Kcnk5 (potassium two pore domain channel subfamily K member 5) - Rat Genome Database

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Gene: Kcnk5 (potassium two pore domain channel subfamily K member 5) Rattus norvegicus
Analyze
Symbol: Kcnk5
Name: potassium two pore domain channel subfamily K member 5
RGD ID: 1564985
Description: Predicted to enable outward rectifier potassium channel activity and potassium ion leak channel activity. Predicted to be involved in potassium ion export across plasma membrane and stabilization of membrane potential. Predicted to act upstream of or within potassium ion import across plasma membrane. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human KCNK5 (potassium two pore domain channel subfamily K member 5); INTERACTS WITH (+)-pilocarpine; 1-naphthyl isothiocyanate; 2,3,4,7,8-Pentachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC364241; potassium channel subfamily K member 5; potassium channel, subfamily K, member 5; potassium channel, two pore domain subfamily K, member 5; similar to potassium channel TASK2; TASK2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8154,171,625 - 4,213,896 (+)NCBIGRCr8
mRatBN7.2154,122,442 - 4,164,718 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl154,122,442 - 4,164,718 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx154,132,875 - 4,175,140 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0155,519,298 - 5,561,571 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0154,131,691 - 4,173,970 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0154,554,603 - 4,597,000 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl154,554,603 - 4,597,000 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0158,654,573 - 8,696,350 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4154,380,157 - 4,424,377 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera15435,951 - 478,379 (-)NCBICelera
Cytogenetic Map15p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diazinon  (ISO)
dibutyl phthalate  (ISO)
dorsomorphin  (ISO)
epoxiconazole  (ISO)
furan  (EXP)
glycidol  (EXP)
inulin  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
methoxychlor  (EXP)
N-methylformamide  (ISO)
nickel atom  (ISO)
O-methyleugenol  (ISO)
orphenadrine  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (ISO)
phenobarbital  (ISO)
pirinixic acid  (EXP)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sotorasib  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trametinib  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11834308   PMID:12477932   PMID:19424094   PMID:20351106   PMID:21976511   PMID:22017174  


Genomics

Comparative Map Data
Kcnk5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8154,171,625 - 4,213,896 (+)NCBIGRCr8
mRatBN7.2154,122,442 - 4,164,718 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl154,122,442 - 4,164,718 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx154,132,875 - 4,175,140 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0155,519,298 - 5,561,571 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0154,131,691 - 4,173,970 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0154,554,603 - 4,597,000 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl154,554,603 - 4,597,000 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0158,654,573 - 8,696,350 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4154,380,157 - 4,424,377 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera15435,951 - 478,379 (-)NCBICelera
Cytogenetic Map15p16NCBI
KCNK5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38639,188,971 - 39,229,475 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl639,188,971 - 39,229,475 (-)EnsemblGRCh38hg38GRCh38
GRCh37639,156,747 - 39,197,251 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36639,264,725 - 39,305,229 (-)NCBINCBI36Build 36hg18NCBI36
Build 34639,264,726 - 39,305,204NCBI
Celera640,710,161 - 40,750,667 (-)NCBICelera
Cytogenetic Map6p21.2NCBI
HuRef638,875,187 - 38,915,691 (-)NCBIHuRef
CHM1_1639,159,411 - 39,199,898 (-)NCBICHM1_1
T2T-CHM13v2.0639,013,409 - 39,053,895 (-)NCBIT2T-CHM13v2.0
Kcnk5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391420,190,125 - 20,231,850 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1420,190,125 - 20,231,877 (-)EnsemblGRCm39 Ensembl
GRCm381420,140,057 - 20,181,782 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1420,140,057 - 20,181,809 (-)EnsemblGRCm38mm10GRCm38
MGSCv371420,959,280 - 21,001,004 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361418,930,754 - 18,972,478 (-)NCBIMGSCv36mm8
Celera1416,520,969 - 16,562,590 (-)NCBICelera
Cytogenetic Map14A3NCBI
cM Map1411.43NCBI
Kcnk5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554374,275,784 - 4,313,774 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554374,275,806 - 4,313,772 (+)NCBIChiLan1.0ChiLan1.0
KCNK5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2553,685,936 - 53,726,507 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1649,555,540 - 49,596,095 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0638,778,331 - 38,818,792 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1639,958,996 - 39,999,513 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl639,958,996 - 39,999,513 (-)Ensemblpanpan1.1panPan2
KCNK5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1128,115,839 - 8,154,716 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl128,117,650 - 8,154,350 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha128,139,269 - 8,178,117 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0128,593,324 - 8,632,176 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl128,593,320 - 8,632,176 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1128,120,655 - 8,159,472 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0128,198,134 - 8,236,983 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0128,303,704 - 8,342,554 (-)NCBIUU_Cfam_GSD_1.0
Kcnk5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494643,508,018 - 43,549,602 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647620,410,594 - 20,452,183 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647620,410,631 - 20,452,172 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNK5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl734,617,956 - 34,656,697 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1734,617,948 - 34,656,705 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2739,704,462 - 39,743,271 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCNK5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11732,906,328 - 32,946,761 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1732,906,990 - 32,947,190 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604439,196,362 - 39,236,439 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnk5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475419,093,655 - 19,129,480 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475419,093,702 - 19,129,243 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kcnk5
231 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:582
Count of miRNA genes:265
Interacting mature miRNAs:332
Transcripts:ENSRNOT00000075153
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
5684946Bss98Bone structure and strength QTL 983.90.0026tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)15105825014481294Rat
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)colorectal tumor number (CMO:0001794)15226636822711984Rat
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15226636822711984Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat

Markers in Region
D15Got20  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2154,158,870 - 4,159,034 (+)MAPPERmRatBN7.2
Rnor_6.0154,591,156 - 4,591,318NCBIRnor6.0
Rnor_5.0158,690,479 - 8,690,664UniSTSRnor5.0
RGSC_v3.4154,418,507 - 4,418,695UniSTSRGSC3.4
RGSC_v3.4154,418,506 - 4,418,695RGDRGSC3.4
RGSC_v3.1154,418,507 - 4,418,695RGD
RH 3.4 Map1567.6UniSTS
RH 3.4 Map1567.6RGD
Cytogenetic Map15p16UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 8 8 8 8 35 10
Low 40 49 33 19 33 8 11 54 29 11 8
Below cutoff 3 12 2

Sequence


RefSeq Acc Id: ENSRNOT00000075153   ⟹   ENSRNOP00000065715
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl154,122,442 - 4,164,718 (+)Ensembl
Rnor_6.0 Ensembl154,554,603 - 4,597,000 (+)Ensembl
RefSeq Acc Id: NM_001039516   ⟹   NP_001034605
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8154,171,625 - 4,213,896 (+)NCBI
mRatBN7.2154,122,442 - 4,164,718 (+)NCBI
Rnor_6.0154,554,603 - 4,597,000 (+)NCBI
Rnor_5.0158,654,573 - 8,696,350 (+)NCBI
RGSC_v3.4154,380,157 - 4,424,377 (+)RGD
Celera15435,951 - 478,379 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001034605 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI29069 (Get FASTA)   NCBI Sequence Viewer  
  CAJ76245 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000065715
  ENSRNOP00000065715.3
RefSeq Acc Id: NP_001034605   ⟸   NM_001039516
- UniProtKB: Q2KTA6 (UniProtKB/TrEMBL),   M0R8B9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000065715   ⟸   ENSRNOT00000075153
Protein Domains
Potassium channel

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R8B9-F1-model_v2 AlphaFold M0R8B9 1-503 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699569
Promoter ID:EPDNEW_R10093
Type:single initiation site
Name:Kcnk5_1
Description:potassium two pore domain channel subfamily K member 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0154,554,615 - 4,554,675EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564985 AgrOrtholog
BioCyc Gene G2FUF-14526 BioCyc
Ensembl Genes ENSRNOG00000047005 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000075153 ENTREZGENE
  ENSRNOT00000075153.3 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7387039 IMAGE-MGC_LOAD
InterPro 2pore_dom_K_chnl UniProtKB/TrEMBL
  2pore_dom_K_chnl_TASK UniProtKB/TrEMBL
  Ion_trans_2 UniProtKB/TrEMBL
KEGG Report rno:364241 UniProtKB/TrEMBL
MGC_CLONE MGC:156464 IMAGE-MGC_LOAD
NCBI Gene 364241 ENTREZGENE
PANTHER POTASSIUM CHANNEL SUBFAMILY K MEMBER 5 UniProtKB/TrEMBL
  PTHR11003 UniProtKB/TrEMBL
Pfam Ion_trans_2 UniProtKB/TrEMBL
PhenoGen Kcnk5 PhenoGen
PRINTS 2POREKCHANEL UniProtKB/TrEMBL
  TASKCHANNEL UniProtKB/TrEMBL
RatGTEx ENSRNOG00000047005 RatGTEx
Superfamily-SCOP Voltage-gated potassium channels UniProtKB/TrEMBL
UniProt M0R8B9 ENTREZGENE
  Q2KTA6 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary M0R8B9 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kcnk5  potassium two pore domain channel subfamily K member 5  Kcnk5  potassium channel, two pore domain subfamily K, member 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcnk5  potassium channel, two pore domain subfamily K, member 5  Kcnk5  potassium channel, subfamily K, member 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 Kcnk5  potassium channel, subfamily K, member 5  LOC364241  similar to potassium channel TASK2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 LOC364241  similar to potassium channel TASK2      Symbol and Name status set to provisional 70820 PROVISIONAL