-01-22 Rex2l3a  reduced expression 2 like 3a  Rex2l2  reduced expression 2 like 2  Name and Symbol changed 629549 APPROVED
2023-09-19 Rex2l2  reduced expression 2 like 2  RGD1565622  RGD1565622  Symbol and Name Changed 1299863 APPROVED
2022-06-02 RGD1565622  RGD1565622  RGD1565622  RGD1565622  Data merged from RGD:149736251 737654 PROVISIONAL
2021-08-09 RGD1565622  RGD1565622      Symbol and Name status set to provisional 45752 PROVISIONAL
2008-04-30 RGD1565622  RGD1565622   RGD1565622_predicted  RGD1565622 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1565622_predicted  RGD1565622 (predicted)  LOC500582  LOC500582  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC500582  LOC500582      Symbol and Name status set to provisional 70820 PROVISIONAL