Ctsml1 (cathepsin M like 1) - Rat Genome Database

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Pathways
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Gene: Ctsml1 (cathepsin M like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Ctsml1 (Ensembl: RGD1564827)
Name: cathepsin M like 1 (Ensembl:similar to cathepsin M)
RGD ID: 1564827
Description: Predicted to enable cysteine-type endopeptidase activator activity involved in apoptotic process and cysteine-type endopeptidase activity. Predicted to be involved in immune response; positive regulation of apoptotic signaling pathway; and proteolysis involved in protein catabolic process. Predicted to be active in extracellular space and lysosome; INTERACTS WITH bisphenol A; testosterone; trichloroethene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cathepsin M-like; Ctcml1; LOC498689; RGD1564827; similar to cathepsin M
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8173,757,611 - 3,765,657 (-)NCBIGRCr8
mRatBN7.2173,752,000 - 3,760,046 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl173,752,000 - 3,760,046 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx173,771,541 - 3,779,585 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0175,313,179 - 5,321,221 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0173,767,984 - 3,776,026 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0174,119,288 - 4,123,365 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl174,118,600 - 4,123,302 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0176,346,721 - 6,428,163 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4179,401,380 - 9,445,597 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera173,881,115 - 3,885,039 (-)NCBICelera
Cytogenetic Map17p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Ctsml1
37 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:85
Count of miRNA genes:77
Interacting mature miRNAs:82
Transcripts:ENSRNOT00000039754
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122871563Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131701463Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17131990913Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)17211514921881669Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat
631499Stl1Serum triglyceride level QTL 13.6blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)17327139827389946Rat

Markers in Region
RH140558  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map1731.2UniSTS
Cytogenetic Map17p14UniSTS
AI013770  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2173,704,578 - 3,704,696 (+)MAPPERmRatBN7.2
Rnor_6.0174,067,900 - 4,068,017NCBIRnor6.0
Rnor_5.0176,297,132 - 6,297,249UniSTSRnor5.0
RGSC_v3.4179,424,911 - 9,425,028UniSTSRGSC3.4
Celera173,833,495 - 3,833,612UniSTS
RH 3.4 Map1747.6UniSTS
Cytogenetic Map17p14UniSTS
AI180278  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2173,240,823 - 3,241,939 (+)MAPPERmRatBN7.2
mRatBN7.2173,752,325 - 3,753,435 (+)MAPPERmRatBN7.2
Rnor_6.0174,119,536 - 4,120,655NCBIRnor6.0
Rnor_6.0173,824,574 - 3,825,689NCBIRnor6.0
Rnor_5.0176,045,812 - 6,046,927UniSTSRnor5.0
Rnor_5.0176,346,938 - 6,348,057UniSTSRnor5.0
RGSC_v3.4178,935,435 - 8,936,550UniSTSRGSC3.4
Celera173,372,178 - 3,373,293UniSTS
RH 3.4 Map1716.0UniSTS
Cytogenetic Map17p14UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system hemolymphoid system nervous system reproductive system
High
Medium
Low 9 2
Below cutoff 18 2 9 12

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000039754   ⟹   ENSRNOP00000036689
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl173,752,000 - 3,760,046 (-)Ensembl
Rnor_6.0 Ensembl174,118,600 - 4,123,302 (-)Ensembl
RefSeq Acc Id: NM_001402532   ⟹   NP_001389461
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8173,757,611 - 3,765,657 (-)NCBI
mRatBN7.2173,752,000 - 3,760,046 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001389461 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000036689
  ENSRNOP00000036689.7
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000036689   ⟸   ENSRNOT00000039754
RefSeq Acc Id: NP_001389461   ⟸   NM_001402532
- Peptide Label: precursor
- UniProtKB: D3ZFE5 (UniProtKB/TrEMBL)
Protein Domains
Cathepsin propeptide inhibitor   Peptidase C1A papain C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZFE5-F1-model_v2 AlphaFold D3ZFE5 1-334 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564827 AgrOrtholog
BioCyc Gene G2FUF-10475 BioCyc
Ensembl Genes ENSRNOG00000017806 Ensembl
  ENSRNOG00000069712 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000039754 ENTREZGENE
  ENSRNOT00000039754.7 UniProtKB/TrEMBL
Gene3D-CATH Cysteine proteinases UniProtKB/TrEMBL
InterPro Papain_like_cys_pep_sf UniProtKB/TrEMBL
  Pept_his_AS UniProtKB/TrEMBL
  Peptidase_C1A UniProtKB/TrEMBL
  Peptidase_C1A_C UniProtKB/TrEMBL
  Peptidase_C1A_papain-like UniProtKB/TrEMBL
  Prot_inhib_I29 UniProtKB/TrEMBL
KEGG Report rno:498689 UniProtKB/TrEMBL
NCBI Gene 498689 ENTREZGENE
PANTHER CATHEPSIN M-RELATED UniProtKB/TrEMBL
  CYSTEINE PROTEASE FAMILY C1-RELATED UniProtKB/TrEMBL
Pfam Inhibitor_I29 UniProtKB/TrEMBL
  Peptidase_C1 UniProtKB/TrEMBL
PhenoGen Ctsml1 PhenoGen
PRINTS PAPAIN UniProtKB/TrEMBL
PROSITE THIOL_PROTEASE_HIS UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017806 RatGTEx
  ENSRNOG00000069712 RatGTEx
SMART Inhibitor_I29 UniProtKB/TrEMBL
  Pept_C1 UniProtKB/TrEMBL
Superfamily-SCOP SSF54001 UniProtKB/TrEMBL
UniProt D3ZFE5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Ctsml1  cathepsin M like 1  RGD1564827  similar to cathepsin M  Symbol and Name Changed 1299863 APPROVED
2022-06-02 RGD1564827  similar to cathepsin M  RGD1564827  similar to cathepsin M  Data merged from RGD:149736328 737654 PROVISIONAL
2021-08-09 RGD1564827  similar to cathepsin M      Symbol and Name status set to provisional 45752 PROVISIONAL
2013-05-24 RGD1564827  similar to cathepsin M  LOC683347  similar to cathepsin M  Data merged from RGD:1588022 1643240 APPROVED
2008-04-30 RGD1564827  similar to cathepsin M   RGD1564827_predicted  similar to cathepsin M (predicted)  'predicted' is removed 2292626 APPROVED
2006-11-19 LOC683347  similar to cathepsin M      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-07 RGD1564827_predicted  similar to cathepsin M (predicted)  LOC498689  similar to cathepsin M  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498689  similar to cathepsin M      Symbol and Name status set to provisional 70820 PROVISIONAL