Cd36l1 (CD36 molecule like 1) - Rat Genome Database

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Gene: Cd36l1 (CD36 molecule like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Cd36l1 (Ensembl: RGD1565355)
Name: CD36 molecule like 1 (Ensembl:similar to fatty acid translocase/CD36)
RGD ID: 1565355
Description: Enables scavenger receptor activity; thrombospondin receptor activity; and transforming growth factor beta binding activity. Involved in several processes, including amyloid-beta clearance by cellular catabolic process; energy homeostasis; and response to fatty acid. Located in brush border membrane and cell surface. Human ortholog(s) of this gene implicated in several diseases, including blood platelet disease (multiple); hemolytic-uremic syndrome; osteoarthritis; pulmonary tuberculosis; and type 2 diabetes mellitus. Orthologous to human CD36 (CD36 molecule (CD36 blood group)); PARTICIPATES IN cell-extracellular matrix signaling pathway; eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; malaria pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Cd36 antigen-like; cell surface protein CD36; FAT; fatty acid translocase/CD36; fatty acid transporter; LOC100910000; LOC103690020; LOC499985; platelet glycoprotein 4-like; RGD1565355; similar to fatty acid translocase/CD36
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8418,316,806 - 18,357,863 (+)NCBIGRCr8
mRatBN7.2417,424,749 - 17,465,808 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl417,354,466 - 17,513,903 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx422,555,338 - 22,582,974 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0418,370,915 - 18,398,609 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0416,753,279 - 16,780,921 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0414,071,705 - 14,112,330 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl414,001,761 - 14,249,749 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0414,181,115 - 14,221,373 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4413,576,484 - 13,604,065 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera412,963,120 - 12,990,602 (+)NCBICelera
Cytogenetic Map4q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. FAT/CD36: a major regulator of neuronal fatty acid sensing and energy homeostasis in rats and mice. Le Foll C, etal., Diabetes. 2013 Aug;62(8):2709-16. doi: 10.2337/db12-1689. Epub 2013 Apr 4.
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. CD36 is indispensable for thermogenesis under conditions of fasting and cold stress. Putri M, etal., Biochem Biophys Res Commun. 2015 Feb 20;457(4):520-5. doi: 10.1016/j.bbrc.2014.12.124. Epub 2015 Jan 13.
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. IL-4-induced selective clearance of oligomeric beta-amyloid peptide(1-42) by rat primary type 2 microglia. Shimizu E, etal., J Immunol. 2008 Nov 1;181(9):6503-13.
9. Luminal lipid regulates CD36 levels and downstream signaling to stimulate chylomicron synthesis. Tran TT, etal., J Biol Chem. 2011 Jul 15;286(28):25201-10. doi: 10.1074/jbc.M111.233551. Epub 2011 May 24.
10. Activation of rat alveolar macrophage-derived latent transforming growth factor beta-1 by plasmin requires interaction with thrombospondin-1 and its cell surface receptor, CD36. Yehualaeshet T, etal., Am J Pathol. 1999 Sep;155(3):841-51.
Additional References at PubMed
PMID:7688729   PMID:9315741   PMID:10409247   PMID:12477932  


Genomics

Variants

.
Variants in Cd36l1
530 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:87
Count of miRNA genes:67
Interacting mature miRNAs:81
Transcripts:ENSRNOT00000067543
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61351Bp33Blood pressure QTL 330.0018arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4127716890Rat
61408Scl23Serum cholesterol level QTL 230.0005blood HDL phospholipid amount (VT:0010504)serum high density lipoprotein phospholipid level (CMO:0001567)4127716890Rat
724557Plsm1Polydactyly-luxate syndrome (PLS) morphotypes QTL 10.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)4127716890Rat
1641905Colcr1Colorectal carcinoma resistance QTL 14.30.0003intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)4129494328Rat
61333Gluco16Glucose level QTL 164.30.00001adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)4130372989Rat
9589097Slep11Serum leptin concentration QTL 115.090.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)4131934116Rat
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4131934116Rat
9589046Scfw2Subcutaneous fat weight QTL 25.540.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)4131934116Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4131934116Rat
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4132584199Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4133250345Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4133250345Rat
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4139505420Rat
634323Hc2Hypercalciuria QTL 22.15urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)421079645210796Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
1358201Gluco12Glucose level QTL121.6adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake (CMO:0000870)4521839229593287Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4994088544463908Rat
1300141Bp178Blood pressure QTL 178arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)41002490139524530Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41008408955084089Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41008408955084089Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41008408955084089Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41008408955084089Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41467806559678065Rat

Markers in Region
RH132455  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 31 25 14 15 14 8 9 2 10 8
Low 3 12 31 26 4 26 2 9 35 38 1
Below cutoff 1 1 1 61 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000008319   ⟹   ENSRNOP00000008319
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl417,432,132 - 17,462,526 (+)Ensembl
Rnor_6.0 Ensembl414,151,414 - 14,188,215 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000061687   ⟹   ENSRNOP00000058398
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl417,487,573 - 17,513,903 (+)Ensembl
Rnor_6.0 Ensembl414,151,343 - 14,191,498 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000066224   ⟹   ENSRNOP00000061162
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl414,071,507 - 14,249,749 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000067543   ⟹   ENSRNOP00000063867
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl417,432,156 - 17,513,903 (+)Ensembl
Rnor_6.0 Ensembl414,213,587 - 14,237,989 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000075878   ⟹   ENSRNOP00000068345
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl414,039,977 - 14,241,272 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000075962   ⟹   ENSRNOP00000068147
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl417,354,466 - 17,406,805 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000075974
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl414,001,866 - 14,071,161 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000076519   ⟹   ENSRNOP00000067925
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl414,001,761 - 14,167,505 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000076573   ⟹   ENSRNOP00000067980
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl417,354,466 - 17,513,903 (+)Ensembl
Rnor_6.0 Ensembl414,151,374 - 14,246,665 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000076946   ⟹   ENSRNOP00000068300
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl417,354,466 - 17,406,801 (+)Ensembl
Rnor_6.0 Ensembl414,212,925 - 14,241,272 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000077219   ⟹   ENSRNOP00000074542
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl417,432,132 - 17,462,882 (+)Ensembl
Rnor_6.0 Ensembl414,151,374 - 14,246,665 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000077505   ⟹   ENSRNOP00000070601
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl414,070,553 - 14,249,718 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000091249   ⟹   ENSRNOP00000069273
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl417,354,525 - 17,410,081 (+)Ensembl
Rnor_6.0 Ensembl414,039,977 - 14,241,269 (+)Ensembl
RefSeq Acc Id: NM_001109218   ⟹   NP_001102688
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8418,316,806 - 18,357,863 (+)NCBI
mRatBN7.2417,432,132 - 17,464,888 (+)NCBI
Rnor_6.0414,071,705 - 14,112,330 (+)NCBI
Rnor_5.0414,181,115 - 14,221,373 (+)NCBI
RGSC_v3.4413,576,484 - 13,604,065 (+)RGD
Celera412,963,120 - 12,990,602 (+)RGD
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001102688   ⟸   NM_001109218
- UniProtKB: A0A0G2K8B4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074542   ⟸   ENSRNOT00000077219
RefSeq Acc Id: ENSRNOP00000008319   ⟸   ENSRNOT00000008319
RefSeq Acc Id: ENSRNOP00000068345   ⟸   ENSRNOT00000075878
RefSeq Acc Id: ENSRNOP00000058398   ⟸   ENSRNOT00000061687
RefSeq Acc Id: ENSRNOP00000070601   ⟸   ENSRNOT00000077505
RefSeq Acc Id: ENSRNOP00000061162   ⟸   ENSRNOT00000066224
RefSeq Acc Id: ENSRNOP00000069273   ⟸   ENSRNOT00000091249
RefSeq Acc Id: ENSRNOP00000067980   ⟸   ENSRNOT00000076573
RefSeq Acc Id: ENSRNOP00000067925   ⟸   ENSRNOT00000076519
RefSeq Acc Id: ENSRNOP00000063867   ⟸   ENSRNOT00000067543
RefSeq Acc Id: ENSRNOP00000068300   ⟸   ENSRNOT00000076946
RefSeq Acc Id: ENSRNOP00000068147   ⟸   ENSRNOT00000075962

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F7F5B5-F1-model_v2 AlphaFold F7F5B5 1-472 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565355 AgrOrtholog
BioCyc Gene G2FUF-45915 BioCyc
Ensembl Genes ENSRNOG00000005906 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000008319.9 UniProtKB/TrEMBL
  ENSRNOT00000061687.6 UniProtKB/TrEMBL
  ENSRNOT00000067543.4 UniProtKB/TrEMBL
  ENSRNOT00000076946.3 UniProtKB/TrEMBL
  ENSRNOT00000077219 ENTREZGENE
  ENSRNOT00000077219.2 UniProtKB/TrEMBL
  ENSRNOT00000091249.2 UniProtKB/TrEMBL
InterPro CD36 UniProtKB/TrEMBL
  CD36_antigen UniProtKB/TrEMBL
KEGG Report rno:499985 UniProtKB/TrEMBL
NCBI Gene 499985 ENTREZGENE
PANTHER CD36 UniProtKB/TrEMBL
  PTHR11923:SF12 UniProtKB/TrEMBL
Pfam CD36 UniProtKB/TrEMBL
PhenoGen Cd36l1 PhenoGen
PRINTS CD36ANTIGEN UniProtKB/TrEMBL
  CD36FAMILY UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005906 RatGTEx
  ENSRNOG00065018245 RatGTEx
UniProt A0A096MJX7_RAT UniProtKB/TrEMBL
  A0A0G2JUY0_RAT UniProtKB/TrEMBL
  A0A0G2K8B4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8J8YQ28_RAT UniProtKB/TrEMBL
  F7F5B5_RAT UniProtKB/TrEMBL
  F7F6C5_RAT UniProtKB/TrEMBL
  Q5BKE5_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Cd36l1  CD36 molecule like 1  RGD1565355  similar to fatty acid translocase/CD36  Symbol and Name Changed 1299863 APPROVED
2021-03-09 RGD1565355  similar to fatty acid translocase/CD36  LOC103690020  platelet glycoprotein 4-like  Data merged from RGD:9322705 737654 PROVISIONAL
2015-07-29 RGD1565355  similar to fatty acid translocase/CD36  LOC100910000  platelet glycoprotein 4-like  Data merged from RGD:6500760 737654 PROVISIONAL
2014-08-25 LOC103690020  platelet glycoprotein 4-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2012-07-05 LOC100910000  platelet glycoprotein 4-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 RGD1565355  similar to fatty acid translocase/CD36   RGD1565355_predicted  similar to fatty acid translocase/CD36 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1565355_predicted  similar to fatty acid translocase/CD36 (predicted)  LOC499985  similar to fatty acid translocase/CD36  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC499985  similar to fatty acid translocase/CD36      Symbol and Name status set to provisional 70820 PROVISIONAL