Magee2 (MAGE family member E2) - Rat Genome Database

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Gene: Magee2 (MAGE family member E2) Rattus norvegicus
Analyze
Symbol: Magee2
Name: MAGE family member E2
RGD ID: 1564872
Description: Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human MAGEE2 (MAGE family member E2); INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; endosulfan.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC302392; melanoma antigen, family E, 2; melanoma-associated antigen E2; RGD1564872; similar to melanoma antigen family E, 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X73,951,433 - 74,010,525 (+)NCBIGRCr8
mRatBN7.2X69,885,751 - 69,944,824 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX69,942,533 - 69,944,657 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX71,451,596 - 71,453,720 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X74,951,881 - 74,954,005 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X72,511,457 - 72,513,581 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X75,737,684 - 75,795,206 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX75,792,931 - 75,795,055 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X76,537,710 - 76,595,148 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X92,944,523 - 92,946,647 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX71,286,892 - 71,289,016 (+)NCBICelera
Cytogenetic MapXq22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IBA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Magee2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X73,951,433 - 74,010,525 (+)NCBIGRCr8
mRatBN7.2X69,885,751 - 69,944,824 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX69,942,533 - 69,944,657 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX71,451,596 - 71,453,720 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X74,951,881 - 74,954,005 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X72,511,457 - 72,513,581 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X75,737,684 - 75,795,206 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX75,792,931 - 75,795,055 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X76,537,710 - 76,595,148 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X92,944,523 - 92,946,647 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX71,286,892 - 71,289,016 (+)NCBICelera
Cytogenetic MapXq22NCBI
MAGEE2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X75,782,987 - 75,785,254 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX75,782,987 - 75,785,254 (-)EnsemblGRCh38hg38GRCh38
GRCh37X75,002,822 - 75,005,089 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X74,919,548 - 74,921,796 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X74,785,843 - 74,788,092NCBI
CeleraX75,286,151 - 75,288,407 (-)NCBICelera
Cytogenetic MapXq13.3NCBI
HuRefX68,636,741 - 68,638,996 (-)NCBIHuRef
CHM1_1X74,895,669 - 74,897,925 (-)NCBICHM1_1
T2T-CHM13v2.0X74,216,673 - 74,218,940 (-)NCBIT2T-CHM13v2.0
Magee2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X103,898,558 - 103,900,873 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX103,898,558 - 103,900,873 (-)EnsemblGRCm39 Ensembl
GRCm38X104,854,952 - 104,857,267 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX104,854,952 - 104,857,267 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X102,050,291 - 102,052,606 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X101,057,671 - 101,059,875 (-)NCBIMGSCv36mm8
CeleraX91,728,756 - 91,731,078 (-)NCBICelera
Cytogenetic MapXDNCBI
cM MapX46.77NCBI
Magee2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555621,804,437 - 1,807,099 (-)NCBIChiLan1.0ChiLan1.0
MAGEE2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X75,429,205 - 75,431,629 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X75,432,855 - 75,435,242 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X65,030,659 - 65,033,059 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X75,141,998 - 75,144,309 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX75,142,500 - 75,144,068 (-)Ensemblpanpan1.1panPan2
MAGEE2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X58,877,193 - 58,879,518 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX58,877,722 - 58,879,293 (-)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0X60,109,448 - 60,111,767 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX60,109,982 - 60,111,553 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X57,797,220 - 57,799,539 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X59,417,054 - 59,419,373 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X59,015,922 - 59,018,241 (-)NCBIUU_Cfam_GSD_1.0
Magee2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X43,256,515 - 43,258,796 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366831,689,463 - 1,691,034 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366831,688,981 - 1,691,250 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAGEE2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX60,709,534 - 60,711,829 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X60,707,490 - 60,711,883 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MAGEE2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X65,244,718 - 65,247,582 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX65,245,359 - 65,246,930 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606716,359,398 - 16,362,396 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Magee2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248365,040,440 - 5,042,334 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Magee2
98 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:265
Count of miRNA genes:187
Interacting mature miRNAs:212
Transcripts:ENSRNOT00000037575
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X65612192120568734Rat

Markers in Region
UniSTS:238063  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X69,943,972 - 69,944,067 (+)MAPPERmRatBN7.2
Rnor_6.0X75,794,371 - 75,794,465NCBIRnor6.0
Rnor_5.0X76,594,328 - 76,594,422UniSTSRnor5.0
RGSC_v3.4X92,945,963 - 92,946,057UniSTSRGSC3.4
CeleraX71,288,332 - 71,288,426UniSTS
Cytogenetic MapXq31UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 33 6
Low 1 26 7 6 6 41 20 34
Below cutoff 2 10 21 17 5 17 4 4 12 1 9 4

Sequence


RefSeq Acc Id: ENSRNOT00000037575   ⟹   ENSRNOP00000038850
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX69,942,533 - 69,944,657 (+)Ensembl
Rnor_6.0 EnsemblX75,792,931 - 75,795,055 (+)Ensembl
RefSeq Acc Id: NM_001106941   ⟹   NP_001100411
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X74,008,229 - 74,010,353 (+)NCBI
mRatBN7.2X69,942,533 - 69,944,657 (+)NCBI
Rnor_6.0X75,792,931 - 75,795,055 (+)NCBI
Rnor_5.0X76,537,710 - 76,595,148 (+)NCBI
RGSC_v3.4X92,944,523 - 92,946,647 (+)RGD
CeleraX71,286,892 - 71,289,016 (+)RGD
Sequence:
RefSeq Acc Id: XM_006257144   ⟹   XP_006257206
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X73,951,433 - 74,010,525 (+)NCBI
mRatBN7.2X69,885,751 - 69,944,824 (+)NCBI
Rnor_6.0X75,737,684 - 75,795,206 (+)NCBI
Rnor_5.0X76,537,710 - 76,595,148 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001100411 (Get FASTA)   NCBI Sequence Viewer  
  XP_006257206 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM07160 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000038850
  ENSRNOP00000038850.4
RefSeq Acc Id: NP_001100411   ⟸   NM_001106941
- UniProtKB: D4A6M8 (UniProtKB/TrEMBL),   A6IV20 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257206   ⟸   XM_006257144
- Peptide Label: isoform X1
- UniProtKB: D4A6M8 (UniProtKB/TrEMBL),   A6IV20 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000038850   ⟸   ENSRNOT00000037575
Protein Domains
MAGE

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A6M8-F1-model_v2 AlphaFold D4A6M8 1-523 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564872 AgrOrtholog
BioCyc Gene G2FUF-1977 BioCyc
Ensembl Genes ENSRNOG00000021400 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000037575 ENTREZGENE
  ENSRNOT00000037575.5 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.1200 UniProtKB/TrEMBL
  1.10.10.1210 UniProtKB/TrEMBL
InterPro MAGE UniProtKB/TrEMBL
  MAGE UniProtKB/TrEMBL
  MAGE_WH1 UniProtKB/TrEMBL
  MAGE_WH2 UniProtKB/TrEMBL
KEGG Report rno:302392 UniProtKB/TrEMBL
NCBI Gene 302392 ENTREZGENE
PANTHER MELANOMA-ASSOCIATED ANTIGEN E2 UniProtKB/TrEMBL
  PTHR11736 UniProtKB/TrEMBL
Pfam MAGE UniProtKB/TrEMBL
PhenoGen Magee2 PhenoGen
PROSITE MAGE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000021400 RatGTEx
SMART MAGE UniProtKB/TrEMBL
UniProt A6IV20 ENTREZGENE, UniProtKB/TrEMBL
  D4A6M8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-19 Magee2  MAGE family member E2  Magee2  melanoma antigen, family E, 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Magee2  melanoma antigen, family E, 2   Magee2_predicted  melanoma antigen, family E, 2 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Magee2_predicted  melanoma antigen, family E, 2 (predicted)  RGD1564872_predicted  similar to melanoma antigen family E, 2 (predicted)  Symbol and Name updated 1299863 APPROVED
2006-03-07 RGD1564872_predicted  similar to melanoma antigen family E, 2 (predicted)  LOC302392  similar to melanoma antigen family E, 2  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC302392  similar to melanoma antigen family E, 2      Symbol and Name status set to provisional 70820 PROVISIONAL