Slc7a3l1 (solute carrier family 7 member 3 like 1) - Rat Genome Database

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Gene: Slc7a3l1 (solute carrier family 7 member 3 like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Slc7a3l1 (Ensembl: LOC292543)
Name: solute carrier family 7 member 3 like 1 (Ensembl:similar to solute carrier family 7 (cationic amino acid transporter, y+ system), member 3)
RGD ID: 1565097
Description: Predicted to enable L-lysine transmembrane transporter activity and L-ornithine transmembrane transporter activity. Predicted to be involved in L-arginine import across plasma membrane and L-ornithine transmembrane transport. Predicted to be active in plasma membrane.
Type: protein-coding
RefSeq Status: PREDICTED
Previously known as: hypothetical protein LOC292543; LOC292543; MGC116223; similar to solute carrier family 7 (cationic amino acid transporter, y+ system), member 3; uncharacterized protein LOC292543
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8174,968,538 - 74,982,432 (+)NCBIGRCr8
mRatBN7.2166,053,135 - 66,067,042 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl166,053,268 - 66,067,039 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx171,500,946 - 71,514,663 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0179,923,920 - 79,937,620 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0173,257,190 - 73,270,886 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0164,618,347 - 64,632,132 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl164,618,506 - 64,632,131 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0163,610,393 - 63,624,069 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4164,378,810 - 64,392,101 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera163,774,569 - 63,788,083 (+)NCBICelera
Cytogenetic Map1q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Genomics

Variants

.
Variants in Slc7a3l1
103 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
1357400Bw62Body weight QTL624.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)12234064767340647Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)12887978078430678Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)13344984878449848Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)13344984878449848Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)13483685879836858Rat
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)13523959878430678Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)13523959878430678Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14580314078430678Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14936146582174945Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)15389511782174945Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15389511782174945Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 2 9 1 9 1 8 10 10
Below cutoff 2 27 24 16 10 16 8 9 9 10 26 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000091279   ⟹   ENSRNOP00000071240
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl166,053,268 - 66,067,039 (+)Ensembl
Rnor_6.0 Ensembl164,618,506 - 64,632,131 (+)Ensembl
RefSeq Acc Id: NM_001025639   ⟹   NP_001020810
RefSeq Status: PREDICTED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8174,968,721 - 74,982,432 (+)NCBI
mRatBN7.2166,053,318 - 66,067,042 (+)NCBI
Rnor_6.0164,618,506 - 64,632,132 (+)NCBI
Rnor_5.0163,610,393 - 63,624,069 (+)NCBI
RGSC_v3.4164,378,810 - 64,392,101 (+)RGD
Celera163,774,569 - 63,788,083 (+)RGD
Sequence:
RefSeq Acc Id: XM_006228022   ⟹   XP_006228084
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8174,968,538 - 74,982,285 (+)NCBI
mRatBN7.2166,053,135 - 66,066,863 (+)NCBI
Rnor_6.0164,618,427 - 64,631,678 (+)NCBI
Rnor_5.0163,610,393 - 63,624,069 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001020810 (Get FASTA)   NCBI Sequence Viewer  
  XP_006228084 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH98062 (Get FASTA)   NCBI Sequence Viewer  
  EDL84953 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000071240
  ENSRNOP00000071240.2
Reference Protein Sequences
RefSeq Acc Id: NP_001020810   ⟸   NM_001025639
- UniProtKB: Q4V799 (UniProtKB/TrEMBL),   D3ZBE1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006228084   ⟸   XM_006228022
- Peptide Label: isoform X1
- UniProtKB: D3ZBE1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000071240   ⟸   ENSRNOT00000091279
Protein Domains
Cationic amino acid transporter C-terminal

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565097 AgrOrtholog
BioCyc Gene G2FUF-60990 BioCyc
Ensembl Genes ENSRNOG00000054438 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000091279 ENTREZGENE
  ENSRNOT00000091279.2 UniProtKB/TrEMBL
Gene3D-CATH Amino acid/polyamine transporter I UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7458331 IMAGE-MGC_LOAD
InterPro AA/rel_permease1 UniProtKB/TrEMBL
  Cat_AA_permease UniProtKB/TrEMBL
  CAT_C UniProtKB/TrEMBL
KEGG Report rno:292543 UniProtKB/TrEMBL
MGC_CLONE MGC:116223 IMAGE-MGC_LOAD
NCBI Gene 292543 ENTREZGENE
PANTHER EXPRESSED SEQUENCE AU018091 UniProtKB/TrEMBL
  INNER MEMBRANE TRANSPORTER YGJI-RELATED UniProtKB/TrEMBL
Pfam AA_permease_2 UniProtKB/TrEMBL
  AA_permease_C UniProtKB/TrEMBL
PhenoGen Slc7a3l1 PhenoGen
PIRSF AA_transporter UniProtKB/TrEMBL
RatGTEx ENSRNOG00000054438 RatGTEx
UniProt D3ZBE1 ENTREZGENE, UniProtKB/TrEMBL
  Q4V799 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Slc7a3l1  solute carrier family 7 member 3 like 1  LOC292543  similar to solute carrier family 7 (cationic amino acid transporter, y+ system), member 3  Symbol and Name Changed 1299863 APPROVED
2006-02-09 LOC292543  similar to solute carrier family 7 (cationic amino acid transporter, y+ system), member 3      Symbol and Name status set to provisional 70820 PROVISIONAL